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Article: Factors associated with functional decline in COVID-19 elderly survivors hospitalized in a tertiary care center.

Sandoval-Valdez, Darío A / Aguilar-Navarro, Sara G

2023 Volume 159, Issue 5, Page(s) 405–413

Abstract: Background: The information on functional decline after hospitalization for COVID-19 is limited in older adults (OAs).: Objective: To determine the association of inflammation (ferritin) and coagulation markers (D-dimer) and clinical factors with the ...

Title translation	Factores asociados al deterioro funcional en adultos mayores sobrevivientes de COVID-19 hospitalizados en un centro de tercer nivel.
Abstract	Background: The information on functional decline after hospitalization for COVID-19 is limited in older adults (OAs). Objective: To determine the association of inflammation (ferritin) and coagulation markers (D-dimer) and clinical factors with the functional status of OAs who suffered from COVID-19 six months after hospital discharge in Mexico. Material and methods: Ambispective cohort study of 158 patients older than 65 years hospitalized for moderate-severe COVID-19 with complete electronic records that would allow to collect information and to contact them six months after discharge. Functional impairment was defined as a decrease ≥ 10 points on the Barthel index. Using logistic regression analysis, the risk of association of biochemical and clinical factors with functional deterioration during follow-up was determined. Results: 46.2% of participants exhibited functional decline. Associated factors included age ≥ 73 years (OR = 2.53), chronic kidney disease (OR = 4.57), an ABC-Goals score ≥ 8 (OR = 2.4), ferritin ≥ 605 ng/mL (OR = 3.94) and D-dimer ≥ 930 ng/mL (OR = 17.56). Conclusion: COVID-19 infection did not only represent a disease with a high risk of mortality during the acute phase, but is also associated with a high risk of functional impairment after hospital discharge.
MeSH term(s)	Humans ; Aged ; COVID-19/epidemiology ; Cohort Studies ; Tertiary Care Centers ; Hospitalization ; Ferritins ; Risk Factors
Chemical Substances	Ferritins (9007-73-2)
Language	English
Publishing date	2023-12-14
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
DOI	10.24875/GMM.M23000822
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Article: ASSOCIATION BETWEEN APOE-ε

Mimenza-Alvarado, Alberto J / Suing-Ortega, María J / Tusie-Luna, Teresa / Juárez-Cedillo, Teresa / Ávila-Funes, José A / Aguilar-Navarro, Sara G

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2022 Volume 74, Issue 2, Page(s) 113–120

Abstract: Background: The pathogenesis of mild cognitive impairment (MCI) is multifactorial and includes the presence of genetic variants such as the ε: Objective: The objective of the study was to determine the association between APOE-ε: Methods: A cross- ... ...

Abstract	Background: The pathogenesis of mild cognitive impairment (MCI) is multifactorial and includes the presence of genetic variants such as the ε Objective: The objective of the study was to determine the association between APOE-ε Methods: A cross-sectional study of 72 adults aged 60 years or above who underwent an exhaustive clinical, neuroimaging, and neuropsychological evaluation. Multivariate logistic regression models were constructed to determine the association between APOE-ε Results: Mean age was 75.2 years (± 7.2) and 64% were female. Twenty-one participants were cognitively normal and 51 had MCI. Almost 56% were APOE-ε Conclusion: The APOE-ε
MeSH term(s)	Aged ; Alzheimer Disease/genetics ; Apolipoprotein E4/genetics ; Cognitive Dysfunction/genetics ; Cross-Sectional Studies ; Female ; Humans ; Middle Aged ; Neuroimaging
Chemical Substances	Apolipoprotein E4
Language	English
Publishing date	2022-03-30
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
DOI	10.24875/RIC.21000550
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Article: OLFACTORY DISORDERS IN SARS-COV-2 INFECTION: CONSIDERATIONS IN AGING.

Mimenza-Alvarado, Alberto J / Avila-Funes, José A / Aguilar-Navarro, Sara G

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2020 Volume 72, Issue 3, Page(s) 135–137

MeSH term(s)	Aged ; Aged, 80 and over ; Aging/physiology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Humans ; Olfaction Disorders/epidemiology ; Olfaction Disorders/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-06-17
Publishing country	Mexico
Document type	Journal Article ; Review
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
DOI	10.24875/RIC.20000157
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Article: Association between vitamin B

Aguilar-Navarro, Sara G / Carbajal-Silva, Juan C / Palacios-Hernández, María G I / Gutiérrez-Gutierrez, Lidia A / Ávila-Funes, José A / Mimenza-Alvarado, Alberto J

Gaceta medica de Mexico

2023 Volume 159, Issue 1, Page(s) 32–37

Abstract: Introduction: Whether vitamin B: Objective: To determine the association between vitamin B: Methods: Two-hundred and forty-one adults aged ≥ 60 years who had serum vitamin B: Results: Mean age was 81.4 ± 8.0 years; 68% were females; 17.8 % and ... ...

Title translation	Asociación entre los niveles de vitamina B
Abstract	Introduction: Whether vitamin B Objective: To determine the association between vitamin B Methods: Two-hundred and forty-one adults aged ≥ 60 years who had serum vitamin B Results: Mean age was 81.4 ± 8.0 years; 68% were females; 17.8 % and 39.8% had absolute and subclinical vitamin B Conclusions: A statistically significant association was observed between global cognitive performance and levels of vitamin B
MeSH term(s)	Female ; Humans ; Aged ; Aged, 80 and over ; Male ; Vitamin B 12 ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/etiology ; Cognition Disorders ; Cognition ; Dementia/epidemiology ; Dementia/etiology ; Vitamins
Chemical Substances	Vitamin B 12 (P6YC3EG204) ; Vitamins
Language	English
Publishing date	2023-03-17
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
DOI	10.24875/GMM.M22000733
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Article ; Online: Prevalence and incidence of possible vascular dementia among Mexican older adults: Analysis of the Mexican Health and Aging Study.

Yeverino-Castro, Sara G / Mejía-Arango, Silvia / Mimenza-Alvarado, Alberto J / Cantú-Brito, Carlos / Avila-Funes, José A / Aguilar-Navarro, Sara G

PloS one

2021 Volume 16, Issue 7, Page(s) e0253856

Abstract: Introduction: Vascular dementia is the second most common cause of dementia. Physical disability and cognitive impairment due to stroke are conditions that considerably affect quality of life. We estimated the prevalence and incidence of possible ... ...

Abstract	Introduction: Vascular dementia is the second most common cause of dementia. Physical disability and cognitive impairment due to stroke are conditions that considerably affect quality of life. We estimated the prevalence and incidence of possible vascular dementia (PVD) in older adults using data from the Mexican Health and Aging Study (MHAS 2012 and 2015 waves). Methods: The MHAS is a representative longitudinal cohort study of Mexican adults aged ≥50 years. Data from 14, 893 participants from the 2012 cohort and 14,154 from the 2015 cohort were analyzed to estimate the prevalence and incidence of PVD. Self-respondents with history of stroke were classified as PVD if scores in two or more cognitive domains in the Cross-Cultural Cognitive Examination were ≥ 1.5 standard deviations below the mean on reference norms and if limitations in ≥ 1 instrumental activities of daily living were present. For proxy respondents with history of stroke, we used a score ≥3.4 on the Informant Questionnaire on Cognitive Decline in the Elderly. Crude and standardized rates of prevalent and incident PVD were estimated. Results: Prevalence of PVD was 0.6% (95% CI, 0.5-0.8) (0.5 with age and sex- standardization). Rates increased with age reaching 2.0% among those aged 80 and older and decreased with educational attainment. After 3.0 years of follow-up, 87 new cases of PVD represented an overall incident rate of 2.2 (95% CI, 1.7-2.6) per 1,000 person-years (2.0 with age and sex- standardization). Incidence also increased with advancing age reaching an overall rate of 9.4 (95% CI, 6.3-13.6) per 1,000 person-years for participants aged >80 years. Hypertension and depressive symptoms were strong predictors of incident PVD. Conclusion: These data provide new estimates of PVD prevalence and incidence in the Mexican population. We found that PVD incidence increased with age. Males aged 80 years or older showed a greater incidence rate when compared to females, which is comparable to previous estimates from other studies.
MeSH term(s)	Activities of Daily Living ; Age Factors ; Aged ; Aged, 80 and over ; Aging/physiology ; Dementia, Vascular/diagnosis ; Dementia, Vascular/epidemiology ; Dementia, Vascular/etiology ; Dementia, Vascular/physiopathology ; Female ; Health Surveys/statistics & numerical data ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Prevalence ; Quality of Life ; Risk Factors ; Sex Factors ; Stroke/complications ; Stroke/epidemiology
Language	English
Publishing date	2021-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0253856
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Article: Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older Adults.

Aguilar-Navarro, Sara G / Gonzalez-Aparicio, Itzel I / Avila-Funes, José Alberto / Juárez-Cedillo, Teresa / Tusié-Luna, Teresa / Mimenza-Alvarado, Alberto Jose

Brain sciences

2021 Volume 11, Issue 1

Abstract: Mild cognitive impairment (MCI) (amnestic or non-amnestic) has different clinical and neuropsychological characteristics, and its evolution is heterogeneous. Cardiovascular risk factors (CVRF), such as hypertension, diabetes, or dyslipidemia, and the ... ...

Abstract	Mild cognitive impairment (MCI) (amnestic or non-amnestic) has different clinical and neuropsychological characteristics, and its evolution is heterogeneous. Cardiovascular risk factors (CVRF), such as hypertension, diabetes, or dyslipidemia, and the presence of the Apolipoprotein E ε4 (ApoE ε4) polymorphism have been associated with an increased risk of developing Alzheimer's disease (AD) and other dementias but the relationship is inconsistent worldwide. We aimed to establish the association between the ApoE ε4 carrier status and CVRF on MCI subtypes (amnestic and non-amnestic) in Mexican older adults. Cross-sectional study including 137 older adults (
Language	English
Publishing date	2021-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci11010068
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Article ; Online: The Social Vulnerability Index, Mortality and Disability in Mexican Middle-Aged and Older Adults.

Sánchez-Garrido, Natalia / Aguilar-Navarro, Sara G / Ávila-Funes, José Alberto / Theou, Olga / Andrew, Melissa / Pérez-Zepeda, Mario Ulises

Geriatrics (Basel, Switzerland)

2021 Volume 6, Issue 1

Abstract: The social vulnerability index (SVI) independently predicts mortality and others adverse outcomes across different populations. There is no evidence that the SVI can predict adverse outcomes in individuals living in countries with high social ... ...

Abstract	The social vulnerability index (SVI) independently predicts mortality and others adverse outcomes across different populations. There is no evidence that the SVI can predict adverse outcomes in individuals living in countries with high social vulnerability such as Latin America. The aim of this study was to analyze the association of the SVI with mortality and disability in Mexican middle-aged and older adults. This is a longitudinal study with a follow-up of 47 months, the Mexican Health and Aging Study, including people over the age of 40 years. A SVI was calculated using 42 items stratified in three categories low (<0.36), medium (0.36-0.47), and high (>0.47) vulnerability. We examined the association of SVI with three-year mortality and incident disability. Cox and logistic regression models were fitted to test these associations. We included 14,217 participants (58.4% women) with a mean age of 63.9 years (±SD 10.1). The mean SVI was of 0.42 (±SD 0.12). Mortality rate at three years was 6% (n = 809) and incident disability was 13.2% (n = 1367). SVI was independently associated with mortality, with a HR of 1.4 (95% CI 1.1-1.8,
Language	English
Publishing date	2021-03-08
Publishing country	Switzerland
Document type	Journal Article
ISSN	2308-3417
ISSN (online)	2308-3417
DOI	10.3390/geriatrics6010024
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Article ; Online: Five-Word Test, Screening of Mixed Dementia in Older Adults. Validation Study.

Mimenza-Alvarado, Alberto J / Bombón-Albán, Paulina / Duarte-Flores, J Octavio / Gutiérrez-Gutiérrez, Lidia / Ávila-Funes, J Alberto / Aguilar-Navarro, Sara G

Revista Colombiana de psiquiatria (English ed.)

2021

Abstract: Introduction and objectives: The prevalence of mixed dementia (MixD), defined as the coexistence of Alzheimer's disease (AD) and vascular dementia (VaD), is likely to increase as the population ages. The five-word test (5WT) is a neuropsychological test ...

Abstract	Introduction and objectives: The prevalence of mixed dementia (MixD), defined as the coexistence of Alzheimer's disease (AD) and vascular dementia (VaD), is likely to increase as the population ages. The five-word test (5WT) is a neuropsychological test that differentiates between major and mild neurocognitive disorder (NCD). The objective of the study is to validate 5WT for the detection of MixD. Methods: 230 participants were evaluated: cognitively healthy (CH) (n=70), mild NCD (n=70), and major NCD (n=90): AD (n=30), VaD (n=30), and MixD (n=30). The Spearman's coefficient, d Sommer and ROC curves were used to determine the construct validity of the 5WT. The linear regression model was performed to determine the association between age and education with 5WT performance. Results: The mean age was 79 ±7.7 years (P≤.001), 58% were female (P=.252), and the mean education was 9 ±5.3 years (P≤.001). Construct validity when comparing 5WT and MMSE was: Spearman's correlation ρ=.830 (P<.001) and d Sommer=.41 (P<.001). The area under the curve in the total weighted score (TWS) for MixD was .985, with 98% sensitivity (95%CI, 0.96-1.00) and 99% specificity (95%CI, 0.94-1.00), PPV of 88% (95%CI, 0.82-0.89), NPV of 100% (95%CI, 0.96-1.00), and cut-off point ≤16/20 (P<.001). Conclusions: 5WT is a rapid test with neuropsychological validation for the exploration of cognitive characteristics in major NCD type MixD, regardless of age and education.
Language	Spanish
Publishing date	2021-07-02
Publishing country	Spain
Document type	Journal Article
ISSN	2530-3120
ISSN (online)	2530-3120
DOI	10.1016/j.rcp.2021.04.009
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Article ; Online: Prevalence of Dementia and Main Subtypes in Mexico: The Study on Aging and Dementia in Mexico (SADEM).

Juarez-Cedillo, Teresa / Gonzelez-Figueroa, Evangelina / Gutierez-Gutierez, Lidia / Aguilar-Navarro, Sara G / Garcia-Cruz, Juan Carlos / Escobedo de la Peña, Jorge / Suerna-Hernandez, Alan

Journal of Alzheimer's disease : JAD

2022 Volume 89, Issue 3, Page(s) 931–941

Abstract: Background: Dementia is a priority public health issue due to its high prevalence worldwide and its economic, social, and health impact. However, there are few reports in Mexico based on formal tests and with a clinical approach based on the Diagnostic ... ...

Abstract	Background: Dementia is a priority public health issue due to its high prevalence worldwide and its economic, social, and health impact. However, there are few reports in Mexico based on formal tests and with a clinical approach based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5). Objective: This study estimates the prevalence of the main types of dementia among elderly people living in the community in Mexico City. Methods: A population-based, two-step study was conducted, including 6,204 elderly individuals aged 60 or above with in-home assessment. All participants were screened for cognitive impairment; those who presented some cognitive problem underwent a standardized neurological examination. Each diagnosis was based on the criteria for dementia in the DSM-5, and the final consensus diagnosis of dementia was determined by an expert panel. Results: The global estimated prevalence of dementia in the Mexican population was 7.8% met the criteria for Alzheimer's disease, 4.3% for vascular dementia, and 2.1% for mixed dementia. The prevalence of dementia was higher in women than in men (15.3% versus 12.5%, respectively). Conclusion: These results provide evidence to propose strategies for Latin American countries where dementia represents a challenge due to the heterogeneity of the populations and socioeconomic disparities, requiring early diagnosis and at the first levels of care.
MeSH term(s)	Aged ; Aging ; Alzheimer Disease/diagnosis ; Dementia/diagnosis ; Dementia/epidemiology ; Dementia/psychology ; Female ; Humans ; Male ; Mexico/epidemiology ; Prevalence
Language	English
Publishing date	2022-08-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-220012
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Article: Olfactory Disorders in Sars-cov-2 Infection: Considerations in Aging

Mimenza-Alvarado, Alberto J / Avila-Funes, José A / Aguilar-Navarro, Sara G

Rev Invest Clin

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #617011
Database	COVID19

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