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Article ; Online: Novel Therapeutic Approaches to Prevent Atherothrombotic Ischemic Stroke in Patients with Carotid Atherosclerosis.

Puig, Núria / Solé, Arnau / Aguilera-Simon, Ana / Griñán, Raquel / Rotllan, Noemi / Camps-Renom, Pol / Benitez, Sonia

International journal of molecular sciences

2023 Volume 24, Issue 18

Abstract: Atherothrombotic stroke represents approximately 20% of all ischemic strokes. It is caused by large-artery atherosclerosis, mostly in the internal carotid artery, and it is associated with a high risk of early recurrence. After an ischemic stroke, tissue ...

Abstract	Atherothrombotic stroke represents approximately 20% of all ischemic strokes. It is caused by large-artery atherosclerosis, mostly in the internal carotid artery, and it is associated with a high risk of early recurrence. After an ischemic stroke, tissue plasminogen activator is used in clinical practice, although it is not possible in all patients. In severe clinical situations, such as high carotid stenosis (≥70%), revascularization by carotid endarterectomy or by stent placement is carried out to avoid recurrences. In stroke prevention, the pharmacological recommendations are based on antithrombotic, lipid-lowering, and antihypertensive therapy. Inflammation is a promising target in stroke prevention, particularly in ischemic strokes associated with atherosclerosis. However, the use of anti-inflammatory strategies has been scarcely studied. No clinical trials are clearly successful and most preclinical studies are focused on protection after a stroke. The present review describes novel therapies addressed to counteract inflammation in the prevention of the first-ever or recurrent stroke. The putative clinical use of broad-spectrum and specific anti-inflammatory drugs, such as monoclonal antibodies and microRNAs (miRNAs) as regulators of atherosclerosis, will be outlined. Further studies are necessary to ascertain which patients may benefit from anti-inflammatory agents and how.
MeSH term(s)	Humans ; Ischemic Stroke ; Tissue Plasminogen Activator ; Carotid Artery Diseases/complications ; Carotid Artery Diseases/drug therapy ; Atherosclerosis/complications ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Stroke/drug therapy ; Stroke/etiology ; Stroke/prevention & control ; Inflammation
Chemical Substances	Tissue Plasminogen Activator (EC 3.4.21.68)
Language	English
Publishing date	2023-09-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241814325
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Article ; Online: Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by

Garcia, Eduardo / Camps-Renom, Pol / Puig, Núria / Fernández-Leon, Alejandro / Aguilera-Simón, Ana / Benitez-Amaro, Aleyda / Solé, Arnau / Vilades, David / Sanchez-Quesada, José Luis / Martí-Fàbregas, Joan / Jiménez-Xarrié, Elena / Benitez, Sonia / Llorente-Cortés, Vicenta

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 131

Abstract: Background: 18: Aim: Our aim was to evaluate the performance of soluble low-density lipoprotein receptor-related protein 1 (sLRP1) as an indicator of carotid plaque inflammation.: Methods: A prospective study was conducted among adult patients ... ...

Abstract	Background: 18 Aim: Our aim was to evaluate the performance of soluble low-density lipoprotein receptor-related protein 1 (sLRP1) as an indicator of carotid plaque inflammation. Methods: A prospective study was conducted among adult patients with recent (< 7 days) anterior circulation ischemic stroke and at least one atherosclerotic plaque in the ipsilateral internal carotid artery. Patients underwent an early (< 15 days from inclusion) Results: The study was conducted with 64 participants, of which 57.8% had ≥ 50% carotid stenosis. The multivariable linear and logistic regression analyses showed that sLRP1 was independently associated with (i) SUVmax within the plaque (β = 0.159, 95% CI 0.062-0.257, p = 0.002) and (ii) a probability of presenting SUVmax ≥ 2.85 g/mL (OR = 1.31, 95% CI 1.00-1.01, p = 0.046), respectively. Participants with stroke recurrence showed higher sLRP1 levels at baseline [6447 ng/mL (4897-11163) vs. 3713 ng/mL (2793-4730); p = 0.018]. Conclusions: sLRP1 was independently associated with carotid plaque inflammation as measured by
MeSH term(s)	Adult ; Humans ; Ischemic Stroke ; Fluorodeoxyglucose F18 ; Plaque, Atherosclerotic/diagnostic imaging ; Prospective Studies ; Stroke/diagnostic imaging ; Biomarkers ; Inflammation ; Lipoproteins, LDL
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Biomarkers ; Lipoproteins, LDL
Language	English
Publishing date	2023-02-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-022-03867-w
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Article ; Online: Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke.

Puig, Núria / Camps-Renom, Pol / Camacho, Mercedes / Aguilera-Simón, Ana / Jiménez-Altayó, Francesc / Fernández-León, Alejandro / Marín, Rebeca / Martí-Fàbregas, Joan / Sánchez-Quesada, Jose Luis / Jiménez-Xarrié, Elena / Benitez, Sonia

Translational stroke research

2022 Volume 13, Issue 5, Page(s) 745–756

Abstract: ... ...

Abstract	18
MeSH term(s)	Biomarkers ; Carotid Stenosis/complications ; Carotid Stenosis/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Inflammation/complications ; Intercellular Adhesion Molecule-1 ; Ischemic Stroke ; Plaque, Atherosclerotic/complications ; Plaque, Atherosclerotic/diagnostic imaging ; Positron-Emission Tomography ; Prospective Studies ; Stroke/complications
Chemical Substances	Biomarkers ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Intercellular Adhesion Molecule-1 (126547-89-5)
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541897-X
ISSN	1868-601X ; 1868-4483
ISSN (online)	1868-601X
ISSN	1868-4483
DOI	10.1007/s12975-022-01002-x
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Article ; Online: Electronegative LDL Is Associated with Plaque Vulnerability in Patients with Ischemic Stroke and Carotid Atherosclerosis

Puig, Núria / Camps-Renom, Pol / Solé, Arnau / Aguilera-Simón, Ana / Jiménez-Xarrié, Elena / Fernández-León, Alejandro / Camacho, Mercedes / Guasch-Jiménez, Marina / Marin, Rebeca / Martí-Fàbregas, Joan / Martínez-Domeño, Alejandro / Prats-Sánchez, Luis / Casoni, Francesca / Pérez, Belén / Jiménez-Altayó, Francesc / Sánchez-Quesada, Jose Luis / Benitez, Sonia

Antioxidants. 2023 Feb. 10, v. 12, no. 2

2023

Abstract: Owing to the high risk of recurrence, identifying indicators of carotid plaque vulnerability in atherothrombotic ischemic stroke is essential. In this study, we aimed to identify modified LDLs and antioxidant enzymes associated with plaque vulnerability ... ...

Abstract	Owing to the high risk of recurrence, identifying indicators of carotid plaque vulnerability in atherothrombotic ischemic stroke is essential. In this study, we aimed to identify modified LDLs and antioxidant enzymes associated with plaque vulnerability in plasma from patients with a recent ischemic stroke and carotid atherosclerosis. Patients underwent an ultrasound, a CT-angiography, and an ¹⁸F-FDG PET. A blood sample was obtained from patients (n = 64, 57.8% with stenosis ≥50%) and healthy controls (n = 24). Compared to the controls, patients showed lower levels of total cholesterol, LDL cholesterol, HDL cholesterol, apolipoprotein B (apoB), apoA-I, apoA-II, and apoE, and higher levels of apoJ. Patients showed lower platelet-activating factor acetylhydrolase (PAF-AH) and paraoxonase-1 (PON-1) enzymatic activities in HDL, and higher plasma levels of oxidized LDL (oxLDL) and electronegative LDL (LDL(−)). The only difference between patients with stenosis ≥50% and <50% was the proportion of LDL(−). In a multivariable logistic regression analysis, the levels of LDL(−), but not of oxLDL, were independently associated with the degree of carotid stenosis (OR: 5.40, CI: 1.15–25.44, p < 0.033), the presence of hypoechoic plaque (OR: 7.52, CI: 1.26–44.83, p < 0.027), and of diffuse neovessels (OR: 10.77, CI: 1.21–95.93, p < 0.033), indicating that an increased proportion of LDL(−) is associated with vulnerable atherosclerotic plaque.
Keywords	antioxidants ; apolipoprotein B ; atherosclerosis ; blood sampling ; high density lipoprotein cholesterol ; low density lipoprotein cholesterol ; oxidation ; platelet-activating factor ; regression analysis ; risk ; stroke ; ultrasonics
Language	English
Dates of publication	2023-0210
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12020438
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Article: Electronegative LDL Is Associated with Plaque Vulnerability in Patients with Ischemic Stroke and Carotid Atherosclerosis.

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 2

Abstract	Owing to the high risk of recurrence, identifying indicators of carotid plaque vulnerability in atherothrombotic ischemic stroke is essential. In this study, we aimed to identify modified LDLs and antioxidant enzymes associated with plaque vulnerability in plasma from patients with a recent ischemic stroke and carotid atherosclerosis. Patients underwent an ultrasound, a CT-angiography, and an
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12020438
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Article ; Online: Ischaemic stroke patients present sex differences in gut microbiota.

Lledós, Miquel / Prats-Sánchez, Luís / Llucià-Carol, Laia / Cárcel-Márquez, Jara / Muiño, Elena / Cullell, Natalia / Gallego-Fabrega, Cristina / Martín-Campos, Jesús M / Aguilera-Simón, Ana / Guasch-Jiménez, Marina / Guisado-Alonso, Daniel / Ramos-Pachón, Anna / Martínez-Domeño, Alejandro / Izquierdo, Artur / Marín, Rebeca / Camps-Renom, Pol / Martí-Fàbregas, Joan / Fernández-Cadenas, Israel

European journal of neurology

2023 Volume 30, Issue 11, Page(s) 3497–3506

Abstract: Background: Gut microbiota plays a role in the pathophysiology of ischaemic stroke (IS) through the bidirectional gut-brain axis. Nevertheless, little is known about sex-specific microbiota signatures in IS occurrence.: Methods: A total of 89 IS ... ...

Abstract	Background: Gut microbiota plays a role in the pathophysiology of ischaemic stroke (IS) through the bidirectional gut-brain axis. Nevertheless, little is known about sex-specific microbiota signatures in IS occurrence. Methods: A total of 89 IS patients and 12 healthy controls were enrolled. We studied the taxonomic differences of the gut microbiota between men and women with IS by shotgun metagenomic sequencing. To evaluate the causal effect of several bacteria on IS risk, we performed a two-sample Mendelian randomisation (MR) with inverse-variance weighting (IVW) using genome-wide association analysis (GWAS) summary statistics from two cohorts of 5959 subjects with genetic and microbiota data and 1,296,908 subjects with genetic and IS data, respectively. Results: α-Diversity analysis measured using Observed Species (p = 0.017), Chao1 (p = 0.009) and Abundance-based Coverage Estimator (p = 0.012) indexes revealed that IS men have a higher species richness compared with IS women. Moreover, we found sex-differences in IS patients in relation to the phylum Fusobacteria, class Fusobacteriia, order Fusobacteriales and family Fusobacteriaceae (all Bonferroni-corrected p < 0.001). MR confirmed that increased Fusobacteriaceae levels in the gut are causally associated with an increased risk of IS (IVW p = 0.02, β = 0.32). Conclusions: Our study is the first to indicate that there are gut microbiome differences between men and women with IS, identifying high levels of Fusobacteriaceae in women as a specific risk factor for IS. Incorporating sex stratification analysis is important in the design, analysis and interpretation of studies on stroke and the gut microbiota.
Language	English
Publishing date	2023-07-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.15931
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Article ; Online: Asymptomatic parenchymal haemorrhage following endovascular treatment: Impact on functional outcome in patients with acute ischaemic stroke.

Toscano-Prat, Clara / Martínez-González, José Pablo / Guasch-Jiménez, Marina / Ramos-Pachón, Anna / Martí-Fàbregas, Joan / Blanco-Sanroman, Nerea / Coronel-Coronel, Melissa Fabiola / Domine, María Constanza / Martínez-Domeño, Alejandro / Prats-Sánchez, Luis / Marín-Bueno, Rebeca / Aguilera-Simón, Ana / Lambea-Gil, Álvaro / Ezcurra-Díaz, Garbiñe / Camps-Renom, Pol

European journal of neurology

2023 Volume 31, Issue 2, Page(s) e16112

Abstract: Background and purpose: In patients with acute ischaemic stroke (AIS), haemorrhagic transformation (HT) following endovascular treatment (EVT) is associated with poor functional outcome. However, the impact of asymptomatic HT, not linked to neurological ...

Abstract	Background and purpose: In patients with acute ischaemic stroke (AIS), haemorrhagic transformation (HT) following endovascular treatment (EVT) is associated with poor functional outcome. However, the impact of asymptomatic HT, not linked to neurological deterioration in the acute phase, is unknown. We aimed to investigate the impact of asymptomatic PH1 (aPH1) and PH2 (aPH2) subtypes of HT on the functional outcome of patients treated with EVT. Methods: We conducted a retrospective study of patients with AIS who were consecutively admitted to our comprehensive stroke centre between January 2019 and December 2022, and who underwent EVT. We collected clinical, radiological, and procedural data. HTs were categorized according to the Heidelberg classification. The primary outcome was the shift on the modified Rankin Scale (mRS) at 3 months of follow-up. We performed bivariate and multivariable ordinal regression analyses to test the association between aPH1/aPH2 and the primary outcome. Results: We included 314 patients (mean age = 72.5 years [SD = 13.6], 171 [54.5%] women). We detected 54 (17.2%) patients with HT; 23 (7.3%) were classified as PH2 (11 asymptomatic) and 17 (5.4%) as PH1 (16 asymptomatic). The adjusted common odds ratio for aPH2 of worsening 1 point on the 3-month mRS was 3.32 (95% confidence interval = 1.16-9.57, p = 0.026). No association was observed for aPH1. aPH2 was also independently associated with lower odds of achieving a favourable outcome (mRS = 0-2). Neither aPH1 nor aPH2 was associated with mortality. Conclusions: In patients with AIS treated with EVT, aPH2 is independently associated with unfavourable functional outcome.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Stroke/complications ; Stroke/surgery ; Brain Ischemia/complications ; Brain Ischemia/surgery ; Retrospective Studies ; Ischemic Stroke/complications ; Hemorrhage/etiology ; Endovascular Procedures/adverse effects ; Treatment Outcome ; Thrombectomy
Language	English
Publishing date	2023-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.16112
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Article ; Online: Early automated cerebral edema assessment following endovascular therapy: impact on stroke outcome.

Guasch-Jiménez, Marina / Dhar, Rajat / Kumar, Atul / Cifarelli, Julien / Ezcurra-Díaz, Garbiñe / Lambea-Gil, Álvaro / Ramos-Pachón, Anna / Martínez-Domeño, Alejandro / Prats-Sánchez, Luis / Guisado-Alonso, Daniel / Fernández-Cadenas, Israel / Aguilera-Simón, Ana / Marín, Rebeca / Martínez-González, José Pablo / Ortega-Quintanilla, Joaquin / Fernández-Pérez, Isabel / Avellaneda-Gómez, Carla / Rodríguez-Pardo, Jorge / de Celis, Elena /

Moniche, Francisco / Freijo, María Del Mar / Cortijo, Elisa / Trillo, Santiago / Camps-Renom, Pol / Martí-Fábregas, Joan

Journal of neurointerventional surgery

2024

Abstract: Background: Cerebral edema (CED) is associated with poorer outcome in patients with acute ischemic stroke (AIS). The aim of the study was to investigate the factors contributing to greater early CED formation in patients with AIS who underwent ... ...

Abstract	Background: Cerebral edema (CED) is associated with poorer outcome in patients with acute ischemic stroke (AIS). The aim of the study was to investigate the factors contributing to greater early CED formation in patients with AIS who underwent endovascular therapy (EVT) and its association with functional outcome. Methods: We conducted a multicenter cohort study of patients with an anterior circulation AIS undergoing EVT. The volume of cerebrospinal fluid (CSF) was extracted from baseline and 24-hour follow-up CT using an automated algorithm. The severity of CED was quantified by the percentage reduction in CSF volume between CT scans (∆CSF). The primary endpoint was a shift towards an unfavorable outcome, assessed by modified Rankin Scale (mRS) score at 3 months. Multivariable ordinal logistic regression analyses were performed. The ∆CSF threshold that predicted unfavorable outcome was selected using receiver operating characteristic curve analysis. Results: We analyzed 201 patients (mean age 72.7 years, 47.8% women) in whom CED was assessable for 85.6%. Higher systolic blood pressure during EVT and failure to achieve modified Thrombolysis In Cerebral Infarction (mTICI) 3 were found to be independent predictors of greater CED. ∆CSF was independently associated with the probability of a one-point worsening in the mRS score (common odds ratio (cOR) 1.05, 95% CI 1.03 to 1.08) after adjusting for age, baseline mRS, National Institutes of Health Stroke Scale (NIHSS), and number of passes. Displacement of more than 25% of CSF was associated with an unfavorable outcome (OR 6.09, 95% CI 3.01 to 12.33) and mortality (OR 6.72, 95% CI 2.94 to 15.32). Conclusions: Early CED formation in patients undergoing EVT was affected by higher blood pressure and incomplete reperfusion. The extent of early CED, measured by automated ∆CSF, was associated with worse outcomes.
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/jnis-2024-021641
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Zs.A 6845: Show issues

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Article ; Online: Endothelial Progenitor Cells Count after Acute Ischemic Stroke Predicts Functional Outcome in Patients with Carotid Atherosclerosis.

Camps-Renom, Pol / Jiménez-Xarrié, Elena / Soler, Marta / Puig, Núria / Aguilera-Simón, Ana / Marín, Rebeca / Prats-Sánchez, Luis / Delgado-Mederos, Raquel / Martínez-Domeño, Alejandro / Guisado-Alonso, Daniel / Guasch-Jiménez, Marina / Martí-Fàbregas, Joan

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2021 Volume 30, Issue 12, Page(s) 106144

Abstract: Objectives: Circulating Endothelial Progenitor Cells (EPCs) predict cardiovascular outcomes in patients with coronary disease. However, the predictive value of EPCs after ischemic stroke is not well established. We aimed to study the prognostic role of ... ...

Abstract	Objectives: Circulating Endothelial Progenitor Cells (EPCs) predict cardiovascular outcomes in patients with coronary disease. However, the predictive value of EPCs after ischemic stroke is not well established. We aimed to study the prognostic role of EPCs in patients with acute ischemic stroke and carotid atherosclerosis, focusing on post-stroke functional outcome and stroke recurrences. Materials and methods: We studied consecutive adult patients with an acute (<7 days) anterior circulation ischemic stroke and carotid atherosclerosis. Cardioembolic strokes were excluded. We measured circulating EPCs by flow cytometry (CD34+/CD133+/KDR+) at inclusion (7±1 days after stroke) and at one year of follow-up. At three months and at one year we registered the modified Rankin Scale score, stroke recurrences and coronary syndromes during the follow-up. Results: We studied 80 patients with a mean age of 74.3±10.4 years. We divided the population in tertiles according to the EPCs count. At three months we observed a favorable outcome in 25/36 (69.4%) patients in the lowest, 19/22 (86.4%) in the medium and 21/22 (95.5%) in the highest tercile (p=0.037). In the multivariable analysis a higher EPCs count was associated with favorable functional outcome after adjusting for age and baseline NIHSS score (OR=3.61, 95%CI 1.34-9.76; p=0.011). This association persisted at one year of follow-up. We did not find association between counts of EPCs and stroke recurrence. Conclusions: In patients with acute ischemic stroke and carotid atherosclerosis, a higher count of EPCs was associated with favorable functional outcome in the mid and long-term follow-up. Counts of EPCs did not predict stroke recurrences.
MeSH term(s)	Aged ; Aged, 80 and over ; Carotid Artery Diseases/physiopathology ; Cell Count ; Endothelial Progenitor Cells ; Humans ; Ischemic Stroke/pathology ; Middle Aged ; Prognosis ; Recurrence
Language	English
Publishing date	2021-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2021.106144
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Zs.A 3519: Show issues

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Article ; Online: Biological Age Acceleration Is Lower in Women With Ischemic Stroke Compared to Men.

Stroke

2022 Volume 53, Issue 7, Page(s) 2320–2330

Abstract: Background: Stroke onset in women occurs later in life compared with men. The underlying mechanisms of these differences have not been established. Epigenetic clocks, based on DNA methylation (DNAm) profiles, are the most accurate biological age ... ...

Abstract	Background: Stroke onset in women occurs later in life compared with men. The underlying mechanisms of these differences have not been established. Epigenetic clocks, based on DNA methylation (DNAm) profiles, are the most accurate biological age estimate. Epigenetic age acceleration (EAA) measures indicate whether an individual is biologically younger or older than expected. Our aim was to analyze whether sexual dichotomy at age of stroke onset is conditioned by EAA. Methods: We used 2 DNAm datasets from whole blood samples of case-control genetic studies of ischemic stroke (IS), a discovery cohort of 374 IS patients (N women=163, N men=211), from GRECOS (Genotyping Recurrence Risk of Stroke) and SEDMAN (Dabigatran Study in the Early Phase of Stroke, New Neuroimaging Markers and Biomarkers) studies and a replication cohort of 981 IS patients (N women=411, N men=570) from BASICMAR register. We compared chronological age, 2 DNAm-based biomarkers of aging and intrinsic and extrinsic epigenetic age acceleration EAA (IEAA and extrinsic EAA, respectively), in IS as well as in individual IS etiologic subtypes. Horvath and Hannum epigenetic clocks were used to assess the aging rate. A proteomic study using the SOMAScan multiplex assay was performed on 26 samples analyzing 1305 proteins. Results: Women present lower Hannum-extrinsic EAA values, whereas men have higher Hannum-extrinsic EAA values (women=-0.64, men=1.24, Conclusions: This study shows that sex-specific underlying biological mechanisms associated with stroke onset could be due to differences in biological age acceleration between men and women.
MeSH term(s)	Acceleration ; Aging ; Child, Preschool ; DNA Methylation ; Epigenesis, Genetic ; Female ; Genetic Markers ; Humans ; Ischemic Stroke ; Male ; Proteomics
Chemical Substances	Genetic Markers
Language	English
Publishing date	2022-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.121.037419
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