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Book ; Online: Por una Asamblea Constituyente Constitución

Quiero Aguirre, Francisco / Gajardo Falcón, Jaime

mecanismos, procesos y contenidos para una nueva

2016

Keywords	Constitution: government & the state ; History of the Americas ; Political Science ; History ; Latin American Studies
Language	Spanish
Size	1 Online-Ressource
Publisher	CLACSO
Document type	Book ; Online
Note	Spanish
HBZ-ID	HT030609634
ISBN	9789567074150 ; 9567074151
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Optimizing opioid prescribing practices after minimally invasive lung resection through a quality-improvement intervention.

Barber, Evan / Whidden, Melissa / Aguirre, Francisco / Graham, Andrew

Canadian journal of surgery. Journal canadien de chirurgie

2023 Volume 66, Issue 3, Page(s) E228–E235

Abstract: Background: In their 2019 guideline on the prescribing and management of opioids after elective ambulatory thoracic surgery, the Canadian Association of Thoracic Surgeons (CATS) recommended 120 morphine milligram equivalents (MME) after minimally ... ...

Abstract	Background: In their 2019 guideline on the prescribing and management of opioids after elective ambulatory thoracic surgery, the Canadian Association of Thoracic Surgeons (CATS) recommended 120 morphine milligram equivalents (MME) after minimally invasive (video-assisted thoracoscopic surgery [VATS]) lung resection. We conducted a quality-improvement project to optimize opioid prescribing after VATS lung resection. Methods: We assessed baseline prescribing practices for opioid-naive patients. Using a mixed-methods approach, we selected 2 quality-improvement interventions: formal incorporation of the CATS guideline into our postoperative care pathway, and development of a patient information handout regarding opioids. The intervention was initiated on Oct. 1, 2020, and was formally implemented on Dec. 1, 2020. The outcome measure was average MME of discharge opioid prescriptions, the process measure was proportion of discharge prescriptions exceeding the recommended dosage, and the balancing measure was opioid prescription refills. We analyzed the data using control charts, and compared all measures between the pre-intervention (12 mo before) and postintervention (12 mo after) groups. Results: A total of 348 patients who underwent VATS lung resection were identified, 173 before the intervention and 175 after the intervention. Significantly less MME was prescribed after the intervention (100 v. 158, Conclusion: After implementation of the CATS opioid guideline, there was a significant reduction in opioids prescribed at discharge and no increase in opioid prescription refills. Control charts are a valuable resource for monitoring outcomes on an ongoing basis and for assessing the effects of an intervention.
MeSH term(s)	Humans ; Analgesics, Opioid/therapeutic use ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Practice Patterns, Physicians' ; Canada ; Lung
Chemical Substances	Analgesics, Opioid ; MME (78185-58-7)
Language	English
Publishing date	2023-05-02
Publishing country	Canada
Document type	Journal Article
ZDB-ID	410651-9
ISSN	1488-2310 ; 0008-428X
ISSN (online)	1488-2310
ISSN	0008-428X
DOI	10.1503/cjs.008122
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Article: Role of the ubiquitin-proteasome system in the sarcopenic-like phenotype induced by CCL5/RANTES.

Conejeros-Lillo, Sabrina / Aguirre, Francisco / Cabrera, Daniel / Simon, Felipe / Peñailillo, Luis / Cabello-Verrugio, Claudio

European journal of translational myology

2024 Volume 34, Issue 1

Abstract: Sarcopenia is characterized by reduced muscle strength and mass and a decline in muscle fiber diameter and amount of sarcomeric proteins. Sarcopenia involves the activation of the ubiquitin-proteasome system (UPS). MuRF-1 and atrogin-1 are E3 ubiquitin ... ...

Abstract	Sarcopenia is characterized by reduced muscle strength and mass and a decline in muscle fiber diameter and amount of sarcomeric proteins. Sarcopenia involves the activation of the ubiquitin-proteasome system (UPS). MuRF-1 and atrogin-1 are E3 ubiquitin ligases belonging to UPS, leading to proteolysis mediated by the PSMB 5, 6, and 7 subunits of 20S proteasome. CCL5/RANTES induces a sarcopenic-like effect in muscle cells. The present work explored the impact of CCL5 on UPS components and the influence of UPS on its sarcopenic-like effect. We demonstrated that CCL5 increased MuRF-1 and atrogin-1 protein levels and mRNA levels of subunits PSMB 5, 6, and 7. We used the MG132 inhibitor to elucidate the role of the 20S proteasome in the CCL5-induced sarcopenic-like effect. This inhibitor prevented the decrease in troponin and MHC protein levels and partially prevented the reduction in the diameter of single-isolated FDB muscle fibers induced by CCL5. These findings indicate that CCL5 actively modulates the UPS. Moreover, our results show the direct participation of UPS in the sarcopenic-like phenotype induced by CCL5.
Language	English
Publishing date	2024-02-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2545577-1
ISSN	2037-7460 ; 2037-7452
ISSN (online)	2037-7460
ISSN	2037-7452
DOI	10.4081/ejtm.2024.12249
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Article ; Online: Exercise Programs Combined with Diet Supplementation Improve Body Composition and Physical Function in Older Adults with Sarcopenia: A Systematic Review.

Hernández-Lepe, Marco Antonio / Miranda-Gil, Michelle Itzel / Valbuena-Gregorio, Edith / Olivas-Aguirre, Francisco Javier

Nutrients

2023 Volume 15, Issue 8

Abstract: Sarcopenia is a progressive and frequent syndrome among older adults highly related to physical inactivity and malnutrition. Nowadays, it is considered a pathology that triggers multiple health complications associated with the loss of muscle mass, ... ...

Abstract	Sarcopenia is a progressive and frequent syndrome among older adults highly related to physical inactivity and malnutrition. Nowadays, it is considered a pathology that triggers multiple health complications associated with the loss of muscle mass, strength, autonomy, and quality of life. The objective of the present systematic review was to evaluate the effect of exercise programs combined with dietary supplementation on body composition as the primary outcome. This systematic review was carried out in accordance with the elements considered for planning a systematic review by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and the search was performed in the Scopus, EBSCO, and PubMed databases for the last 10 years. A total of 16 studies met the inclusion criteria and were included in this systematic review. Regular resistance exercise together with daily essential amino acids or whey protein and vitamin D supplementation improve the maintenance or gains in appendiceal/skeletal muscle mass and total lean mass in sarcopenic older adults. The data suggest a synergistic effect not only on the primary outcome, but also on other variables such as strength, speed, stability, and other indicators of quality of life. This systematic review was registered in PROSPERO, ID: CRD42022344284.
MeSH term(s)	Humans ; Aged ; Sarcopenia ; Muscle Strength ; Quality of Life ; Dietary Supplements ; Body Composition ; Resistance Training ; Diet ; Muscle, Skeletal/metabolism
Language	English
Publishing date	2023-04-21
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15081998
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Complementarities and tensions in NGO-state relations in agricultural development

Aguirre, Francisco / Namdar-Irani, Mina

the trajectory of AGRARIA (Chile)

(Network paper / Agricultural Administration Network ; 32)

1992

Author's details	Francisco Aguirre ; Mina Namdar-Irani
Series title	Network paper / Agricultural Administration Network ; 32 Network paper / Overseas Development Institute, Agricultural Administration Unit, Agricultural Administration Network
Collection	Network paper / Overseas Development Institute, Agricultural Administration Unit, Agricultural Administration Network
Size	III, 32 S. : Kt.
Publisher	ODI
Publishing place	London
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT009723696
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
998/121	available for loan (reading room)	Freihandmagazin (U1)

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Article: Is There an Adequate Therapeutic Approach to Thyroid Pathology in Patients with Down Syndrome?

Murillo-Llorente, Maria Teresa / Pérez-Bermejo, Marcelino / Llacer-Heredia, Verónica / Tomás-Aguirre, Beatriz / Valls-Arévalo, Angel / Tomás-Aguirre, Francisco

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 23

Abstract: Thyroid dysfunction stands as the most prevalent endocrine disorder in individuals with Down syndrome, particularly showcasing both clinical and subclinical hypothyroidism. TSH and FT4 blood values serve as common diagnostic and treatment adjustment ... ...

Abstract	Thyroid dysfunction stands as the most prevalent endocrine disorder in individuals with Down syndrome, particularly showcasing both clinical and subclinical hypothyroidism. TSH and FT4 blood values serve as common diagnostic and treatment adjustment markers. In Down syndrome (DS), hormone values may deviate from those observed in the general population, which may lead to overdiagnosis and consequent iatrogenesis of subclinical hypothyroidism. The objective of this study was to analyze the appropriateness of the replacement therapeutic approach by identifying the TSH and FT4 values that can be considered normal in these patients. Methods: A cross-sectional study was conducted in 503 subjects with DS of both sexes and without age limit drawn from the Health Program for individuals with DS in Valencia (Spain) from February 1993 to November 2021. The exclusion criteria included hyperthyroidism, nodules, tumors, or individuals under treatment with drugs influencing iodine metabolism. The normality of data distribution was assessed using the Shapiro-Wilk test. Outliers were detected using the Reed's criterion. Hormone values were estimated using quantile regression models for the 2.5th and 97.5th percentiles. Results: The normal values identified were 0.88-11.25 mIU/L for TSH and 0.71-1.63 ng/dL for FT4. The Wald test indicated no significant differences in the reference intervals based on age or sex. Conclusion: The establishment of these values, which, in people with DS, can be considered unique, is of great importance, allowing a watchful waiting attitude to be maintained before starting replacement therapy that is unnecessarily or adjusting medication in diagnosed cases.
Language	English
Publishing date	2023-11-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13233499
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: [No title information]

García, Abad / Valero-Morales, Isabel / Valbuena-Gregorio, Edith / Olivas-Aguirre, Francisco Javier / Tolentino-Mayo, Lizbeth / Barquera, Simón / Nieto, Claudia

Salud publica de Mexico

2023 Volume 65, Issue 4, jul-ago, Page(s) 377–386

Abstract: Objetivo: Identificar los mensajes persuasivos usados por la industria de alimentos y bebidas no saludables en las redes sociales más visitadas por niñas, niños y adolescentes mexicanos y determinar a qué grupo de edad estaban dirigidos. Material y ... ...

Title translation	Mensajes persuasivos en redes sociales de la industria de alimentos y bebidas no saludables.
Abstract	Objetivo: Identificar los mensajes persuasivos usados por la industria de alimentos y bebidas no saludables en las redes sociales más visitadas por niñas, niños y adolescentes mexicanos y determinar a qué grupo de edad estaban dirigidos. Material y métodos. Se analizaron 892 anuncios de los 20 productos y marcas de alimentos y bebidas no saludables más consumidas en México publicados en las cuentas oficiales de dichos productos y marcas en YouTube, Facebook e Instagram. Se determinó el mensaje primario y el público objetivo (niños, adolescentes o ambos) y se clasificó como emocional o racional. Resultados: En Facebook, la proporción de anuncios con mensajes emocionales (50.7%) y mensajes racionales (49.3%) fue similar. En YouTube hubo mayor proporción de mensajes racionales (60.2%). Se encontraron 2.9 más posibilidades de que un mensaje persuasivo emocional se dirija a niños o adolescentes en comparación con mensajes que no tienen publicidad dirigida. Conclusión. La naturaleza de los mensajes persuasivos analizados depende de la red social en la que se presentaron. La industria alimentaria dirige sus mensajes a niños o adolescentes, razón por la que es importante regular la publicidad de alimentos y bebidas no saludables en redes sociales que busca influir en el comportamiento y las decisiones de compra de niñas, niños y adolescentes.
Language	Spanish
Publishing date	2023-07-15
Publishing country	Mexico
Document type	English Abstract ; Journal Article
ZDB-ID	954220-6
ISSN	1606-7916 ; 0036-3634
ISSN (online)	1606-7916
ISSN	0036-3634
DOI	10.21149/14308
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Article ; Online: Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux.

Orozco-Aguilar, Josué / Tacchi, Franco / Aguirre, Francisco / Valero-Breton, Mayalen / Castro-Sepulveda, Mauricio / Simon, Felipe / Cabello-Verrugio, Claudio

Biological research

2023 Volume 56, Issue 1, Page(s) 28

Abstract: Background: Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and decreased strength and muscle ... ...

Abstract	Background: Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and decreased strength and muscle function, a syndrome known as sarcopenia. Recently, our laboratory described secondary sarcopenia in a chronic cholestatic liver disease (CCLD) mouse model. Interestingly, the administration of ursodeoxycholic acid (UDCA), a hydrophilic bile acid, is an effective therapy for cholestatic hepatic alterations. However, the effect of UDCA on skeletal muscle mass and functionality has never been evaluated, nor the possible involved mechanisms. Methods: We assessed the ability of UDCA to generate sarcopenia in C57BL6 mice and develop a sarcopenic-like phenotype in C Results: UDCA induced sarcopenia in healthy mice, evidenced by decreased strength, muscle mass, and physical function, with a decline in the fiber's diameter and the troponin I protein levels. In the C Conclusions: Our results indicate that UDCA induces sarcopenia in mice and sarcopenic-like features in C
MeSH term(s)	Mice ; Animals ; Sarcopenia/chemically induced ; Sarcopenia/pathology ; Ursodeoxycholic Acid/pharmacology ; Ursodeoxycholic Acid/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Troponin I/metabolism ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism
Chemical Substances	Ursodeoxycholic Acid (724L30Y2QR) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; Troponin I
Language	English
Publishing date	2023-05-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1138990-4
ISSN	0717-6287 ; 0716-9760
ISSN (online)	0717-6287
ISSN	0716-9760
DOI	10.1186/s40659-023-00431-8
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Article: Analysis of the Psychosocial Sphere of Older Adults in Extreme Poverty in the Peruvian Amazon.

Murillo-Llorente, María Teresa / Caballero Coloma, Nerea / Tomás-Aguirre, Francisco / Tejeda-Adell, Manuel / Ventura, Ignacio / Perez-Bermejo, Marcelino

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 23

Abstract: The situation of social exclusion in which older adults live in extreme poverty is a problem that leads to psychological alterations such as depression or cognitive deterioration. Our objective was to analyze the living conditions and the psychosocial ... ...

Abstract	The situation of social exclusion in which older adults live in extreme poverty is a problem that leads to psychological alterations such as depression or cognitive deterioration. Our objective was to analyze the living conditions and the psychosocial sphere of older adult people living in extreme poverty in Requena del Tapiche in Peru. This was an observational, descriptive, cross-sectional study. Sixty participants between 60 and 100 years of age of both sexes were included who gave their informed consent. Sociodemographic variables were analyzed, and the Gijón, family Apgar, Yesavage, and Pfeiffer scales were used. The sample was composed of 55% women and 45% men, with a mean age of 79.2 years (SD 6.67). More than half live alone or with their spouse. Fifty-seven percent sleep on the floor or on wood, and about 82% do not have safe water. Family dysfunction is found in 40%, and 98% are at social risk or with an established social problem and a precarious economic situation. More than 60% suffer from depressive symptoms, which are more frequent in women. We conclude that older adults perceive deficient family support, observing a deteriorated social situation. Most of them are at risk of social exclusion and loneliness, making them more vulnerable. They show sadness, with a high rate of depression. People with more cognitive impairment live alone, and those in social exclusion suffer a higher degree of depression. More cooperative projects and health promotion interventions developed in the peripheral neighborhoods of Requena del Tapiche are needed to improve the impact on the health of older adult people in extreme poverty.
Language	English
Publishing date	2023-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11233022
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Article: The extreme rainfall gradient of the Cape Horn Biosphere Reserve and its impact on forest bird richness.

Quilodrán, Claudio S / Sandvig, Erik M / Aguirre, Francisco / de Aguilar, Juan Rivero / Barroso, Omar / Vásquez, Rodrigo A / Rozzi, Ricardo

Biodiversity and conservation

2022 Volume 31, Issue 2, Page(s) 613–627

Abstract: A natural laboratory is a place supporting the conditions for hypothesis testing under non-anthropogenic settings. Located at the southern end of the Magellanic sub-Antarctic ecoregion in southwestern South America, the Cape Horn Biosphere Reserve (CHBR) ...

Abstract	A natural laboratory is a place supporting the conditions for hypothesis testing under non-anthropogenic settings. Located at the southern end of the Magellanic sub-Antarctic ecoregion in southwestern South America, the Cape Horn Biosphere Reserve (CHBR) has one of the most extreme rainfall gradients in the world. Subject to oceanic climate conditions, it is also characterized by moderate thermal fluctuations throughout the year. This makes it a unique natural laboratory for studying the effects of extreme rainfall variations on forest bird communities. Here, we monitor the bird species richness in the different forest types present in the CHBR. We found that species richness decreased with increasing precipitation, in which an increase of 100 mm in average annual precipitation showed about 1% decrease in species richness. Similar patterns were found among different forest types within the CHBR. These results provide a baseline to investigate the interactions between physical and biotic factors in a subpolar region that climatically contrasts with boreal forests, which is subject to continental climatic conditions. This research highlights the importance of ecological and ornithological long-term studies in the CHBR, which can contribute both to a higher resolution of the heterogeneity of climate changes in different regions of the world, and to orient conservation policies in the Magellanic sub-Antarctic ecoregion in the face of growing development pressures.
Language	English
Publishing date	2022-01-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2000787-5
ISSN	1572-9710 ; 0960-3115
ISSN (online)	1572-9710
ISSN	0960-3115
DOI	10.1007/s10531-022-02353-5
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