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  1. Article: Quality of Life and Glucose Regulation in Pediatric Patients with Type 1 Diabetes: A Study in the Ningxia Hui Autonomous Region.

    Bai, Hua / He, Na / Zhang, Yan / Ahmad, Aqsa / Yang, Xing-Xing / Ma, Yan / Liang, Li-Jun

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2024  Volume 17, Page(s) 1267–1278

    Abstract: Objective: In this study, we aimed to evaluate the current status of the quality of life (QOL) of pediatric patients and plasma glucose concentration regulation in children with type 1 diabetes (T1DM) in the Ningxia Hui autonomous region.: Methods: ... ...

    Abstract Objective: In this study, we aimed to evaluate the current status of the quality of life (QOL) of pediatric patients and plasma glucose concentration regulation in children with type 1 diabetes (T1DM) in the Ningxia Hui autonomous region.
    Methods: The study involved children with T1DM admitted to the General Hospital of Ningxia Medical University between October 2011 and October 2021. The children and their parents completed general information and quality of life (QOL) questionnaires. The regulation of plasma glucose concentration was assessed based on HbA1c levels, and plasma glucose and QOL-influencing components were investigated.
    Results: Among the 136 pediatric patients diagnosed with T1DM, the mean glycated hemoglobin (HbA1c) level was recorded at 8.7% (7.2%, 10.5%). A breakdown of the patient cohort revealed that 44 patients (32.4%) demonstrated good regulation of plasma glucose, 33 patients (24.3%) exhibited acceptable glycemic control, and 59 patients (43.3%) displayed poor regulation of plasma glucose. The control of plasma glucose in pediatric patients diagnosed with T1DM was affected by the duration of the disease, the patient's age, the frequency of daily plasma glucose measurements, the use of CGM, diabetic ketoacidosis (DKA), and the education level of the mother. The control of plasma glucose, dietary management, DKA, the ability to learn, and health education are interfering factors of quality of life in children diagnosed with T1DM. Effective control of plasma glucose may ensure the QOL in children with T1DM, and DKA was the risk factor for QOL.
    Conclusion: In Ningxia, the regulation of plasma glucose in pediatric and adolescent patients with T1DM remains suboptimal, leading to poor QOL. There is a pressing need to enhance glucose regulation and QOL through comprehensive strategies, which include reinforced dietary management, rigorous monitoring of plasma glucose levels, and heightened health education levels.
    Language English
    Publishing date 2024-03-12
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S446387
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  2. Article ; Online: Spinel nanocomposite (nMnZnFe2O4) synchronously promotes grain yield and Fe–Zn biofortification in non-aromatic rice

    Shafiq, Fahad / Ahmad, Aqsa / Anwar, Sumera / Nisa, Mehr-un / Iqbal, Muhammad / Raza, Syed Hammad / Mahmood, Arslan / Ashraf, Muhammad

    Plant Physiology and Biochemistry. 2023 Aug., v. 201 p.107830-

    2023  

    Abstract: Soils deficient in essential micro-nutrients produce nutritionally starved crops that do not fulfill human nutritional requirements. This is getting serious since progressively increasing nutritional disorders are being diagnosed in residents of third- ... ...

    Abstract Soils deficient in essential micro-nutrients produce nutritionally starved crops that do not fulfill human nutritional requirements. This is getting serious since progressively increasing nutritional disorders are being diagnosed in residents of third-world countries like Pakistan. During this study, we synthesized a spinel nanocomposite (nMnZnFe₂O₄) and investigated its effectiveness in improving the micronutrient status and yield traits of rice. The nMnZnFe₂O₄ exhibited a cubic structure at the most prominent peak (311); a crystallite size of 44 nm, and an average grain size ranging from 7 to 9 μm. Foliar application of this nanocomposite was performed to 45 days old plants at concentrations 0, 10, 20, 30, 40, and 50 mg L⁻¹, and data from rice plant parts (straw, husk, and grain) was recorded at maturity. Agronomic traits like the number of tillers, straw dry weight, root dry biomass, and grain yield per plant were improved by nMnZnFe₂O₄ application (+34.4% yield). Whereas some biochemical traits like amino acids, soluble sugars, flavonoids, and phenolics varied significantly in rice plant parts compared to the control. Above all, the maximum Zn and Fe concentrations in rice grain were recorded through foliar application of spinel nanocomposite (40 and 50 mg L⁻¹). Therefore, results indicated that micronutrient supply in the form of a nanocomposite could positively regulate nutritional quality and rice grain yield.
    Keywords biofortification ; biomass ; crystallites ; flavonoids ; foliar application ; grain yield ; hulls ; humans ; nanocomposites ; phenolic compounds ; plant physiology ; rice ; straw ; Pakistan ; Iron ; Manganese ; Nanocomposite ; Yield ; Zinc
    Language English
    Dates of publication 2023-08
    Publishing place Elsevier Masson SAS
    Document type Article ; Online
    ZDB-ID 742978-2
    ISSN 1873-2690 ; 0981-9428
    ISSN (online) 1873-2690
    ISSN 0981-9428
    DOI 10.1016/j.plaphy.2023.107830
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  3. Article: Decontamination of seed borne disease in pepper (Capsicum annuum L.) seed and the enhancement of seed quality by the emulated plasma technology

    Ahmad, Aqsa / Sripong, Kanlaya / Uthairatanakij, Apiradee / Photchanachai, Songsin / Pankasemsuk, Tanachai / Jitareerat, Pongphen

    Scientia horticulturae. 2022 Jan. 03, v. 291

    2022  

    Abstract: Fungal diseases are a leading cause of crop destruction. The antifungal impact of plasma technology emulation against phytopathogenic fungi is documented in this research. The purpose of this research was to analyze the impact of plasma technology ... ...

    Abstract Fungal diseases are a leading cause of crop destruction. The antifungal impact of plasma technology emulation against phytopathogenic fungi is documented in this research. The purpose of this research was to analyze the impact of plasma technology emulation against mycelium growth and spore germination of Colletotrichum gloeosporioides, a causal agent of anthracnose disease in pepper (Capsicum annuum L.) seeds and its effect on pepper seed quality. The emulation of plasma condition in liquid media was simply created by treating sterilized water or hydrogen peroxide (H₂O₂) solution with UV-C irradiation to obtain the emulation of plasma activated water (EPAW) and plasma activated H₂O₂ solution (EPAS-H₂O₂), respectively. Accordingly, in vitro study, mycelium and spores of C. gloeosporioides fungi like (Cgfl) were treated with sterilized water (control), H₂O₂ solution at 1, 3 and 5%, EPAW and EPAS-H₂O₂ at 1, 3 and 5% for 60 min. The treated mycelium and spores were placed on PDA medium and incubated at 25 ± 3 ℃. The results revealed that only EPAS-5% H₂O₂ treatment completely inhibited both mycelium growth and spore germination. Spores were more sensitive to EPAW and EPAS-H₂O₂ than mycelium. Under scanning, the electron microscope (SEM) showed that the EPAW and EPAS-H₂O₂ condition destroyed the cell structure of fungal pathogens, leading to the loss of cell membrane integrity and morphological changes. The effects of 5% H₂O₂, EPAW and EPAS-5% H₂O₂ on the quality of artificially inoculated pepper seeds were determined in comparison with fungicide (0.15% w/v captan) treated seeds and non-treated seeds (only water). The results indicated that EPAS-5% H₂O₂ showed the best result to suppress the seed infection and improved seed germination as compared to other treatments, and stimulated seed quality as employing high germination index, seedling growth rate and fresh and dry weight of seedlings. This study implies that the application of plasma technology emulation is the simple and innovative treatment, which proved to be extremely effective towards seed decontamination and enhancement of pepper seed quality.
    Keywords Capsicum annuum ; Glomerella cingulata ; anthracnose ; captan ; cell membranes ; decontamination ; hydrogen peroxide ; irradiation ; liquids ; mycelium ; pepper ; seed germination ; seed quality ; seedling growth ; spore germination
    Language English
    Dates of publication 2022-0103
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 185557-8
    ISSN 0304-4238
    ISSN 0304-4238
    DOI 10.1016/j.scienta.2021.110568
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  4. Article ; Online: Spinel nanocomposite (nMnZnFe

    Shafiq, Fahad / Ahmad, Aqsa / Anwar, Sumera / Nisa, Mehr-Un / Iqbal, Muhammad / Raza, Syed Hammad / Mahmood, Arslan / Ashraf, Muhammad

    Plant physiology and biochemistry : PPB

    2023  Volume 201, Page(s) 107830

    Abstract: Soils deficient in essential micro-nutrients produce nutritionally starved crops that do not fulfill human nutritional requirements. This is getting serious since progressively increasing nutritional disorders are being diagnosed in residents of third- ... ...

    Abstract Soils deficient in essential micro-nutrients produce nutritionally starved crops that do not fulfill human nutritional requirements. This is getting serious since progressively increasing nutritional disorders are being diagnosed in residents of third-world countries like Pakistan. During this study, we synthesized a spinel nanocomposite (nMnZnFe
    MeSH term(s) Humans ; Biofortification ; Zinc/metabolism ; Oryza/metabolism ; Edible Grain/metabolism ; Micronutrients/analysis ; Micronutrients/metabolism
    Chemical Substances Zinc (J41CSQ7QDS) ; spinell ; Micronutrients
    Language English
    Publishing date 2023-06-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 742978-2
    ISSN 1873-2690 ; 0981-9428
    ISSN (online) 1873-2690
    ISSN 0981-9428
    DOI 10.1016/j.plaphy.2023.107830
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  5. Article ; Online: COVID-19 and comorbidities of hepatic diseases in a global perspective.

    Ahmad, Aqsa / Ishtiaq, Syeda Momna / Khan, Junaid Ali / Aslam, Rizwan / Ali, Sultan / Arshad, Muhammad Imran

    World journal of gastroenterology

    2021  Volume 27, Issue 13, Page(s) 1296–1310

    Abstract: The worldwide outbreak of coronavirus disease 2019 (COVID-19) has challenged the priorities of healthcare system in terms of different clinical management and infection transmission, particularly those related to hepatic-disease comorbidities. ... ...

    Abstract The worldwide outbreak of coronavirus disease 2019 (COVID-19) has challenged the priorities of healthcare system in terms of different clinical management and infection transmission, particularly those related to hepatic-disease comorbidities. Epidemiological data evidenced that COVID-19 patients with altered liver function because of hepatitis infection and cholestasis have an adverse prognosis and experience worse health outcomes. COVID-19-associated liver injury is correlated with various liver diseases following a severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) infection that can progress during the treatment of COVID-19 patients with or without pre-existing liver disease. SARS-CoV-2 can induce liver injury in a number of ways including direct cytopathic effect of the virus on cholangiocytes/hepatocytes, immune-mediated damage, hypoxia, and sepsis. Indeed, immediate cytopathogenic effects of SARS-CoV-2
    MeSH term(s) COVID-19 ; Comorbidity ; Humans ; Liver Diseases/diagnosis ; Liver Diseases/epidemiology ; Liver Diseases/therapy ; SARS-CoV-2
    Language English
    Publishing date 2021-04-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v27.i13.1296
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    Zs.A 6039: Show issues Location:
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  6. Article ; Online: A Critical Review on the Development, Physicochemical Variations and Technical Concerns of Gluten Free Extrudates in Food Systems

    Sajid Mushtaq, Bilal / Zhang, Wenhui / Al-Ansi, Waleed / Ul Haq, Faizan / Rehman, Abdur / Omer, Rabia / Mahmood Khan, Imran / Niazi, Sobia / Ahmad, Aqsa / Ali Mahdi, Amer / Al-Maqtari, Qais Ali / Walayat, Noman / Wang, Li

    Food Reviews International. 2023 July 04, v. 39, no. 5 p.2806-2834

    2023  

    Abstract: The prevalence of celiac disease (CD) and other gluten-intolerant disorders is still growing over time partially attributed to more clinical investigations and improved diagnosis capacity, even mainly reported in many developed countries. Consequently, ... ...

    Abstract The prevalence of celiac disease (CD) and other gluten-intolerant disorders is still growing over time partially attributed to more clinical investigations and improved diagnosis capacity, even mainly reported in many developed countries. Consequently, the demand for gluten-free (GF) food products is receiving increasing interest because of its use as profitable therapy for gluten-related disorders and the improved physiochemical and structural attributes. Recently, extrusion cooking, an emerging processing technique, largely has become the leading direction for the food industries in order to develop a large number of products such as pasta, noodles, snacks, etc. having different shapes, better nutritional, sensory, and functional characteristics. This vast range of GF-based extruded products is produced by different raw materials, such as pseudocereals, corn, rice, sorghum, and legumes at different extrusion parameters. Extrusion technology enables the control of various processes, such as mixing, cooking, shearing, and shaping of products. However, there are several concerns, such as starch-protein interaction, chemical structure capability, and textural, nutritional, and sensorial characteristics, that must be addressed for a successful and effective processing for GF foods. This review aims to provide complete details about the use of extrusion processing for the development of GF extrudates and the effect of parameters on the physicochemical, textural, and structural properties of extrudates. Additionally, it highlights the approaches to enhance the functional attributes of GF extrudates. There is a need to design unique food formulations as well as the extrusion process to meet the requirement of gluten-intolerant patients. Further work is warranted in developing and evaluating more GF-based extruded products, specifically the development of healthy and nutritious food products, and still, there is a great need to find a unique way to enrich the bio-functional components into the gluten-free extruded products.
    Keywords celiac disease ; chemical structure ; corn ; extrusion ; gluten ; pasta ; pseudocereals ; rice ; therapeutics ; gluten-intolerant ; gluten-free extrudate ; extrusion cooking ; bio-functional component
    Language English
    Dates of publication 2023-0704
    Size p. 2806-2834.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 53834-6
    ISSN 1525-6103 ; 8755-9129
    ISSN (online) 1525-6103
    ISSN 8755-9129
    DOI 10.1080/87559129.2021.1976793
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  7. Article: Pattern of clinical drug resistance and occurrence of Gram negative bacterial neonatal sepsis at a tertiary care hospital.

    Ahmad, Aqsa / Sarwar, Noreen / Aslam, Rizwan / Ali, Sultan / Aslam, Bilal / Adnan Arshad, Muhammad / Hameed, Hira / Imran Arshad, Muhammad

    Pakistan journal of pharmaceutical sciences

    2021  Volume 34, Issue 5(Supplementary), Page(s) 1873–1878

    Abstract: Sepsis is a leading cause of neonatal deaths across the world. Gram-negative rods such as Klebsiella and E. coli are major cause of sepsis in neonates. With a mortality rate of 1-4 deaths per thousand live births, sepsis is the second most important ... ...

    Abstract Sepsis is a leading cause of neonatal deaths across the world. Gram-negative rods such as Klebsiella and E. coli are major cause of sepsis in neonates. With a mortality rate of 1-4 deaths per thousand live births, sepsis is the second most important cause of neonatal deaths in the developing countries. The present study was designed to determine the occurrence of Gram-negative bacteria in neonatal sepsis and to find antibiotic susceptibility of isolated microbes. Blood samples of 100 neonates (1-89 days old) were sub cultured on MacConkey's and Blood agar for isolation of Gram-negative bacteria. A total of four bacterial species were isolated including Klebsiella (35.71%), E. coli (28.57%), Acinetobacter (21.42%) and Proteus (14.28%). Gram-negative bacteria were isolated more commonly from EOS (early onset sepsis) as compared to LOS (late onset sepsis). Klebsiella isolates from neonates showed sensitivity to imipenem (70%) followed by ceftazidime (40%) and cefotaxime (40%) and high resistance was shown by sulfamethoxazole (80%) and amikacin (70%). E. coli associated with neonatal sepsis were sensitive to imipenem (63%) while highly resistant to cefotaxime (75%) and ciprofloxacin (62%). For Acinetobacter high sensitivity was found for ceftazidime (50%) and resistance was shown to ciprofloxacin and sulfamethoxazole (100%). Proteus showed high sensitivity to amikacin (75%) and high resistance to imipenem and ciprofloxacin (75%). In conclusion, Gram-negative associated neonatal sepsis was found in the studied subjects and drug resistance was observed to clinically used antibiotics.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Female ; Gram-Negative Bacteria ; Gram-Negative Bacterial Infections/epidemiology ; Gram-Negative Bacterial Infections/microbiology ; Humans ; Infant ; Infant, Newborn ; Male ; Microbial Sensitivity Tests ; Neonatal Sepsis/epidemiology ; Neonatal Sepsis/microbiology ; Pakistan/epidemiology ; Tertiary Care Centers
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-09-11
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
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