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Article ; Online: Continuous Real-Time Detection of Serotonin Using an Aptamer-Based Electrochemical Biosensor.

Ahmad, Habib M N / Andrade, Arturo / Song, Edward

2023 Volume 13, Issue 11

Abstract: Serotonin (5-HT) is a critical neurotransmitter involved in many neuronal functions, and 5-HT depletion has been linked to several mental diseases. The fast release and clearance of serotonin in the extracellular space, low analyte concentrations, and a ... ...

Abstract	Serotonin (5-HT) is a critical neurotransmitter involved in many neuronal functions, and 5-HT depletion has been linked to several mental diseases. The fast release and clearance of serotonin in the extracellular space, low analyte concentrations, and a multitude of interfering species make the detection of serotonin challenging. This work presents an electrochemical aptamer-based biosensing platform that can monitor 5-HT continuously with high sensitivity and selectivity. Our electrochemical sensor showed a response time of approximately 1 min to a step change in the serotonin concentration in continuous monitoring using a single-frequency EIS (electrochemical impedance spectroscopy) technique. The developed sensing platform was able to detect 5-HT in the range of 25-150 nM in the continuous sample fluid flow with a detection limit (LOD) of 5.6 nM. The electrochemical sensor showed promising selectivity against other species with similar chemical structures and redox potentials, including dopamine (DA), norepinephrine (NE), L-tryptophan (L-TP), 5-hydroxyindoleacetic acid (5-HIAA), and 5-hydroxytryptophan (5-HTP). The proposed sensing platform is able to achieve high selectivity in the nanomolar range continuously in real-time, demonstrating the potential for monitoring serotonin from neurons in organ-on-a-chip or brain-on-a-chip-based platforms.
MeSH term(s)	Serotonin ; Dopamine ; Norepinephrine ; Tryptophan ; Oligonucleotides ; Biosensing Techniques ; Electrochemical Techniques
Chemical Substances	Serotonin (333DO1RDJY) ; Dopamine (VTD58H1Z2X) ; Norepinephrine (X4W3ENH1CV) ; Tryptophan (8DUH1N11BX) ; Oligonucleotides
Language	English
Publishing date	2023-11-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios13110983
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Code of Conduct Information System Using Simple Multi-Attribute Rating Technique (SMART) Method at SMK XYZ

Ahmad Habib / Dafid Ainur Rozi / Geri Kusnanto

Intensif: Jurnal Ilmiah Penelitian Teknologi dan Penerapan Sistem Informasi, Vol 5, Iss 1, Pp 86-

2021 Volume 104

Abstract: SMK XYZ is a vocational high school with approximately 2550 students with various majors and backgrounds, so there are many problems. For subscribers, each student gets a notebook on discipline and order; if a student commits a violation, it will be ... ...

Abstract	SMK XYZ is a vocational high school with approximately 2550 students with various majors and backgrounds, so there are many problems. For subscribers, each student gets a notebook on discipline and order; if a student commits a violation, it will be written by the discipline taught in the book. Furthermore, the counseling guidance teacher, together with the class teacher, conducts coaching; this activity is a manual system that has not been computerized. It hinders the performance of these teachers. From these problems, an order information system's analysis and design are carried out, which can facilitate and accelerate teachers in planning, directing, and monitoring. The SMART method's application to the discipline information system is based on the science of facts, which states a criterion with value; each weighted value can show and reflect comparisons between standards related to planning, direction, and supervision of students carried out by teachers. Subscription to violations using the discipline information system with the SMART method is carried out computerized, including determining sanctions and their actions to support the performance of teachers.
Keywords	smk xyz ; information system ; code of conduct ; smart ; Information technology ; T58.5-58.64 ; Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Universitas Nusantara PGRI Kediri
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Use of Multimedia Interactive based on PjBL (Project Based-Learning)

Ahmad Habib / I Made Astra / Erry Utomo

International Journal of Multicultural and Multireligious Understanding, Vol 8, Iss 5, Pp 628-

Study Effectiveness of Student Creativity in Subject Natural Sciences

2021 Volume 636

Abstract: 21st-century learning requires holistic learning oriented towards developing higher-order thinking skills. The results of the Program for International Student Assessment (PISA) show that the performance of Indonesian students in science is still low and ...

Abstract	21st-century learning requires holistic learning oriented towards developing higher-order thinking skills. The results of the Program for International Student Assessment (PISA) show that the performance of Indonesian students in science is still low and few have high-level thinking skills. The purpose of this study was to determine the effectiveness of using interactive multimedia based on PjBL in increasing student creativity in science subjects. This type of research is a Mix Mathods with one group pre test-post test design. The results of this study indicate that interactive multimedia based on PjBL is quite effective in increasing student creativity in science subjects so that it can be used as a media to support science learning.
Keywords	interactive multimedia ; project based learning ; science learning ; elementary schools ; Social Sciences ; H ; Social sciences (General) ; H1-99
Subject code	370
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	International journal of multicultural and multireligious understanding
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rancang Bangun Sistem Informasi Manajemen Keuangan Sekolah

Ahmad Habib / Berlian Al Kindhi

Intensif: Jurnal Ilmiah Penelitian Teknologi dan Penerapan Sistem Informasi, Vol 2, Iss 2, Pp 136-

2018 Volume 146

Abstract: School financial data processing if done manually then the result is less effective. So required financial information management information system to improve the quality of service to students and accelerate the performance of employees in school. It ... ...

Abstract	School financial data processing if done manually then the result is less effective. So required financial information management information system to improve the quality of service to students and accelerate the performance of employees in school. It is expected that this system can improve the performance of employees or teachers in school including chairman institutionalized in making decisions. The purpose of this study is to make school financial management information system designed and built by using PHP programming language and MySQL database so that it can process the school finance data such as tuition fee payment and making financial reports done efficiently and effectively. In this study, the author uses two methods, namely data collection methods and methods of system development. For data collection method, we use three way, that is observation, interview and study of library for development of system method used by writer that is incremental method having 5 stages, that is communication, planning, modeling, construction, deployment.
Keywords	Information technology ; T58.5-58.64 ; Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2018-08-01T00:00:00Z
Publisher	Universitas Nusantara PGRI Kediri
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development of an Online Sales Information System for SMEs Using Incremental Methods

Ahmad Habib / Andrey Kartika W. H.

Intensif: Jurnal Ilmiah Penelitian Teknologi dan Penerapan Sistem Informasi, Vol 4, Iss 1, Pp 51-

2020 Volume 62

Abstract: Home Industry Shoes is one of the SMEs that are engaged in the production and sale of shoes. Shoes SMEs in marketing and sales have been still relying on customers from surrounding areas of production activities. Current business competition is stringent, ...

Abstract	Home Industry Shoes is one of the SMEs that are engaged in the production and sale of shoes. Shoes SMEs in marketing and sales have been still relying on customers from surrounding areas of production activities. Current business competition is stringent, thus making SME shoes demanded to be more advanced in marketing and sales to be able to stay afloat. Shoes SMEs have problems with promotional media and sales, which does not yet have an independent online sales system. Therefore, the authors feel the need to help SMEs by creating an online sales information system that can be used as a promotional media as well as a media for selling independently and easy to use. In this study, the authors apply the incremental method in system development and also observation in gathering data on the needs of the system developed. Achievements in this study, the authors, produce an online sales information system for SMEs, in particular, the production of home industry shoes that can be used independently by SMEs to carry out promotions and sales online.
Keywords	information system ; sales ; online ; shoes smes ; Information technology ; T58.5-58.64 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	070
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	Universitas Nusantara PGRI Kediri
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Outcome of low-dose prednisolone use for the induction of remission in lupus nephritis patients.

Bandhan, Iftekhar Hussain / Islam, Md Nazrul / Ahmad, Habib Imtiaz / Ahmedullah, Abul Khair

International journal of rheumatic diseases

2021 Volume 25, Issue 2, Page(s) 121–130

Abstract: Objectives: This study aimed to compare the efficacy of low-dose prednisolone with conventional high-dose regimen in proliferative lupus nephritis (LN) for remission.: Methods: This open-label randomized clinical trial was conducted in the Department ...

Abstract	Objectives: This study aimed to compare the efficacy of low-dose prednisolone with conventional high-dose regimen in proliferative lupus nephritis (LN) for remission. Methods: This open-label randomized clinical trial was conducted in the Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. A total of 32 LN patients were randomized into low-dose (experimental) and high-dose (control) groups. All subjects received standard dose of intravenous (I/V) methylprednisolone and pulse I/V cyclophosphamide. Oral prednisolone, 0.5 mg/kg/d and 1 mg/kg/d were given to experimental and control groups respectively for initially 4 weeks then tapered. The patients were followed for 24 weeks. The rates of renal remission (complete and partial) were assessed at 24 weeks. The disease activity, biochemical markers, and quality of life were evaluated at baseline and at 24 weeks. Results: Complete renal remission was achieved by 66.7% of patients in each group (P = .99). Renal remission (partial/complete) was achieved by 86.7% and 83.3% of patients in the prednisolone low-dose group and high-dose group respectively (P = .99). In between groups, no significant difference was observed in the improvement of active urinary sediments, serum creatinine level, anti-double-stranded DNA level, complements level, disease activity and Short Form-12 score. The prednisolone dose-related adverse events like cushingoid facies, abdominal stria, infections and serious adverse events like death occurred more in the high-dose prednisolone group. Conclusions: It has been observed that low-dose prednisolone regimen may be effective in LN. Steroid dose-related side effects and rate of infections were lower in this group.
MeSH term(s)	Adult ; Bangladesh ; Dose-Response Relationship, Drug ; Female ; Glucocorticoids/administration & dosage ; Humans ; Lupus Nephritis/drug therapy ; Male ; Prednisolone/administration & dosage ; Remission Induction/methods
Chemical Substances	Glucocorticoids ; Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	2021-12-11
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.14265
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Article ; Online: Pseudoacromegaly Associated with Non-Functioning Pituitary Adenoma

Awatef Alotaibi / Ahmad Habib / Moutaz Osman / Khaled Alzahrani / Faisal Alzahrani

European Journal of Case Reports in Internal Medicine (2020)

2020

Abstract: Acromegaly is characterized by excess skin and soft tissue growth due to increased growth hormone (GH) levels. Patients with similar physical findings but without somatotroph axis abnormalities are considered to have pseudoacromegaly. The list of ... ...

Abstract	Acromegaly is characterized by excess skin and soft tissue growth due to increased growth hormone (GH) levels. Patients with similar physical findings but without somatotroph axis abnormalities are considered to have pseudoacromegaly. The list of pseudoacromegaly differential diagnoses is long. It may be caused by several congenital and acquired conditions and diagnosis can be challenging due to its rarity and occasional overlapping of some of these conditions. The presence of a pituitary tumour in such cases may lead to a misdiagnosis of acromegaly, and thus, biochemical evaluation is key. Here, we present a case of pseudoacromegaly with an acromegaloid phenotype, normal IGF levels, a supressed GH response to an oral glucose tolerance test, moderate insulin resistance and non-functioning pituitary microadenoma.
Keywords	pituitary ; growth factors ; acromegaly ; pseudoacromegaly ; adenoma ; Medicine ; R
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	SMC MEDIA SRL
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Contrasting maternal and paternal genetic histories among five ethnic groups from Khyber Pakhtunkhwa, Pakistan.

Tariq, Muhammad / Ahmad, Habib / Hemphill, Brian E / Farooq, Umar / Schurr, Theodore G

Scientific reports

2022 Volume 12, Issue 1, Page(s) 1027

Abstract: Northwest Pakistan has served as a point of entry to South Asia for different populations since ancient times. However, relatively little is known about the population genetic history of the people residing within this region. To better understand human ... ...

Abstract	Northwest Pakistan has served as a point of entry to South Asia for different populations since ancient times. However, relatively little is known about the population genetic history of the people residing within this region. To better understand human dispersal in the region within the broader history of the subcontinent, we analyzed mtDNA diversity in 659 and Y-chromosome diversity in 678 individuals, respectively, from five ethnic groups (Gujars, Jadoons, Syeds, Tanolis and Yousafzais), from Swabi and Buner Districts, Khyber Pakhtunkhwa Province, Pakistan. The mtDNAs of all individuals were subject to control region sequencing and SNP genotyping, while Y-chromosomes were analyzed using 54 SNPs and 19 STR loci. The majority of the mtDNAs belonged to West Eurasian haplogroups, with the rest belonging to either South or East Asian lineages. Four of the five Pakistani populations (Gujars, Jadoons, Syeds, Yousafzais) possessed strong maternal genetic affinities with other Pakistani and Central Asian populations, whereas one (Tanolis) did not. Four haplogroups (R1a, R1b, O3, L) among the 11 Y-chromosome lineages observed among these five ethnic groups contributed substantially to their paternal genetic makeup. Gujars, Syeds and Yousafzais showed strong paternal genetic affinities with other Pakistani and Central Asian populations, whereas Jadoons and Tanolis had close affinities with Turkmen populations from Central Asia and ethnic groups from northeast India. We evaluate these genetic data in the context of historical and archeological evidence to test different hypotheses concerning their origins and biological relationships.
MeSH term(s)	Chromosomes, Human, Y/genetics ; DNA, Mitochondrial/genetics ; Ethnicity/genetics ; Genetics, Population ; Haplotypes ; Humans ; Male ; Pakistan/ethnology ; Phylogeny ; Polymorphism, Single Nucleotide
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2022-01-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-05076-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Role of a Manager’s Intangible Capabilities in Resource Acquisition and Sustainable Competitive Performance

Ying, Qianwei / Ahmad, Habib / Hassan, Hazrat

Sustainability. 2019 Jan. 19, v. 11, no. 2

2019

Abstract: The answer to the challenging question, “Should one either invest in tangible resources or intangible resources/capabilities?” is still fragmented. In prior studies, more emphasis is given to tangible resources, while intangible resources have ... ...

Abstract	The answer to the challenging question, “Should one either invest in tangible resources or intangible resources/capabilities?” is still fragmented. In prior studies, more emphasis is given to tangible resources, while intangible resources have comparatively received minor attention, despite their significant role in the success of small and medium enterprises (SMEs). Particularly the role of the intangible skills; intellectual capital, financial literacy (FL), and business experience (BE) in resource acquisition and sustainable competitive performance has missed in prior studies. Grounded on the resource-based view and upper echelon theory, this study examines the role of intellectual capital in sustainable competitive performance with a mediating role of resource acquisition. This research also assesses the moderating role of financial literacy and business experience between intellectual capital and resource acquisition. Data are collected through structured questionnaires from 384 owners/managers of Pakistani SMEs. After analyzing the data through structural equation modeling (SEM), the results indicate that intellectual capital helps managers in acquiring valuable resources, which in turn enhance sustainable competitive performance. Resource acquisition partially mediates the relation between intellectual capital and sustainable competitive performance. Financial literacy is a significant predictor of resource acquisition, but it does not significantly moderate the relation between intellectual capital and sustainable competitive performance. Business experience significantly boosts the acquisition of resources and strengthens the path between intellectual capital and resource acquisition. SMEs should encourage their managers to acquire unique, rare, and immutable external resources in the turbulent markets.
Keywords	human capital ; literacy ; managers ; markets ; questionnaires ; small and medium enterprises ; structural equation modeling
Language	English
Dates of publication	2019-0119
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518383-7
ISSN	2071-1050
ISSN	2071-1050
DOI	10.3390/su11020527
Database	NAL-Catalogue (AGRICOLA)

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Article: Salinity imposed stress on principal cereal crops and employing seed priming as a sustainable management approach

Majeed, Abdul / Ahmad, Habib / Islam, Saiful / Muhammad, Zahir

Ecological Society of China Acta ecologica Sinica. 2019 Aug., v. 39, no. 4

2019

Abstract: Cereal crops specifically maize, wheat, and rice have a prominent role in feeding the world's population. In the context of a growing population and a potential increase in food demand in coming years, yield output of cereals is certainly necessary. ... ...

Abstract	Cereal crops specifically maize, wheat, and rice have a prominent role in feeding the world's population. In the context of a growing population and a potential increase in food demand in coming years, yield output of cereals is certainly necessary. Concurrently, the production of these crops is challenged with several abiotic and biotic stresses. Salinity, a leading abiotic stress in global agriculture, significantly reduce growth, yield and overall production of cereals and if not managed through successive efforts, global food security will be uncertain in the future. Thus, employment of sustainable approaches in achieving the targets of food demands of increasing population needs focused attention. Integration of agronomic and biotechnological methods can manage salinity induced drastic effects on crops which would lead to increased crop productivity. In this review, we focus on employing seed priming techniques as possible salt stress management approaches in three major cereal crops (maize, rice, and wheat).
Keywords	biotic stress ; corn ; food security ; grain crops ; population growth ; rice ; salinity ; salt stress ; seed priming ; stress management ; wheat
Language	English
Dates of publication	2019-08
Size	p. 280-283.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2233694-1
ISSN	1872-2032 ; 1000-0933
ISSN (online)	1872-2032
ISSN	1000-0933
DOI	10.1016/j.chnaes.2018.09.004
Database	NAL-Catalogue (AGRICOLA)

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