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  1. Article ; Online: In-silico analysis and transformation of OsMYB48 transcription factor driven by CaMV35S promoter in model plant -

    Ahmad, Yumna / Haider, Saqlain / Iqbal, Javed / Naseer, Sana / Attia, Kotb A / Mohammed, Arif Ahmed / Fiaz, Sajid / Mahmood, Tariq

    GM crops & food

    2024  Volume 15, Issue 1, Page(s) 130–149

    Abstract: Global crop yield has been affected by a number of abiotic stresses. Heat, salinity, and drought stress are at the top of the list as serious environmental growth-limiting factors. To enhance crop productivity, molecular approaches have been used to ... ...

    Abstract Global crop yield has been affected by a number of abiotic stresses. Heat, salinity, and drought stress are at the top of the list as serious environmental growth-limiting factors. To enhance crop productivity, molecular approaches have been used to determine the key regulators affecting stress-related phenomena. MYB transcription factors (TF) have been reported as one of the promising defensive proteins against the unfavorable conditions that plants must face. Different roles of MYB TFs have been suggested such as regulation of cellular growth and differentiation, hormonal signaling, mediating abiotic stress responses, etc. To gain significant insights, a comprehensive in-silico analysis of OsMYB TF was carried out in comparison with 21 dicot MYB TFs and 10 monocot MYB TFs. Their chromosomal location, gene structure, protein domain, and motifs were analyzed. The phylogenetic relationship was also studied, which resulted in the classification of proteins into four basic groups: groups A, B, C, and D. The protein motif analysis identified several conserved sequences responsible for cellular activities. The gene structure analysis suggested that proteins that were present in the same class, showed similar intron-exon structures. Promoter analysis revealed major cis-acting elements that were found to be responsible for hormonal signaling and initiating a response to abiotic stress and light-induced mechanisms. The transformation of OsMYB TF into tobacco was carried out using the
    MeSH term(s) Transcription Factors/genetics ; Transcription Factors/metabolism ; Nicotiana/genetics ; Phylogeny ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Gene Expression Regulation, Plant ; Crops, Agricultural/genetics ; Stress, Physiological/genetics
    Chemical Substances Transcription Factors ; Plant Proteins
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706099-8
    ISSN 2164-5701 ; 2164-5701
    ISSN (online) 2164-5701
    ISSN 2164-5701
    DOI 10.1080/21645698.2024.2334476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Out of the Blue: A Case of Blue Subungual Discoloration Associated with Prolonged Tetracycline Use.

    Ahmad, Yumna / Boutros, Heidi / Hanna, Karim

    Cureus

    2020  Volume 12, Issue 4, Page(s) e7810

    Abstract: Tetracycline derivatives are antibiotics such as minocycline and doxycycline that have been commonly utilized for inflammatory dermatological conditions such as acne and rosacea. Hyperpigmentation of the skin, nails, thyroid, oral mucosa, teeth, and ... ...

    Abstract Tetracycline derivatives are antibiotics such as minocycline and doxycycline that have been commonly utilized for inflammatory dermatological conditions such as acne and rosacea. Hyperpigmentation of the skin, nails, thyroid, oral mucosa, teeth, and bones is a known but rare side effect of prolonged tetracycline use. The hyperpigmentation typically takes months to years to develop. There may also be residual changes to the skin after discontinuation of the medication. For this reason, the time tetracyclines are used should be minimized and patients should be monitored for the skin findings. Subungual discoloration carries a broad differential including infectious, inflammatory, metabolic, malignant or systemic diseases. Knowledge of this side effect is crucial in order to avoid unnecessary testing in determining the etiology of the subungual discoloration. We report on a case of a patient who has been on long-term minocycline use for adult acne management. He was initially on minocycline for six years, but due to minocycline-induced hyperpigmentation of his ears and fingernails, he had switched to doxycycline. One year later, the skin hyperpigmentation of the ears regressed; however, the blue subungual hyperpigmentation of his hands progressively become more prominent without any other significant symptoms.
    Language English
    Publishing date 2020-04-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.7810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: In Silico Characterization and Expression Profiles of Heat Shock Transcription Factors (HSFs) in Maize (Zea mays L.)

    Haider, Saqlain / Rehman, Shazia / Ahmad, Yumna / Raza, Ali / Tabassum, Javaria / Javed, Talha / Osman, Hany S. / Mahmood, Tariq

    Agronomy. 2021 Nov. 18, v. 11, no. 11

    2021  

    Abstract: Heat shock transcription factors (HSFs) regulate many environmental stress responses and biological processes in plants. Maize (Zea mays L.) is a major cash crop that is grown worldwide. However, the growth and yield of maize are affected by several ... ...

    Abstract Heat shock transcription factors (HSFs) regulate many environmental stress responses and biological processes in plants. Maize (Zea mays L.) is a major cash crop that is grown worldwide. However, the growth and yield of maize are affected by several adverse environmental stresses. Therefore, investigating the factors that regulate maize growth and development and resistance to abiotic stress is an essential task for developing stress-resilient maize varieties. Thus, a comprehensive genome-wide identification analysis was performed to identify HSFs genes in the maize genome. The current study identified 25 ZmHSFs, randomly distributed throughout the maize genome. Phylogenetic analysis revealed that ZmHSFs are divided into three classes and 13 sub-classes. Gene structure and protein motif analysis supported the results obtained through the phylogenetic analysis. Segmental duplication is shown to be responsible for the expansion of ZmHSFs. Most of the ZmHSFs are localized inside the nucleus, and the ZmHSFs which belong to the same group show similar physio-chemical properties. Previously reported and publicly available RNA-seq analysis revealed a major role of class A HSFs including ZmHSFA-1a and ZmHSFA-2a in all the maize growth stages, i.e., seed, vegetative, and reproductive development. Under abiotic stress conditions (heat, drought, cold, UV, and salinity), members of class A and B ZmHSFs are induced. Gene ontology and protein–protein interaction analysis indicated a major role of ZmHSFs in resistance to environmental stress and regulation of primary metabolism. To summarize, this study provides novel insights for functional studies on the ZmHSFs in maize breeding programs.
    Keywords Zea mays ; agronomy ; amino acid motifs ; cash crops ; cold ; computer simulation ; corn ; drought ; gene ontology ; genes ; heat ; heat stress ; metabolism ; phylogeny ; protein-protein interactions ; salinity ; sequence analysis
    Language English
    Dates of publication 2021-1118
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy11112335
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Molecular mechanisms of plant tolerance to heat stress: current landscape and future perspectives

    Haider, Saqlain / Iqbal, Javed / Naseer, Sana / Yaseen, Tabassum / Shaukat, Muzaffar / Bibi, Haleema / Ahmad, Yumna / Daud, Hina / Abbasi, Nayyab Laiba / Mahmood, Tariq

    Plant cell reports. 2021 Dec., v. 40, no. 12

    2021  

    Abstract: KEY MESSAGE: We summarize recent studies focusing on the molecular basis of plant heat stress response (HSR), how HSR leads to thermotolerance, and promote plant adaptation to recurring heat stress events. The global crop productivity is facing ... ...

    Abstract KEY MESSAGE: We summarize recent studies focusing on the molecular basis of plant heat stress response (HSR), how HSR leads to thermotolerance, and promote plant adaptation to recurring heat stress events. The global crop productivity is facing unprecedented threats due to climate change as high temperature negatively influences plant growth and metabolism. Owing to their sessile nature, plants have developed complex signaling networks which enable them to perceive changes in ambient temperature. This in turn activates a suite of molecular changes that promote plant survival and reproduction under adverse conditions. Deciphering these mechanisms is an important task, as this could facilitate development of molecular markers, which could be ultimately used to breed thermotolerant crop cultivars. In current article, we summarize mechanisms involve in plant heat stress acclimation with special emphasis on advances related to heat stress perception, heat-induced signaling, heat stress-responsive gene expression and thermomemory that promote plant adaptation to short- and long-term-recurring heat-stress events. In the end, we will discuss impact of emerging technologies that could facilitate the development of heat stress-tolerant crop cultivars.
    Keywords acclimation ; ambient temperature ; climate change ; cultivars ; gene expression ; heat ; heat shock response ; heat stress ; heat tolerance ; landscapes ; metabolism ; plant adaptation ; plant growth ; reproduction
    Language English
    Dates of publication 2021-12
    Size p. 2247-2271.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 8397-5
    ISSN 1432-203X ; 0721-085X ; 0721-7714
    ISSN (online) 1432-203X
    ISSN 0721-085X ; 0721-7714
    DOI 10.1007/s00299-021-02696-3
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 85/705: Show issues

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  5. Article ; Online: Molecular mechanisms of plant tolerance to heat stress: current landscape and future perspectives.

    Haider, Saqlain / Iqbal, Javed / Naseer, Sana / Yaseen, Tabassum / Shaukat, Muzaffar / Bibi, Haleema / Ahmad, Yumna / Daud, Hina / Abbasi, Nayyab Laiba / Mahmood, Tariq

    Plant cell reports

    2021  Volume 40, Issue 12, Page(s) 2247–2271

    Abstract: Key message: We summarize recent studies focusing on the molecular basis of plant heat stress response (HSR), how HSR leads to thermotolerance, and promote plant adaptation to recurring heat stress events. The global crop productivity is facing ... ...

    Abstract Key message: We summarize recent studies focusing on the molecular basis of plant heat stress response (HSR), how HSR leads to thermotolerance, and promote plant adaptation to recurring heat stress events. The global crop productivity is facing unprecedented threats due to climate change as high temperature negatively influences plant growth and metabolism. Owing to their sessile nature, plants have developed complex signaling networks which enable them to perceive changes in ambient temperature. This in turn activates a suite of molecular changes that promote plant survival and reproduction under adverse conditions. Deciphering these mechanisms is an important task, as this could facilitate development of molecular markers, which could be ultimately used to breed thermotolerant crop cultivars. In current article, we summarize mechanisms involve in plant heat stress acclimation with special emphasis on advances related to heat stress perception, heat-induced signaling, heat stress-responsive gene expression and thermomemory that promote plant adaptation to short- and long-term-recurring heat-stress events. In the end, we will discuss impact of emerging technologies that could facilitate the development of heat stress-tolerant crop cultivars.
    MeSH term(s) Calcium Signaling ; Chromatin/genetics ; Chromatin/metabolism ; Crops, Agricultural ; Epigenesis, Genetic ; Heat-Shock Response/physiology ; Lipid Metabolism ; Plant Breeding ; Plant Physiological Phenomena ; Plant Proteins/genetics ; Plant Proteins/metabolism ; RNA, Plant/genetics ; RNA, Plant/metabolism ; Thermotolerance/physiology
    Chemical Substances Chromatin ; Plant Proteins ; RNA, Plant
    Language English
    Publishing date 2021-04-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8397-5
    ISSN 1432-203X ; 0721-085X ; 0721-7714
    ISSN (online) 1432-203X
    ISSN 0721-085X ; 0721-7714
    DOI 10.1007/s00299-021-02696-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 85/705: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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