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  1. AU="Ahmadi, Parimah"
  2. AU="Hufert, F T" AU="Hufert, F T"
  3. AU="Maximilian Radtke"
  4. AU="Hinchliffe, Rod F" AU="Hinchliffe, Rod F"
  5. AU="Pourdowlat, Guitti"
  6. AU="Kurskoy Аndrey Yu."
  7. AU="Kuo, Albert"
  8. AU="Haustraete, Eglantine"
  9. AU="Li, Ziying"
  10. AU="Kimura, Kasane"
  11. AU="Gleeson, Sarah"
  12. AU="Hong, Ki Hyun"
  13. AU="Adalbert, V’kovski Philip"
  14. AU="Witte, Martin D"
  15. AU=Sun Yuan
  16. AU=Khan Zeashan Hameed AU=Khan Zeashan Hameed
  17. AU=Andrade D M
  18. AU="Miyata, Fumika"
  19. AU="Ahmad Rizal"
  20. AU="Aponte, Nelson"
  21. AU=Manfredonia Ilaria
  22. AU="Ryu, Jae Sung"
  23. AU="Lo, Bernard"
  24. AU="Pandya, Hardi"
  25. AU="Evans, J Anthony"
  26. AU="Chang, Hanxuan" AU="Chang, Hanxuan"
  27. AU="Bellamy, Kyle" AU="Bellamy, Kyle"
  28. AU="Jensen, Kara L"
  29. AU=Wang Yun
  30. AU=Seimiya H
  31. AU="Victor Babos, Diego"
  32. AU="Giuseppe Sergi"
  33. AU="Nackers, Elke"
  34. AU=Grobler Chistine
  35. AU="Norman H. L. Chiu"
  36. AU="Ioannis Politis"
  37. AU="Scott Nugent"
  38. AU="Sepideh MONSEF"
  39. AU="Wang, Zhaoqi"

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  1. Buch ; Dissertation / Habilitation: Untersuchungen zum COPII-abhängigen anterograden Transport der GIcNAc-1-Phosphotransferase aus dem endoplasmatischen reticulum

    Ahmadi, Parimah

    Analysis of the COPII dependent anterograde transport of GIcNAc-1-Phosphotransferase from the endoplasmic reticulum

    2013  

    Titelvarianten Analysis of the COPII dependent anterograde transport of GIcNAc-1-Phosphotransferase from the endoplasmic reticulum
    Verfasserangabe von Parimah Ahmadi
    Sprache Deutsch
    Umfang 57 Bl., Ill., graph. Darst., Tab
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Univ., FB Biol. Bachelorarbeit--Hamburg, 2013
    Anmerkung nur Zsfassung auch in engl. Sprache
    Begleitmaterial 1 CD-ROM
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  2. Artikel ; Online: Two simple and inexpensive methods for preparing DNA suitable for digital PCR from a small number of cells in 96-well plates.

    Zou, Ziang / Guo, Linna / Ahmadi, Parimah / Hartjen, Philip / Gosau, Martin / Smeets, Ralf / Kluwe, Lan

    Journal of clinical laboratory analysis

    2020  Band 35, Heft 1, Seite(n) e23513

    Abstract: Background: Although DNA of high quality can be easily prepared from cultured cells with commercially available kits, many studies involve a large number of samples which increases the cost drastically. We optimized two simple and inexpensive methods ... ...

    Abstract Background: Although DNA of high quality can be easily prepared from cultured cells with commercially available kits, many studies involve a large number of samples which increases the cost drastically. We optimized two simple and inexpensive methods for preparing DNA suitable for digital PCR from a small number of cells directly from wells of 96-well plates.
    Methods: Cells (number: 10
    Results: For 1000 cells from one primary culture and two tumor cell lines, DNA was reproducible and obtained with recovery rate (obtained/expected amount of DNA) in the range of 50%-90% as measured by the fluorometer dyes instrument Qubit. Using 8 out of a total of 10 µL DNA solution for 1000 cells, both conventional PCR and digital PCR were successful. For digital PCR, more than 1600 positive droplets were obtained for DNA from 1000 cells using the Direct PCR
    Conclusions: Two methods are efficient, especially the Direct PCR
    Mesh-Begriff(e) Cell Line, Tumor ; Cells, Cultured ; DNA/analysis ; DNA/genetics ; DNA/isolation & purification ; Humans ; Polymerase Chain Reaction/methods ; Polymerase Chain Reaction/standards
    Chemische Substanzen DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2020-08-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.23513
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2471: Hefte anzeigen Standort:
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  3. Artikel ; Online: Human dental pulp cells modulate CD8

    Ahmadi, Parimah / Yan, Ming / Bauche, Andreas / Smeets, Ralf / Müller, Christa E / Koch-Nolte, Friedrich / Haag, Friedrich / Fliegert, Ralf / Kluwe, Lan / Schulze Zur Wiesch, Julian / Hartjen, Philip

    Cellular immunology

    2022  Band 380, Seite(n) 104589

    Abstract: The pulp of human teeth contains a population of self-renewing stem cells that can regulate the functions of immune cells. When applied to patients, these cells can protect tissues from damage by excessive inflammation. We confirm that dental pulp cells ... ...

    Abstract The pulp of human teeth contains a population of self-renewing stem cells that can regulate the functions of immune cells. When applied to patients, these cells can protect tissues from damage by excessive inflammation. We confirm that dental pulp cells effectively inhibit the proliferation and activation of cytotoxic T cells in vitro, and show that they carry high levels of CD73, a key enzyme in the conversion of pro-inflammatory extracellular ATP to immunosuppressive adenosine. Given their accessibility and abundance, as well as their potential for allogeneic administration, dental pulp cells provide a valuable source for immunomodulatory therapy.
    Mesh-Begriff(e) 5'-Nucleotidase/metabolism ; Adenosine/metabolism ; Adenosine Triphosphate/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Cell Proliferation ; Dental Pulp ; Humans
    Chemische Substanzen Adenosine Triphosphate (8L70Q75FXE) ; 5'-Nucleotidase (EC 3.1.3.5) ; Adenosine (K72T3FS567)
    Sprache Englisch
    Erscheinungsdatum 2022-08-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2022.104589
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 417: Hefte anzeigen Standort:
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  4. Artikel ; Online: Toward Tailoring the Degradation Rate of Magnesium-Based Biomaterials for Various Medical Applications: Assessing Corrosion, Cytocompatibility and Immunological Effects.

    Hartjen, Philip / Wegner, Nils / Ahmadi, Parimah / Matthies, Levi / Nada, Ola / Fuest, Sandra / Yan, Ming / Knipfer, Christian / Gosau, Martin / Walther, Frank / Smeets, Ralf

    International journal of molecular sciences

    2021  Band 22, Heft 2

    Abstract: Magnesium (Mg)-based biomaterials hold considerable promise for applications in regenerative medicine. However, the degradation of Mg needs to be reduced to control toxicity caused by its rapid natural corrosion. In the process of developing new Mg ... ...

    Abstract Magnesium (Mg)-based biomaterials hold considerable promise for applications in regenerative medicine. However, the degradation of Mg needs to be reduced to control toxicity caused by its rapid natural corrosion. In the process of developing new Mg alloys with various surface modifications, an efficient assessment of the relevant properties is essential. In the present study, a WE43 Mg alloy with a plasma electrolytic oxidation (PEO)-generated surface was investigated. Surface microstructure, hydrogen gas evolution in immersion tests and cytocompatibility were assessed. In addition, a novel in vitro immunological test using primary human lymphocytes was introduced. On PEO-treated WE43, a larger number of pores and microcracks, as well as increased roughness, were observed compared to untreated WE43. Hydrogen gas evolution after two weeks was reduced by 40.7% through PEO treatment, indicating a significantly reduced corrosion rate. In contrast to untreated WE43, PEO-treated WE43 exhibited excellent cytocompatibility. After incubation for three days, untreated WE43 killed over 90% of lymphocytes while more than 80% of the cells were still vital after incubation with the PEO-treated WE43. PEO-treated WE43 slightly stimulated the activation, proliferation and toxin (perforin and granzyme B) expression of CD8
    Mesh-Begriff(e) Animals ; Cells, Cultured ; Coated Materials, Biocompatible/chemistry ; Coated Materials, Biocompatible/pharmacokinetics ; Coated Materials, Biocompatible/pharmacology ; Corrosion ; Equipment and Supplies ; Humans ; Immune System/drug effects ; Lymphocytes/drug effects ; Lymphocytes/physiology ; Magnesium/chemistry ; Magnesium/pharmacokinetics ; Magnesium/pharmacology ; Magnesium Compounds/chemistry ; Magnesium Compounds/pharmacokinetics ; Magnesium Compounds/pharmacology ; Materials Testing/methods ; Mice ; Oxidation-Reduction
    Chemische Substanzen Coated Materials, Biocompatible ; Magnesium Compounds ; Magnesium (I38ZP9992A)
    Sprache Englisch
    Erscheinungsdatum 2021-01-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22020971
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73

    Ahmadi, Parimah / Hartjen, Philip / Kohsar, Matin / Kummer, Silke / Schmiedel, Stefan / Bockmann, Jan-Hendrik / Fathi, Anahita / Huber, Samuel / Haag, Friedrich / Schulze Zur Wiesch, Julian

    Cells

    2020  Band 9, Heft 8

    Abstract: The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19. Here, we analyzed CD39 and CD73 on different lymphocyte ... ...

    Abstract The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19. Here, we analyzed CD39 and CD73 on different lymphocyte populations in a small cohort of COVID-19 patients and in healthy individuals. We describe a significantly lower level of expression of CD73 on cytotoxic lymphocyte populations, including CD8
    Mesh-Begriff(e) 5'-Nucleotidase/metabolism ; Adenosine/metabolism ; Adult ; Aged ; Apyrase/metabolism ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/enzymology ; Coronavirus Infections/immunology ; Female ; GPI-Linked Proteins/metabolism ; Granzymes/metabolism ; Humans ; Inflammation/enzymology ; Inflammation/immunology ; Interferon-gamma/metabolism ; Killer Cells, Natural/immunology ; Male ; Middle Aged ; Natural Killer T-Cells/immunology ; Pandemics ; Perforin/metabolism ; Pneumonia, Viral/enzymology ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Signal Transduction/immunology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemische Substanzen GPI-Linked Proteins ; Tumor Necrosis Factor-alpha ; Perforin (126465-35-8) ; Interferon-gamma (82115-62-6) ; 5'-Nucleotidase (EC 3.1.3.5) ; NT5E protein, human (EC 3.1.3.5) ; Granzymes (EC 3.4.21.-) ; Apyrase (EC 3.6.1.5) ; ENTPD1 protein, human (EC 3.6.1.5) ; Adenosine (K72T3FS567)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9081750
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19.

    Wildner, Nils H / Ahmadi, Parimah / Schulte, Sophia / Brauneck, Franziska / Kohsar, Matin / Lütgehetmann, Marc / Beisel, Claudia / Addo, Marylyn M / Haag, Friedrich / Schulze Zur Wiesch, Julian

    Journal of leukocyte biology

    2020  Band 109, Heft 1, Seite(n) 77–90

    Abstract: B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation. In this study, we used 16-color flow cytometry analysis to investigate the frequency, ... ...

    Abstract B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation. In this study, we used 16-color flow cytometry analysis to investigate the frequency, differentiation, and activation status of peripheral B cells of patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared with the healthy individuals. As a main result, we observed an increase of the frequency of (CD27
    Mesh-Begriff(e) Adult ; Aged ; Antigens, CD/immunology ; COVID-19/immunology ; COVID-19/pathology ; Female ; Humans ; Immunologic Memory ; Malaria, Falciparum/immunology ; Malaria, Falciparum/pathology ; Male ; Middle Aged ; Plasma Cells/immunology ; Plasma Cells/pathology ; Plasmodium falciparum/immunology ; SARS-CoV-2/immunology
    Chemische Substanzen Antigens, CD
    Sprache Englisch
    Erscheinungsdatum 2020-12-04
    Erscheinungsland England
    Dokumenttyp Clinical Trial ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.5COVA0620-370RR
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 603: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Über subito bestellen

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  7. Artikel: Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes

    Ahmadi, Parimah / Hartjen, Philip / Kohsar, Matin / Kummer, Silke / Schmiedel, Stefan / Bockmann, Jan-Hendrik / Fathi, Anahita / Huber, Samuel / Haag, Friedrich / Schulze Zur Wiesch, Julian

    Abstract: The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19. Here, we analyzed CD39 and CD73 on different lymphocyte ... ...

    Abstract The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19. Here, we analyzed CD39 and CD73 on different lymphocyte populations in a small cohort of COVID-19 patients and in healthy individuals. We describe a significantly lower level of expression of CD73 on cytotoxic lymphocyte populations, including CD8+ T, natural killer T (NKT), and natural killer (NK) cells, during COVID-19. Interestingly, the decrease of CD73 on CD8+ T cells and NKT cells correlated with serum ferritin levels. Furthermore, we observed distinct functional differences between the CD73+ and CD73- subsets of CD8+ T cells and NKT cells with regard to cytokine/toxin secretion. In COVID-19 patients, the majority of the CD73-CD8+ T cells were capable of secreting granzyme B, perforin, tumor necrosis factor (TNF-α) or interferon-gamma (IFN-γ). To conclude, in this first study of CD39 and CD73 expression of lymphocytes in COVID-19, we show that CD8+ T cells and NKT cells lacking CD73 possess a significantly higher cytotoxic effector functionality compared to their CD73+ counterparts. Future studies should investigate differences of cellular CD39 and CD73 expression in patients at different disease stages and their potential as prognostic markers or targets for immunomodulatory therapies.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #669617
    Datenquelle COVID19

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