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Article ; Online: Numerical modelling of mode-I cracking in asphalt concrete

Ahmed Awais / Khan Rawid

E3S Web of Conferences, Vol 347, p

2022 Volume 01018

Abstract: This paper presents a numerical model to simulate mode-I fracture in asphalt concrete. The phase field method is used to simulate diffuse damage in asphalt concrete. In addition to the displacement degrees of freedom, a scalar damage degree of freedom is ...

Abstract	This paper presents a numerical model to simulate mode-I fracture in asphalt concrete. The phase field method is used to simulate diffuse damage in asphalt concrete. In addition to the displacement degrees of freedom, a scalar damage degree of freedom is added at each node of a finite element. Evolution of the damage variable is governed by a crack potential which regularizes a sharp crack over a finite volume. The phase field method does not suffer from mesh dependency problem like the continuum damage models and therefore preferred for damage analysis. A single edge notch beam is analysed to show the performance of the model. The damage pattern as well as load versus crack mouth opening displacement graph is compared with the experimental data. The numerical results show good agreement with the experimental observations.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Anxiolytic and Antidepressant Potential of Methanolic Extract of

Khalid, Ahmed Awais / Jabeen, Qaiser / Javaid, Faraza

Dose-response : a publication of International Hormesis Society

2023 Volume 21, Issue 2, Page(s) 15593258231169584

Abstract: ... Neurada ... ...

Abstract	Neurada procumbens
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2440820-7
ISSN	1559-3258
ISSN	1559-3258
DOI	10.1177/15593258231169584
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Article: Natural history, clinical characteristics, outcomes, and long-term follow-up of pain-free chronic pancreatitis.

Ahmed, Awais / Shah, Ishani / Bocchino, Rachel / Freedman, Steven D / Kothari, Darshan J / Sheth, Sunil G

Gastroenterology report

2023 Volume 11, Page(s) goad024

Abstract: Background: Chronic pancreatitis (CP) is characterized by chronic abdominal pain and functional insufficiency. However, a small subset of patients with prior acute pancreatitis (AP) and/or underlying risk factors for developing CP may be pain-free at ... ...

Abstract	Background: Chronic pancreatitis (CP) is characterized by chronic abdominal pain and functional insufficiency. However, a small subset of patients with prior acute pancreatitis (AP) and/or underlying risk factors for developing CP may be pain-free at diagnosis and may have a different clinical course. We aimed to compare the clinical characteristics, outcomes, and healthcare utilization between CP patients with and without pain. Methods: Reviewed patients with established CP were followed in our Pancreas Center between January 2016 and April 2021. Patients without risk factors for developing CP and/or without AP prior to their diagnosis and only with incidental radiologic features of CP were excluded, so as to minimize confounding factors of pancreatopathy unrelated to CP. Patients were divided into painful and pain-free groups to analyze differences in demographics, outcomes, and healthcare utilization. Results: Of 368 CP patients, 49 (13.3%) were pain-free at diagnosis and had remained so for >9 years. There were no significant differences in body mass index, race, sex, or co-morbidities between the two groups. Pain-free patients were older at diagnosis (53.9 vs 45.7, Conclusions: We described a unique subset of patients with underlying risk factors for CP and/or prior AP who were pain-free at diagnosis. They were older at diagnosis, had less EPI and RAP, and overall favorable outcomes with minimal resource utilization.
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2710871-5
ISSN	2052-0034
ISSN	2052-0034
DOI	10.1093/gastro/goad024
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Article: An Unusual Case of Sublingual Epidermoid Cyst Mimicking Plunging Ranula.

Asad Ullah, Muhammad / Ahmed, Awais / Hyder, Syed Muhammad Shahnawaz / Javed, Khalid / Naeem, Muhammad Qasim

Cureus

2023 Volume 15, Issue 8, Page(s) e42874

Abstract: Epidermoid cyst in the oral cavity is uncommon. It is even more rare to see an epidermoid cyst in the sublingual region. We report the case of a 30-year-old male presenting with a swelling in the floor of the mouth extending into the submental and ... ...

Abstract	Epidermoid cyst in the oral cavity is uncommon. It is even more rare to see an epidermoid cyst in the sublingual region. We report the case of a 30-year-old male presenting with a swelling in the floor of the mouth extending into the submental and submandibular regions. The midline swelling was painless, soft, and dome-shaped. CT scan contrast revealed the site and extent of swelling. The complete surgical excision of the lesion was performed via a transcervical approach. Histopathology revealed cystic fibrocollagenous tissue covered by squamous epithelium containing some keratin flakes.
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42874
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Article: Racial and Ethnic Disparities in Opioid Prescriptions for Patients with Abdominal Pain: Analysis of the National Ambulatory Medical Care Survey.

Ahmed, Awais / McHenry, Nicole / Gulati, Shivani / Shah, Ishani / Sheth, Sunil G

Journal of clinical medicine

2023 Volume 12, Issue 15

Abstract: Background: Disparities in pain control have been extensively studied in the hospital setting, but less is known regarding the racial/ethnic disparities in opioid prescriptions for patients with abdominal pain in ambulatory clinics.: Methods: We ... ...

Abstract	Background: Disparities in pain control have been extensively studied in the hospital setting, but less is known regarding the racial/ethnic disparities in opioid prescriptions for patients with abdominal pain in ambulatory clinics. Methods: We examined opioid prescriptions during visits by patients presenting with abdominal pain between the years of 2006 and 2015, respectively, in the National Ambulatory Medical Care Survey database. Data weights for national-level estimates were applied. Results: We identified 4006 outpatient visits, equivalent to 114 million weighted visits. Rates of opioid use was highest among non-Hispanic White patients (12%), and then non-Hispanic Black patients (11%), and was the lowest in Hispanic patients (6%). Hispanic patients had lower odds of receiving opioid prescriptions compared to non-Hispanic White patients (OR = 0.49; 95% CI, 0.31-0.77, Conclusions: Rates of opioid prescriptions for abdominal pain patients were substantially lower for the Hispanic patients compared with the non-Hispanic patients, despite having a decreased rate of high-risk features, such as alcohol use and depression. The root cause of this disparity needs further research to ensure equitable access to pain management.
Language	English
Publishing date	2023-07-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12155030
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Article ; Online: GlycA: Evaluation of a New Biomarker of Acute Pancreatitis.

Shah, Ishani / Yakah, William / Ahmed, Awais / Freedman, Steven D / Jiang, Zhenghui G / Sheth, Sunil G

Biomolecules

2023 Volume 13, Issue 10

Abstract: Background: Acute pancreatitis (AP) is a leading cause of gastrointestinal hospital admissions, with up to 40% mortality in patients with moderate-severe AP. Glycoprotein acetylation (GlycA) is measured as a nuclear magnetic resonance signal (NMR) of ... ...

Abstract	Background: Acute pancreatitis (AP) is a leading cause of gastrointestinal hospital admissions, with up to 40% mortality in patients with moderate-severe AP. Glycoprotein acetylation (GlycA) is measured as a nuclear magnetic resonance signal (NMR) of the post-translational modification of glycosylated acute-phase proteins released during inflammation. We aimed to investigate the role of GlycA as an inflammatory biomarker of AP. Methods: We prospectively enrolled 20 AP patients and 22 healthy controls and collected EDTA plasma samples at admission and discharge. NMR spectra were acquired from these samples using a 400 MHz Vantera Results: Demographic comparisons were similar, except for a higher BMI in AP patients compared to healthy controls (29.9 vs. 24.8 kg/m Conclusion: Our pilot study highlights the use of GlycA as a novel diagnostic biomarker of inflammation in patients with AP. Our study shows that GlycA levels were significantly higher in hospitalized AP patients compared to healthy controls. Patients with moderate-to-severe AP had higher GlycA levels compared to patients with mild AP at the time of their hospital discharge, suggesting persistent inflammation in patients with severe disease.
MeSH term(s)	Humans ; Acetylation ; Acute Disease ; Pilot Projects ; Pancreatitis/diagnosis ; Inflammation ; Biomarkers ; Glycoproteins ; Protein Processing, Post-Translational
Chemical Substances	Biomarkers ; Glycoproteins
Language	English
Publishing date	2023-10-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13101530
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Article ; Online: Long-Term Follow-up of Disabled Patients With Chronic Pancreatitis: Evaluation of Clinical Characteristics, Outcomes, and Predictors.

Liyen Cartelle, Anabel / Shah, Ishani / Bocchino, Rachel / Ahmed, Awais / Freedman, Steven D / Kothari, Darshan J / Sheth, Sunil G

Journal of clinical gastroenterology

2024 Volume 58, Issue 1, Page(s) 98–102

Abstract: Background/aims: Patients with chronic pancreatitis (CP) often report a poor quality of life and may be disabled. Our study identifies clinical characteristics, predictors and outcomes in CP patients with disability.: Methods: A review of established ...

Abstract	Background/aims: Patients with chronic pancreatitis (CP) often report a poor quality of life and may be disabled. Our study identifies clinical characteristics, predictors and outcomes in CP patients with disability. Methods: A review of established CP patients followed in our Pancreas Center between January 1, 2016 and April 30, 2021. Patients were divided into 2 groups based on disability. Univariate analysis was performed to identify differences in demographics, risk factors, comorbidities, complications, controlled medications, and resource utilization. Multivariate analysis was conducted to identify predictors for disability. Results: Out of 404 CP patients, 18% were disabled. These patients were younger (53.8 vs. 58.8, P =0.001), had alcoholic CP (54.1% vs. 30%; P <0.001), more recurrent pancreatitis (83.6% vs. 61.1%; P =0.001), chronic abdominal pain (96.7% vs. 78.2%; P =0.001), exocrine pancreatic insufficiency (83.6% vs. 55.5%; P <0.001), concurrent alcohol (39.3% vs. 23.3%; P =0.001) and tobacco abuse (42.6% vs. 26%; P =0.02), anxiety (23% vs. 18.2%; P <0.001), and depression (57.5% vs. 28.5%; P <0.001). A higher proportion was on opiates (68.9% vs. 43.6%; P <0.001), nonopiate controlled medications (47.5% vs. 23.9%; P <0.001), neuromodulators (73.3% vs. 44%; P <0.001), and recreational drugs (27.9% vs. 15.8%; P =0.036). Predictors of disability were chronic pain (OR 8.71, CI 2.61 to 12.9, P < 0.001), celiac block (OR 4.66, 2.49 to 8.41; P <0.001), neuromodulator use (OR 3.78, CI 2.09 to 6.66; P <0.001), opioid use (OR3.57, CI 2.06 to 6.31; P < 0.001), exocrine pancreatic insufficiency (OR3.56, CI 1.89 to 6.82; P <0.001), non-opioid controlled medications (OR 3.45, CI 2.01 to 5.99; P <0.001), history of recurrent acute pancreatitis (OR 2.49, CI 1.25 to 4.77; P <0.001), depression (OR 2.26, CI 1.79 to 3.01; P <0.001), and active smoking (OR1.8, CI 1.25 to 2.29; P <0.001). Conclusion: CP patients with disability have unique characteristics and predictors, which can be targeted to reduce disease burden and health care expenditure in this population.
MeSH term(s)	Humans ; Follow-Up Studies ; Quality of Life ; Acute Disease ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/therapy ; Pancreatitis, Chronic/epidemiology ; Exocrine Pancreatic Insufficiency/epidemiology ; Exocrine Pancreatic Insufficiency/etiology ; Risk Factors ; Delivery of Health Care
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000001804
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Book ; Online: Machine Learning and Data Science approach towards trend and predictors analysis of CDC Mortality Data for the USA

Nadeem, Yasir / Ahmed, Awais

2020

Abstract: The research on mortality is an active area of research for any country where the conclusions are driven from the provided data and conditions. The domain knowledge is an essential but not a mandatory skill (though some knowledge is still required) in ... ...

Abstract	The research on mortality is an active area of research for any country where the conclusions are driven from the provided data and conditions. The domain knowledge is an essential but not a mandatory skill (though some knowledge is still required) in order to derive conclusions based on data intuition using machine learning and data science practices. The purpose of conducting this project was to derive conclusions based on the statistics from the provided dataset and predict label(s) of the dataset using supervised or unsupervised learning algorithms. The study concluded (based on a sample) life expectancy regardless of gender, and their central tendencies; Marital status of the people also affected how frequent deaths were for each of them. The study also helped in finding out that due to more categorical and numerical data, anomaly detection or under-sampling could be a viable solution since there are possibilities of more class labels than the other(s). The study shows that machine learning predictions aren't as viable for the data as it might be apparent.
Keywords	Computer Science - Machine Learning ; Computer Science - Computers and Society
Publishing date	2020-09-11
Publishing country	us
Document type	Book ; Online
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Article ; Online: Swirling flow of fluid containing (SiO

Zhang, Juan / Ahmed, Awais / Naveed Khan, Muhammad / Wang, Fuzhang / Abdelmohsen, Shaimaa Am / Tariq, Hadia

Journal of applied biomaterials & functional materials

2022 Volume 20, Page(s) 22808000221094685

Abstract: Investigation of heat transport mechanism in swirling flow of viscous fluid containing silicon ... ...

Abstract	Investigation of heat transport mechanism in swirling flow of viscous fluid containing silicon dioxide
MeSH term(s)	Hot Temperature ; Molybdenum ; Nanoparticles ; Silicon Dioxide ; Viscosity
Chemical Substances	Silicon Dioxide (7631-86-9) ; Molybdenum (81AH48963U)
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2673624-X
ISSN	2280-8000 ; 2280-8000
ISSN (online)	2280-8000
ISSN	2280-8000
DOI	10.1177/22808000221094685
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Article ; Online: Impact of recurrent acute pancreatitis on the natural history and progression to chronic pancreatitis.

Shah, Ishani / Bocchino, Rachel / Ahmed, Awais / Freedman, Steven D / Kothari, Darshan J / Sheth, Sunil G

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

2022 Volume 22, Issue 8, Page(s) 1084–1090

Abstract: Background and aims: It is believed that acute pancreatitis (AP), recurrent AP (RAP) and chronic pancreatitis (CP) represent stages of the same disease spectrum. We aimed to identify risk factors, clinical presentation and outcomes in patients with ... ...

Abstract	Background and aims: It is believed that acute pancreatitis (AP), recurrent AP (RAP) and chronic pancreatitis (CP) represent stages of the same disease spectrum. We aimed to identify risk factors, clinical presentation and outcomes in patients with prior RAP who develop CP. Methods: We retrospectively reviewed patients with CP who were seen at our Pancreas Center during 2016-2021. We divided them into two groups: with and without RAP (≥2 episodes of AP). We compared demographics, clinical presentation and resource utilization between the two groups. Results: We identified 440 patients with CP, of which 283 (64%) patients had preceding RAP. These patients were younger (55.6 vs 63.1 years), active smokers (36% vs 20%) and had alcohol-related CP (49% vs 25%) compared to those without RAP and CP (p < 0.05). More patients with RAP had chronic abdominal pain (89% vs 67.9%), nausea (43.3% vs 27.1%) and exocrine pancreatic insufficiency (65.8% vs 46.5%) (p < 0.05). More patients with RAP used opioids (58.4% vs 32.3%) and gabapentinoids (56.6% vs 34.8%) (p < 0.05). They also had more ED visits resulting in an opioid prescription (9.68% vs 2%) and more CP flares requiring hospitalization (3.09 vs 0.87) (p < 0.05). Conclusion: Young age, smoking and alcohol use are seen in patients with RAP who progress to CP. These patients are highly symptomatic and use more healthcare resources, suggestive of an overall a more course compared to those patients who develop CP without preceding RAP. Early identification and counselling of these patients may slow down progression to CP.
MeSH term(s)	Humans ; Acute Disease ; Retrospective Studies ; Recurrence ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/epidemiology ; Risk Factors
Language	English
Publishing date	2022-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2056680-3
ISSN	1424-3911 ; 1424-3903
ISSN (online)	1424-3911
ISSN	1424-3903
DOI	10.1016/j.pan.2022.09.237
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