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  1. Article ; Online: Retrospective review of non-ST segment elevation acute coronary syndrome presenting to the emergency department of a major tertiary center in Saudi Arabia.

    Qureshi, Muhammad Nauman / Ahmed, Eman Nayaz / Ahmed, Khaled Abdulrahman / Bashtawi, Eyad

    Annals of Saudi medicine

    2024  Volume 44, Issue 1, Page(s) 1–10

    Abstract: Background: Acute coronary syndrome (ACS) comprises a spectrum of diseases ranging from unstable angina (UA), non-ST elevation myocardial infarction (non-STEMI) and ST elevation myocardial infarction (STEMI). Treatment of ACS without STEMI (NSTEMI-ACS) ... ...

    Abstract Background: Acute coronary syndrome (ACS) comprises a spectrum of diseases ranging from unstable angina (UA), non-ST elevation myocardial infarction (non-STEMI) and ST elevation myocardial infarction (STEMI). Treatment of ACS without STEMI (NSTEMI-ACS) can vary, depending on the severity of presentation and multiple other factors.
    Objective: Analyze the NSTEMI-ACS patients in our institution.
    Design: Retrospective observational.
    Setting: A tertiary care institution with accredited chest pain center.
    Patients and methods: The travel time from ED booking to the final disposition for patients presenting with chest pain was retrieved over a period of 6 months. The duration of each phase of management was measured with a view to identify the factors that influence their management and time from the ED to their final destination. The data was analyzed using descriptive statistics.
    Main outcome measures: Travel time from ED to final destination.
    Sample size: 300 patients.
    Results: The majority of patients were males (64%) between 61 and 80 years of age (45%). The median disposition time (from ED booking to admission order by the cardiology team) was 5 hours and 19 minutes. Cardiology admissions took 10 hours and 20 minutes from ED booking to the inpatient bed. UA was diagnosed in 153 (51%) patients and non-STEMI in 52 (17%). Coronary catheterization was required in 79 (26%) patients, 24 (8%) had coronary artery bypass grafting (CABG) and 8 (3%) had both catheterization and CABG.
    Conclusion: The time from ED booking to final destination for NSTEMI-ACS patients is delayed due to multiple factors, which caused significant delays in overall management. Additional interventional steps can help improve the travel times, diagnosis, management and disposition of these patients.
    Limitations: Single center study done in a tertiary care center so the results from this study may not be extrapolated to other centers.
    MeSH term(s) Male ; Humans ; Female ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/therapy ; Saudi Arabia ; Retrospective Studies ; Non-ST Elevated Myocardial Infarction/diagnosis ; Non-ST Elevated Myocardial Infarction/therapy ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/therapy ; Emergency Service, Hospital
    Language English
    Publishing date 2024-02-01
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 639014-6
    ISSN 0975-4466 ; 0256-4947
    ISSN (online) 0975-4466
    ISSN 0256-4947
    DOI 10.5144/0256-4947.2024.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrigendum: Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy.

    Shafqat, Areez / Omer, Mohamed H / Ahmed, Eman Nayaz / Mushtaq, Ali / Ijaz, Eman / Ahmed, Zara / Alkattan, Khaled / Yaqinuddin, Ahmed

    Frontiers in immunology

    2023  Volume 14, Page(s) 1252998

    Abstract: This corrects the article DOI: 10.3389/fimmu.2023.1200941.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2023.1200941.].
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1252998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy.

    Shafqat, Areez / Omer, Mohamed H / Ahmed, Eman Nayaz / Mushtaq, Ali / Ijaz, Eman / Ahmed, Zara / Alkattan, Khaled / Yaqinuddin, Ahmed

    Frontiers in immunology

    2023  Volume 14, Page(s) 1200941

    Abstract: This review focuses on the immunosuppressive effects of tumor angiogenesis and coagulation on the tumor microenvironment (TME). We summarize previous research efforts leveraging these observations and targeting these processes to enhance immunotherapy ... ...

    Abstract This review focuses on the immunosuppressive effects of tumor angiogenesis and coagulation on the tumor microenvironment (TME). We summarize previous research efforts leveraging these observations and targeting these processes to enhance immunotherapy outcomes. Clinical trials have documented improved outcomes when combining anti-angiogenic agents and immunotherapy. However, their overall survival benefit over conventional therapy remains limited and certain tumors exhibit poor response to anti-angiogenic therapy. Additionally, whilst preclinical studies have shown several components of the tumor coagulome to curb effective anti-tumor immune responses, the clinical studies reporting combinations of anticoagulants with immunotherapies have demonstrated variable treatment outcomes. By reviewing the current state of the literature on this topic, we address the key questions and future directions in the field, the answers of which are crucial for developing effective strategies to reprogram the TME in order to further the field of cancer immunotherapy.
    MeSH term(s) Humans ; Immunotherapy ; Neoplasms/therapy ; Immunomodulation ; Neovascularization, Pathologic/therapy ; Thrombosis ; Tumor Microenvironment
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1200941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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