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Article: Antidiabetic activity of

Mehdi, Shumaila / Mehmood, Malik Hassan / Ahmed, Mobeen Ghulam / Ashfaq, Usman Ali

2023 Volume 14, Page(s) 1085013

Abstract: Medicinal plants play a key role in protection of chronic non-communicable ailments like diabetes, hypertension and dyslipidemia. ...

Abstract	Medicinal plants play a key role in protection of chronic non-communicable ailments like diabetes, hypertension and dyslipidemia.
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1085013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Caryopteris odorata

Ahmed, Mobeen Ghulam / Mehmood, Malik Hassan / Mehdi, Shumaila / Farrukh, Maryam

Frontiers in pharmacology

2023 Volume 14, Page(s) 1097407

Abstract: Caryopteris ... ...

Abstract	Caryopteris odorata
Language	English
Publishing date	2023-03-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1097407
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Stress Perfusion Cardiac Magnetic Resonance Imaging With a 3.0-Tesla Scanner for Myocardial Viability in a Patient With a Conditional Pacemaker.

Motazedian, Pouya / Prosperi-Porta, Graeme / Ahmed, Mobeen / Hafeez, Moiz / Merchant, Naeem / Heydari, Bobak

CJC open

2022 Volume 4, Issue 6, Page(s) 581–584

Abstract: Cardiac magnetic resonance (CMR) imaging provides images with high spatial and temporal resolution, with high diagnostic and prognostic performance. An abundance of data indicate the safety and efficacy of noncardiac magnetic resonance imaging at both 1 ... ...

Abstract	Cardiac magnetic resonance (CMR) imaging provides images with high spatial and temporal resolution, with high diagnostic and prognostic performance. An abundance of data indicate the safety and efficacy of noncardiac magnetic resonance imaging at both 1.5 Tesla (T) and 3T in patients with cardiac implantable electronic devices (CIEDs). Safety and efficacy have also been evaluated for stress perfusion (SP)-CMR for pateints with CIEDs, using 1.5T scanners, but no previous reports have been made of SP-CMR using 3T scanners. Herein, we report a case of a patient with a CIED who successfully and safely underwent SP-CMR imaging using a 3T scanner.
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Case Reports
ISSN	2589-790X
ISSN (online)	2589-790X
DOI	10.1016/j.cjco.2022.02.009
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Article: Non-operative treatment of hepatic trauma: A changing paradigm. A Six year review of liver trauma patient in a single institute.

Siddiqui, Nadeem Ahmed / Jawed, Misaal / Pirzada, Ammar / Ahmed, Mobeen / Khan, Rehan Nasir

JPMA. The Journal of the Pakistan Medical Association

2020 Volume 70Suppl 1, Issue 2, Page(s) S27–S32

Abstract: Objective: To review the managing strategies of adult patients with liver trauma in a tertiary care hospital during a six years period.: Methods: The medical records of all patients admitted with a diagnosis of liver trauma from January 2012 to ... ...

Abstract	Objective: To review the managing strategies of adult patients with liver trauma in a tertiary care hospital during a six years period. Methods: The medical records of all patients admitted with a diagnosis of liver trauma from January 2012 to December 2017 in the Aga Khan University Hospital were retrospectively reviewed. The details of demographic, clinical, and outcome variables including morbidity and mortality rates were noted. Results: A total of 182 patients were admitted at AKUH with liver trauma between January 2012 and December 2017. Twenty-two patients were excluded according to our study criteria. Of 160 patients, 139 were male and 21 were female. One hundred twenty seven (79.4%) patients were less than 45 years of age. Most patients (89.4%) had no comorbids and 48 (44%) arrived at the hospital within 4 hours of injury. Majority, 101 (63.1%) of the patients had blunt trauma and 142 (89%) met with road accidents. A total of 109 (68.1%) patients were stable at arrival and 77 (48.1%) had abdominal signs present on examination. FAST ultrasound was done on 75 (46.9%) patients and CT scan abdomen on 145 (90.6 %) patients. Liver injuries were associated with other abdominal or systemic injuries in 139 (86.6%) patients. Low grade (Grade I & II) liver injuries were found in only 41 (25.6%) patients, with the remainder being high grade (Grade III- 41 patients, Grade IV-42 patients and Grade V-2 patients). Conservative treatment was offered to 68 (41.9%) patients, of which 57 (85.1%) remained stable and were eventually discharged. Of these, 2 expired and 3 required intervention. There were a total of 92 (57.2%) interventions done of which 60 patients were cured, 14 expired and 18 readmitted. Interventions included perihepatic packing (n=18), hepatorraphy (n=3), angioembolization (n=12) and hepatectomy (n=1). There were 16(10%) deaths in which liver haemorrhage and sepsis were the most common cause of mortality. Mean hospital stay in our study population was 8.9 days. Second admission was observed in 28 (17.5%) patients (n=28). Morbidity rate in our patients was 17.5% (n=28). The most common complication noted was that of a liver abscess, developing in 2 (1.3%) patients. Other significant problems were intra-abdominal collections (n=2) and biliary complications (n=3). Unstable haemodynamic status at arrival and prolonged stay in high dependency unit were noted to be independent risk factors for mortality. Conclusions: Conservative treatment was found successful in most of our patients with an intervention rate of 57.5% and overall mortality rate of 10%. So, NOMLI can be safely offered to liver trauma patients, even in high grade injuries.
MeSH term(s)	Abdominal Injuries/complications ; Abdominal Injuries/mortality ; Abdominal Injuries/therapy ; Accidents, Traffic ; Adolescent ; Adult ; Cause of Death ; Conservative Treatment ; Embolization, Therapeutic ; Female ; Focused Assessment with Sonography for Trauma ; Hemorrhage/etiology ; Hemorrhage/mortality ; Hemorrhage/therapy ; Hepatectomy ; Humans ; Length of Stay ; Liver/injuries ; Liver Abscess/etiology ; Liver Abscess/therapy ; Liver Diseases/etiology ; Liver Diseases/mortality ; Liver Diseases/therapy ; Male ; Multiple Trauma ; Patient Readmission ; Proportional Hazards Models ; Sepsis/mortality ; Tertiary Care Centers ; Tomography, X-Ray Computed ; Trauma Severity Indices ; Wounds, Nonpenetrating/complications ; Wounds, Nonpenetrating/therapy ; Wounds, Penetrating/complications ; Wounds, Penetrating/therapy ; Young Adult
Language	English
Publishing date	2020-02-11
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Magnetic Resonance Left Ventricle Mass-Index/Fibrosis: Long-Term Predictors for Ventricular Arrhythmia in Hypertrophic Cardiomyopathy-A Retrospective Registry.

Khan, Habib Rehman / Rodwell, Philip / Taha, Ahmed Hasan / Goha, Ahmed / Ahmed, Mobeen / Thain, Andrew Peter / Somarakis, Konstantinos / Al-Atta, Ayman / Erhayiem, Bara / Uddin, Akhlaque / Mathew, Thomas

Journal of cardiovascular development and disease

2023 Volume 10, Issue 3

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd10030120
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Article: Segment IV hepatic artery in potential donors for living related liver transplantation: Evaluation with multi-detector CT.

Nazer, Rashed / Nasir Khan, Ahmed Kamal / Ahmed, Awais / Ahmed, Mobeen / Raza, Farheen / Rafique, Muhammad Salman

JPMA. The Journal of the Pakistan Medical Association

2019 Volume 69, Issue 6, Page(s) 799–805

Abstract: Objective: To assess segment IV hepatic arterial anatomy and its variation on multi-detector computed tomography in potential liver donors.: Methods: The retrospective study was conducted at Shifa International Hospital, Islamabad and comprised data ... ...

Abstract	Objective: To assess segment IV hepatic arterial anatomy and its variation on multi-detector computed tomography in potential liver donors. Methods: The retrospective study was conducted at Shifa International Hospital, Islamabad and comprised data of potential liver transplant donors related to the period between January 2012 and June 2017. Computed tomography scans were performed using multi-detector scanners. Images were transferred to work station for postprocessing and were analysed regarding the origination and variation of the arteries by two independent experienced radiologists. Results: Of the 455 patients whose records were evaluated, 299(65.7%) were males and 156(34.3%) were females. Six types of segment IV artery were defined based on their points of origin: left hepatic artery 285(62.6%), right hepatic artery 111(24.4 %), proper hepatic artery 9(1.8 %), common hepatic artery 29(6.4%), gastro duodenal artery 3(0.7 %), and dual 18(4.1 %).313 of total cases (68.8%) had normal anatomy with no variation. Those with aberrant/variant anatomy constituted 142(31.2%) of the total. Conclusions: Multi-detector computed tomography angiography was found to be a fast, reliable and non-invasive technique that could evaluate normal as well as anatomical variants of segment IV arteries.
MeSH term(s)	Adult ; Computed Tomography Angiography ; Female ; Hepatic Artery/diagnostic imaging ; Hepatic Artery/transplantation ; Humans ; Liver Transplantation ; Living Donors ; Male ; Multidetector Computed Tomography ; Pakistan ; Retrospective Studies
Language	English
Publishing date	2019-06-12
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lymphoepithelioma-Like Carcinoma of the Esophagus: A Rare Tumor.

Khokhar, Nasir / Nasir, Humaira / Amir, Mohammad / Hassan, Saira / Khan, Khushal / Ahmed, Mobeen

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2017 Volume 27, Issue 9, Page(s) S114–S116

Abstract: Lymphoepithelioma-like carcinoma of esophagus is a rare tumor with about 20 cases reported worldwide. It can involve the salivary gland, esophagus, stomach, thymus, thyroid, breast, lung, uterus, cervix, urinary bladder, and the skin. Its association ... ...

Abstract	Lymphoepithelioma-like carcinoma of esophagus is a rare tumor with about 20 cases reported worldwide. It can involve the salivary gland, esophagus, stomach, thymus, thyroid, breast, lung, uterus, cervix, urinary bladder, and the skin. Its association with Epstein Barr virus has been postulated. We report the case of a 45-year female who had been treated for hepatitis C and esophageal tuberculosis and recovered fully from these conditions. She presented with dysphagia of 2-3 month duration. Endoscopic examination revealed narrowing of the esophageal lumen with a fungating mass at the lower end of esophagus with no extension into the stomach. ACTscan confirmed a mass at the lower end of esophagus with multiple enlarged mediastinal lymph nodes. Histological and immunohistochemistry of esophageal biopsy sample showed lymphoepithelioma-like carcinoma. She was managed with chemotherapy comprising of capecitabine, epirubicin and cisplatin followed by esophagectomy and made full recovery.
Language	English
Publishing date	2017-09
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	279
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Article ; Online: Validation of ethnopharmacological uses of Murraya paniculata in disorders of diarrhea, asthma and hypertension

Saqib, Fatima / Ahmed, Mobeen Ghulam / Janbaz, Khalid Hussain / Dewanjee, Saikat / Jaafar, Hawa ZE / Zia-Ul-Haq, Muhammad

BMC Complement Altern Med. 2015 Dec., v. 15, no. 1 p.319-319

2015

Abstract: BACKGROUND: Murraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted for provision of pharmacological rationalization for folkloric uses of Murraya paniculata in gut, air way and ... ...

Abstract	BACKGROUND: Murraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted for provision of pharmacological rationalization for folkloric uses of Murraya paniculata in gut, air way and cardiovascular problems. METHODS: Aqueous-ethanolic extract of Mp.Cr was tested using in vitro techniques on isolated tissue of rabbit (jejunum, trachea and aorta) to detect the possible presence of spasmolytic activity. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. RESULTS: Application of the extract of Mp.Cr relaxed spontaneous and high K⁺ (80mM)-induced contraction in rabbit jejunum preparation. Because it shifted the CRCs (Calcium response curve) towards the right side so the possible blockade was of calcium channel similar to verapamil. In rabbit trachea, extract of Mp.Cr produced relaxation of carbachol and high K⁺ induced contractions. When plant extract was checked further on isolated aorta for its possible vasodilator effect, it caused relaxation of phenylephrine and high K⁺-induced spastic contractions at different doses. CONCLUSION: These results indicate that Murraya paniculata shows anti-spasmodic, bronchodilator and vasodilator activity facilitated through Ca⁺⁺ antagonist mechanisms.
Keywords	Murraya paniculata ; air ; antagonists ; aorta ; asthma ; bronchodilators ; calcium ; calcium channels ; carbachol ; complement ; data collection ; diarrhea ; hypertension ; jejunum ; parasympatholytics ; phenylephrine ; plant extracts ; rabbits ; traditional medicine ; verapamil
Language	English
Dates of publication	2015-12
Size	p. 319.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2050429-9
ISSN	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-015-0837-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: T2DiACoD

Jyoti Rani / Inna Mittal / Atreyi Pramanik / Namita Singh / Namita Dube / Smriti Sharma / Bhanwar Lal Puniya / Muthukurussi Varieth Raghunandanan / Ahmed Mobeen / Srinivasan Ramachandran

Scientific Reports, Vol 7, Iss 1, Pp 1-

A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders

2017 Volume 21

Abstract: Abstract We performed integrative analysis of genes associated with type 2 Diabetes Mellitus (T2DM) associated complications by automated text mining with manual curation and also gene expression analysis from Gene Expression Omnibus. They were analysed ... ...

Abstract	Abstract We performed integrative analysis of genes associated with type 2 Diabetes Mellitus (T2DM) associated complications by automated text mining with manual curation and also gene expression analysis from Gene Expression Omnibus. They were analysed for pathogenic or protective role, trends, interaction with risk factors, Gene Ontology enrichment and tissue wise differential expression. The database T2DiACoD houses 650 genes, and 34 microRNAs associated with T2DM complications. Seven genes AGER, TNFRSF11B, CRK, PON1, ADIPOQ, CRP and NOS3 are associated with all 5 complications. Several genes are studied in multiple years in all complications with high proportion in cardiovascular (75.8%) and atherosclerosis (51.3%). T2DM Patients’ skeletal muscle tissues showed high fold change in differentially expressed genes. Among the differentially expressed genes, VEGFA is associated with several complications of T2DM. A few genes ACE2, ADCYAP1, HDAC4, NCF1, NFE2L2, OSM, SMAD1, TGFB1, BDNF, SYVN1, TXNIP, CD36, CYP2J2, NLRP3 with details of protective role are catalogued. Obesity is clearly a dominant risk factor interacting with the genes of T2DM complications followed by inflammation, diet and stress to variable extents. This information emerging from the integrative approach used in this work could benefit further therapeutic approaches. The T2DiACoD is available at www.http://t2diacod.igib.res.in/ .
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2017-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Validation of ethnopharmacological uses of Murraya paniculata in disorders of diarrhea, asthma and hypertension.

Saqib, Fatima / Ahmed, Mobeen Ghulam / Janbaz, Khalid Hussain / Dewanjee, Saikat / Jaafar, Hawa Z E / Zia-Ul-Haq, Muhammad

BMC complementary and alternative medicine

2015 Volume 15, Page(s) 319

Abstract: Background: Murraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted for provision of pharmacological rationalization for folkloric uses of Murraya paniculata in gut, air way and ... ...

Abstract	Background: Murraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted for provision of pharmacological rationalization for folkloric uses of Murraya paniculata in gut, air way and cardiovascular problems. Methods: Aqueous-ethanolic extract of Mp.Cr was tested using in vitro techniques on isolated tissue of rabbit (jejunum, trachea and aorta) to detect the possible presence of spasmolytic activity. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results: Application of the extract of Mp.Cr relaxed spontaneous and high K(+) (80mM)-induced contraction in rabbit jejunum preparation. Because it shifted the CRCs (Calcium response curve) towards the right side so the possible blockade was of calcium channel similar to verapamil. In rabbit trachea, extract of Mp.Cr produced relaxation of carbachol and high K(+) induced contractions. When plant extract was checked further on isolated aorta for its possible vasodilator effect, it caused relaxation of phenylephrine and high K(+)-induced spastic contractions at different doses. Conclusion: These results indicate that Murraya paniculata shows anti-spasmodic, bronchodilator and vasodilator activity facilitated through Ca(++) antagonist mechanisms.
MeSH term(s)	Animals ; Aorta/drug effects ; Asthma/metabolism ; Autonomic Agents/pharmacology ; Diarrhea/metabolism ; Ethnopharmacology ; Hypertension/metabolism ; Jejunum/drug effects ; Models, Biological ; Murraya/chemistry ; Plant Extracts/pharmacology ; Rabbits ; Trachea/drug effects
Chemical Substances	Autonomic Agents ; Plant Extracts
Language	English
Publishing date	2015-09-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2050429-9
ISSN	1472-6882 ; 1472-6882
ISSN (online)	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-015-0837-7
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