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  1. Article: Flavonoids: A treasure house of prospective pharmacological potentials.

    Hasnat, Hasin / Shompa, Suriya Akter / Islam, Md Mirazul / Alam, Safaet / Richi, Fahmida Tasnim / Emon, Nazim Uddin / Ashrafi, Sania / Ahmed, Nazim Uddin / Chowdhury, Md Nafees Rahman / Fatema, Nour / Hossain, Md Sakhawat / Ghosh, Avoy / Ahmed, Firoj

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27533

    Abstract: Flavonoids are organic compounds characterized by a range of phenolic structures, which are abundantly present in various natural sources such as fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. The health advantages of these ... ...

    Abstract Flavonoids are organic compounds characterized by a range of phenolic structures, which are abundantly present in various natural sources such as fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. The health advantages of these natural substances are renowned, and initiatives are being taken to extract the flavonoids. Apigenin, galangin, hesperetin, kaempferol, myricetin, naringenin, and quercetin are the seven most common compounds belonging to this class. A thorough analysis of bibliographic records from reliable sources including Google Scholar, Web of Science, PubMed, ScienceDirect, MEDLINE, and others was done to learn more about the biological activities of these flavonoids. These flavonoids appear to have promising anti-diabetic, anti-inflammatory, antibacterial, antioxidant, antiviral, cytotoxic, and lipid-lowering activities, according to evidence from
    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Analysis of bioactive compounds present in different crude extracts of Benincasa hispida and Cucurbita moschata seeds by gas chromatography-mass spectrometry

    Muzahid, Ali Ahsan / Sharmin, Samia / Hossain, Md. Sakhawat / Ahamed, Kutub Uddin / Ahmed, Nasim / Yeasmin, Most. Sarmina / Ahmed, Nazim Uddin / Saha, Barun Kanti / Rana, G.M. Masud / Maitra, Bijoy / Bhuiyan, Md Nurul Huda

    Heliyon. 2023 Jan., v. 9, no. 1 p.e12702-

    2023  

    Abstract: Plant seeds are the resources of many different bioactive components. The chemical composition of the different crude extracts from Benincasa hispida (White pumpkin) and Cucurbita moschata (Pumpkin) seeds with three different polarity-based solvents (n- ... ...

    Abstract Plant seeds are the resources of many different bioactive components. The chemical composition of the different crude extracts from Benincasa hispida (White pumpkin) and Cucurbita moschata (Pumpkin) seeds with three different polarity-based solvents (n-hexane, n-hexane-chloroform (2:1), and methanol) was analyzed to identify the biologically active compounds. Each of the extracts was analyzed by gas chromatography-mass spectrometry. Different extracts of targeted seeds showed different biologically active compounds that have different pharmacological potentialities. 9, 12-Octadecadienoic acid (ZZ) was the most potent bioactive compound present in three different extracts of both B. hispida and C. moschata. Another bioactive compound comparatively low percentage present in both plants was n-hexadecanoic acid. Other major pharmacologically active compounds present in both plants were 9- Octadecenoic acid (Z)-, methyl ester, and 9, 12-Octadecadienoic acid methyl ester (E, E). Besides these compounds, a few more biologically active compounds were present in the two plants separately. The findings of this study support the use of these seeds in modern functional foods, nutraceuticals, and medicinal purposes, and the whole seeds would give better health benefits rather than use any extract. Although further pharmacological examinations should be carried out to conclude the medicinal application of the seeds of these two plants as well as to understand the mechanism of the potential health benefits.
    Keywords Benincasa hispida ; Cucurbita moschata ; bioactive compounds ; dietary supplements ; gas chromatography-mass spectrometry ; hexane ; medicinal properties ; methanol ; pumpkins ; GC–MS analysis ; Seed
    Language English
    Dates of publication 2023-01
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e12702
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Analysis of bioactive compounds present in different crude extracts of

    Muzahid, Ali Ahsan / Sharmin, Samia / Hossain, Md Sakhawat / Ahamed, Kutub Uddin / Ahmed, Nasim / Yeasmin, Most Sarmina / Ahmed, Nazim Uddin / Saha, Barun Kanti / Rana, G M Masud / Maitra, Bijoy / Bhuiyan, Md Nurul Huda

    Heliyon

    2022  Volume 9, Issue 1, Page(s) e12702

    Abstract: Plant seeds are the resources of many different bioactive components. The chemical composition of the different crude extracts ... ...

    Abstract Plant seeds are the resources of many different bioactive components. The chemical composition of the different crude extracts from
    Language English
    Publishing date 2022-12-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e12702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Whole Leea macrophylla ethanolic extract normalizes kidney deposits and recovers renal impairments in an ethylene glycol-induced urolithiasis model of rats.

    Nizami, Abu Nasim / Rahman, Md Atiar / Ahmed, Nazim Uddin / Islam, Md Shahidul

    Asian Pacific journal of tropical medicine

    2012  Volume 5, Issue 7, Page(s) 533–538

    Abstract: Objective: To investigate the antilithiatic effect of the whole Leea macrophylla (L. macrophylla) Roxb (Leeaceae) ethanol extract in ethylene glycol-induced urolithiasis model of rats.: Methods: Forty two seven weeks old male wistar albino rats were ... ...

    Abstract Objective: To investigate the antilithiatic effect of the whole Leea macrophylla (L. macrophylla) Roxb (Leeaceae) ethanol extract in ethylene glycol-induced urolithiasis model of rats.
    Methods: Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely: preventive (n=18) and therapeutic (n=24). Preventive group was further subdivided into 3 groups of 6 rats namely: preventive control (PC), preventive lithiatic control (PLC) and preventive lithiatic L. macrophylla (PLLM). Similarly, therapeutic group was also subdivided into 4 groups of 6 rats namely: therapeutic control (TC), therapeutic lithiatic control (TLC), therapeutic lithitatic L. macrophylla (TLLM) and therapeutic lithiatic cystone (TLCYS). The lithiasis was induced by 0.75% (v/v) ethylene glycol in the drinking water of all groups except the PC and TC groups. The urinary ionic parameters such as calcium, inorganic phosphate, oxalate, magnesium & creatinine and renal morphology were altered by ethylene glycol, which were partially recovered by 14 d preventive and almost fully recovered by 28 d therapeutic intervention trials with L. macrophylla extract (500 mg/kg BW daily).
    Results: Significant difference on recovery was observed between preventive and therapeutic interventional trials. Anti-urolithiatic effect of cystone was significantly (P<0.001) higher than extracts. L. macrophylla extract was found nontoxic in the acute toxicity test.
    Conclusion: The results of this study demonstrated very promising anti-urolithiatic effect of L. macrophylla extract with preventive and therapeutic treatments in this experimental condition.
    MeSH term(s) Animals ; Calcium Oxalate/metabolism ; Calcium Phosphates/metabolism ; Creatinine/metabolism ; Ethanol/pharmacology ; Ethylene Glycol/toxicity ; Kidney Calculi/pathology ; Kidney Calculi/prevention & control ; Kidney Calculi/urine ; Magnesium/metabolism ; Male ; Organ Size/drug effects ; Phytotherapy/methods ; Plant Extracts/pharmacology ; Random Allocation ; Rats ; Rats, Wistar ; Renal Insufficiency/chemically induced ; Renal Insufficiency/drug therapy ; Renal Insufficiency/urine ; Wound Healing/drug effects
    Chemical Substances Calcium Phosphates ; Plant Extracts ; Calcium Oxalate (2612HC57YE) ; Ethanol (3K9958V90M) ; calcium phosphate (97Z1WI3NDX) ; Creatinine (AYI8EX34EU) ; Ethylene Glycol (FC72KVT52F) ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2012-07
    Publishing country China
    Document type Journal Article
    ISSN 2352-4146
    ISSN (online) 2352-4146
    DOI 10.1016/S1995-7645(12)60094-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root.

    Kabir, Md Golam / Rahman, Md Monsor / Ahmed, Nazim Uddin / Fakruddin, Md / Islam, Saiful / Mazumdar, Reaz Mohammad

    Biological research

    2014  Volume 47, Page(s) 36

    Abstract: Background: This study was subjected to investigate different pharmacological properties of ethanol extract of Solena amplexicaulis root.: Results: The extract contains flavonoid, alkaloid, saponin and steroid compounds. The extract exhibited ... ...

    Abstract Background: This study was subjected to investigate different pharmacological properties of ethanol extract of Solena amplexicaulis root.
    Results: The extract contains flavonoid, alkaloid, saponin and steroid compounds. The extract exhibited excellent antioxidant activity in DPPH radical scavenging activity. The extract also showed potent activity in brine shrimp lethality bioassay. The LC50 value was found to 44.677 μg/ml. The extract showed better anti-bacterial activity against gram-negative bacteria. In antifungal assay, the maximum 79.31% of anti-mycotic activity was observed against Aspergillus ochraceus while minimum 44.2% against Rhizopus oryzae. MIC value ranged between 1500-3000 μg/ml. The extract was found moderately toxic with a 24-hr LD50 value of 81.47 mg/kg in Swiss albino mice. The degree of inhibition by the ethanolic extract of the root was found less than that of standard analgesic drug diclofenac sodium. The extract also showed moderate anti-inflammatory and antinociceptive activity and anti-diabetic property. Reducing power of the extract was comparable with standard ascorbic acid. Moderate in vitro thrombolytic activity, lipid peroxidation inhibition property, metal chelating ability and stress-protective activity was also observed.
    Conclusion: Ethanol extract of Solena amplexicaulis root can be valuable for treatment of different diseases.
    MeSH term(s) Analgesics/pharmacology ; Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Antifungal Agents/pharmacology ; Antioxidants/pharmacology ; Artemia/drug effects ; Aspergillus/drug effects ; Bacillus/drug effects ; Chelating Agents/pharmacology ; Cucurbitaceae/chemistry ; Fibrinolytic Agents/pharmacology ; Free Radical Scavengers/pharmacology ; Hypoglycemic Agents/pharmacology ; Lethal Dose 50 ; Lipid Peroxidation/drug effects ; Mice ; Microbial Sensitivity Tests ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Roots/chemistry ; Reducing Agents/pharmacology ; Saccharomyces cerevisiae/drug effects ; Shigella/drug effects
    Chemical Substances Analgesics ; Anti-Bacterial Agents ; Anti-Infective Agents ; Anti-Inflammatory Agents ; Antifungal Agents ; Antioxidants ; Chelating Agents ; Fibrinolytic Agents ; Free Radical Scavengers ; Hypoglycemic Agents ; Plant Extracts ; Reducing Agents
    Language English
    Publishing date 2014-08-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1138990-4
    ISSN 0717-6287 ; 0716-9760
    ISSN (online) 0717-6287
    ISSN 0716-9760
    DOI 10.1186/0717-6287-47-36
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Antioxidative Potential of the Polyphenolics of Stephania japonica var. Discolor (Blume) Forman: A Chromatographic (High-Performance Liquid Chromatography) and Spectrophotometric Measure

    Uddin, Md. Nazim / Ahmed, Nazim Uddin / Rahman, Md. Atiar / Akter, Rasheda / Akter, Rehana

    International journal of food properties

    Volume v. 19,, Issue no. 4

    Abstract: This study investigated the quantitative phytochemical contents, total phenolics, total flavonoids, total carotenoids, antioxidative capacity, tannin, proanthocyanidins, lycopene, chlorophyll a, and chlorophyll b of the Stephania japonica extract. ... ...

    Abstract This study investigated the quantitative phytochemical contents, total phenolics, total flavonoids, total carotenoids, antioxidative capacity, tannin, proanthocyanidins, lycopene, chlorophyll a, and chlorophyll b of the Stephania japonica extract. Comprehensive antioxidative effects of the extract were also investigated. Quantitative assays were conducted through both spectrophotometric and high-performance liquid chromatographic methods. Antioxidative effects were measured through FeCl ₃ reducing power, metal chelating power, reducing power, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) scavenging activity, N, N-dimethyl-1,4-diaminobenzene free radical scavenging activity, superoxide radical scavenging activity, and nitric oxide scavenging effect. The contents of total phenolics, total flavonoids, total carotenoids, total antioxidative capacity, tannin, proanthocyanidins, lycopene, chlorophyll a, and chlorophyll b were found to be 47.32 ± 0.75 mg tannic acid equivalent, 61.41 ± 1.58 mg catechin equivalent, 63.29 ± 2.21 mg, 22.85 ± 0.70 mg ascorbic acid equivalent, 76.17 ± 0.97 mg tannic acid equivalent, 94.96 ± 4.49 mg catechin equivalent, 22.19 ± 0.79 µg, 22.19 ± 0.79 µg, 7.52 ± 1.24 mg, and 10.43 ± 2.11 mg, respectively, in 1 g of ethanol extract. A high concentration of epicatechin, p -coumaric acid, and rutin hydrate and moderate concentration of caffeic acid and quercetin was detected in the extract. The IC ₅₀ value for ferric reducing power assay, metal chelating assay, reducing power assay, ABTS scavenging assay, N, N-dimethyl-1,4-diaminobenzene scavenging assay, superoxide scavenging assay and nitric oxide (NO) assay were 465.06 ± 7.32 µmol ascorbic acid/g, 1656.52, 270.55, 457.27, 632.74, 217.5, and 464.00 µg/mL, respectively. No beta carotene was detected in the extract. The extract was demonstrated to be a very potential source of antioxidative metabolites.
    Keywords proanthocyanidins ; metabolites ; tannins ; ascorbic acid ; caffeic acid ; superoxide anion ; catechin ; nitric oxide ; rutin ; inhibitory concentration 50 ; chlorophyll ; antioxidant activity ; Stephania japonica ; ethanol ; quercetin ; free radical scavengers ; lycopene ; epicatechin ; high performance liquid chromatography ; beta-carotene
    Language English
    Document type Article
    ISSN 1532-2386
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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