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  1. Article ; Online: Natural Flavonoids: Chemistry, Therapeutic Potentials, Therapeutic Targets and Mechanisms of Actions.

    Ahmed, Osama M

    Current pharmaceutical design

    2021  Volume 27, Issue 4, Page(s) 455

    MeSH term(s) Flavonoids/pharmacology ; Humans
    Chemical Substances Flavonoids
    Language English
    Publishing date 2021-03-30
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161282704210210113537
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    Zs.A 4714: Show issues Location:
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  2. Article: Transcriptional profiling of

    Ahmed, Osama M / Crocker, Amanda / Murthy, Mala

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... ...

    Abstract In
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.07.566045
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  3. Article: Ovicidal, larvicidal and adulticidal activity of black pepper (

    Mohamed, Hend Ibrahim / Arafa, Waleed M / Ahmed, Osama M / El-Dakhly, Khaled Mohamed

    Journal of parasitic diseases : official organ of the Indian Society for Parasitology

    2024  Volume 48, Issue 1, Page(s) 117–133

    Abstract: Haemonchosis is a worldwide helminthic disease affecting ruminants. The anthelminthic resistance has become raised. Medicinal plants are safely used as synthetic anthelmintics. Currently, the efficacy of black pepper essential oil (BPO) and tea tree oil ( ...

    Abstract Haemonchosis is a worldwide helminthic disease affecting ruminants. The anthelminthic resistance has become raised. Medicinal plants are safely used as synthetic anthelmintics. Currently, the efficacy of black pepper essential oil (BPO) and tea tree oil (TTO) were in vitro evaluated against
    Language English
    Publishing date 2024-02-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2548456-4
    ISSN 0975-0703 ; 0971-7196
    ISSN (online) 0975-0703
    ISSN 0971-7196
    DOI 10.1007/s12639-024-01650-w
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  4. Article ; Online: Neuroscience: Tantalized Flies Are Primed for Satiety.

    Ahmed, Osama M / Murthy, Mala

    Current biology : CB

    2019  Volume 29, Issue 21, Page(s) R1146–R1148

    Abstract: How animals maintain and switch between distinct motivational states is an important question in neuroscience. New work in Drosophila identifies an excitatory neuronal circuit that builds up mating drive while priming itself for satiety. ...

    Abstract How animals maintain and switch between distinct motivational states is an important question in neuroscience. New work in Drosophila identifies an excitatory neuronal circuit that builds up mating drive while priming itself for satiety.
    MeSH term(s) Animals ; Courtship ; Drosophila ; Drosophila Proteins ; Drosophila melanogaster ; Neurons
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2019-11-05
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2019.09.029
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  5. Article ; Online: Omentin roles in physiology and pathophysiology: an up-to-date comprehensive review.

    Hussein, Aida A / Ahmed, Noha A / Sakr, Hader I / Atia, Tarek / Ahmed, Osama M

    Archives of physiology and biochemistry

    2023  , Page(s) 1–14

    Abstract: Omentin (intelectin) was first detected in the visceral omental adipose tissue. It has mainly two isoforms, omentin-1 and -2, with isoform-1 being the main form in human blood. It possesses insulin-sensitizing, anti-inflammatory, anti-atherogenic, cardio- ...

    Abstract Omentin (intelectin) was first detected in the visceral omental adipose tissue. It has mainly two isoforms, omentin-1 and -2, with isoform-1 being the main form in human blood. It possesses insulin-sensitizing, anti-inflammatory, anti-atherogenic, cardio-protective, and oxidative stress-decreasing effects. Omentin's cardiovascular protective actions are caused by the improved endothelial cell survival and function, increased endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) bioavailability, enhanced vascular smooth muscle cells (VSMCs) relaxation with reduced proliferation, decreased inflammation, and suppressed oxidative stress. Omentin may also have a potential role in different cancer types and rheumatic diseases. Thus, omentin is an excellent therapeutic target in many diseases, including diabetes mellitus (DM), metabolic syndrome (MetS), cardiovascular diseases (CVDs), inflammatory diseases, and cancer. This review demonstrates the physiological functions of omentin in ameliorating insulin resistance (IR), vascular function, and inflammation and its possible share in managing obesity-linked diseases, such as metabolic disorders, DM, and cardiovascular conditions.
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1238320-x
    ISSN 1744-4160 ; 1381-3455
    ISSN (online) 1744-4160
    ISSN 1381-3455
    DOI 10.1080/13813455.2023.2283685
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  6. Article ; Online: In-vitro and in-vivo assessment of pH-responsive core-shell nanocarrier system for sequential delivery of methotrexate and 5-fluorouracil for the treatment of breast cancer.

    Mansour, Amira / Fytory, Mostafa / Ahmed, Osama M / Rahman, Fatema El-Zahraa S Abdel / El-Sherbiny, Ibrahim M

    International journal of pharmaceutics

    2023  Volume 648, Page(s) 123608

    Abstract: Breast cancer (BC) is one of the leading fatal diseases affecting females worldwide. Despite the presence of tremendous chemotherapeutic agents, the resistance emergence directs the recent research towards synergistic drugs' combination along with ... ...

    Abstract Breast cancer (BC) is one of the leading fatal diseases affecting females worldwide. Despite the presence of tremendous chemotherapeutic agents, the resistance emergence directs the recent research towards synergistic drugs' combination along with encapsulation inside biocompatible smart nanocarriers. Methotrexate (MTX) and 5-fluorouracil (Fu) are effective against BC and have sequential synergistic activity. In this study, a core-shell nanocarrier composed of mesoporous silica nanoparticles (MSN) as the core and zeolitic imidazolate framework-8 nano metal organic frameworks (ZIF-8 NMOF) as the shell was developed and loaded with Fu and MTX, respectively. The developed nanostructure; Fu-MSN@MTX-NMOF was validated by several characterization techniques and conferred high drugs' entrapment efficiency (EE%). In-vitro assessment revealed a pH-responsive drug release pattern in the acidic pH where MTX was released followed by Fu. The cytotoxicity evaluation indicated enhanced anticancer effect of the Fu-MSN@MTX-NMOF relative to the free drugs in addition to time-dependent fortified cytotoxic effect due to the sequential drugs' release. The in-vivo anticancer efficiency was examined using Ehrlich ascites carcinoma (EAC) animal model where the anticancer effect of the developed Fu-MSN@MTX-NMOF was compared to the sequentially administrated free drugs. The results revealed enhanced anti-tumor effect while maintaining the normal functions of the vital organs as the heart, kidney and liver.
    MeSH term(s) Animals ; Female ; Fluorouracil/chemistry ; Methotrexate/pharmacology ; Drug Carriers/chemistry ; Neoplasms ; Nanoparticles/chemistry ; Hydrogen-Ion Concentration
    Chemical Substances Fluorouracil (U3P01618RT) ; Methotrexate (YL5FZ2Y5U1) ; Drug Carriers
    Language English
    Publishing date 2023-11-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2023.123608
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    Zs.A 1409: Show issues Location:
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  7. Article ; Online: The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action.

    Morsy, Hadeer M / Ahmed, Osama M / Zoheir, Khairy M A / Abdel-Moneim, Adel

    Apoptosis : an international journal on programmed cell death

    2023  Volume 28, Issue 7-8, Page(s) 1184–1197

    Abstract: This study was designed to assess the ameliorative effects of eugenol and to propose the possible mechanisms of action of eugenol in diethylnitrosamine (DENA)/acetylaminofluorene (AAF)-caused lung cancer in Wistar rats. To induce lung cancer, DENA at a ... ...

    Abstract This study was designed to assess the ameliorative effects of eugenol and to propose the possible mechanisms of action of eugenol in diethylnitrosamine (DENA)/acetylaminofluorene (AAF)-caused lung cancer in Wistar rats. To induce lung cancer, DENA at a dose of 150 mg/kg body weight (b.wt) for 2 weeks were intraperitoneally injected once each week and AAF was administered orally at a dose of 20 mg/kg b.wt. four times each week for the next 3 weeks. DENA/AAF-administered rats were orally supplemented with eugenol at a dose of 20 mg/kg b.wt administered once a day until 17 weeks starting from the 1st week of DENA administration. Lung histological lesions, including sheets of tumor cells, micropapillary adenocarcinoma, and apoptotic cells, resulting from the DENA/AAF dosage, were ameliorated by eugenol treatment. However, a significant drop in the levels of LPO in the lungs and a remarkable rise in GSH content and GPx and SOD activities were observed in DENA/AAF-administered rats treated with eugenol compared with those in DENA/AAF-administered controls. Moreover, in DENA/AAF-administered rats, eugenol supplementation significantly reduced TNF-α and IL-1β levels and mRNA expression levels of NF-κB, NF-κB p65, and MCP-1 but significantly elevated the level of Nrf2. Furthermore, the DENA/AAF-administered rats treated with eugenol exhibited a significant downregulation of Bcl-2 expression levels in addition to a significant upregulation in P53 and Bax expression levels. Otherwise, the administration of DENA/AAF elevated the protein expression level of Ki-67, and this elevation was reversed by eugenol treatment. In conclusion, eugenol has effective antioxidant, anti-inflammatory, proapoptotic, and antiproliferative properties against lung cancer.
    MeSH term(s) Rats ; Animals ; Rats, Wistar ; Anticarcinogenic Agents/pharmacology ; Anticarcinogenic Agents/therapeutic use ; 2-Acetylaminofluorene/adverse effects ; 2-Acetylaminofluorene/metabolism ; Diethylnitrosamine/toxicity ; Diethylnitrosamine/metabolism ; Eugenol/adverse effects ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Apoptosis ; Lung Neoplasms/chemically induced ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Liver/pathology ; Liver Neoplasms, Experimental/chemically induced ; Liver Neoplasms, Experimental/metabolism ; Liver Neoplasms, Experimental/pathology
    Chemical Substances Anticarcinogenic Agents ; 2-Acetylaminofluorene (9M98QLJ2DL) ; Diethylnitrosamine (3IQ78TTX1A) ; Eugenol (3T8H1794QW) ; NF-kappa B
    Language English
    Publishing date 2023-05-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1452360-7
    ISSN 1573-675X ; 1360-8185
    ISSN (online) 1573-675X
    ISSN 1360-8185
    DOI 10.1007/s10495-023-01852-2
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    Zs.A 5178: Show issues Location:
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  8. Article: In vitro antioxidant, anticancer, anti-inflammatory, anti-diabetic and anti-Alzheimer potentials of innovative macroalgae bio-capped silver nanoparticles

    Azeem, Manal N. Abdel / Ahmed, Osama M. / Shaban, Mohamed / Elsayed, Khaled N. M.

    Environmental science and pollution research. 2022 Aug., v. 29, no. 39

    2022  

    Abstract: The antagonistic side effects of chemical medications led to the search for safe strategies such as biogenic agents. Correspondingly, this study aims to create biogenic, appropriate, auspicious and innovative therapeutic agents like Galaxaura elongata { ... ...

    Abstract The antagonistic side effects of chemical medications led to the search for safe strategies such as biogenic agents. Correspondingly, this study aims to create biogenic, appropriate, auspicious and innovative therapeutic agents like Galaxaura elongata {GE}, Turbinaria ornata {TO} and Enteromorpha flexuosa {EF} macroalgae-based silver nanoparticles (Ag-NPs). The Ag⁺ reduction and the creation of Ag[GE]-NPs, Ag[TO]-NPs and Ag[EF]-NPs have been validated using UV–visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and zeta potential analysis, and the chemical composition of macroalgae crude extracts was estimated through gas chromatography–mass spectrometry (GC–MS). Further, macroalgae-based Ag-NPs were tested for their free radical scavenging activity DPPH, ABTS, anticancer activity in human liver carcinoma (HepG2) cell line, distinctive inflammation forms and elevated α-amylase. Results showed that the biosynthesized Ag-NPs have unique mechanical and physicochemical characters attributed to their high relative surface area, nanosized dimensions and spherical shape. At dose of 200 µg/mL, the DPPH radical scavenging capacity was maximized with Ag[TO]-NPs (67.26%); however, Ag[EF]-NPs was the most potent as ABTs scavenger (97.74%). Additionally, Ag[GE]-NPs had the maximum proteinase inhibitory action with 59.78%. The 1000 µg/mL of Ag[GE]-NPs, Ag[TO]-NPs and Ag[EF]-NPs revealed significant inhibitions of cell growth of HepG2 resulting in cell viabilities 5.92%, 4.44% and 11.33%, respectively. These findings suggest that macroalgae bio-capped Ag-NPs have magnificent biological potentials for safe biomedical applications.
    Keywords Fourier transform infrared spectroscopy ; Galaxaura ; Turbinaria ornata ; Ulva ; alpha-amylase ; antineoplastic activity ; antioxidants ; biosynthesis ; carcinoma ; cell growth ; cell lines ; chemical composition ; free radicals ; gas chromatography-mass spectrometry ; humans ; inflammation ; liver ; macroalgae ; nanosilver ; pollution ; proteinases ; research ; surface area ; therapeutics ; ultraviolet-visible spectroscopy ; zeta potential
    Language English
    Dates of publication 2022-08
    Size p. 59930-59947.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-20039-x
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  9. Article ; Online: Protective effects of Persea americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities

    Ahmed, Osama M. / Fahim, Hanaa I. / Mohamed, Eman E. / Abdel-Moneim, Adel

    Environ Sci Pollut Res. 2022 June, v. 29, no. 29 p.43858-43873

    2022  

    Abstract: This study aims to explore the chemopreventive mechanisms of hydroethanolic extracts from avocado (Persea Americana) in diethylnitrosamine (DEN)/2-acetylaminofluorene (2AAF)-induced hepatocarcinogenesis. Chemical induction of hepatocarcinogenesis was ... ...

    Abstract This study aims to explore the chemopreventive mechanisms of hydroethanolic extracts from avocado (Persea Americana) in diethylnitrosamine (DEN)/2-acetylaminofluorene (2AAF)-induced hepatocarcinogenesis. Chemical induction of hepatocarcinogenesis was induced by intraperitoneal injection of DEN at 150 mg/kg body weight (b.w.) twice a week for a fortnight, followed by oral administration of 2AAF at 20 mg/kg b.w. four times a week for 3 weeks. Rats administered DEN/2AAF were orally treated with hydroethanolic extracts of avocado fruits and seeds at a dose of 50 mg/kg b.w. every other day for 20 weeks. Moreover, rats administered DEN/2AAF and treated with avocado extracts revealed a marked decrease in liver enzyme activities, total bilirubin levels, and elevated liver tumor markers, but revealed an increase in total protein and albumin levels. The hepatocytes with hyperchromatic and bile duct cystadenoma observed in the liver of rats administered DEN/2AAF were reduced due to treatment with avocado extracts. Furthermore, the treatments prevented the elevation of lipid peroxidation levels and ameliorated the lowered glutathione peroxidase, glutathione-S-transferase, superoxide dismutase activities, and glutathione content in the liver tissues. Also, antigen Ki-67, cyclooxygenase-2, and nuclear factor kappa-B expression levels were decreased, but of the suppressor proteins p53 and BAX levels were increased in the liver of rats administered DEN/2AAF and treated with avocado extracts. In conclusion, the current results demonstrated that avocado extracts could abate hepatocarcinogenesis in rats administered DEN/2AAF through activation of antioxidant, anti-inflammatory, and apoptotic properties.
    Keywords Persea americana ; albumins ; antigens ; antioxidants ; apoptosis ; avocados ; bile ducts ; bilirubin ; body weight ; chemoprevention ; diethylnitrosamine ; fruits ; glutathione ; glutathione peroxidase ; glutathione transferase ; hepatocytes ; intraperitoneal injection ; lipid peroxidation ; liver ; liver neoplasms ; oral administration ; prostaglandin synthase ; protein content ; superoxide dismutase
    Language English
    Dates of publication 2022-06
    Size p. 43858-43873.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-18902-y
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  10. Article ; Online: Bee Venom: From Venom to Drug.

    Khalil, Abdelwahab / Elesawy, Basem H / Ali, Tarek M / Ahmed, Osama M

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 16

    Abstract: Insects of the order Hymenoptera have a defensive substance that contains many biologically active compounds. Specifically, venom from honeybees ( ...

    Abstract Insects of the order Hymenoptera have a defensive substance that contains many biologically active compounds. Specifically, venom from honeybees (
    MeSH term(s) Allergens/adverse effects ; Allergens/chemistry ; Animals ; Bee Venoms/chemistry ; Bee Venoms/enzymology ; Bee Venoms/therapeutic use ; Bees/chemistry ; Enzymes/chemistry ; Humans ; Insect Bites and Stings ; Peptides/chemistry ; Peptides/therapeutic use ; Pharmaceutical Preparations/chemistry
    Chemical Substances Allergens ; Bee Venoms ; Enzymes ; Peptides ; Pharmaceutical Preparations
    Language English
    Publishing date 2021-08-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26164941
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