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Article ; Online: Lipid nanoparticle mediated small interfering RNA delivery as a potential therapy for Alzheimer's disease.

Ahmed, Tanvir

2024

Abstract: Alzheimer's disease (AD) is a neurodegenerative condition that exhibits a gradual decline in cognitive function and is prevalent among a significant number of individuals globally. The use of small interfering RNA (siRNA) molecules in RNA interference ( ... ...

Abstract	Alzheimer's disease (AD) is a neurodegenerative condition that exhibits a gradual decline in cognitive function and is prevalent among a significant number of individuals globally. The use of small interfering RNA (siRNA) molecules in RNA interference (RNAi) presents a promising therapeutic strategy for AD. Lipid nanoparticles (LNPs) have been developed as a delivery vehicle for siRNA, which can selectively suppress target genes, by enhancing cellular uptake and safeguarding siRNA from degradation. Numerous research studies have exhibited the effectiveness of LNP-mediated siRNA delivery in reducing amyloid beta (Aβ) levels and enhancing cognitive function in animal models of AD. The feasibility of employing LNP-mediated siRNA delivery as a therapeutic approach for AD is emphasized by the encouraging outcomes reported in clinical studies for other medical conditions. The use of LNP-mediated siRNA delivery has emerged as a promising strategy to slow down or even reverse the progression of AD by targeting the synthesis of tau phosphorylation and other genes linked to the condition. Improvement of the delivery mechanism and determination of the most suitable siRNA targets are crucial for the efficacious management of AD. This review focuses on the delivery of siRNA through LNPs as a promising therapeutic strategy for AD, based on the available literature.
Language	English
Publishing date	2024-04-15
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.16336
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Article ; Online: Biomaterial-based

Ahmed, Tanvir

Cancer pathogenesis and therapy

2023 Volume 1, Issue 3, Page(s) 177–194

Abstract: Adult-onset brain cancers, such as glioblastomas, are particularly lethal. People with glioblastoma multiforme (GBM) do not anticipate living for more than 15 months if there is no cure. The results of conventional treatments over the past 20 years have ... ...

Abstract	Adult-onset brain cancers, such as glioblastomas, are particularly lethal. People with glioblastoma multiforme (GBM) do not anticipate living for more than 15 months if there is no cure. The results of conventional treatments over the past 20 years have been underwhelming. Tumor aggressiveness, location, and lack of systemic therapies that can penetrate the blood-brain barrier are all contributing factors. For GBM treatments that appear promising in preclinical studies, there is a considerable rate of failure in phase I and II clinical trials. Unfortunately, access becomes impossible due to the intricate architecture of tumors.
Language	English
Publishing date	2023-01-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2949-7132
ISSN (online)	2949-7132
DOI	10.1016/j.cpt.2023.01.002
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Article ; Online: Lessons learned from pandemic response to COVID-19 in Bangladesh: NGO-based emergency response framework for low- and middle-income countries.

Ahmed, Tanvir / Musarrat, Parsa / Kabir, Zarina Nahar

BMC health services research

2023 Volume 23, Issue 1, Page(s) 656

Abstract: Background: Response to COVID-19 pandemic in Bangladesh was led by the Government of Bangladesh aided by Non-Government Organisations (NGO) among others. The aim of the study was to explore the activities of such an NGO to understand the philosophy, ... ...

Abstract	Background: Response to COVID-19 pandemic in Bangladesh was led by the Government of Bangladesh aided by Non-Government Organisations (NGO) among others. The aim of the study was to explore the activities of such an NGO to understand the philosophy, aspiration and strategy to plan and implement an effective response to COVID-19 pandemic in Bangladesh. Methods: A case study of a Bangladeshi NGO called SAJIDA Foundation (SF) is presented. From September to November 2021, using document review, field observation and in-depth interviews, four aspects of their COVID-19 pandemic related activities was explored - a) why and how SF initiated their COVID response; b) what adaptations were made to their usual programmes; c) how SF's response to COVID-19 were designed and what were the anticipated challenges including overcoming measures; and d) perception of the staff about SF's activities related to COVID-19. Fifteen in-depth interviews were conducted with three groups of SF staff: frontliners, managers and leaders. Result: The impact of COVID-19 has been beyond health emergencies and posed multidimensional challenges. SF took a two-pronged approach - aid the government to respond to the emergency and adopt an all-inclusive plan to address diverse challenges related to overall well-being of the population. The underlying strategy of their response has been to: define the challenge of COVID-19 and identify required expertise and resources, ensure people's health and social wellbeing, adjust existing organisational processes, ensure functional partnership with other organisations for effective resource and task sharing, and safeguard health and wellbeing of the organisation's own employees. Conclusion: The findings suggest a '4C framework' including four components as the basis of a comprehensive response to emergencies by NGOs: 1. Capability assessment to identify who are in need and what is needed; 2. Collaboration with stakeholders to pool resources and expertise; 3. Compassionate leadership to ensure health and social safety of the employees which ensures their dedication in managing the emergency; and 4. Communication for quick and effective decision making, decentralisation, monitoring and coordination. It is expected that this '4C framework' can help NGOs to embark on a comprehensive response to manage emergencies in resource constrained low- and middle-income countries.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Pandemics ; Developing Countries ; Bangladesh/epidemiology ; Emergencies
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-023-09643-w
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Article ; Online: Modifiable and nonmodifiable factors associated with anxiety, depression, and stress after one year of the COVID-19 pandemic.

Islam, Azharul / Mahbuba, Papia / Ahmed, Tanvir / Haque, Shamsul

PloS one

2023 Volume 18, Issue 3, Page(s) e0283422

Abstract: Background: People worldwide have experienced various mental health issues during the COVID-19 pandemic. This study investigates the modifiable and nonmodifiable predictors of anxiety, depression, and stress among Bangladeshi participants after one year ...

Abstract	Background: People worldwide have experienced various mental health issues during the COVID-19 pandemic. This study investigates the modifiable and nonmodifiable predictors of anxiety, depression, and stress among Bangladeshi participants after one year of the pandemic. Method: A large group of adult participants (N = 1897), recruited from eight administrative divisions in Bangladesh, completed an online survey in May and June 2021 when the Movement Control Order was in place. We used the Beck Anxiety Inventory, Patient Health Questionnaire-9, and Perceived Stress Scale-4 to assess the participants' anxiety, depression, and stress. We also gave the Mindful Attention Awareness Scale and Life-Orientation Test-Revised to assess mindfulness and optimism. Results: The results revealed that the prevalence rates for anxiety and depression were 62.5% and 45.3%, respectively. Multivariate analyses showed that several nonmodifiable factors, such as those who were students, unmarried and females, and those living in the Northern region (Rajshahi and Mymensingh division) and dwelling in the rural areas, suffered from worse mental health (accounted for 5%-23% of the variances in the mental health outcome scores). Modifiable factors accounted for an additional 10%-25% of the variances in the same outcome variables. Adults with higher mindfulness and optimism, living in the country's Southern region (Chattogram division) and those who took both vaccine doses and had no history of mental illness reported better mental health. Conclusion: Anxiety, depression, and stress remained high in Bangladeshi adults after one year of the pandemic. The community-based interventions should aim to increase the mindfulness and optimism levels among the sufferers. More accelerated vaccination programs across the country could protect people from suffering from overall mental distress.
MeSH term(s)	Adult ; Female ; Humans ; COVID-19/epidemiology ; Pandemics ; Depression/epidemiology ; Depression/psychology ; SARS-CoV-2 ; Stress, Psychological/epidemiology ; Stress, Psychological/psychology ; Bangladesh/epidemiology ; Anxiety/epidemiology ; Anxiety/psychology
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0283422
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Article ; Online: A machine learning-based generalized approach for predicting unauthorized immigration flow considering dynamic border security nexus.

Aziz, Ridwan Al / Ahmed, Tanvir / Zhuang, Jun

Risk analysis : an official publication of the Society for Risk Analysis

2023

Abstract: Unauthorized immigration has been a long-standing and contentious challenge for developed and developing countries. Numerous continually evolving push and pull factors across international borders, such as economy, employment, population density, unrest, ...

Abstract	Unauthorized immigration has been a long-standing and contentious challenge for developed and developing countries. Numerous continually evolving push and pull factors across international borders, such as economy, employment, population density, unrest, corruption, and climate have driven this migration. Large-scale pandemics such as COVID-19, causing further instability in countries' financial well-being, can initiate or alter emigration flow from different countries. In light of such a complex confluence of factors, climate change, and demographic shifts in migrant communities, it is high time to shift toward machine learning-reinforced generalized approaches from the traditional parametric approaches based on migrant community-specific localized surveys. To our best knowledge, no literature has explored the nonparametric approach and developed a comprehensive database independent of localized surveys to analyze unauthorized migration. This article fills this gap by deploying nine nonparametric machine learning algorithms for predicting unauthorized immigration flow considering the dynamic border security nexus. This framework considers the Seasonal Autoregressive Integrated Moving Average model as the null model. The proposed novel framework removes the dependency on localized survey-based studies and provides a more cost-effective, faster, and big data-friendly approach. This study finds the Bayesian Additive Regression Tree model as the best predictive model.
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	778660-8
ISSN	1539-6924 ; 0272-4332
ISSN (online)	1539-6924
ISSN	0272-4332
DOI	10.1111/risa.14254
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Article ; Online: Black Garlic and Its Bioactive Compounds on Human Health Diseases: A Review.

Ahmed, Tanvir / Wang, Chin-Kun

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 16

Abstract: Black garlic (BG) is a form of aged garlic obtained from raw garlic ( ...

Abstract	Black garlic (BG) is a form of aged garlic obtained from raw garlic (
MeSH term(s)	Disease ; Food Handling ; Garlic/chemistry ; Health ; Humans
Language	English
Publishing date	2021-08-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26165028
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Article: Challenges in the profitability of small-scale broiler farming by avoiding injudicious use of drugs and additives.

Das, Shubash Chandra / Zubiatin Tasmin, Mosammad / Afrin, Afifa / Ahmed, Tanvir / Lahiry, Ankon / Rahman, Shahina

Heliyon

2024 Volume 10, Issue 3, Page(s) e25001

Abstract: The aim of the current study was to determine the present scenario of injudicious use of drugs and additives in small-scale broiler operations and whether broilers can be produced successfully and profitably without the injudicious use of drugs and ... ...

Abstract	The aim of the current study was to determine the present scenario of injudicious use of drugs and additives in small-scale broiler operations and whether broilers can be produced successfully and profitably without the injudicious use of drugs and additives. First, a survey was undertaken in relation to farmers' basic information and general management methods in commercial broilers, with special attention given to the usage of medications and additives in drinking water. Second, based on the survey data, an experimental trial was carried out to compare the growth performance and economic profitability of rearing broilers with and without the use of said drugs and additives. A total of 540 broiler DOCs were allotted into three treatments: T
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25001
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Article ; Online: Bioenergy-producing two-stage septic tank and floating wetland for onsite wastewater treatment: Circuit connection and external aeration.

Saeed, Tanveer / Al-Muyeed, Abdullah / Zaman, Takrim / Hasan, Mehedi / Ahmed, Tanvir

Journal of environmental management

2024 Volume 359, Page(s) 121011

Abstract: This study designed a two-stage, electrode-integrated septic tank-floating wetland system and assessed their pollutant removal performances under variable operational conditions. The two-stage system achieved mean organic, nitrogen, phosphorus, and ... ...

Abstract	This study designed a two-stage, electrode-integrated septic tank-floating wetland system and assessed their pollutant removal performances under variable operational conditions. The two-stage system achieved mean organic, nitrogen, phosphorus, and coliform removal percentages of 99, 78, 99, and 97%, respectively, throughout the experimental run. The mean metals (chromium, cadmium, nickel, copper, zinc, lead, iron, and manganese) removal percentages ranged between 81 and 98%. Accumulated sludge, filler media, and the hanging root mass contributed to pollutant removals by supporting physicochemical and biological pathways. The mean effluent organic concentration and coliform number across the two-stage system were 20 mg/L and 1682 CFU/100 mL, respectively, during the closed-circuit protocol, which was beneath the open-circuit-based performance profiles, i.e., 32 mg/L and 2860 CFU/100 mL, respectively. Effluent organic, nitrogen, phosphorus, metals, and coliform number ranges across the two-stage system were 9-17 mg/L, 13-24 mg/L, 1-1.5 mg/L, 0.001-0.2 mg/L, and 1410-2270 CFU/100 mL, respectively during intermittent and continuous aeration periods. The air supply rate differences influenced pollutant removal depending on the associated removal mechanisms. The non-aeration phase produced higher effluent pollutant concentrations than the aeration periods-based profiles. The overall mean power density production of the septic tank ranged between 107 and 596 mW/m
Language	English
Publishing date	2024-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.121011
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Article ; Online: Point-of-care detection devices for wound care and monitoring

Huang, Shu-Wei / Wu, Yufeng / Ahmed, Tanvir / Pan, Shin-Chen / Cheng, Chao-Min

Trends in Biotechnology. 2023 Aug. 08,

2023

Abstract: Healthcare resources are heavily burdened by infections that impede the wound-healing process. A wide range of advanced technologies have been developed for detecting and quantifying infection biomarkers. Finding a timely, accurate, non-invasive ... ...

Abstract	Healthcare resources are heavily burdened by infections that impede the wound-healing process. A wide range of advanced technologies have been developed for detecting and quantifying infection biomarkers. Finding a timely, accurate, non-invasive diagnostic alternative that does not require a high level of training is a critical step toward arresting common clinical patterns of wound health decline. There is growing interest in the development of innovative diagnostics utilizing a variety of emerging technologies, and new biomarkers have been investigated as potential indicators of wound infection. In this review, we summarize diagnostics available for wound infection, including those used in clinics and still under development.
Keywords	biomarkers ; biotechnology ; decline ; diagnostic techniques ; point-of-care systems ; wound ; diagnostics ; smart technology ; wound care technology ; wound management
Language	English
Dates of publication	2023-0808
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2023.07.001
Database	NAL-Catalogue (AGRICOLA)

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Article: "Working in the Dark": Experiences of Frontline Health Workers in Bangladesh During COVID-19 Pandemic.

Das Pooja, Shangjucta / Nandonik, Ahmed Jojan / Ahmed, Tanvir / Kabir, Zarina Nahar

Journal of multidisciplinary healthcare

2022 Volume 15, Page(s) 869–881

Abstract: Introduction: Frontline health workers (FHW) are working relentlessly to combat the COVID-19 pandemic globally. This is particularly challenging for low- and middle-income countries such as Bangladesh because of resource scarcity. Therefore, it is ... ...

Abstract	Introduction: Frontline health workers (FHW) are working relentlessly to combat the COVID-19 pandemic globally. This is particularly challenging for low- and middle-income countries such as Bangladesh because of resource scarcity. Therefore, it is critical to understand the challenges of healthcare providers to help shaping a contextual pandemic response plan address current and future similar crises. Aim: This study aimed to describe the challenges faced by FHWs in Bangladesh in terms of information on COVID-19, managing patients with COVID-19, and what motivated them to continue providing service during the pandemic. Methods: This qualitative study explored the experiences of 18 FHWs who were purposely recruited from different health interventions of a development organization in Bangladesh. In-depth interviews and focus group discussions were conducted during July-August 2020 using a semi-structured interview guide. The interviews were transcribed verbatim and content analysis was used to analyze the data which led to four categories. Results: Four main categories and ten sub-categories emerged from the analysis. Categories derived from the analysis were as follows: i) experiences of the FHWs regarding information on COVID-19: "Working in the dark", ii) experience of providing care: "Patients are grateful", iii) impact on personal/family life: "Life is still in lockdown" and iv) motivation to carry on providing care. Conclusion: FHWs desire a stable information source to prepare themselves for future health care crises. Organizational support is essential for them to overcome physical and mental struggles and keep themselves motivated to continue service provision during pandemics.
Language	English
Publishing date	2022-04-25
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2453343-9
ISSN	1178-2390
ISSN	1178-2390
DOI	10.2147/JMDH.S357815
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