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Article ; Online: CRP, but not fibrinogen, is associated with gait speed as early as middle age, in females but not males.

Ahmed-Yousef, Noha Shekh / Dilian, Omer / Iktilat, Khalil / Agmon, Maayan

2023 Volume 13, Issue 1, Page(s) 15571

Abstract: Low grade systemic inflammation and age-related gait speed decline are known to be related in older adults, but their relations in the early stages of the aging process are yet to be fully described. The aim of this study was to examine the relationship ... ...

Abstract	Low grade systemic inflammation and age-related gait speed decline are known to be related in older adults, but their relations in the early stages of the aging process are yet to be fully described. The aim of this study was to examine the relationship between gait speed and two inflammation markers-c-reactive protein (CRP) and fibrinogen-in a cohort of middle-aged adults in Israel. 326 healthy, middle-aged, Muslim-Arabs from three villages in northern Israel participated in this cross-sectional study. Serum CRP and fibrinogen were measured via blood tests, and gait speed was assessed with the 6-min walk test (6MWT). After adjusting for sex, age, height, BMI, systolic blood pressure, fasting blood glucose and triglycerides, executive function, smoking status and aerobic physical activity, gait speed was negatively and significantly associated with CRP (b = - 0.01, p = 0.029). When stratifying by gender, this link remained significant only among females (b = - 0.012, p = 0.041), such as that an increase of one SD unit of CRP was associated with a 0.047 m/s decrease in gait speed. No significant link was found between fibrinogen levels and gait speed. Blood CRP levels are associated with a slower walking speed already in middle age, independent of age, executive function and cardio-metabolic factors, among female Arab-Muslims in Israel. Future studies should examine this relationship longitudinally and investigate a broader array of inflammation markers. Systemic inflammation may serve as an early marker for people at risk of decreased walking or accelerated aging; Early identification and intervention among at-risk individuals may help prevent or slow gait speed decline, and promote healthier aging.
MeSH term(s)	Female ; Middle Aged ; Humans ; Aged ; Fibrinogen ; C-Reactive Protein ; Walking Speed ; Cross-Sectional Studies ; Hemostatics ; Inflammation
Chemical Substances	Fibrinogen (9001-32-5) ; C-Reactive Protein (9007-41-4) ; Hemostatics
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-42183-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Electrochemical sensor based on PEDOT/CNTs-graphene oxide for simultaneous determination of hazardous hydroquinone, catechol, and nitrite in real water samples.

Ahmed, Yousef M / Eldin, Mahmoud A / Galal, Ahmed / Atta, Nada F

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5654

Abstract: Hydroquinone (HQ), catechol (CC) and nitrite (NT) are considered aquatic environmental pollutants. They are highly toxic, harm humans' health, and damage the environment. Thus, in the present work we introduce a simple and efficient electrochemical ... ...

Abstract	Hydroquinone (HQ), catechol (CC) and nitrite (NT) are considered aquatic environmental pollutants. They are highly toxic, harm humans' health, and damage the environment. Thus, in the present work we introduce a simple and efficient electrochemical sensor for determination of HQ, CC, and NT simultaneously in wastewater sample. The sensor is fabricated by modifying the surface of a glassy carbon electrode (GCE) by two successive thin films from poly(3,4-ethylenedioxythiophene) (PEDOT) and a mixture of carbon nanotubes-graphene oxide (CNT-GRO). Under optimized conditions the HQ, CC, and NT are successfully detected simultaneously in wastewater sample with changing their concentrations in the ranges (0.04 → 100 µM), (0.01 → 100 µM) and (0.05 → 120 µM), the detection limits are 8.5 nM, 3.8 nM and 6.1 nM, respectively. Good potential peak separations: 117 mV and 585 mV are obtained between the HQ-CC, and CC-NT. The sensor has an excellent catalytic capability toward the oxidation of HQ, CC, and NT due to good synergism between its composite components: PEDOT, GRO and CNTs. The features of the sensor are large active surface area, good electrical conductivity, perfect storage stability, good reproducibility, anti-interference capability and accepted recovery rate for HQ, CC, and NT determination in wastewater sample.
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54683-9
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Article ; Online: Electrochemical sensor for simultaneous determination of antiviral favipiravir drug, paracetamol and vitamin C based on host-guest inclusion complex of β-CD/CNTs nanocomposite.

Ahmed, Yousef M / Eldin, Mahmoud A / Galal, Ahmed / Atta, Nada F

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19910

Abstract: Favipiravir (FVI) is extensively used as an effective medication against several diverse infectious RNA viruses. It is widely administered as an anti-influenza drug. Combination therapy formed from FVI, paracetamol (PAR) and vitamin C (VC) is needed for ... ...

Abstract	Favipiravir (FVI) is extensively used as an effective medication against several diverse infectious RNA viruses. It is widely administered as an anti-influenza drug. Combination therapy formed from FVI, paracetamol (PAR) and vitamin C (VC) is needed for treating patients diseased by RNA viruses. Thus, an efficient electrochemical sensor is developed for detecting FVI in human serum samples. The sensor is fabricated by casting a thin layer of carbon nanotubes (CNTs) over a glassy carbon (GC) electrode surface followed by electrodeposition of another layer of β-cyclodextrin (β-CD). Under optimized conditions, the sensor shows excellent catalytic effect for FVI, PAR and VC oxidation in the concentration ranges (0.08 µM → 80 µM), (0.08 µM → 50 µM) and (0.8 µM → 80 µM) with low detection limits of 0.011 μM, 0.042 μM and 0.21 μM, respectively. The combined effect of host-guest interaction ability of β-CD for the drugs, and a large conductive surface area of CNTs improves the sensing performance of the electrode. The sensor exhibits stable response over 4 weeks, good reproducibility, and insignificant interference from common species present in serum samples. The reliability of using the sensor in serum samples shows good recovery of FVI, PAR and VC.
MeSH term(s)	Humans ; Ascorbic Acid ; Nanotubes, Carbon ; Acetaminophen ; Reproducibility of Results ; Antiviral Agents ; beta-Cyclodextrins ; Vitamins ; Electrodes ; Nanocomposites ; Electrochemical Techniques
Chemical Substances	Ascorbic Acid (PQ6CK8PD0R) ; Nanotubes, Carbon ; Acetaminophen (362O9ITL9D) ; favipiravir (EW5GL2X7E0) ; Antiviral Agents ; beta-Cyclodextrins ; Vitamins
Language	English
Publishing date	2023-11-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45353-3
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Article ; Online: Electrochemical sensor for simultaneous determination of trifluoperazine and dopamine in human serum based on graphene oxide-carbon nanotubes/iron-nickel nanoparticles.

Ahmed, Yousef M / Eldin, Mahmoud A / Galal, Ahmed / Atta, Nada F

RSC advances

2023 Volume 13, Issue 36, Page(s) 25209–25217

Abstract: Trifluoperazine (TFLP) is an important psychiatric medication that balances the dopamine (DA) level in the brain for patients suffering from neurological disorder diseases. An efficient electrochemical sensor is developed for detecting TFLP in real human ...

Abstract	Trifluoperazine (TFLP) is an important psychiatric medication that balances the dopamine (DA) level in the brain for patients suffering from neurological disorder diseases. An efficient electrochemical sensor is developed for detecting TFLP in real human serum samples. The sensor is fabricated by casting the GC surface with two consecutive thin layers, namely a graphene oxide-carbon nanotubes mixture (GRO-CNT), and iron-nickel nanoparticles (Fe-Ni). The diffusion-controlled oxidation process of TFLP at the composite surface includes one electron transfer process. Under optimized conditions, the sensor in human serum shows excellent catalytic effect for simultaneous determination of TFLP and dopamine (DA) in the same concentration range (0.5 μM to 18 μM) with low detection limits of 0.13 μM and 0.32 μM respectively. The combined effect of a large conductive surface area and the excellent catalytic activity of the nanocomposite improves the sensor's performance. The sensor exhibits a stable current response over four weeks, excellent reproducibility, and insignificant interference from common species present in human serum samples. The reliability test of using the sensor in serum samples shows good recovery of TFLP.
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra04334g
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Article ; Online: Implementation of Personal Protective Measures by The public during COVID-19 Pandemic in Damietta Governorate, Egypt

Mohamed Nour / Mohamed Aboal Asaad / Marzouk Marzouk / Ahmed Yousef

International Journal of Medical Arts, Vol 3, Iss 2, Pp 1247-

2021 Volume 1256

Abstract: Background:In Egypt, the arrival of COVID-19 pandemic triggered national preparedness and integrated response including public commitment to personal protective measures [PPM]. The aim of the work: To investigate the public implementation of PPM in ... ...

Abstract	Background:In Egypt, the arrival of COVID-19 pandemic triggered national preparedness and integrated response including public commitment to personal protective measures [PPM]. The aim of the work: To investigate the public implementation of PPM in Damietta Governorate – Egypt during COVID-19 pandemic. Patients and Methods: This was a cross-sectional study based on web-based survey. A total of 500 adult participants [59% female: 18–72 years] were selected between April 10 and July 15, 2020, from Damietta, Egypt to complete a questionnaire. Participants were asked about their sources of knowledge and to indicate how often they implemented PPM recommended by World Health Organization [WHO] including hand hygiene, respiratory hygiene & etiquette, social distancing, and self-isolation. Results: The best practices were frequent hand washing [38.2%] followed by covering nose & mouth [23.6%] while avoiding hand greeting, self-isolation, social distancing and wearing face mask ranged only from 10%–15%. In total, only 11.6% reported accepted implementation of all PPM representing the overall prevalence. Reliable sources of information were represented by 13%–43.5% while 66% depended on social media. Participants with older age, female, married, university education or higher, urban residents, nonsmokers and working in health field were more likely to report accepted implementation of overall PPM. Conclusion: The protective measures implemented by ordinary citizens in Damietta are insufficient and further public awareness activities are required.
Keywords	implementation ; personal protective measures ; covid-19 ; pandemic ; damietta ; Medicine (General) ; R5-920
Subject code	150
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Al-Azhar University, Faculty of Medicine (Damietta)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hospital Outcomes in Patients Who Developed Acute Respiratory Distress Syndrome After Community-Acquired Pneumonia.

Kasotakis, George / Pant, Praruj / Patel, Akash D / Ahmed, Yousef / Raghunathan, Karthik / Krishnamoorthy, Vijay / Ohnuma, Tetsu

Journal of intensive care medicine

2024 , Page(s) 8850666241248568

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	632828-3
ISSN	1525-1489 ; 0885-0666
ISSN (online)	1525-1489
ISSN	0885-0666
DOI	10.1177/08850666241248568
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Article ; Online: Prevalence and drug resistance patterns of Gram-negative enteric bacterial pathogens from diarrheic patients in Ethiopia

Achenef Melaku Beyene / Mucheye Gezachew / Desalegn Mengesha / Ahmed Yousef / Baye Gelaw

PLoS ONE, Vol 17, Iss 3, p e

A systematic review and meta-analysis.

2022 Volume 0265271

Abstract: Background Diarrhoea is the leading cause of morbidity and mortality in the world particularly in developing countries and among vulnerable groups of the population. Gram-negative enteric bacterial pathogens (GNEBPs) are a group of organisms that reside ... ...

Abstract	Background Diarrhoea is the leading cause of morbidity and mortality in the world particularly in developing countries and among vulnerable groups of the population. Gram-negative enteric bacterial pathogens (GNEBPs) are a group of organisms that reside mainly in the intestine and induce diarrhoea. Antimicrobial agents are usually the part of their treatment regimen. The therapeutic effect of antimicrobials is hindered by the emergence and spread of drug-resistant strains. The information regarding the prevalence and antimicrobial resistance patterns of GNEBPs in Ethiopia is limited and found in a scattered form. Objectives This study was designed to determine the pooled prevalence and drug resistance patterns of GNEBPs by meta-analysis of data from diarrhoeic patients in Ethiopia. Method A comprehensive literature search was conducted through internet searches using Google Scholar, PubMed, Science Direct, HINARI databases, and reference lists of previous studies. Published articles were included in the study based on priorly set inclusion and exclusion criteria. Results were presented in the forest plot, tables, and figures with a 95% confidence interval (CI). The inconsistency index (I2) test statistics was used to assess heterogeneity across studies. The pooled prevalence estimate of GNEBPs and their drug resistance patterns were computed by a random-effects model. Software for Statistics and Data Science (STATA) version 14 statistical software was used for the analysis. Result After removing those articles which did not fulfil the inclusion criteria, 43 studies were included in the analysis. Studies were conducted in 8 regions of the country and most of the published articles were from the Amhara region (30.23%) followed by Oromia (18.60%) and Southern Nations, Nationalities, and Peoples' region (SNNP) (18.60%). The pooled prevalence of GNEBPs was 15.81% (CI = 13.33-18.29). The funnel plot indicated the presence of publication bias. The pooled prevalence of GNEBPs in Addis Ababa, Amhara, SNNP, and Oromia ...
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prevalence and drug resistance patterns of Gram-negative enteric bacterial pathogens from diarrheic patients in Ethiopia

Achenef Melaku Beyene / Mucheye Gezachew / Desalegn Mengesha / Ahmed Yousef / Baye Gelaw

PLoS ONE, Vol 17, Iss

A systematic review and meta-analysis

2022 Volume 3

Abstract	Background Diarrhoea is the leading cause of morbidity and mortality in the world particularly in developing countries and among vulnerable groups of the population. Gram-negative enteric bacterial pathogens (GNEBPs) are a group of organisms that reside mainly in the intestine and induce diarrhoea. Antimicrobial agents are usually the part of their treatment regimen. The therapeutic effect of antimicrobials is hindered by the emergence and spread of drug-resistant strains. The information regarding the prevalence and antimicrobial resistance patterns of GNEBPs in Ethiopia is limited and found in a scattered form. Objectives This study was designed to determine the pooled prevalence and drug resistance patterns of GNEBPs by meta-analysis of data from diarrhoeic patients in Ethiopia. Method A comprehensive literature search was conducted through internet searches using Google Scholar, PubMed, Science Direct, HINARI databases, and reference lists of previous studies. Published articles were included in the study based on priorly set inclusion and exclusion criteria. Results were presented in the forest plot, tables, and figures with a 95% confidence interval (CI). The inconsistency index (I2) test statistics was used to assess heterogeneity across studies. The pooled prevalence estimate of GNEBPs and their drug resistance patterns were computed by a random-effects model. Software for Statistics and Data Science (STATA) version 14 statistical software was used for the analysis. Result After removing those articles which did not fulfil the inclusion criteria, 43 studies were included in the analysis. Studies were conducted in 8 regions of the country and most of the published articles were from the Amhara region (30.23%) followed by Oromia (18.60%) and Southern Nations, Nationalities, and Peoples’ region (SNNP) (18.60%). The pooled prevalence of GNEBPs was 15.81% (CI = 13.33–18.29). The funnel plot indicated the presence of publication bias. The pooled prevalence of GNEBPs in Addis Ababa, Amhara, SNNP, and Oromia ...
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Atomic and Electronic Structures of Correlated SrRuO3/SrTiO3 Superlattices

Jeong, Seung Gyo / Mohamed, Ahmed Yousef / Cho, Deok-Yong / Choi, Woo Seok

2023

Abstract: Atomic-scale precision epitaxy of perovskite oxide superlattices provides unique opportunities for controlling the correlated electronic structures, activating effective control knobs for intriguing functionalities including electromagnetic, ... ...

Abstract	Atomic-scale precision epitaxy of perovskite oxide superlattices provides unique opportunities for controlling the correlated electronic structures, activating effective control knobs for intriguing functionalities including electromagnetic, thermoelectric, and electrocatalytic behaviors. In this study, we investigated the close interplay between the atomic and electronic structures of correlated superlattices synthesized by atomic-scale precision epitaxy. In particular, we employ superlattices composed of correlated magnetic SrRuO3 (SRO) and quantum paraelectric SrTiO3 (STO) layers. In those superlattices, RuO6 octahedral distortion is systematically controlled from 167 to 175 degrees depending on the thickness of the STO layers, also affecting the TiO6 octahedral distortion within the STO layer. Customized octahedral distortion within SRO/STO superlattices in turn modifies the electronic structures of both the Ti and Ru compounds, observed by X-ray absorption spectroscopy. Our results identify the close correlation between atomic lattice and electronic structures enabled by the facile controllability of atomic-scale epitaxy, which would be useful for designing future correlated oxide devices. Comment: 14 pages
Keywords	Condensed Matter - Materials Science ; Condensed Matter - Strongly Correlated Electrons
Subject code	530
Publishing date	2023-01-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chemical Structure and Magnetism of FeO x /Fe 2 O 3 Interface Studied by X-ray Absorption Spectroscopy

Ahmed Yousef Mohamed / Won Goo Park / Deok-Yong Cho

Magnetochemistry, Vol 6, Iss 33, p

2020 Volume 33

Abstract: The chemical and magnetic states of Fe/Fe 2 O 3 thin films prepared by e-beam evaporation were investigated by using element-specific techniques, X-ray absorption spectroscopy (XAS) and X-ray magnetic circular dichroism (XMCD). It was clearly shown that ... ...

Abstract	The chemical and magnetic states of Fe/Fe 2 O 3 thin films prepared by e-beam evaporation were investigated by using element-specific techniques, X-ray absorption spectroscopy (XAS) and X-ray magnetic circular dichroism (XMCD). It was clearly shown that the Fe layers are oxidized to form an antiferromagnetic (AFM) FeO x<1 , while the bottom oxide remained a weak ferromagnet (wFM) (α+γ)-type Fe 2 O 3 . Dependences of the peak intensities and lineshapes on the Fe thickness and measurement geometry further demonstrate that FeO x<1 layers reside mostly at the interface realizing an FM (Fe)/AFM (FeO x )/wFM (Fe 2 O 3 ), whilst the spin directions lie in the sample plane for all the samples. The self-stabilized intermediate oxide can act as a physical barrier for spins to be injected into the wFM oxide, implying a substantial influence on tailoring the spin tunneling efficiency for spintronics application.
Keywords	FeOx ; Fe 2 O 3 ; X-ray absorption spectroscopy ; X-ray magnetic circular dichroism ; ferromagnet ; antiferromagnet ; Chemistry ; QD1-999
Subject code	290
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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