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  1. Article ; Online: Electrochemical sensor based on PEDOT/CNTs-graphene oxide for simultaneous determination of hazardous hydroquinone, catechol, and nitrite in real water samples.

    Ahmed, Yousef M / Eldin, Mahmoud A / Galal, Ahmed / Atta, Nada F

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5654

    Abstract: Hydroquinone (HQ), catechol (CC) and nitrite (NT) are considered aquatic environmental pollutants. They are highly toxic, harm humans' health, and damage the environment. Thus, in the present work we introduce a simple and efficient electrochemical ... ...

    Abstract Hydroquinone (HQ), catechol (CC) and nitrite (NT) are considered aquatic environmental pollutants. They are highly toxic, harm humans' health, and damage the environment. Thus, in the present work we introduce a simple and efficient electrochemical sensor for determination of HQ, CC, and NT simultaneously in wastewater sample. The sensor is fabricated by modifying the surface of a glassy carbon electrode (GCE) by two successive thin films from poly(3,4-ethylenedioxythiophene) (PEDOT) and a mixture of carbon nanotubes-graphene oxide (CNT-GRO). Under optimized conditions the HQ, CC, and NT are successfully detected simultaneously in wastewater sample with changing their concentrations in the ranges (0.04 → 100 µM), (0.01 → 100 µM) and (0.05 → 120 µM), the detection limits are 8.5 nM, 3.8 nM and 6.1 nM, respectively. Good potential peak separations: 117 mV and 585 mV are obtained between the HQ-CC, and CC-NT. The sensor has an excellent catalytic capability toward the oxidation of HQ, CC, and NT due to good synergism between its composite components: PEDOT, GRO and CNTs. The features of the sensor are large active surface area, good electrical conductivity, perfect storage stability, good reproducibility, anti-interference capability and accepted recovery rate for HQ, CC, and NT determination in wastewater sample.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54683-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Electrochemical sensor for simultaneous determination of antiviral favipiravir drug, paracetamol and vitamin C based on host-guest inclusion complex of β-CD/CNTs nanocomposite.

    Ahmed, Yousef M / Eldin, Mahmoud A / Galal, Ahmed / Atta, Nada F

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 19910

    Abstract: Favipiravir (FVI) is extensively used as an effective medication against several diverse infectious RNA viruses. It is widely administered as an anti-influenza drug. Combination therapy formed from FVI, paracetamol (PAR) and vitamin C (VC) is needed for ... ...

    Abstract Favipiravir (FVI) is extensively used as an effective medication against several diverse infectious RNA viruses. It is widely administered as an anti-influenza drug. Combination therapy formed from FVI, paracetamol (PAR) and vitamin C (VC) is needed for treating patients diseased by RNA viruses. Thus, an efficient electrochemical sensor is developed for detecting FVI in human serum samples. The sensor is fabricated by casting a thin layer of carbon nanotubes (CNTs) over a glassy carbon (GC) electrode surface followed by electrodeposition of another layer of β-cyclodextrin (β-CD). Under optimized conditions, the sensor shows excellent catalytic effect for FVI, PAR and VC oxidation in the concentration ranges (0.08 µM → 80 µM), (0.08 µM → 50 µM) and (0.8 µM → 80 µM) with low detection limits of 0.011 μM, 0.042 μM and 0.21 μM, respectively. The combined effect of host-guest interaction ability of β-CD for the drugs, and a large conductive surface area of CNTs improves the sensing performance of the electrode. The sensor exhibits stable response over 4 weeks, good reproducibility, and insignificant interference from common species present in serum samples. The reliability of using the sensor in serum samples shows good recovery of FVI, PAR and VC.
    MeSH term(s) Humans ; Ascorbic Acid ; Nanotubes, Carbon ; Acetaminophen ; Reproducibility of Results ; Antiviral Agents ; beta-Cyclodextrins ; Vitamins ; Electrodes ; Nanocomposites ; Electrochemical Techniques
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Nanotubes, Carbon ; Acetaminophen (362O9ITL9D) ; favipiravir (EW5GL2X7E0) ; Antiviral Agents ; beta-Cyclodextrins ; Vitamins
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-45353-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Electrochemical sensor for simultaneous determination of trifluoperazine and dopamine in human serum based on graphene oxide-carbon nanotubes/iron-nickel nanoparticles.

    Ahmed, Yousef M / Eldin, Mahmoud A / Galal, Ahmed / Atta, Nada F

    RSC advances

    2023  Volume 13, Issue 36, Page(s) 25209–25217

    Abstract: Trifluoperazine (TFLP) is an important psychiatric medication that balances the dopamine (DA) level in the brain for patients suffering from neurological disorder diseases. An efficient electrochemical sensor is developed for detecting TFLP in real human ...

    Abstract Trifluoperazine (TFLP) is an important psychiatric medication that balances the dopamine (DA) level in the brain for patients suffering from neurological disorder diseases. An efficient electrochemical sensor is developed for detecting TFLP in real human serum samples. The sensor is fabricated by casting the GC surface with two consecutive thin layers, namely a graphene oxide-carbon nanotubes mixture (GRO-CNT), and iron-nickel nanoparticles (Fe-Ni). The diffusion-controlled oxidation process of TFLP at the composite surface includes one electron transfer process. Under optimized conditions, the sensor in human serum shows excellent catalytic effect for simultaneous determination of TFLP and dopamine (DA) in the same concentration range (0.5 μM to 18 μM) with low detection limits of 0.13 μM and 0.32 μM respectively. The combined effect of a large conductive surface area and the excellent catalytic activity of the nanocomposite improves the sensor's performance. The sensor exhibits a stable current response over four weeks, excellent reproducibility, and insignificant interference from common species present in human serum samples. The reliability test of using the sensor in serum samples shows good recovery of TFLP.
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra04334g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Prehospital Combat Wound Medication Pack Administration in Iraq and Afghanistan: A Department of Defense Trauma Registry Analysis.

    Schauer, Steven G / Naylor, Jason F / Ahmed, Yousef M / Maddry, Joseph K / April, Michael D

    Journal of special operations medicine : a peer reviewed journal for SOF medical professionals

    2020  Volume 20, Issue 3, Page(s) 76–80

    Abstract: Background: The United States (US) military utilizes combat wound medication packs (CWMP) to provide analgesia and wound prophylaxis in casualties who are still able to fight. We compared characteristics of combat casualties receiving CWMP to those not ... ...

    Abstract Background: The United States (US) military utilizes combat wound medication packs (CWMP) to provide analgesia and wound prophylaxis in casualties who are still able to fight. We compared characteristics of combat casualties receiving CWMP to those not receiving CWMP. We also describe the proportions of casualties with injury patterns consistent with Tactical Combat Casualty Care (TCCC) guideline indications for CWMP use who received this intervention.
    Methods: This is a secondary analysis of Department of a Defense Trauma Registry (DODTR) dataset of US military personnel from January 2007 to August 2016. We searched for all subjects with documented use of at least one medication from the CWMP (acetaminophen, meloxicam, moxifloxacin).
    Results: Within our dataset, 11,665 casualties were US military Servicemembers. Overall, <1% (84) of our study population received the CWMP. The median age and mechanism of injuries were similar between CWMP nonrecipients versus recipients. Median composite injury scores were higher for nonrecipients than recipients (6 versus 4, P < .001). Proportions of casualties with injury patterns meeting TCCC guideline CWMP indications who received this intervention were low: gunshot wound, <1% (14 of 1805), tourniquet applied, <1% (11 of 1912), major amputation, <1% (5 of 803), and open fracture, <1% (10 of 2425). Based on serious injuries by body region, we had similar findings for the thorax (<1%; 3 of 1122), abdomen (<1%; 1 of 736), and extremities (<1%; 11 of 2699).
    Conclusions: Subjects receiving the CWMP were less severely injured compared to those who did not receive this intervention. The CWMP had very infrequent use among those casualties with injury patterns meeting indications specified in the TCCC Guidelines for use of this intervention.
    MeSH term(s) Afghan Campaign 2001- ; Afghanistan/epidemiology ; Emergency Medical Services ; Humans ; Iraq/epidemiology ; Iraq War, 2003-2011 ; Military Medicine ; Military Personnel ; Registries ; United States/epidemiology ; Wounds, Gunshot
    Language English
    Publishing date 2020-09-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3006517-3
    ISSN 1553-9768
    ISSN 1553-9768
    DOI 10.55460/X4E8-NNXE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Recurrence of Postoperative Stress-Induced Cardiomyopathy Resulting from Status Epilepticus.

    Miller, Grant A / Ahmed, Yousef M / Tarant, Nicki S

    Case reports in critical care

    2017  Volume 2017, Page(s) 8063837

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2017-01-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2927720-6
    ISSN 2090-6439 ; 2090-6420
    ISSN (online) 2090-6439
    ISSN 2090-6420
    DOI 10.1155/2017/8063837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cost minimization in treatment of adult degenerative scoliosis.

    Uddin, Omar M / Haque, Raqeeb / Sugrue, Patrick A / Ahmed, Yousef M / El Ahmadieh, Tarek Y / Press, Joel M / Koski, Tyler / Fessler, Richard G

    Journal of neurosurgery. Spine

    2015  Volume 23, Issue 6, Page(s) 798–806

    Abstract: Object: Back pain is an increasing concern for the aging population. This study aims to evaluate if minimally invasive surgery presents cost-minimization benefits compared with open surgery in treating adult degenerative scoliosis.: Methods: Seventy- ... ...

    Abstract Object: Back pain is an increasing concern for the aging population. This study aims to evaluate if minimally invasive surgery presents cost-minimization benefits compared with open surgery in treating adult degenerative scoliosis.
    Methods: Seventy-one patients with adult degenerative scoliosis received 2-stage, multilevel surgical correction through either a minimally invasive spine surgery (MIS) approach with posterior instrumentation (n = 38) or an open midline (Open) approach (n = 33). Costs were derived from hospital and rehabilitation charges. Length of stay, blood loss, and radiographic outcomes were obtained from electronic medical records. Functional outcomes were measured with Oswestry Disability Index (ODI) and visual analog scale (VAS) surveys.
    Results: Patients in both cohorts were similar in age (Age(MIS) = 65.68 yrs, Age(Open) = 63.58 yrs, p = 0.28). The mean follow-up was 18.16 months and 21.82 months for the MIS and Open cohorts, respectively (p = 0.34). MIS and Open cohorts had an average of 4.37 and 7.61 levels of fusion, respectively (p < 0.01). Total inpatient charges were lower for the MIS cohort ($269,807 vs $391,889, p < 0.01), and outpatient rehabilitation charges were similar ($41,072 vs $49,272, p = 0.48). MIS patients experienced reduced length of hospital stay (7.03 days vs 14.88 days, p < 0.01) and estimated blood loss (EBL) (EBL(MIS) = 470.26 ml, EBL(Open)= 2872.73 ml, p < 0.01). Baseline ODI scores were lower in the MIS cohort (40.03 vs 48.04, p = 0.03), and the cohorts experienced similar 1-year improvement (ΔODI(MIS) = -15.98, ΔODI(Open) = -21.96, p = 0.25). Baseline VAS scores were similar (VAS(MIS) = 6.56, VAS(Open)= 7.10, p = 0.32), but MIS patients experienced less reduction after 1 year (ΔVAS(MIS) = -3.36, ΔVAS(Open) = -4.73, p = 0.04). Preoperative sagittal vertical axis (SVA) were comparable (preoperative SVA(MIS) = 63.47 mm, preoperative SVA(Open) = 71.3 mm, p = 0.60), but MIS patients had larger postoperative SVA (postoperative SVA(MIS) = 51.17 mm, postoperative SVA(Open) = 28.17 mm, p = 0.03).
    Conclusions: Minimally invasive surgery demonstrated reduced costs, blood loss, and hospital stays, whereas open surgery exhibited greater improvement in VAS scores, deformity correction, and sagittal balance. Additional studies with more patients and longer follow-up will determine if MIS provides cost-minimization opportunities for treatment of adult degenerative scoliosis.
    MeSH term(s) Adult ; Aged ; Cost-Benefit Analysis ; Female ; Health Care Costs ; Humans ; Intervertebral Disc Degeneration/complications ; Intervertebral Disc Degeneration/economics ; Intervertebral Disc Degeneration/surgery ; Length of Stay/economics ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures/economics ; Retrospective Studies ; Scoliosis/economics ; Scoliosis/etiology ; Scoliosis/surgery ; Treatment Outcome
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2015.3.SPINE14560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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