Article: Effect of turmeric on colon histology, body weight, ulcer, IL-23, MPO and glutathione in acetic-acid-induced inflammatory bowel disease in rats
BMC complementary and alternative medicine. 2016 Dec., v. 16, no. 1
2016
Abstract: BACKGROUND: This study investigates the protective effects of turmeric (Curcuma longa, CL) on acetic acid-induced colitis in rats. METHOD: Inflammatory bowel disease (IBD) was induced in male Wistar rats by intra-rectal administration of 1Â ml of 4Â % ... ...
| Abstract | BACKGROUND: This study investigates the protective effects of turmeric (Curcuma longa, CL) on acetic acid-induced colitis in rats. METHOD: Inflammatory bowel disease (IBD) was induced in male Wistar rats by intra-rectal administration of 1 ml of 4 % acetic acid at 8 cm proximal to the anus for 30 s. Curcuma longa (CL) powder, (1, 10, or 100 mg/kg/day) was administered for either 3 days before or after IBD for 7 days. The body weight, macroscopic and microscopic analysis of the colon of CL-treated IBD rats and that of control rats (no IBD, no CL) were performed on 0 day, 2, 4 and 7th day. Myeloperoxidase (MPO), IL-23 and glutathione levels in control, untreated and treated rats were measured by ELISA. RESULTS: CL significantly (Pâ<â0.05) improved IBD-induced reduction in mean body weight and mean macroscopic ulcer score. Administration of CL also significantly (Pâ<â0.01) reduced the mean microscopic ulcer score when compared to untreated IBD control. Intake of CL by rats resulted in a significant (Pâ<â0.05) increase in the mean serum glutathione level compared to untreated control. CL reduced both MPO and IL-23 levels in the colonic mucosa of the rat. CONCLUSION: CL improved body weight gain, mean macroscopic and microscopic ulcer scores in the colon of rats suffering from acetic acid-induced IBD. CL reduced both MPO and IL-23 in the mucosa of the colon. The increase in the mean serum glutathione level may help in the reduction of oxidative stress associated with IBD. |
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| Keywords | Curcuma longa ; acetic acid ; alternative medicine ; anus ; blood serum ; body weight changes ; colitis ; colon ; enzyme-linked immunosorbent assay ; glutathione ; histology ; interleukin-23 ; males ; mucosa ; myeloperoxidase ; oxidative stress ; protective effect ; rats ; turmeric |
| Language | English |
| Dates of publication | 2016-12 |
| Size | p. 72. |
| Publishing place | BioMed Central |
| Document type | Article |
| ZDB-ID | 2050429-9 |
| ISSN | 1472-6882 |
| ISSN | 1472-6882 |
| DOI | 10.1186/s12906-016-1057-5 |
| Database | NAL-Catalogue (AGRICOLA) |
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