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  1. Article ; Online: Cognitive Impairment in Alzheimer’s Disease

    Betül Çiçek / Erol Akpınar / Ahmet Hacımüftüoğlu

    Archives of Basic and Clinical Research, Vol 4, Iss 1, Pp 35-

    Targeting the Histaminergic System

    2022  Volume 41

    Keywords Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The evaluation of the cortex neurons viability in CdS nanoparticles induced toxicity

    Atefeh Varmazyari / Ali Taghizadehghalehjoughi / Ozlem Baris / Aysegul Yilmaz / Ahmet Hacimuftuoglu

    Nanomedicine Journal, Vol 8, Iss 3, Pp 211-

    2021  Volume 219

    Abstract: Objective(s): Cadmium sulfur (CdS) is a type of quantum dot which is a unique light-emitting semiconductor nanocrystal. Quantum dots have wide applications in optoelectronics, solar cells, biology, and medicine fields.Materials and Methods: Morphological ...

    Abstract Objective(s): Cadmium sulfur (CdS) is a type of quantum dot which is a unique light-emitting semiconductor nanocrystal. Quantum dots have wide applications in optoelectronics, solar cells, biology, and medicine fields.Materials and Methods: Morphological properties and structural analysis for CdS were tested by using different methods (TEM, XPS and XRD). Cortical neuron cells were used for toxicity investigations. The cells were treated with different concentrations of CdS (100, 10, 1, 0.1, 0.01 µg/mL) and incubated for 24 h (5% CO2; 37°C). In vitro studies were done by examining cellular viability (MTT assay) and oxidative stress/status (TAC/TOS). Results: According to our results, the increasing concentration of CdS resulted in decreased cell viability. Total antioxidant capacity (TAC) of neurons increased following exposure to the lowest concentrations of CdS. In addition, inverse to our TAC findings, total oxidant status (TOS) was decreased following exposure to lower concentrations of CdS. Conclusion: Recently, because of advances in diagnostic and drug delivery systems ingestion rate of CdS by humans were increased. Hence, this study aimed to investigate the toxic effects of CdS on Cortex Neurons cell cultures. The production of CdS quantum dot particles was done by using the Viridibacillus arenosi K64 (biosynthesis method) which provides environmentally friendly, economical, reliable, and controlled production.
    Keywords cds ; cortex neurons ; tem ; xrd ; xps ; Medicine (General) ; R5-920
    Subject code 500
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Mashhad University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Etanercept Protects Neurons Against Glutamate-Induced Neurotoxicity

    Irmak FERAH OKKAY / Ufuk OKKAY / Yeşim YENİ / Özge BALPINAR / Ahmet HACIMÜFTÜOĞLU

    Veterinary Sciences and Practices, Vol 17, Iss 2, Pp 66-

    An In Vitro Study

    2022  Volume 70

    Keywords Veterinary medicine ; SF600-1100
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Use of bee venom in preventive medicine

    Mustafa Bayraktar / Ahmet Hacımüftüoğlu / Ufuk Okkay / Mehmet Nuri Koçak / Murat Kösedağ / Erdal Tekin / Muhammet Çelik / Irmak Ferah Okkay / Cemil Bayram / Muhammet Sait Ertuğrul / Selma Sezen

    Veterinary Medicine and Science, Vol 10, Iss 1, Pp n/a-n/a (2024)

    An experimental hepatic encephalopathy study in rats

    2024  

    Abstract: Abstract Objectives Bee venom is used for medicinal purposes, including the treatment of neurological and liver diseases, but its use as a primary health care approach for preventive purposes requires further exploration. The aim of this study was to ... ...

    Abstract Abstract Objectives Bee venom is used for medicinal purposes, including the treatment of neurological and liver diseases, but its use as a primary health care approach for preventive purposes requires further exploration. The aim of this study was to provide the first investigation into the possible protective effects of bee venom against hepatic encephalopathy, a serious neurodegenerative disease. Materials and Methods An experimental animal study was conducted in which healthy albino Sprague–Dawley rats were randomized into three groups: healthy, control and bee venom groups. All rats were tested for locomotor activity at the beginning and end of the study. No intervention was made in the healthy group, whereas hepatic encephalopathy was induced in the control and bee venom groups by the administration of thioacetamide (TAA) (200 mg/kg/day). The bee venom group also received bee venom (5 mg/kg/day) subcutaneously every day for 14 days prior to the TAA administration. Results The results for the final locomotor activity tests were statistically better in the bee venom group than in the control group, supporting a beneficial effect of prophylactic bee venom application. Blood ammonia levels and liver weights, determined as indicators of inflammation, were lower in the bee venom group than in the control group and were close to levels in the healthy group, but not statistically significant. Conclusions Bee venom administration has protective effects against the development of hepatic encephalopathy and offers a promising therapeutic opportunity in preventive medicine.
    Keywords Bee venom ; hepatic encephalopathy ; prevention ; primary care ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Melatonin receptors increase Momordica’s anticancer effects against PC-3 and HT-29

    Ahmet Hacimuftuoglu / David R Wallace / Ali Taghizadehghalehjoughi / Sıdıka Genç / Zeynep Çakır / Yeşim Yeni

    Journal of Contemporary Medicine, Vol 11, Iss 2, Pp 166-

    2021  Volume 173

    Abstract: Aim: The aim of our study is to the evaluation of melatonin (MLT) and Momordica charantia (MC) combination on PC-3 and HT-29 cancer lines and to address the question of where or not MLT increases MC antitumor effect in the PC-3 and HT-29 cancer lines. ... ...

    Abstract Aim: The aim of our study is to the evaluation of melatonin (MLT) and Momordica charantia (MC) combination on PC-3 and HT-29 cancer lines and to address the question of where or not MLT increases MC antitumor effect in the PC-3 and HT-29 cancer lines. Material and Method: The PC-3 and HT-29 cell lines were grown in a manufacturer-specified culture medium. Cisplatin, MLT, increasing concentrations of MC, 40 μg/ml MLT + increasing concentrations MC were applied to PC-3 and HT-29 cell lines for 72 hours. 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) cell viability, Total Antioxidant Capacity (TAC), Total Oxidant Status (TOS), Cellular Migration (Wound Healing test), and Lactate Dehydrogenase (LDH) tests were done 72 hours after drug administration. Results: The combination of MLT 40 μg/ml + MC 100 µg/ml reduced cell viability in both PC-3 and HT-29 cells. Besides, TAC and TOS levels showed a correlation with LDH and MTT assays and were found to be statistically significant (P
    Keywords ht-29 ; ldh ; melatonin ; momordica ; pc-3 ; Medicine ; R
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Rabia Yılmaz
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Does Intravitreal Dopamine Agonist and Antagonist Administration Have Effects on the Brain? An Experimental Study in Rats

    Mehmet Nuri Kocak / Orhan Ates / Ahmet Hacımuftuoglu / Irem Ates / Erdal Tekin / Onur Ceylan / Ufuk Okkay

    Eurasian Journal of Medicine, Vol 54, Iss 1, Pp 54-

    2022  Volume 60

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Renoprotective Effect of Taxifolin in Paracetamol-Induced Nephrotoxicity

    Ismail Topal / Mustafa Yaşar Özdamar / Tulin Catakli / İsmail Malkoc / Ahmet Hacimuftuoglu / Charalampos Mamoulakis / Aristidis Tsatsakis / Konstantinos Tsarouhas / Christina Tsitsimpikou / Ali Taghizadehghalehjoughi

    Journal of Clinical Medicine, Vol 12, Iss 876, p

    Emerging Evidence from an Animal Model

    2023  Volume 876

    Abstract: Background: Taxifolin (TXF) is a flavonoid found abundantly in citrus/onion. Encouraging results on its renoprotective effect have been reported in a limited number of drug-induced nephrotoxicity animal models. The present study aimed to evaluate for the ...

    Abstract Background: Taxifolin (TXF) is a flavonoid found abundantly in citrus/onion. Encouraging results on its renoprotective effect have been reported in a limited number of drug-induced nephrotoxicity animal models. The present study aimed to evaluate for the first time the potential renoprotective effects of TXF in a paracetamol (PAR)-induced nephrotoxicity rat model. Methods: Rats were divided into three equal groups ( n = 6 animals per group). Group 1 (PAR group, PARG) received PAR diluted in normal saline by gavage (1000 mg/kg). Group 2 (TXF group, TXFG) received TXF diluted in normal saline by gavage (50 mg/kg) one hour after PAR administration. Group 3 (control group, CG) received normal saline. Twenty-four hours after PAR administration, all animals were sacrificed using high-dose anesthesia. Blood samples were collected and kidneys were removed. Results: The serum blood urea nitrogen, creatinine levels and serum malondialdehyde levels were significantly increased in the PARG. The serum glutathione peroxidase, glutathione reductase and total glutathione levels were significantly higher in the TXFG. At the same time, the kidneys of the PARG animals demonstrated tubular epithelium swelling, distension and severe vacuolar degeneration. The kidneys of the TXFG animals showed mildly dilated/congested blood vessels. Conclusions: The TXF renoprotective effects are promising in preventing PAR-induced nephrotoxicity, mainly through antioxidant activity, and warrant further testing in future studies.
    Keywords acute kidney injury ; kidney ; nephropathy ; paracetamol ; renal injury ; taxifolin ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Does Umbelliferone Protect Primary Cortical Neuron Cells Against Glutamate Excitotoxicity?

    Alper Kürşat DEMİRKAYA / Gülşah GÜNDOĞDU / Songül KARAKAYA / Şeymanur YILMAZ TAŞCI / Kemal Alp NALCI / Ahmet HACIMÜFTÜOĞLU

    Kafkas Universitesi Veteriner Fakultesi Dergisi, Vol 27, Iss 3, Pp 339-

    2021  Volume 346

    Abstract: Glutamate is the major excitatory neurotransmitter in the central nervous system. Excessive glutamate is known to cause excitotoxicity. Umbelliferone is a coumarin derivative compound and has antioxidant, anti-inflammatory, and neuroprotective effects. ... ...

    Abstract Glutamate is the major excitatory neurotransmitter in the central nervous system. Excessive glutamate is known to cause excitotoxicity. Umbelliferone is a coumarin derivative compound and has antioxidant, anti-inflammatory, and neuroprotective effects. Also, umbelliferone can show neuroprotective eff ect by crossing the blood-brain barrier. In our study, it was aimed to investigate the neuroprotective effect of umbelliferone on primary cortical neuron (PCN) culture. Umbelliferone was isolated from the roots of Ferulago cassia dichloromethane sub-extract. The cerebral cortex of newborn Sprague Dawley rats was used to obtain PCNs. To stimulate glutamate excitotoxicity, cells were exposed to 6x10-5M glutamate. Then different concentrations (10-1000 μM) of umbelliferone were added into the medium and allowed to incubate for 24 and 72 h. MTT assay was used to measure cell viability. Total Antioxidant Status (TAS) and Total Oxidant Status (TOS) analyzes were used to evaluate reactive oxygen species. MTT results showed that cell viability was decreased with glutamate application. 25-250 µM umbelliferone had a significant protective eff ect against glutamate excitotoxicity at 72 h (P<0.05). Consistent with MTT results, TAS analysis results showed 50-250 µM umbelliferone increase the level of antioxidants in cells, which can help protect neurons against glutamate-induced excitotoxicity. In this study, umbelliferone showed a neuroprotective effect in PCN against glutamate excitotoxicity. These results suggest that umbelliferone may be used as therapeutic agent against glutamate excitotoxicity.
    Keywords glutamate ; ferulago ; primary cortical neuron culture ; umbelliferone ; Veterinary medicine ; SF600-1100
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher University of Kafkas
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The effects Metformin/Irinotecan-loaded PLGA nanoparticles on glutamate re-uptake time and alteration EAAT1 gene expression level in vitro

    Ali Taghizadehghalehjoughi / Ahmet Hacimuftuoglu / Meltem Cetin / Afifie ugur / Selcuk butuner / Numan Taspinar / Maryam mohammadzadeh

    Nanomedicine Journal, Vol 6, Iss 1, Pp 35-

    2019  Volume 42

    Abstract: Objective(s): The present study was designed to evaluate of Metformin/Irinotecan-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) effects on glutamate re-uptake time and receptor expression status in both glioblastoma multiforme (GBM) and ... ...

    Abstract Objective(s): The present study was designed to evaluate of Metformin/Irinotecan-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) effects on glutamate re-uptake time and receptor expression status in both glioblastoma multiforme (GBM) and cortex neuron cultures. The study was performed on glioblastoma cell line and primer cortex neuron.Materials and Methods: The re-uptake time and gene expression status of pure drugs and MET- or IRI-loaded-PLGA NPs on healthy neuron cells and U-87 MG cell line were investigated by using glutamate specific voltammetry electrodes technique and real time PCR. Results: Both MET and MET-PLGA NPs (1 and 2 mM) exhibited significant cytotoxicity on both U87MG and neuron cells. MET and MET-PLGA NPs (0.5 mM) showed lower cytotoxic effects on both cells. IRI and IRI-PLGA NPs (100 µM) had significant cytotoxic effects on both cell lines. Conclusion: All drug-loaded NPs caused a significant reduction in glutamate reuptake time compared with free drugs, blank NPs and cancer cells control groups. Consequently, MET- and IRI-loaded PLGA NPs may be a promising approach to treat GBM.
    Keywords EAAT1 ; Irinotecan ; Metformin ; PLGA ; Voltammetry ; Medicine (General) ; R5-920
    Subject code 571
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Mashhad University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression

    Yesim Yeni / Zeynep Cakir / Ahmet Hacimuftuoglu / Ali Taghizadehghalehjoughi / Ufuk Okkay / Sidika Genc / Serkan Yildirim / Yavuz Selim Saglam / Daniela Calina / Aristidis Tsatsakis / Anca Oana Docea

    Journal of Personalized Medicine, Vol 12, Iss 246, p

    2022  Volume 246

    Abstract: Glutamate release and reuptake play a key role in the pathophysiology of depression. glutamatergic nerves in the hippocampus region are modulated by histaminergic afferents. Excessive accumulation of glutamate in the synaptic area causes degeneration of ... ...

    Abstract Glutamate release and reuptake play a key role in the pathophysiology of depression. glutamatergic nerves in the hippocampus region are modulated by histaminergic afferents. Excessive accumulation of glutamate in the synaptic area causes degeneration of neuron cells. The H4 receptor is defined as the main immune system histamine receptor with a pro-inflammatory role. To understand the role of this receptor, the drug JNJ7777120 was used to reveal the chronic depression-glutamate relationship. We have important findings showing that the H4 antagonist increases the glutamate transporters’ instantaneous activity. In our experiment, it has been shown that blocking the H4 receptor leads to increased neuron cell viability and improvement in behavioral ability due to glutamate. Therefore, JNJ can be used to prevent neurotoxicity, inhibit membrane phospholipase activation and free radical formation, and minimize membrane disruption. In line with our findings, results have been obtained that indicate that JNJ will contribute to the effective prevention and treatment of depression.
    Keywords depression ; glutamate ; H4 ; hippocampus ; JNJ7777120 ; Medicine ; R
    Subject code 572
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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