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Article ; Online: Catalytic Ozonation by Iron Coated Pumice for the Degradation of Natural Organic Matters

Alper Alver / Ahmet Kılıç

Catalysts, Vol 8, Iss 5, p

2018 Volume 219

Abstract: The use of iron-coated pumice (ICP) in heterogeneous catalytic ozonation significantly enhanced the removal efficiency of natural organic matters (NOMs) in water, due to the synergistic effect of hybrid processes when compared to sole ozonation and ... ...

Abstract	The use of iron-coated pumice (ICP) in heterogeneous catalytic ozonation significantly enhanced the removal efficiency of natural organic matters (NOMs) in water, due to the synergistic effect of hybrid processes when compared to sole ozonation and adsorption. Multiple characterization analyses (BET, TEM, XRD, DLS, FT-IR, and pHPZC) were employed for a systematic investigation of the catalyst surface properties. This analysis indicated that the ICP crystal structure was α-FeOOH, the surface hydroxyl group of ICP was significantly increased after coating, the particle size of ICP was about 200–250 nm, the BET surface area of ICP was about 10.56 m2 g−1, the pHPZC value of ICP was about 7.13, and that enhancement by iron loading was observed in the FT-IR spectra. The contribution of surface adsorption, hydroxyl radicals, and sole ozonation to catalytic ozonation was determined as 21.29%, 66.22%, and 12.49%, respectively. The reaction kinetic analysis with tert-Butyl alcohol (TBA) was used as a radical scavenger, confirming that surface ferrous iron loading promoted the role of the hydroxyl radicals. The phosphate was used as an inorganic probe, and significantly inhibited the removal efficiency of catalytic NOM ozonation. This is an indication that the reactions which occur are more dominant in the solution phase.
Keywords	catalytic ozonation ; iron coated pumice ; surface properties ; natural organic matter ; reaction kinetics ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pulmonary artery transection for resection of a middle mediastinal paraganglioma

Alice L. Zhou / Meghan E. Halub / Mira Lotfalla / Benjamin L. Shou / Ahmet Kilic

Clinical Case Reports, Vol 10, Iss 4, Pp n/a-n/a (2022)

2022

Abstract: Abstract We report the case of a 65‐year‐old male patient who presented with chest pain and was found to have a mediastinal paraganglioma between the left atrium and main pulmonary artery. This is the first reported case of a mediastinal paraganglioma ... ...

Abstract	Abstract We report the case of a 65‐year‐old male patient who presented with chest pain and was found to have a mediastinal paraganglioma between the left atrium and main pulmonary artery. This is the first reported case of a mediastinal paraganglioma resection utilization transection of the main pulmonary artery.
Keywords	cardiac tumor ; cardiothoracic surgery ; paraganglioma ; pulmonary artery transection ; tumor resection ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Parental Anxiety Levels of Patients Admitted to Pediatric Emergency Clinic Due to Febrile Convulsion

Esra Türe / Fatih Akın / Abdullah Yazar / Necati Uzun / Ahmet Kılıç

Journal of Contemporary Medicine, Vol 10, Iss 2, Pp 220-

2020 Volume 223

Abstract: Aim: This study aims to determine the anxiety levels of the parents of patients admitted to the pediatric emergency clinic due to febrile convulsion, and to evaluate factors that may affect anxiety levels. In addition, it is aimed to investigate the ... ...

Abstract	Aim: This study aims to determine the anxiety levels of the parents of patients admitted to the pediatric emergency clinic due to febrile convulsion, and to evaluate factors that may affect anxiety levels. In addition, it is aimed to investigate the effect of the febrile convulsion on parents' behavior and emotional status in order to improve our attitude towards parents in the future. Materials-Methods: The study was done at Necmettin Erbakan University Meram Medical Faculty Faculty Hospital Pediatric Emergency Department between February 2017 and September 2018 with febril convulsion and fever were included in this study. The patients were evaluated in two groups as those with febril convulsion and those who complained of fever only. The State-Trait Anxiety Inventory was used to determine the level of anxiety of parents. Results: Of the patients included in the study, 323 (48.6%) were admitted with febril convulsion and 341 (51.4%) with fever complaints. When compared to the mean of the state anxiety score and the trait anxiety score between the groups, it was found that the mean of the state anxiety score was statistically higher in the febrile convulsion group than the non-seizure fever group (p=0.001), while the trait anxiety score was also high in the febril convulsion group, but no statistical significance was found between the non-seizure fever group (p>0,05). When the anxiety level of parents was examined according to the number of seizures of the patients in the febril convulsion group, it was found that the parents of patients with their first seizures were statistically significantly higher than their parents with multiple seizures (p=0.007, p=0.001). No statistical significance was found between the education level of the parents and their anxiety scores (p> 0.05). Conclusion: Parents of patients who have applied to health institutions with a fever complaint, providing fever and febrile convulsion training, explaining the first interventions to the patient who has a seizure, and raising ...
Keywords	febrile convulsion ; anxiety ; parents ; child ; pediatric emergency ; ateşli konvülsiyon ; anksiyete ; ebeveyn ; çocuk ; çocuk acil ; Medicine ; R
Subject code	150
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Rabia Yılmaz
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development of Three Dimensional Virtual Court for Legal Education

Sakine Öngöz / Hasan Karal / Mustafa Tüysüz / Adil Yıldız / Ahmet Kılıç

Turkish Online Journal of Qualitative Inquiry, Vol 8, Iss 1, Pp 69-

2017 Volume 90

Abstract: The aim of this study was to develop a three-dimensional virtual court for legal education. The study was carried out as qualitative research, and design-based research method was used in the study. The participants were composed of 4 lawyers, 6 legal ... ...

Abstract	The aim of this study was to develop a three-dimensional virtual court for legal education. The study was carried out as qualitative research, and design-based research method was used in the study. The participants were composed of 4 lawyers, 6 legal practitioners and 5 researchers. Study data were collected by using document analysis, focus group discussions and unstructured interviews. Two focus group discussions were held throughout the study implementation In the first discussion, the participants were informed about potential beneficiaries and purposes of using of virtual courts. The other discussion became the venue for negotiations on how to transfer the structure and functioning of real courts to the virtual environment. In addition, document analysis was conducted on functioning and physical properties of the real courts in Turkey. In the light of the findings from the focus group discussions in combination with document analysis, the qualities were determined which are expected to be featured in a virtual court to be developed for legal education. In the following stage, a three-dimensional virtual courthouse was modelled where hearings can be held. Then it was revised in accordance with opinions of both experienced and legal practitioners by using unstructured interview forms. The court was finally finished as a result of a two-step evaluation process.
Keywords	Sanal mahkeme ; sanal gerçeklik ; hukuk eğitimi ; üç boyutlu modelleme ; Virtual court ; virtual reality ; legal training ; three-dimensional modelling ; Social Sciences ; H
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Turkish Online Journal of Qualitative Inquiry (TOJQI)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dealing with a Porcelain Aorta during Coronary Artery Bypass Grafting

T. M. Ayodele Adesanya / Ahmet Kilic

Case Reports in Surgery, Vol

2014 Volume 2014

Keywords	Surgery ; RD1-811 ; Medicine ; R
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impaired adhesion of induced pluripotent stem cell-derived cardiac progenitor cells (iPSC-CPCs) to isolated extracellular matrix from failing hearts

Elizabeth N. McKown / Joshua L. DeAguero / Benjamin D. Canan / Ahmet Kilic / Yiliang Zhu / Paul M.L. Janssen / Dawn A. Delfín

Heliyon, Vol 4, Iss 10, Pp e00870- (2018)

2018

Abstract: We tested the hypothesis that induced pluripotent stem cell-derived cardiac progenitor cells (iPSC-CPCs) are less able to adhere to the extracellular matrix (ECM) derived from failing human hearts with dilated cardiomyopathy compared to nonfailing human ... ...

Abstract	We tested the hypothesis that induced pluripotent stem cell-derived cardiac progenitor cells (iPSC-CPCs) are less able to adhere to the extracellular matrix (ECM) derived from failing human hearts with dilated cardiomyopathy compared to nonfailing human heart ECM. We also hypothesized that morphological development, cell beating rates, and mRNA levels of Nkx2.5 and cardiac troponin T would be altered after culturing the iPSC-CPCs on the failing heart ECM under cardiomyocyte differentiation conditions. We used microscopy to distinguish between adhered and unadhered cells, and to determine morphological development and cell beating. We used qPCR to determine mRNA levels. iPSC-CPCs show a significantly reduced ability to adhere to the ECM of failing hearts and higher expression of Nkx2.5 mRNA. However, morphological development, cell beating rates, and cardiac troponin T levels were not significantly altered in the cells cultured on the failing heart ECM. Our study shows that the failing heart ECM from patients with dilated cardiomyopathy impairs initial iPSC-CPC adhesion and may have a modest effect on the ability of the cells to transdifferentiate into cardiomyocytes.
Keywords	Cell biology ; Stem cell research ; Cardiology ; Pathology ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2018-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of General and Heart-Specific miRNAs in Sheep (Ovis aries).

Alessandro Laganà / Dario Veneziano / Tyler Spata / Richard Tang / Hua Zhu / Peter J Mohler / Ahmet Kilic

PLoS ONE, Vol 10, Iss 11, p e

2015 Volume 0143313

Abstract: MicroRNAs (miRNAs or miRs) are small regulatory RNAs crucial for modulation of signaling pathways in multiple organs. While the link between miRNAs and heart disease has grown more readily apparent over the past three years, these data are primarily ... ...

Abstract	MicroRNAs (miRNAs or miRs) are small regulatory RNAs crucial for modulation of signaling pathways in multiple organs. While the link between miRNAs and heart disease has grown more readily apparent over the past three years, these data are primarily limited to small animal models or cell-based systems. Here, we performed a high-throughput RNA sequencing (RNAseq) analysis of left ventricle and other tissue from a pre-clinical ovine model. We identified 172 novel miRNA precursors encoding a total of 264 mature miRNAs. Notably, 84 precursors were detected in both the left ventricle and other tissues. However, 10 precursors, encoding 11 mature sequences, were specific to the left ventricle. Moreover, the total 168 novel miRNA precursors included 22 non-conserved ovine-specific sequences. Our data identify and characterize novel miRNAs in the left ventricle of sheep, providing fundamental new information for our understanding of protein regulation in heart and other tissues.
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Nonthoracotomy Myocardial Infarction Model in an Ovine Using Autologous Platelets

Tyler Spata / Daniel Bobek / Bryan A. Whitson / Sampath Parthasarathy / Peter J. Mohler / Robert S. D. Higgins / Ahmet Kilic

BioMed Research International, Vol

2013 Volume 2013

Abstract: Objective. There is a paucity of a biological large animal model of myocardial infarction (MI). We hypothesized that, using autologous-aggregated platelets, we could create an ovine model that was reproducible and more closely mimicked the ... ...

Abstract	Objective. There is a paucity of a biological large animal model of myocardial infarction (MI). We hypothesized that, using autologous-aggregated platelets, we could create an ovine model that was reproducible and more closely mimicked the pathophysiology of MI. Methods. Mepacrine stained autologous platelets from male sheep (n=7) were used to create a myocardial infarction via catheter injection into the mid-left anterior descending (LAD) coronary artery. Serial daily serum troponin measurements were taken and tissue harvested on post-embolization day three. Immunofluorescence microscopy was used to detect the mepacrine-stained platelet-induced thrombus, and histology performed to identify three distinct myocardial (infarct, peri-ischemic “border zone,” and remote) zones. Results. Serial serum troponin levels (μg/mL) measured 0.0±0.0 at baseline and peaked at 297.4±58.0 on post-embolization day 1, followed by 153.0±38.8 on day 2 and 76.7±19.8 on day 3. Staining confirmed distinct myocardial regions of inflammation and fibrosis as well as mepacrine-stained platelets as the cause of intravascular thrombosis. Conclusion. We report a reproducible, unique model of a biological myocardial infarction in a large animal model. This technique can be used to study acute, regional myocardial changes following a thrombotic injury.
Keywords	Medicine ; R
Subject code	630
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Insights into length-dependent regulation of cardiac cross-bridge cycling kinetics in human myocardium

Milani-Nejad, Nima / Jae-Hoon Chung / Benjamin D. Canan / Jonathan P. Davis / Vadim V. Fedorov / Robert S.D. Higgins / Ahmet Kilic / Peter J. Mohler / Paul M.L. Janssen

Archives of biochemistry and biophysics. 2016 July 01, v. 601

2016

Abstract: Cross-bridge cycling kinetics play an essential role in the heart's ability to contract and relax. The rate of tension redevelopment (ktr) slows down as a muscle length is increased in intact human myocardium. We set out to determine the effect of rapid ... ...

Abstract	Cross-bridge cycling kinetics play an essential role in the heart's ability to contract and relax. The rate of tension redevelopment (ktr) slows down as a muscle length is increased in intact human myocardium. We set out to determine the effect of rapid length step changes and protein kinase A (PKA) and protein kinase C-Î²II (PKC-Î²II) inhibitors on the ktr in ultra-thin non-failing and failing human right ventricular trabeculae. After stabilizing the muscle either at L90 (90% of optimal length) or at Lopt (optimal length), we rapidly changed the length to either Lopt or L90 and measured ktr. We report that length-dependent changes in ktr occur very rapidly (in the order of seconds or faster) in both non-failing and failing muscles and that the length at which a muscle had been stabilized prior to the length change does not significantly affect ktr. In addition, at L90 and at Lopt, PKA and PKC-Î²II inhibitors did not significantly change ktr. Our results reveal that length-dependent regulation of cross-bridge cycling kinetics predominantly occurs rapidly and involves the intrinsic properties of the myofilament rather than post-translational modifications that are known to occur in the cardiac muscle as a result of a change in muscle/sarcomere length.
Keywords	cAMP-dependent protein kinase ; humans ; muscles ; post-translational modification ; sarcomeres
Language	English
Dates of publication	2016-0701
Size	p. 48-55.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	523-x
ISSN	1096-0384 ; 0003-9861
ISSN (online)	1096-0384
ISSN	0003-9861
DOI	10.1016/j.abb.2016.02.005
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Calcium-activated potassium current modulates ventricular repolarization in chronic heart failure.

Ingrid M Bonilla / Victor P Long / Pedro Vargas-Pinto / Patrick Wright / Andriy Belevych / Qing Lou / Kent Mowrey / Jae Yoo / Philip F Binkley / Vadim V Fedorov / Sandor Györke / Paulus M L Janssen / Ahmet Kilic / Peter J Mohler / Cynthia A Carnes

PLoS ONE, Vol 9, Iss 10, p e

2014 Volume 108824

Abstract: The role of I(KCa) in cardiac repolarization remains controversial and varies across species. The relevance of the current as a therapeutic target is therefore undefined. We examined the cellular electrophysiologic effects of I(KCa) blockade in controls, ...

Abstract	The role of I(KCa) in cardiac repolarization remains controversial and varies across species. The relevance of the current as a therapeutic target is therefore undefined. We examined the cellular electrophysiologic effects of I(KCa) blockade in controls, chronic heart failure (HF) and HF with sustained atrial fibrillation. We used perforated patch action potential recordings to maintain intrinsic calcium cycling. The I(KCa) blocker (apamin 100 nM) was used to examine the role of the current in atrial and ventricular myocytes. A canine tachypacing induced model of HF (1 and 4 months, n = 5 per group) was used, and compared to a group of 4 month HF with 6 weeks of superimposed atrial fibrillation (n = 7). A group of age-matched canine controls were used (n = 8). Human atrial and ventricular myocytes were isolated from explanted end-stage failing hearts which were obtained from transplant recipients, and studied in parallel. Atrial myocyte action potentials were unchanged by I(KCa) blockade in all of the groups studied. I(KCa) blockade did not affect ventricular myocyte repolarization in controls. HF caused prolongation of ventricular myocyte action potential repolarization. I(KCa) blockade caused further prolongation of ventricular repolarization in HF and also caused repolarization instability and early afterdepolarizations. SK2 and SK3 expression in the atria and SK3 in the ventricle were increased in canine heart failure. We conclude that during HF, I(KCa) blockade in ventricular myocytes results in cellular arrhythmias. Furthermore, our data suggest an important role for I(KCa) in the maintenance of ventricular repolarization stability during chronic heart failure. Our findings suggest that novel antiarrhythmic therapies should have safety and efficacy evaluated in both atria and ventricles.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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