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  1. Article ; Online: Choreiform Movement Disorder Associated with Subdural Hematoma

    Ahmet Özşimşek

    Türk Nöroloji Dergisi, Vol 24, Iss 1, Pp 94-

    A Case Report

    2018  Volume 95

    Keywords Chorea ; craniocerebral trauma ; subdural hematoma ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Atrial Myxoma and Hypersomnia

    Ahmet Özşimşek

    Türk Nöroloji Dergisi, Vol 23, Iss 4, Pp 254-

    2017  Volume 255

    Keywords Disorders of excessive somnolence ; atrial myxoma ; familial cerebral infarction ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Relationship Between the Type of Parkinson’s Disease and Entrapment Neuropathy in the Upper Extremities

    Nihat Şengeze / Ahmet Özşimşek / Hasan Rıfat Koyuncuoğlu / Esra Taşkıran

    Türk Nöroloji Dergisi, Vol 27, Iss 3, Pp 306-

    2021  Volume 310

    Abstract: Objective: Parkinson’s disease (PD) is one of the common neurodegenerative disorders in the community. Compressive neuropathy (CN) is one of the conditions that negatively affect workforce and decreases the quality of life. We aimed to investigate the ... ...

    Abstract Objective: Parkinson’s disease (PD) is one of the common neurodegenerative disorders in the community. Compressive neuropathy (CN) is one of the conditions that negatively affect workforce and decreases the quality of life. We aimed to investigate the effect of repetitive mechanical movement on tremor dominant (TD) or akinetic-rigid syndrome (ARS) PD and CNs, particularly, the relationship between CN and two types of PD. In addition, we aimed to evaluate the relationship between CNs and the affected side at the onset and during the disease in both types of PD. Materials and Methods: Patients with PD who presented to our clinic from October 2017 to September 2018 were enrolled in the study. All patients who underwent electromyography to investigate CN were included in the study. The Padua classification was used in the carpal tunnel and cubital tunnel syndrome and electrophysiological findings were classified according to age and gender. According to the disease duration, patients were compared within the two groups as less than 3 years and ≥3 years. Patients were examined in two groups according to the TD and ARS type of PD and initially affected side. Results: A total of 71 patients suffering from PD were enrolled in the study, wherein 57 (80.3%) were TD, and 14 were (19.7%) ARS. An increased risk of developing carpal tunnel syndrome (CaTS) was found in the TD group with a disease duration of ≥3 years (p=0.026). Conclusion: No relationship was found between the two different types of PD or the affected side and the type of CN. However, the risk of CaTS increased in TD PD over the 3 years.
    Keywords parkinson disease ; compressive neuropathies ; carpal tunnel syndrome ; cubital tunnel syndrome ; akinetic-rigid and tremor-dominant parkinsonism ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  4. Article ; Online: Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients

    Burak Yulug / Ozlem Altay / Xiangyu Li / Lutfu Hanoglu / Seyda Cankaya / Simon Lam / Halil Aziz Velioglu / Hong Yang / Ebru Coskun / Ezgi Idil / Rahim Nogaylar / Ahmet Ozsimsek / Cemil Bayram / Ismail Bolat / Sena Oner / Ozlem Ozdemir Tozlu / Mehmet Enes Arslan / Ahmet Hacimuftuoglu / Serkan Yildirim /
    Muhammad Arif / Saeed Shoaie / Cheng Zhang / Jens Nielsen / Hasan Turkez / Jan Borén / Mathias Uhlén / Adil Mardinoglu

    Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-

    a randomised, double-blinded, placebo-controlled phase-II trial

    2023  Volume 23

    Abstract: Abstract Background Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed that CMA improves the ... ...

    Abstract Abstract Background Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed that CMA improves the AD-associated histological parameters in the animals. CMA promotes mitochondrial fatty acid uptake from the cytosol, facilitates fatty acid oxidation in the mitochondria, and alleviates oxidative stress. Methods Here, we designed a randomised, double-blinded, placebo-controlled phase-II clinical trial and studied the effect of CMA administration on the global metabolism of AD patients. One-dose CMA included 12.35 g L-serine (61.75%), 1 g nicotinamide riboside (5%), 2.55 g N-acetyl-L-cysteine (12.75%), and 3.73 g L-carnitine tartrate (18.65%). AD patients received one dose of CMA or placebo daily during the first 28 days and twice daily between day 28 and day 84. The primary endpoint was the difference in the cognitive function and daily living activity scores between the placebo and the treatment arms. The secondary aim of this study was to evaluate the safety and tolerability of CMA. A comprehensive plasma metabolome and proteome analysis was also performed to evaluate the efficacy of the CMA in AD patients. Results We showed a significant decrease of AD Assessment Scale-cognitive subscale (ADAS-Cog) score on day 84 vs day 0 (P = 0.00001, 29% improvement) in the CMA group. Moreover, there was a significant decline (P = 0.0073) in ADAS-Cog scores (improvement of cognitive functions) in the CMA compared to the placebo group in patients with higher ADAS-Cog scores. Improved cognitive functions in AD patients were supported by the relevant alterations in the hippocampal volumes and cortical thickness based on imaging analysis. Moreover, the plasma levels of proteins and metabolites associated with NAD + and glutathione metabolism were significantly improved after CMA treatment. Conclusion Our results indicate that treatment of AD patients with CMA can lead to ...
    Keywords Alzheimer’s disease ; Combined metabolic activators ; Multi-omics ; Systems biology ; Systems medicine ; Neurology. Diseases of the nervous system ; RC346-429
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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