Article ; Online: Clinical significance of L1CAM expression and its biological role in the progression of oral squamous cell carcinoma.
2023 Volume 49, Issue 4
Abstract: L1 cell adhesion molecule (L1CAM) has been implicated in the progression and metastasis of numerous cancers. However, the role of L1CAM in oral squamous cell carcinoma (OSCC) is not well characterized. In the present study, the expression of L1CAM was ... ...
| Abstract | L1 cell adhesion molecule (L1CAM) has been implicated in the progression and metastasis of numerous cancers. However, the role of L1CAM in oral squamous cell carcinoma (OSCC) is not well characterized. In the present study, the expression of L1CAM was examined in oral tongue squamous cell carcinoma (OTSCC) tissue samples by immunohistochemistry, the clinicopathological significance of L1CAM expression was evaluated by chi‑squared test, and the overall survival (OS) rate was analyzed using Kaplan‑Meier method according to the expression of L1CAM. In addition, it was aimed to elucidate the biological role of L1CAM and the underlying molecular mechanisms by which L1CAM functions in OSCC cells in relation to epithelial‑mesenchymal transition (EMT) and PI3K/AKT/ERK signaling pathways. Thus, the functions of L1CAM on the OSCC cell proliferation, migration and invasion, and the activation of EMT and PI3K/AKT/ERK signaling pathways were investigated |
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| MeSH term(s) | Humans ; Carcinoma, Squamous Cell/pathology ; Squamous Cell Carcinoma of Head and Neck/genetics ; Neural Cell Adhesion Molecule L1/genetics ; Neural Cell Adhesion Molecule L1/metabolism ; Neural Cell Adhesion Molecule L1/therapeutic use ; Mouth Neoplasms/genetics ; Mouth Neoplasms/drug therapy ; Proto-Oncogene Proteins c-akt ; Clinical Relevance ; Phosphatidylinositol 3-Kinases ; Tongue Neoplasms ; Prognosis ; Cell Proliferation/genetics ; Head and Neck Neoplasms ; Cell Movement/physiology ; Cell Line, Tumor | |||||
| Chemical Substances | Neural Cell Adhesion Molecule L1 ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) | |||||
| Language | English | |||||
| Publishing date | 2023-02-24 | |||||
| Publishing country | Greece | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1222484-4 | |||||
| ISSN | 1791-2431 ; 1021-335X | |||||
| ISSN (online) | 1791-2431 | |||||
| ISSN | 1021-335X | |||||
| DOI | 10.3892/or.2023.8504 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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