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  1. Article ; Online: Modified (-)-gallocatechin gallate-enriched green tea extract rescues age-related cognitive deficits by restoring hippocampal synaptic plasticity.

    Ahn, Ji-Woong / Kim, Sohyun / Ko, Sukjin / Kim, Young-Hwan / Jeong, Ji-Hyun / Chung, Seungsoo

    Biochemistry and biophysics reports

    2022  Volume 29, Page(s) 101201

    Abstract: ... ...

    Abstract Aging
    Language English
    Publishing date 2022-01-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2022.101201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Long-lasting restoration of memory function and hippocampal synaptic plasticity by focused ultrasound in Alzheimer's disease.

    Kong, Chanho / Ahn, Ji Woong / Kim, Sohyun / Park, Ji Young / Na, Young Cheol / Chang, Jin Woo / Chung, Seungsoo / Chang, Won Seok

    Brain stimulation

    2023  Volume 16, Issue 3, Page(s) 857–866

    Abstract: Background: Focused ultrasound (FUS) is a medical technology that non-invasively stimulates the brain and has been applied in thermal ablation, blood-brain barrier (BBB) opening, and neuromodulation. In recent years, numerous experiences and indications ...

    Abstract Background: Focused ultrasound (FUS) is a medical technology that non-invasively stimulates the brain and has been applied in thermal ablation, blood-brain barrier (BBB) opening, and neuromodulation. In recent years, numerous experiences and indications for the use of FUS in clinical and preclinical studies have rapidly expanded. Focused ultrasound-mediated BBB opening induces cognitive enhancement and neurogenesis; however, the underlying mechanisms have not been elucidated.
    Methods: Here, we investigate the effects of FUS-mediated BBB opening on hippocampal long-term potentiation (LTP) and cognitive function in a 5xFAD mouse model of Alzheimer's disease (AD). We applied FUS with microbubble to the hippocampus and LTP was measured 6 weeks after BBB opening using FUS. Field recordings were made with a concentric bipolar electrode positioned in the CA1 region using an extracellular glass pipette filled with artificial cerebrospinal fluid. Morris water maze and Y-maze was performed to test cognitive function.
    Results: Our results demonstrated that FUS-mediated BBB opening has a significant impact on increasing LTP at Schaffer collateral - CA1 synapses and rescues cognitive dysfunction and working memory. These effects persisted for up to 7 weeks post-treatment. Also, FUS-mediated BBB opening in the hippocampus increased PKA phosphorylation.
    Conclusion: Therefore, it could be a promising treatment for neurodegenerative diseases as it remarkably increases LTP, thereby improving working memory.
    MeSH term(s) Mice ; Animals ; Alzheimer Disease/therapy ; Brain ; Hippocampus ; Neuronal Plasticity ; Memory, Short-Term
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2023.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6740: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Cav3.2 T-Type Calcium Channel Mediates Acute Itch and Contributes to Chronic Itch and Inflammation in Experimental Atopic Dermatitis.

    Ahn, Ji-Woong / Kim, Song-Ee / Kim, Do-Young / Jeong, Inhye / Kim, Sohyun / Chung, Seungsoo / Lee, Sang Eun

    The Journal of investigative dermatology

    2023  Volume 144, Issue 3, Page(s) 612–620.e6

    Abstract: Voltage-gated calcium channels regulate neuronal excitability. The Cav3.2 isoform of the T-type voltage-activated calcium channel is expressed in sensory neurons and is implicated in pain transmission. However, its role in itch remains unclear. In this ... ...

    Abstract Voltage-gated calcium channels regulate neuronal excitability. The Cav3.2 isoform of the T-type voltage-activated calcium channel is expressed in sensory neurons and is implicated in pain transmission. However, its role in itch remains unclear. In this study, we demonstrated that Cav3.2 is expressed by mechanosensory and peptidergic subsets of mouse dorsal root ganglion neurons and colocalized with TRPV1 and receptors for type 2 cytokines. Cav3.2-positive neurons innervate human skin. A deficiency of Cav3.2 reduces histamine, IL-4/IL-13, and TSLP-induced itch in mice. Cav3.2 channels were upregulated in the dorsal root ganglia of an atopic dermatitis (AD)-like mouse model and mediated neuronal excitability. Genetic knockout of Cav3.2 or T-type calcium channel blocker mibefradil treatment reduced spontaneous and mechanically induced scratching behaviors and skin inflammation in an AD-like mouse model. Substance P and vasoactive intestinal polypeptide levels were increased in the trigeminal ganglia from AD-like mouse model, and genetic ablation or pharmacological inhibition of Cav3.2 reduced their gene expression. Cav3.2 knockout also attenuated the pathologic changes in ex vivo skin explants cocultured with trigeminal ganglia neurons from AD-induced mice. Our study identifies the role of Cav3.2 in both histaminergic and nonhistaminergic acute itch. Cav3.2 channel also contributes to AD-related chronic itch and neuroinflammation.
    MeSH term(s) Mice ; Humans ; Animals ; Dermatitis, Atopic/metabolism ; Calcium Channels, T-Type/genetics ; Calcium Channels, T-Type/metabolism ; Pruritus/metabolism ; Inflammation/metabolism ; Sensory Receptor Cells/metabolism ; Interleukin-13/metabolism ; Ganglia, Spinal/metabolism
    Chemical Substances Calcium Channels, T-Type ; Interleukin-13
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.07.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.124: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Inhibition of K

    Kang, Shin Wook / Ahn, Ji Woong / Ahn, Seung Cheol

    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

    2017  Volume 21, Issue 2, Page(s) 251–257

    Abstract: Inhibition of ... ...

    Abstract Inhibition of K
    Language English
    Publishing date 2017-02-21
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 1387595-4
    ISSN 2093-3827 ; 1226-4512
    ISSN (online) 2093-3827
    ISSN 1226-4512
    DOI 10.4196/kjpp.2017.21.2.251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: (-)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression.

    Ko, Sukjin / Jang, Won Seuk / Jeong, Ji-Hyun / Ahn, Ji Woong / Kim, Young-Hwan / Kim, Sohyun / Chae, Hyeon Kyeong / Chung, Seungsoo

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 910

    Abstract: Post-menopausal depression (PMD) is a common psychological disorder accompanied by a cognitive deficit, which is caused by a series of uncontrolled emotional disruptions by strong environmental stressors during menopause. To overcome PMD-induced ... ...

    Abstract Post-menopausal depression (PMD) is a common psychological disorder accompanied by a cognitive deficit, which is caused by a series of uncontrolled emotional disruptions by strong environmental stressors during menopause. To overcome PMD-induced cognitive deficit, Green tea has been suggested as a dietary supplement because of its ameliorating effect on cognitive dysfunction induced by normal aging or neurodegenerative syndromes; however, its clinical use to improve PMD-accompanied cognitive deficit is still limited due to the controversy for the active ingredients and ambiguous mechanism of its action. Here, we developed modified high-temperature-processed green tea extract (HTP-GTE), which showed lower neuronal toxicity than the conventional green tea extract (GTE). We also demonstrated that HTP-GTE administration prevented the development of learned helplessness (LH) in a rat post-menopausal model. Additionally, HTP-GTE improved LH-induced cognitive impairments simultaneously with rescued the long-term synaptic plasticity. This occurred via the restoration of silent synapse formation by increasing the hippocampal BDNF-tyrosine receptor kinase B pathway in the helpless ovariectomized (OVX) rats. Likewise, we also identified that (-)-gallocatechin gallate was the main contributor of the HTP-GTE effect. Our findings suggested that HTP-GTE has a potential as a preventive nutritional supplement to ameliorate cognitive dysfunctions associated with PMD.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Catechin/analogs & derivatives ; Catechin/metabolism ; Catechin/pharmacology ; Cognition Disorders/diet therapy ; Cognitive Dysfunction/diet therapy ; Depression/diet therapy ; Depression/metabolism ; Dietary Supplements ; Female ; Hippocampus/drug effects ; Hippocampus/metabolism ; Plant Extracts/pharmacology ; Postmenopause/psychology ; Rats ; Rats, Sprague-Dawley ; Synapses/drug effects ; Tea/metabolism
    Chemical Substances Antioxidants ; Plant Extracts ; Tea ; gallocatechin gallate (0C056HB16M) ; Catechin (8R1V1STN48)
    Language English
    Publishing date 2021-01-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-79287-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Characteristics of K(+) Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week.

    Ahn, Ji Woong / Kang, Shin Wook / Ahn, Seung Cheol

    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

    2015  Volume 19, Issue 4, Page(s) 383–388

    Abstract: K(+) outward currents in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), were investigated using a whole cell patch clamp technique. Littermate heterozygous (+/cir) mice of the ... ...

    Abstract K(+) outward currents in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), were investigated using a whole cell patch clamp technique. Littermate heterozygous (+/cir) mice of the same age (postnatal day (P) 0 -P6) were used as controls. Similar slow rising K(+) currents were observed in both genotypes, but their biophysical and pharmacological properties were quite different. The values of Vhalf for activation were significantly different in the heterozygous (+/cir) and homozygous (cir/cir) mice (-8.1±2.2 mV, heterozygous (+/cir) mice (n=7) and -17.2±4.2 mV, homozygous (cir/cir) mice (n=5)). The inactivation curve was expressed by a single first order Boltzmann equation in the homozygous (cir/cir) mice, while it was expressed by a sum of two first order Boltzmann equations in the heterozygous (+/cir) mice. The K(+) current of homozygous (cir/cir) mice was more sensitive to TEA in the 1 to 10 mM range, while the 4-AP sensitivities were not different between the two genotypes. Removal of external Ca(2+) did not affect the K(+) currents in either genotype, indicating that the higher sensitivity of K(+) current to TEA in the homozygous (cir/cir) mice was not due to an early expression of Ca(2+) activated K(+) channels. Our results suggest that the K(+) outward current of developing homozygous (cir/cir) mice OHCs is different in both biophysical and pharmacological aspects than that of heterozygous (+/cir) mice.
    Language English
    Publishing date 2015-06-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 1387595-4
    ISSN 2093-3827 ; 1226-4512
    ISSN (online) 2093-3827
    ISSN 1226-4512
    DOI 10.4196/kjpp.2015.19.4.383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response.

    Kim, Jinyoung / Kim, Seong Hun / Kang, Hyereen / Lee, Soyeon / Park, Shi-Young / Cho, Yoonil / Lim, Yu-Mi / Ahn, Ji Woong / Kim, Young-Hwan / Chung, Seungsoo / Choi, Cheol Soo / Jang, Yeon Jin / Park, Hye Soon / Heo, Yoonseok / Kim, Kook Hwan / Lee, Myung-Shik

    Nature metabolism

    2021  Volume 3, Issue 3, Page(s) 410–427

    Abstract: TFEB, a key regulator of lysosomal biogenesis and autophagy, is induced not only by nutritional deficiency but also by organelle stress. Here, we find that Tfeb and its downstream genes are upregulated together with lipofuscin accumulation in adipose ... ...

    Abstract TFEB, a key regulator of lysosomal biogenesis and autophagy, is induced not only by nutritional deficiency but also by organelle stress. Here, we find that Tfeb and its downstream genes are upregulated together with lipofuscin accumulation in adipose tissue macrophages (ATMs) of obese mice or humans, suggestive of obesity-associated lysosomal dysfunction/stress in ATMs. Macrophage-specific TFEB-overexpressing mice display complete abrogation of diet-induced obesity, adipose tissue inflammation and insulin resistance, which is independent of autophagy, but dependent on TFEB-induced GDF15 expression. Palmitic acid induces Gdf15 expression through lysosomal Ca
    MeSH term(s) Adipose Tissue/metabolism ; Animals ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Growth Differentiation Factor 15/metabolism ; Humans ; Insulin Resistance ; Lysosomes/metabolism ; Macrophages/metabolism ; Mice ; Mice, Transgenic ; Obesity/metabolism ; Obesity/prevention & control ; Stress, Physiological
    Chemical Substances Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; GDF15 protein, human ; Growth Differentiation Factor 15 ; TFEB protein, human
    Language English
    Publishing date 2021-03-22
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-021-00368-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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