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  1. Article ; Online: Group practice impacts on patients, physicians and healthcare systems: a scoping review.

    Zwiep, Terry / Ahn, San Hilalion / Brehaut, Jamie / Balaa, Fady / McIsaac, Daniel I / Rich, Susan / Wallace, Tom / Moloo, Husein

    BMJ open

    2021  Volume 11, Issue 1, Page(s) e041579

    Abstract: Objective: To identify the advantages and disadvantages that group practices have on patients, physicians and healthcare systems.: Study design: A scoping review was performed based on the methodology proposed by Arksey and O'Malley, and refined by ... ...

    Abstract Objective: To identify the advantages and disadvantages that group practices have on patients, physicians and healthcare systems.
    Study design: A scoping review was performed based on the methodology proposed by Arksey and O'Malley, and refined by Levac
    Study setting: MEDLINE, EMBASE and Cochrane databases were searched from database inception to October 2018 for papers which assessed outcomes relevant to the research question.
    Results: Our search strategy returned 2408 papers and 98 were included in the final analysis. Most papers were from the USA, were surveys and assessed physician outcomes. Advantages of group practices for patients included improved satisfaction and quality of care. Studies of physicians reported improved quality of life and income, while disadvantages included increased stress due to poor interpersonal relationships. Studies of healthcare systems reported improved efficiency and better utilisation of resources.
    Conclusions: Group practices have many benefits for patients and physicians. However, further work needs to be done assessing patient outcomes and establishing the elements that make a group practice successful.
    MeSH term(s) Delivery of Health Care ; Group Practice ; Humans ; Personal Satisfaction ; Physicians ; Quality of Life
    Language English
    Publishing date 2021-01-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-041579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development of a bio-magnetic measurement system and sensor configuration analysis for rats.

    Kim, Ji-Eun / Kim, In-Seon / Kim, Kiwoong / Lim, Sanghyun / Kwon, Hyukchan / Kang, Chan Seok / Ahn, San / Yu, Kwon Kyu / Lee, Yong-Ho

    The Review of scientific instruments

    2017  Volume 88, Issue 4, Page(s) 44704

    Abstract: Magnetoencephalography (MEG) based on superconducting quantum interference devices enables the measurement of very weak magnetic fields (10-1000 fT) generated from the human or animal brain. In this article, we introduce a small MEG system that we ... ...

    Abstract Magnetoencephalography (MEG) based on superconducting quantum interference devices enables the measurement of very weak magnetic fields (10-1000 fT) generated from the human or animal brain. In this article, we introduce a small MEG system that we developed specifically for use with rats. Our system has the following characteristics: (1) variable distance between the pick-up coil and outer Dewar bottom (∼5 mm), (2) small pick-up coil (4 mm) for high spatial resolution, (3) good field sensitivity (45∼ 80fT/cm/Hz), (4) the sensor interval satisfies the Nyquist spatial sampling theorem, and (5) small source localization error for the region to be investigated. To reduce source localization error, it is necessary to establish an optimal sensor layout. To this end, we simulated confidence volumes at each point on a grid on the surface of a virtual rat head. In this simulation, we used locally fitted spheres as model rat heads. This enabled us to consider more realistic volume currents. We constrained the model such that the dipoles could have only four possible orientations: the x- and y-axes from the original coordinates, and two tangentially layered dipoles (local x- and y-axes) in the locally fitted spheres. We considered the confidence volumes according to the sensor layout and dipole orientation and positions. We then conducted a preliminary test with a 4-channel MEG system prior to manufacturing the multi-channel system. Using the 4-channel MEG system, we measured rat magnetocardiograms. We obtained well defined P-, QRS-, and T-waves in rats with a maximum value of 15 pT/cm. Finally, we measured auditory evoked fields and steady state auditory evoked fields with maximum values 400 fT/cm and 250 fT/cm, respectively.
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/1.4979071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Streptococcus mutans extracellular DNA is upregulated during growth in biofilms, actively released via membrane vesicles, and influenced by components of the protein secretion machinery.

    Liao, Sumei / Klein, Marlise I / Heim, Kyle P / Fan, Yuwei / Bitoun, Jacob P / Ahn, San-Joon / Burne, Robert A / Koo, Hyun / Brady, L Jeannine / Wen, Zezhang T

    Journal of bacteriology

    2014  Volume 196, Issue 13, Page(s) 2355–2366

    Abstract: Streptococcus mutans, a major etiological agent of human dental caries, lives primarily on the tooth surface in biofilms. Limited information is available concerning the extracellular DNA (eDNA) as a scaffolding matrix in S. mutans biofilms. This study ... ...

    Abstract Streptococcus mutans, a major etiological agent of human dental caries, lives primarily on the tooth surface in biofilms. Limited information is available concerning the extracellular DNA (eDNA) as a scaffolding matrix in S. mutans biofilms. This study demonstrates that S. mutans produces eDNA by multiple avenues, including lysis-independent membrane vesicles. Unlike eDNAs from cell lysis that were abundant and mainly concentrated around broken cells or cell debris with floating open ends, eDNAs produced via the lysis-independent pathway appeared scattered but in a structured network under scanning electron microscopy. Compared to eDNA production of planktonic cultures, eDNA production in 5- and 24-h biofilms was increased by >3- and >1.6-fold, respectively. The addition of DNase I to growth medium significantly reduced biofilm formation. In an in vitro adherence assay, added chromosomal DNA alone had a limited effect on S. mutans adherence to saliva-coated hydroxylapatite beads, but in conjunction with glucans synthesized using purified glucosyltransferase B, the adherence was significantly enhanced. Deletion of sortase A, the transpeptidase that covalently couples multiple surface-associated proteins to the cell wall peptidoglycan, significantly reduced eDNA in both planktonic and biofilm cultures. Sortase A deficiency did not have a significant effect on membrane vesicle production; however, the protein profile of the mutant membrane vesicles was significantly altered, including reduction of adhesin P1 and glucan-binding proteins B and C. Relative to the wild type, deficiency of protein secretion and membrane protein insertion machinery components, including Ffh, YidC1, and YidC2, also caused significant reductions in eDNA.
    MeSH term(s) Biofilms/growth & development ; Cell Membrane/physiology ; DNA, Bacterial/genetics ; DNA, Bacterial/metabolism ; Gene Expression Regulation, Bacterial/physiology ; Protein Biosynthesis/physiology ; Streptococcus mutans/genetics ; Streptococcus mutans/metabolism ; Streptococcus mutans/physiology ; Streptococcus mutans/ultrastructure ; Up-Regulation
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2014-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.01493-14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Streptococcus mutans Extracellular DNA Is Upregulated during Growth in Biofilms, Actively Released via Membrane Vesicles, and Influenced by Components of the Protein Secretion Machinery

    Liao, Sumei / Klein, Marlise I / Heim, Kyle P / Fan, Yuwei / Bitoun, Jacob P / Ahn, San-Joon / Burne, Robert A / Koo, Hyun / Brady, L. Jeannine / Wen, Zezhang T

    Journal of bacteriology. 2014 July 1, v. 196, no. 13

    2014  

    Abstract: Streptococcus mutans, a major etiological agent of human dental caries, lives primarily on the tooth surface in biofilms. Limited information is available concerning the extracellular DNA (eDNA) as a scaffolding matrix in S. mutans biofilms. This study ... ...

    Abstract Streptococcus mutans, a major etiological agent of human dental caries, lives primarily on the tooth surface in biofilms. Limited information is available concerning the extracellular DNA (eDNA) as a scaffolding matrix in S. mutans biofilms. This study demonstrates that S. mutans produces eDNA by multiple avenues, including lysis-independent membrane vesicles. Unlike eDNAs from cell lysis that were abundant and mainly concentrated around broken cells or cell debris with floating open ends, eDNAs produced via the lysis-independent pathway appeared scattered but in a structured network under scanning electron microscopy. Compared to eDNA production of planktonic cultures, eDNA production in 5- and 24-h biofilms was increased by >3- and >1.6-fold, respectively. The addition of DNase I to growth medium significantly reduced biofilm formation. In an in vitro adherence assay, added chromosomal DNA alone had a limited effect on S. mutans adherence to saliva-coated hydroxylapatite beads, but in conjunction with glucans synthesized using purified glucosyltransferase B, the adherence was significantly enhanced. Deletion of sortase A, the transpeptidase that covalently couples multiple surface-associated proteins to the cell wall peptidoglycan, significantly reduced eDNA in both planktonic and biofilm cultures. Sortase A deficiency did not have a significant effect on membrane vesicle production; however, the protein profile of the mutant membrane vesicles was significantly altered, including reduction of adhesin P1 and glucan-binding proteins B and C. Relative to the wild type, deficiency of protein secretion and membrane protein insertion machinery components, including Ffh, YidC1, and YidC2, also caused significant reductions in eDNA.
    Keywords DNA ; Streptococcus mutans ; adhesins ; bacteriology ; biofilm ; culture media ; dental caries ; deoxyribonuclease I ; etiological agents ; gene expression regulation ; glucans ; humans ; mutants ; peptidoglycans ; protein secretion ; scanning electron microscopy ; sortase A ; structural proteins
    Language English
    Dates of publication 2014-0701
    Size p. 2355-2366.
    Publishing place American Society for Microbiology
    Document type Article
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.01493-14
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  5. Article ; Online: 2023 Canadian Surgery Forum: Sept. 20-23, 2023.

    Brière, Raphaëlle / Émond, Marce / Benhamed, Axel / Blanchard, Pierre-Gilles / Drolet, Sébastien / Habashi, Rogeh / Golbon, Bahar / Shellenberger, Jonas / Pasternak, Jesse / Merchant, Shaila / La, Julie / Sawhney, Monakshi / Brogly, Susan / Cadili, Lina / Horkoff, Michael / Ainslie, Scott / Demetrick, Jeffrey / Chai, Brian / Wiseman, Kevin /
    Hwang, Hamish / Alhumoud, Zainab / Salem, Amro / Lau, Rebecca / Aw, Katherine / Nessim, Carolyn / Gawad, Nada / Alibhai, Kameela / Towaij, Chelsea / Doan, Danielle / Raîche, Isabelle / Valji, Rahim / Turner, Simon / Balmes, Patricia Nicole / Hameed, S Morad / Tan, Jun Guang Kendric / Wijesuriya, Ruwan / Hew, Nicole Lee Chui / Lund, Matthew / Hawel, Jeffrey / Gregor, Jamie / Leslie, Ken / Lenet, Tori / McIsaac, Daniel / Hallet, Julie / Jerath, Angela / Lalu, Manoj / Nicholls, Stuart / Presseau, Justin / Tinmouth, Alan / Verret, Michael / Wherrett, Christopher / Fergusson, Dean / Martel, Guillaume / Sharma, Sahil / McKechnie, Tyler / Talwar, Gaurav / Patel, Janhavi / Heimann, Luke / Doumouras, Aristithes / Hong, Dennis / Eskicioglu, Cagla / Wang, Christine / Guo, Michael / Huang, Longlong / Sun, Shaun / Davis, Noelle / Wang, Julian / Skulsky, Samuel / Sikora, Lindsey / Son, Hyo Jin / Gee, Denise / Gomez, David / Jung, James / Selvam, Rajajee / Seguin, Nieve / Zhang, Lisa / Lacaille-Ranger, Ariane / Moloo, Husein / Follett, Alicia / Holly / Organ, Michael / Pace, David / Balvardi, Saba / Kaneva, Pepa / Semsar-Kazerooni, Koorosh / Mueller, Carmen / Vassiliou, Melina / Al Mahroos, Mohammed / Fiore, Julio F / Schwartzman, Kevin / Feldman, Liane / Karimuddin, Ahmer / Liu, Gui Ping / Crump, Trafford / Sutherland, Jason / Hickey, Kala / Bonisteel, Erin M / Umali, Jurgienne / Dogar, Ibrahim / Warden, Geoffrey / Boone, Darrell / Mathieson, Alexander / Hogan, Michael / Li, Yiran / Best, Gordon / Leong, Rachel / Wiseman, Sam / Alaoui, Ahmed Amine / Hajjar, Roy / Wassef, Evelyne / Metellus, Danny Sebastien / Dagbert, François / Loungnarath, Rasmy / Ratelle, Richard / Schwenter, Frank / Debroux, Éric / Wassef, Ramses / Gagnon-Konamna, Marianne / Pomp, Alfons / Richard, Carole S / Sebajang, Herawaty / Santos, Manuela M / Shi, Ge / Leung, Regina / Lim, Christina / Knowles, Sarah / Parmar, Simran / Debru, Estifanos / Mohamed, Fardowsa / Anakin, Megan / Lee, Yung / Samarasinghe, Yasith / Khamar, Jigish / Petrisor, Bradley / Yang, Ilun / Mughal, Hanaa N / Bhugio, Mumtaz / Gok, Muhammed A / Khan, Usman A / Fernandes, Alisha R / Spence, Richard / Porter, Geoffrey / Hoogerboord, C Marius / Neumann, Katerina / Pillar, Michal / Manhas, Neraj / Melck, Adrienne / Kazi, Tania / Jessani, Ghazal / Tessier, Léa / Archer, Vicki / Park, Lily / Cohen, Dan / Parpia, Sameer / Bhandari, Mohit / Dionne, Joanna / Bolin, Sara / Afford, Rebecca / Armstrong, Madeleine / Grant, Aaron / Van Koughnett, Julie Ann / Clement, Elizabeth / Lange, Claire / Roshan, Aishwi / Scott, Tracy / Nadeau, Kara / Macmillan, Jennifer / Wilson, Jaime / Deschenes, Madeleine / Nurullah, Aruba / Cahill, Caitlin / Chen, Victoria H / Patterson, Keiko M / Wiseman, Sam M / Wen, Betty / Bhudial, Joshua / Barton, Anise / Lie, Jessica / Park, Chan Mi / Yang, Laiji / Gouskova, Natalia / Kim, Dae Hyun / Morris-Janzen, Dunavan / McLellan, Alastair / Archer, Victoria / Cloutier, Zacharie / Berg, Annie / Wiercioch, Wojtek / Labonté, Joëlle / Bisson, Pascale / Bégin, André / Cheng-Oviedo, Sonia Gabriela / Collin, Yves / Hossain, Intekhab / Ellsmere, James / El-Kefraoui, Charbel / Do, Uyen / Miller, Andrew / Kouyoumdjian, Araz / Cui, David / Khorasani, Elahe / Landry, Tara / Amar-Zifkin, Alexandre / Lee, Lawrence / Fiore, Julio / Au, Tran Michelle / Oppenheimer, Mark / Logsetty, Sarvesh / AlShammari, Raghad / AlAbri, Mohammad / Brown, Carl / Raval, Manoj J / Phang, Paul Terry / Bird, Samantha / Baig, Zarrukh / Abu-Omar, Nawaf / Gill, Dilip / Suresh, Soumiya / Ginther, Nathan / Karpinski, Marta / Ghuman, Amandeep / Malik, Peter R A / Zabolotniuk, Taryn / Mashal, Sarah / Boulanger, Nathalie / Watt, Larry / Razek, Tarek / Fata, Paola / Grushka, Jeremy / Wong, Evan G / Landry, Maxim / Mackey, Sarah / Fairbridge, Nicholas / Greene, Alison / Borgoankar, Mark / Kim, Cullen / DeCarvalho, Diana / Wigen, Robin / Walser, Emily / Davidson, Jacob / Dorward, Michael / Muszynski, Leanne / Dann, Celia / Seemann, Natashia / Lam, Jennifer / Harding, Kaitlyn / Lowik, A J / Guinard, Caroline / Ma, Odelle / Mocanu, Valentin / Lin, Andrea / Karmali, Shahzeer / Bigam, David / Greaves, Grant / Parker, Brent / Nguyen, Vu / Ahmed, Azim / Yee, Belinda / Perren, Joël / Norman, Mathew / Grey, Morgan / Perini, Rafael / Jowhari, Fahd / Bak, Adrian / Drung, Jeremy / Allen, Laura / Wiseman, Daniele / Moffat, Bradley / Lee, Jeremy K H / McGuire, Catherine / Tudorache, Mihaela / Park, Lily J / Borges, Flavia K / Nenshi, Rahima / Jacka, Michael / Heels-Ansdell, Diane / Simunovic, Marko / Bogach, Jessica / Serrano, Pablo E / Thabane, Lehana / Devereaux, P J / Farooq, Sauleha / Lester, Erica / Kung, Janice / Bradley, Nori / Ahn, San / Prince, Nicole / Cheng-Boivin, Olivia / Wang, Harry / Quartermain, Liam / Tan, Sherry / Shamess, Jennifer / Simard, Mathilde / Vigil, Humberto / Hanna, Mary / Azam, Riordan / Ko, Gary / Zhu, Mayanne / Raveendran, Yanuga / Lam, Christine / Tang, Janet / Bajwa, Amrit / Englesakis, Marina / Reel, Emma / Cleland, Jordan / Snell, Laura / Lorello, Gianni / Cil, Tulin / Ahn, Hilalion San / Dube, Catherine / Smith, David / Leclerc, Alexie / Rostom, Alaa / Calo, Natalia / Thavorn, Kednapa / Laplante, Simon / Liu, Louis / Khan, Nadia / Okrainec, Allan / Bruyninx, Gladys / Georgescu, Ilinca / Khokhotva, Vladislav / Yang, Shuling / Spoyalo, Karina / Rebello, Thais Ayres / Chhipi-Shrestha, Gyan / Mayson, Kelly / Sadiq, Rehan / Hewage, Kasun / MacNeill, Andrea / Muncner, Susan / Li, Mo Yu / Mihajlovic, Igor / Dykstra, Mark / Snelgrove, Ryan / Wang, Haili / Schweitzer, Christina / Garcha, Ivneet / Jogiat, Uzair / Baracos, Vickie / Turner, Simon R / Eurich, Dean / Filafilo, Heather / Rouhi, Armin / Bédard, Alexandre / Bédard, Eric L R / Patel, Yogita S / Alaichi, Jacob A / Agzarian, John / Hanna, Wael C / Provost, Esther / Shayegan, Bobby / Adili, Anthony / Mistry, Nikkita / Gatti, Anthony A / Farrokhyar, Forough / Xie, Feng / Sullivan, Kerrie A / Liberman, Moishe / Gonzalez, Anne V / Nayak, Rahul / Yasufuku, Kazuhiro / Cross, Sam / Haché, Pier-Luc / Galvaing, Geraud / Simard, Serge / Grégoire, Jocelyn / Bussières, Jean / Lacasse, Yves / Sassi, Sami / Champagne, Catherine / Laliberté, Anne-Sophie / Jeong, Jin Yong / Wilson, Hillary / Blakely, Pam / Dang, Jerry / Sun, Warren / Wong, Clarence / Hakim, Suhail Yaqoob / Azizi, Samim / El-Menyar, Ayman / Rizoli, Sandro / Al-Thani, Hassan / French, Daniel / Li, Chao / Gossen, Shiloh / Bailey, Jon / Tibbo, Phil / Crocker, Candice / Bondzi-Simpson, Adom / Ribeiro, Tiago / Kidane, Biniam / Ko, Michael / Coburn, Natalie / Kulkarni, Girish / Ramzee, Ahmed Faidh / Afifi, Ibrahim / Alani, Mushrek / Chughtai, Talat / Huo, Bright / Manos, Daria / Xu, Zhaolin / Kontouli, Katerina-Maria / Chun, Samuel / Fris, John / Wallace, Allison M R / French, Daniel G / Giffin, Catherine / Dayan, Gabriel / Farivar, Alexander / Weessies, Cara / Robinson, Madeline / Bednarek, Leeann / Buduhan, Gordon / Liu, Richard / Tan, Lawrence / Srinathan, Sadeesh K / Nasralla, Awrad / Safieddine, Najib / Gazala, Sayf / Simone, Carmine / Ahmadi, Negar / Hilzenrat, Roy / Blitz, Maurice / Deen, Shaun / Humer, Michael / Jugnauth, Anand / Kerr, Laura / Sun, Simon / Browne, Ikennah / Patel, Yogita / Hanna, Wael / Loshusan, Brandon / Shamsil, Arefin / Naish, Michael D / Qiabi, Mehdi / Patel, Rajni / Malthaner, Richard / Pooja, Patel / Roberto, Ribeiro / Greg, Hirsch / Daniel, French / Huynh, Caroline / Sharma, Sohat / Vieira, Arthur / Jain, Fagun / Lee, Yejun / Mousa-Doust, Dorsa / Costa, Jonice / Mezei, Michelle / Chapman, Kristine / Briemberg, Hannah / Jack, Kristin / Grant, Kyle / Choi, James / Yee, John / McGuire, Anna L / Abdul, Sami Aftab / Khazoom, Francois / Gilbert, Sebastien / Sundaresan, Sudhir / Jones, Daniel / Seely, Andrew J E / Villeneuve, Patrick J / Maziak, Donna E / Pigeon, Claudie-Anne / Frigault, Jonathan / Roy, Ève-Marie / Bujold-Pitre, Kristopher / Courval, Valérie / Tessier, Lea / Gangam, Nirupa / Lee, Jay / Patel, Ashaka / Ichhpuniani, Simarpreet / Elder, Geoffrey / Chen, Andrew / Logie, Kathleen / Benko, Randy / Castelo, Matthew / Paszat, Lawrence / Hansen, Bettina / Scheer, Adena / Faught, Neil / Nguyen, Lena / Baxter, Nancy / Wu, Kathy / Passos, Edward / Sachdeva, Anjali / Fei, Linda Y N / Caycedo, Antonio / Patel, Sunil / Popa, Teodora / Boudreau, Lee / Grin, Andrea / Wang, Tao / Phang, Terry / Raval, Manoj / Candy, Sydney / Nanda, Kareena / Li, Christine / Kroeker, Karen / Roy, Haven / Helewa, Ramzi M / Johnson, Garrett / Singh, Harminder / Hyun, Eric / Moffatt, Dana / Vergis, Ashley / Balmes, Patricia / Liu, Jerry / Webber, Sandra / Shariff, Farhana / Hochman, Dave / Park, Jason / Robitaille, Stephan / Wang, Anna / Maalouf, Michael / Alali, Naser / Elhaj, Hiba / Liberman, Sender / Charlebois, Patrick / Stein, Barry / Hu, Richard / Ahn, San / Williams, Lara / Musselman, Reilly / Lemke, Maddy / Samarasinghe, Nadeesha / Vogt, Kelly / Brackstone, Muriel / Zwiep, Terry / Alam, Armaghan / Ghuman, Anu / James, Nicholas / Laczko, Dora / Lee, Stephanie / Sritharan, Praveen / Hershorn, Olivia / Phang, P Terry / Chen, Alex / Boutros, Marylise / Caminsky, Natasha / Dumitra, Teodora / Faris-Sabboobeh, Sarah / Demian, Marie / Rigas, Georgia / Monton, Olivia / Smith, Allister / Moon, Jeongyoon / Garfinkle, Richard / Vasilevsky, Carol-Ann / Rajabiyazdi, Fateme / Courage, Emily / LeBlanc, Danielle / Benesch, Matthew / Hartwig, Katia / Armstrong, Casey / Engelbrecht, Reniel / Fagan, Mitchell / Borgaonkar, Mark / Shanahan, Jessica / Salama, Ebram / Arsenault, Mylène / Leon, Nathalie / Loiselle, Carmen / Rajabiyazdi, Fatemeh / Brennan, Kelly / Rai, Mandip / Farooq, Ameer / McClintock, Chad / Kong, Weidong / Boukhili, Neyla / Paradis, Tiffany / Liberman, A Sender / Feldman, Liane S / Abner, Deborah / Alam, Tarik / Beyer, Elaine / Evans, Michele / Hill, Mary / Johnston, Debra / Lohnes, Karla / Menard, Svea / Pitcher, Nicole / Sair, Kelly / Smith, Bev / Yarjau, Bonita / LeBlanc, Kimberly / Karimuddin, Ahmer A / Brown, Carl J / MacDonell, Karen / Harvey, Alexandra / Mckechnie, Tyler / Matta, Mirna / Baker, Laura / Hopkins, Jessica / Rochon, Ryan / Buie, Donald / MacLean, Anthony / Macdonald, Hugh / Wiseman, Vanessa / Booth, Chris / Hann, Tim / Ricci, Alessandro / Kakkar, Rohan / Gonzalez, Emmanuel / Fragoso, Gabriela / Oliero, Manon / Rendos, Hervé Vennin / Djediai, Souad / Cuisiniere, Thibault / Laplante, Patrick / Gerkins, Claire / Ajayi, Ayodeji Samuel / Diop, Khoudia / Taleb, Nassima / Thérien, Sophie / Schampaert, Frédéricke / Alratrout, Hefzi / Cailhier, Jean-François / Routy, Bertrand / Annabi, Borhane / Brereton, Nicholas J B / Richard, Carole / Gimon, Tamara / MacRae, Helen / de Buck van Overstraeten, Anthony / Brar, Mantaj / Chadi, Sami / Kennedy, Erin / Rashanov, Pavel / Alsayari, Rehab / Calvé, Annie / Cuisinière, Thibault / Debroux, Eric / Schmocker, Selina / Stotland, Peter / Jhaveri, Kartik / Kirsch, Richard / Alnajem, Hafssah / Alibrahim, Huseen / Giundi, Christian / Munir, Haroon / Safar, Ali / Sabboobeh, Sarah / Holland, Jessica / Abtahi, Sean / Chhor, Allison / Caminsky, Natasha Grace / Moon, Jenny Jeongyoon / Marinescu, Daniel / Pang, Allison / Al-Abri, Mohammed / Gee, Elliott / Morena, Nina / Ben-Zvi, Libby / Hayman, Victoria / Hou, Mary / Nguyen, Diana / Rentschler, Carrie A / Meguerditchian, Ari N / Mir, Zuhaib / Fei, Linda / McKeown, Sandra / Dinchong, Rachelle / Cofie, Nicholas / Dalgarno, Nancy / Cheifetz, Rona / Jaffer, Alisha / Cullinane, Carolyn / Feeney, Gerard / Jalali, Amirhossein / Merrigan, Anne / Baban, Chwanrow / Buckley, Juliette / Tormey, Shona / Wu, Rongrong / Takabe, Kazuaki / O'Brien, Shalana / Kazazian, Karineh / Abdalaty, Ali Hosni / Brezden, Christine / Burkes, Ron / Chen, Eric / Govindarajan, Anand / Jang, Raymond / Lukovic, Jelena / Mesci, Aruz / Quereshy, Fayez / Swallow, Carol / Marini, Wanda / Zheng, Weiyue / Murakami, Kiichi / Ohashi, Pamela / Reedijk, Michael / Ivankovic, Victoria / Han, Lewis / Gresham, Louise / Mallick, Ranjeeta / Auer, Rebecca / Fontebasso, Adam / Lee, Alex / Bernard-Bedard, Ericka / Wong, Boaz / Li, Heidi / Grose, Elysia / Brandts-Longtin, Olivier / Aw, Katie / Abed, Ahmad / Stevenson, James / Sheikh, Rahat / Chen, Richard / Johnson-Obaseki, Stephanie / Hennessey, Rachel Liu / Meneghetti, Adam T / Bildersheim, Michael / Bouchard-Fortier, Antoine / Nelson, Gregg / Mack, Lloyd / Ghasemi, Farhad / Naeini, Mahtab Malekian / Parsyan, Armen / Kaur, Yuvreet / Covelli, Andrea / Elimova, Elena / Panov, Elan / Brierley, James / Burnett, Bev / Eom, Ashley / Kirkwood, David / Hodgson, Nicole / Whelan, Timothy / Levine, Mark / Parvez, Elena / Ng, Deanna / Lee, Kiera / Lu, Yi Qing / Kim, Dae Kyum / Magalhaes, Marco / Grigor, Emma / Arnaout, Angel / Zhang, Jing / Yee, Elliott K / Look Hong, Nicole J / Wright, Frances C / Gandhi, Sonal / Jerzak, Katarzyna J / Eisen, Andrea / Roberts, Amanda / Ben Lustig, Daniel / Quan, May Lynn / Phan, Tien / Cao, 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    Canadian journal of surgery. Journal canadien de chirurgie

    2023  Volume 66, Issue 6 Suppl 1, Page(s) S54–S136

    Language English
    Publishing date 2023-12-13
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 410651-9
    ISSN 1488-2310 ; 0008-428X
    ISSN (online) 1488-2310
    ISSN 0008-428X
    DOI 10.1503/cjs.014223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Streptococcus mutans Extracellular DNA Is Upregulated during Growth in Biofilms, Actively Released via Membrane Vesicles, and Influenced by Components of the Protein Secretion Machinery

    Liao, Sumei / Klein, Marlise I. / Heim, Kyle P. / Fan, Yuwei / Bitoun, Jacob P. / Ahn, San-Joon / Burne, Robert A. / Koo, Hyun / Brady, L. Jeannine / Wen, Zezhang T.

    Journal of bacteriology

    Volume v. 196,, Issue no. 1

    Abstract: Streptococcus mutans, a major etiological agent of human dental caries, lives primarily on the tooth surface in biofilms. Limited information is available concerning the extracellular DNA (eDNA) as a scaffolding matrix in S. mutans biofilms. This study ... ...

    Abstract Streptococcus mutans, a major etiological agent of human dental caries, lives primarily on the tooth surface in biofilms. Limited information is available concerning the extracellular DNA (eDNA) as a scaffolding matrix in S. mutans biofilms. This study demonstrates that S. mutans produces eDNA by multiple avenues, including lysis-independent membrane vesicles. Unlike eDNAs from cell lysis that were abundant and mainly concentrated around broken cells or cell debris with floating open ends, eDNAs produced via the lysis-independent pathway appeared scattered but in a structured network under scanning electron microscopy. Compared to eDNA production of planktonic cultures, eDNA production in 5- and 24-h biofilms was increased by >3- and >1.6-fold, respectively. The addition of DNase I to growth medium significantly reduced biofilm formation. In an in vitro adherence assay, added chromosomal DNA alone had a limited effect on S. mutans adherence to saliva-coated hydroxylapatite beads, but in conjunction with glucans synthesized using purified glucosyltransferase B, the adherence was significantly enhanced. Deletion of sortase A, the transpeptidase that covalently couples multiple surface-associated proteins to the cell wall peptidoglycan, significantly reduced eDNA in both planktonic and biofilm cultures. Sortase A deficiency did not have a significant effect on membrane vesicle production; however, the protein profile of the mutant membrane vesicles was significantly altered, including reduction of adhesin P1 and glucan-binding proteins B and C. Relative to the wild type, deficiency of protein secretion and membrane protein insertion machinery components, including Ffh, YidC1, and YidC2, also caused significant reductions in eDNA.
    Keywords protein secretion ; peptidoglycans ; adhesins ; sortase A ; humans ; gene expression regulation ; mutants ; etiological agents ; biofilm ; culture media ; structural proteins ; deoxyribonuclease I ; DNA ; dental caries ; Streptococcus mutans ; scanning electron microscopy ; bacteriology ; glucans
    Language English
    Document type Article
    ISSN 0021-9193
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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