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  1. Article ; Online: Role of diffusion weighted imaging in diagnosis of cholesteatoma

    Aida A. Abdelmaksoud / Saeda Abd Elwahab* / Usama Tayee

    SVU - International Journal of Medical Sciences, Vol 4, Iss 2, Pp 90-

    A single centre study

    2021  Volume 98

    Abstract: Back ground: Diffusion weighted imaging was introduced to improve the detection of middle ear cholesteatomas. By computed tomography, difficulty was found as cholesteatoma shows middle ear opacity similar to chronic otitis media in cases with no bone ... ...

    Abstract Back ground: Diffusion weighted imaging was introduced to improve the detection of middle ear cholesteatomas. By computed tomography, difficulty was found as cholesteatoma shows middle ear opacity similar to chronic otitis media in cases with no bone erosion, Objectives: Purpose of this study to clarify the role of diffusion-weighted imaging in the diagnosis of cholesteatoma and differentiating it from chronic otitis media. Methods: Cross sectional study of 20 patients, All patient treated medically, followed, surgery was done in those not responding to medical treatment after one month. T2WI and DWI and ADC map were done, results assessed by SPSS system version 20 and Chi square test. Sensitivity, specificity, positive and negative predictive vales assessed. Results: 20 patients (9 males and 11 females), ages 15-35 and mean age = ± 25 year, 10 of them showed middle ear hyperintense signal intensity lesion in T2 weighted image, restricted diffusion, and low apparent diffusion coefficient values, mean value was about = ± 0.75 ± 0.26 x10-3 mm2/s,11 patients were confirmed cholesteatoma. 10 patients showed hyperintense signal intensity lesion in T2WI, facilitated diffusion and high apparent diffusion coefficient values, mean value = ± 1.75 ± 0.14 x10-3 mm2/s, 9 confirmed otitis media by complete resolution after antibiotic treatment and follow up. Sensitivity of diffusion-weighted imagining 90.0%, specificity 88.9%, positive and negative predictive value 90.9% and 88.9%. Conclusion: Diffusion-weighted imagining has a high sensitivity and diagnostic accuracy in differentiation of cholesteatoma from otitis media in overlapping cases.
    Keywords diffusion weighted imaging ; apparent diffusion coefficient value ; cholesteatoma ; chronic otitis media ; Medicine ; R
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher South Valley University, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Effect of Submucosal Injection of Sodium 2- Mercaptoethanesulfonate in Surgical Treatment of Deviated Nasal Septum

    Ahmad Gaber Abdelraheem / Manar Mahran Sadek* / Nehad Hassan Abdelrahman / Aida A. Abdelmaksoud

    SVU - International Journal of Medical Sciences, Vol 5, Pp 105-

    2022  Volume 114

    Abstract: Background: Mucoperichondrial flap elevation is the first step in septoplasty operation. MESNA was used in flap elevation to decrease the amount of bleeding, get better surgical field, decrease the operation time and lessen mucosal damage. Objectives: To ...

    Abstract Background: Mucoperichondrial flap elevation is the first step in septoplasty operation. MESNA was used in flap elevation to decrease the amount of bleeding, get better surgical field, decrease the operation time and lessen mucosal damage. Objectives: To evaluate the effect of submucosal injection of sodium 2- mercaptoethanesulfonate (MESNA) on the operation time, intra-operative blood loss, integrity of the flap in septoplasty and post operative pain. Patients and methods: It is a case control study that was conducted on 60 patients their ages ranged from 18 years to 43 years, all were underwent septoplasty operation by the same surgeon at Otorhinolaryngology Department, Qena University hospitals, Egypt. Results: Results revealed that the mean time of flap elevation was 6.7±1.8 SD minutes in group A, but was 10.9 ± 2.2 SD minutes in group B which was highly statistical significant with p-value < 0.001.As regard the mean of Intra-operative blood loss it was82 ±15.9 SD ml. in group A, but was 109.7 ± 21.8 SD ml. in group B which was highly statistical significant with p-value < 0.001. Conclusion: Submucosal injection of sodium 2- mercaptoethanesulfonate (MESNA) being more advantageous method that make mucoperichondrial flap elevation is convenient and effective and preserving mucosal integrity in surgical treatment of deviated nasal septum .
    Keywords mucoperichondrial flap ; sodium2-mercaptoethanesulfonate ; septoplasty ; deviated nasal septum ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher South Valley University, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Relation between serum levels of Vitamin D and Immunoglobulin E in Allergic Rhinitis in Upper Egypt

    Aida A. Abdelmaksoud / Shamardan ES Bazeed / Mohamed F Alemam / Zaky Aref

    SVU - International Journal of Medical Sciences, Vol 4, Iss 2, Pp 69-

    2021  Volume 75

    Abstract: Objective: The object of this study is to evaluate the relation between 25- hydroxy cholecalciferol (vitamin D3) deficiency and allergic rhinitis by detecting level of 25-hydroxy cholecalciferol and Immunoglobulin E serum levels. Methods: This is a case- ... ...

    Abstract Objective: The object of this study is to evaluate the relation between 25- hydroxy cholecalciferol (vitamin D3) deficiency and allergic rhinitis by detecting level of 25-hydroxy cholecalciferol and Immunoglobulin E serum levels. Methods: This is a case-control study in which we compare two groups; group A included 69 patients diagnosed as allergic rhinitis (AR) and group B included 60 healthy individuals. Serum levels of cholecalciferol and serum levels of immunoglobulin (IgE) were assessed in all participants of both groups of this study. Results: Serum level of 25- hydroxy cholecalciferol in group A (AR patients) was statistically significantly lower (mean ± SD: 14.2±8.04 ng/ml) than serum level of 25-hydroxy cholecalciferol in group B (21.1±8.2ng/ml). Also serum level of IGE in group A was markedly elevated in comparison to group B (494.4±61.7u/l) vs. (189.9±52.9u/l) with highly statistically significant difference (p-value < 0.001). Conclusion: There is statistically significant relation between 25-hydroxy cholecalciferol deficiency and allergic rhinitis; further studies must be done to assess the effect of Vitamin D3 therapy in allergic rhinitis.
    Keywords allergic rhinitis ; ige ; 25 hydroxy cholecalciferol ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher South Valley University, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Endoscopicaly assisted microdebrider adenoidectomy versus conventional curettage adenoidectomy

    Aida A. Abdelmaksoud* / Alshimaa A. Gahlan / Zaki Aref / Usama K. Tayee

    SVU - International Journal of Medical Sciences, Vol 4, Iss 2, Pp 212-

    2021  Volume 218

    Abstract: Abstract Background: Adenoidectomy by conventional method is an old procedure. Several new techniques discovered in this field as an electronic molecular resonance, suction diathermy, microdebrider, endoscopy, and laser. Objectives: to assess advantages ... ...

    Abstract Abstract Background: Adenoidectomy by conventional method is an old procedure. Several new techniques discovered in this field as an electronic molecular resonance, suction diathermy, microdebrider, endoscopy, and laser. Objectives: to assess advantages of endoscopic assessed microdebrider adenoidectomy over the conventional method intra and post operative. Patients and methods: 218 patients were scheduled for adenoidectomy were divided into two groups) underwent conventional curettage, group B (106 patients) underwent endoscopic assessed microdebrider. Follow up for 2 weeks ended by endoscopic evaluation. Results: This study included 218 patients (110 males and 108 females) aged 2 years till 14 years, divided randomly into two groups group A 112 patients group B 106 patients. This study reported statistically longer time of operation in group B than group A (13.7 for group B ± 3.5 versus 3.5 ± 1.3). Blood loss was statistically more in group A ((26.7 ± 7.5 for group A versus 17. 9 ± 5.2). Adenoid tissues remnants in group A were statistically higher than group B (27.4 % ± 11.6 for group A versus 1.7% ± .86). Regarding pain it was significantly lower in group B in the six day (4.2 ± 1.2 for group A versus 2.3 ± .5). Conclusion: endoscopic assessed adenoidectomy is significantly better than conventional adenoidectomy regarding blood loss, post operative remnants and post operative pain.
    Keywords keywords conventional ; endoscopic ; adenoidectomy ; microdebrider ; Medicine ; R
    Subject code 796
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher South Valley University, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Possible relation between H. pylori and bilateral nasal polypi

    Zaki F. Aref / Shahenda Mostafa abdel Aziz* / Sabah Ahmed Mohamed Fadel / Ahmed Gaber Abdel Raheem / Aida A. Abdelmaksoud

    SVU - International Journal of Medical Sciences, Vol 5, Iss 2, Pp 348-

    2022  Volume 354

    Abstract: Background: H.pylori is a Gram-negative bacterium known to be associated with peptic ulcer disease, gastric cancer, gastric lymphoma. Recently it was detected in mucosa of patients with CRS, but relation with bilateral nasal polyposis has not been ... ...

    Abstract Background: H.pylori is a Gram-negative bacterium known to be associated with peptic ulcer disease, gastric cancer, gastric lymphoma. Recently it was detected in mucosa of patients with CRS, but relation with bilateral nasal polyposis has not been demonstrated yet. Objectives: H. pyloriis a pathogen that lives in the gastrointestinal tract (GIT) and has extragastric manifestations. Nasal polypi may be one of these manifestations. This study aims to detect the relation between H.pylori and bilateral nasal polypi. Patients and methods: This study includes 80 cases of nasal polypi, 40 of them were de novo bilateral nasal polypi and 40 were recurrent nasal polypi, biopsies of nasal polypi were taken under sterile conditions and stained with Giemsa stain and Hematoxylin and eosin(H&E) stain. Stool analysis was done to detect presence of H.pylori using rapid urease test. Results: Both groups are age and sex matched. Nasal polyp biopsies showed positive results in 10 % of denovo group and 15 % of recurrent group with p value 0.449 which is not statistically significant. Stool antigen test showed positive results in 52.5 % of denovo group and 60 % of recurrent group with p value 0.449 which is not statistically significant. Conclusion: There is no statistically significant relation between H.pylori and the pathogenesis of bilateral nasal polypi, further studies with large number of patients is recommended.
    Keywords bilateral nasal polypi ; h. pylori ; giemsa stain ; modified mcmullen’s ; stool antigen test ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher South Valley University, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Therapeutic efficacy of macrolides in management of patients with mild COVID-19

    Alaa Rashad / Asmaa Nafady / Mohammed H. Hassan / Haggagy Mansour / Usama Taya / Shamardan Ezzeldin S. Bazeed / Zaki F. Aref / Mennatallah Ali Abdelrhman Sayed / Hanaa Nafady-Hego / Aida A. Abdelmaksoud

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 7

    Abstract: Abstract Evidence on the efficacy of adding macrolides (azithromycin or clarithromycin) to the treatment regimen for COVID-19 is limited. We testify whether adding azithromycin or clarithromycin to a standard of care regimen was superior to standard of ... ...

    Abstract Abstract Evidence on the efficacy of adding macrolides (azithromycin or clarithromycin) to the treatment regimen for COVID-19 is limited. We testify whether adding azithromycin or clarithromycin to a standard of care regimen was superior to standard of supportive care alone in patients with mild COVID-19.This randomized trial included three groups of patients with COVID-19. The azithromycin group included, 107 patients who received azithromycin 500 mg/24 h for 7 days, the clarithromycin group included 99 patients who received clarithromycin 500 /12 h for 7 days, and the control group included 99 patients who received standard care only. All three groups received only symptomatic treatment for control of fever and cough .Clinical and biochemical evaluations of the study participants including assessment of the symptoms duration, real-time reverse transcription-polymerase chain reaction (rRT-PCR), C-reactive protein (CRP), serum ferritin, D-dimer, complete blood count (CBC), in addition to non-contrast chest computed tomography (CT), were performed. The overall results revealed significant early improvement of symptoms (fever, dyspnea and cough) in patients treated with either azithromycin or clarithromycin compared to control group, also there was significant early conversion of SARS-CoV-2 PCR to negative in patients treated with either azithromycin or clarithromycin compared to control group (p < 0.05 for all).There was no significant difference in time to improvement of fever, cough, dyspnea, anosmia, gastrointestinal tract "GIT" symptoms and time to PCR negative conversion between patients treated with azithromycin compared to patients treated with clarithromycin (p > 0.05 for all). Follow up chest CT done after 2 weeks of start of treatment showed significant improvement in patients treated with either azithromycin or clarithromycin compared to control group (p < 0.05 for all).Adding Clarithromycin or azithromycin to the therapeutic protocols for COVID-19 could be beneficial for early control of ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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