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  1. Article ; Online: Prevalence of prediabetes and undiagnosed diabetes in a large urban middle-aged population: the CARVAR 92 cohort.

    Hauguel-Moreau, Marie / Hergault, Hélène / Cazabat, Laure / Pépin, Marion / Beauchet, Alain / Aïdan, Vincent / Ouadahi, Mounir / Josseran, Loïc / Hage, Mirella / Rodon, Christophe / Dubourg, Olivier / Massy, Ziad / Mansencal, Nicolas

    Cardiovascular diabetology

    2023  Volume 22, Issue 1, Page(s) 31

    Abstract: Background: The aim of this study was to assess the prevalence of prediabetes and unknown diabetes and its long-term change in a large middle-aged urban population.: Methods: We conducted a screening campaign between 2007 and 2018 for cardiovascular ... ...

    Abstract Background: The aim of this study was to assess the prevalence of prediabetes and unknown diabetes and its long-term change in a large middle-aged urban population.
    Methods: We conducted a screening campaign between 2007 and 2018 for cardiovascular risk factors in the western suburbs of Paris including subjects aged 40-70 (CARVAR 92). Among subjects who reported no previous diabetes, prediabetes and undiagnosed diabetes were defined as follows: fasting plasma glucose (FPG) ≥ 6.1 mmol/l (110 mg/dl) and < 7 mmol/l (126 mg/dl) for prediabetes according to WHO criteria (FPG between 5.6 and 6.9 mmol/l according to ADA criteria) and FPG ≥ 7.0 mmol/l for undiagnosed diabetes.
    Results: Of the 32,721 subjects in the CARVAR 92 cohort, 32,675 were included in this analysis. The median age of the patients was 56 years [30, 94], 45.4% were male, 5.9% had known diabetes, 36.4% were overweight and 18.7% obese. Among patients without previously known diabetes (n = 30,759), 8.1% had prediabetes according to WHO criteria (27.2% according to ADA criteria) and 2.3% had diabetes. Subjects with prediabetes and unknown diabetes were more likely to be male, older, and overweight or obese than non-diabetic subjects. From 2007 to 2018, the prevalence of prediabetes, unknown diabetes, and known diabetes decreased, except for prediabetes which remained stable for people aged 55-64.
    Conclusion: The prevalence of prediabetes and unknown diabetes remains high but decreased during a 12-year period. About one-quarter of diabetes cases remain undiagnosed. Our results highlight that there is still a room for screening and cardiovascular prevention campaigns.
    Trial registration: IRB00012437.
    MeSH term(s) Middle Aged ; Humans ; Male ; Female ; Prediabetic State/diagnosis ; Prediabetic State/epidemiology ; Overweight ; Prevalence ; Urban Population ; Blood Glucose ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Obesity ; Fasting ; Risk Factors
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2093769-6
    ISSN 1475-2840 ; 1475-2840
    ISSN (online) 1475-2840
    ISSN 1475-2840
    DOI 10.1186/s12933-023-01761-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Virtual reality vs. Kalinox® for management of pain in intensive care unit after cardiac surgery: a randomized study.

    Laghlam, Driss / Naudin, Cecile / Coroyer, Lucas / Aidan, Vincent / Malvy, Julien / Rahoual, Ghilas / Estagnasié, Philippe / Squara, Pierre

    Annals of intensive care

    2021  Volume 11, Issue 1, Page(s) 74

    Abstract: Introduction: The management of pain and anxiety remains a challenge in the intensive care unit. By distracting patients, virtual reality (VR) may have a role in painful procedures. We compared VR vs. an inhaled equimolar mixture of N: Methods: ... ...

    Abstract Introduction: The management of pain and anxiety remains a challenge in the intensive care unit. By distracting patients, virtual reality (VR) may have a role in painful procedures. We compared VR vs. an inhaled equimolar mixture of N
    Methods: Prospective, non-inferiority, open-label study. Patients were randomized, for Kalinox® or VR session during drain removal. The analgesia/nociception index (ANI) was monitored during the procedure for objective assessment of pain and anxiety. The primary endpoint was the ΔANI (ANI
    Results: 200 patients were included, 99 in the VR group and 101 in the Kalinox® group; 90 patients were analysed in both groups in per-protocol analysis. The median age was 68.0 years [60.0-74.8]. The ΔANI was - 15.1 ± 12.9 in the Kalinox® group and - 15.7 ± 11.6 in the VR group (NS). The mean difference was, therefore, - 0.6 [- 3.6 to 2.4], including the non-inferiority margin of 3. Patients in the VR group had a significantly higher pain NRS scale immediately after the drain removal, 5.0 [3.0-7.0] vs. 3.0 [2.0-6.0], p = 0.009, but no difference 10 min after. NRS of anxiety did not differ between the two groups.
    Conclusion: Based on the ANI, the current study showed that VR did not reach the statistical requirements for a proven non-inferiority vs. Kalinox® in managing pain and anxiety during chest drain removal. Moreover, VR was less effective based on NRS. More studies are needed to determine if VR might have a place in the overall approach to pain and anxiety in intensive care units. Trial registration NCT, NCT03956264. Registered 20 May 2019, https://clinicaltrials.gov/ct2/show/NCT03956264.
    Language English
    Publishing date 2021-05-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-021-00866-w
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  3. Article ; Online: Screening of Native Valvular Heart Disease Using a Pocket-Sized Transthoracic Echocardiographic Device.

    Kikoïne, John / Hauguel-Moreau, Marie / Hergault, Hélène / Aidan, Vincent / Ouadahi, Mounir / Dubourg, Olivier / Szymanski, Catherine / Mansencal, Nicolas

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2021  Volume 35, Issue 2, Page(s) 196–202

    Abstract: Background: The authors assessed the performance of pocket-sized transthoracic echocardiography (pTTE) compared with standard transthoracic echocardiography (sTTE) and auscultation for early screening of valvular heart disease (VHD). Early diagnosis of ... ...

    Abstract Background: The authors assessed the performance of pocket-sized transthoracic echocardiography (pTTE) compared with standard transthoracic echocardiography (sTTE) and auscultation for early screening of valvular heart disease (VHD). Early diagnosis of significant VHD is a challenge, but it enables appropriate follow-up and implementation of the best therapeutic strategy.
    Methods: sTTE, pTTE, and auscultation were performed by three different experienced physicians on 284 unselected patients. All cases of VHD detected by each of these three techniques were noted. sTTE was the gold standard. Each physician performed one examination and was blinded to the results of other examinations.
    Results: We diagnosed a total of 301 cases of VHD, with a large predominance of regurgitant lesions: 269 cases (89.3%) of regurgitant VHD and 32 (10.7%) of stenotic VHD. pTTE was highly sensitive (85.7%) and specific (97.9%) for screening for VHD, while auscultation detected only 54.1%. All significant cases of VHD (at least mild severity) were detected on pTTE. The weighted κ coefficient between pTTE and sTTE for the assessment of mitral regurgitation was 0.71 (95% CI, 0.70-0.72), indicating good agreement. The weighted κ coefficients between pTTE and sTTE for the assessment of aortic regurgitation and aortic stenosis were 0.97 (95% CI, 0.96-0.98) and 0.98 (95% CI, 0.97-0.99), respectively, indicating excellent agreement.
    Conclusions: pTTE performed by physicians with level III competency in echocardiography is reliable for identifying significant VHD and should be proposed as a new screening tool.
    MeSH term(s) Aortic Valve Insufficiency ; Aortic Valve Stenosis/diagnostic imaging ; Echocardiography/methods ; Heart Valve Diseases/diagnostic imaging ; Humans ; Mitral Valve Insufficiency/diagnostic imaging
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2021.08.013
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  4. Article: Electrocardiogram abnormalities and prognosis in COVID-19.

    Chevrot, Gabriel / Hauguel-Moreau, Marie / Pépin, Marion / Vieillard-Baron, Antoine / Lot, Anne-Sophie / Ouadahi, Mounir / Hergault, Hélène / Aïdan, Vincent / Greffe, Ségolène / Costantini, Adrien / Dubourg, Olivier / Beaune, Sébastien / Mansencal, Nicolas

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 993479

    Abstract: Background: COVID-19 is a major pandemic with potential cardiovascular complications. Few studies have focused on electrocardiogram (ECG) modifications in COVID-19 patients.: Method and results: We reviewed from our database all patients referred to ... ...

    Abstract Background: COVID-19 is a major pandemic with potential cardiovascular complications. Few studies have focused on electrocardiogram (ECG) modifications in COVID-19 patients.
    Method and results: We reviewed from our database all patients referred to our hospital for COVID-19 between January 1st, 2020, and December 31st, 2020: 669 patients were included and 98 patients died from COVID-19 (14.6%). We systematically analyzed ECG at admission and during hospitalization if available. ECG was abnormal at admission in 478 patients (71.4%) and was more frequently abnormal in patients who did not survive (88.8 vs. 68.5%,
    Conclusion: The presence of abnormal ECG during COVID-19 is frequent. Physicians should be aware of the usefulness of ECG for risk stratification during COVID-19.
    Language English
    Publishing date 2022-10-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.993479
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  5. Article: Usefulness of Longitudinal Strain Adjusted to Regional Thickness in Hypertrophic Cardiomyopathy.

    Urtado, Sophie / Hergault, Hélène / Binsse, Stephen / Aidan, Vincent / Ouadahi, Mounir / Szymanski, Catherine / Mallet, Sophie / Hauguel-Moreau, Marie / Carlier, Robert Yves / Dubourg, Olivier / Mansencal, Nicolas

    Journal of clinical medicine

    2022  Volume 11, Issue 8

    Abstract: Background. We assessed the usefulness of a longitudinal strain adjusted to regional thickness in hypertrophic cardiomyopathy (HCM). Indeed, with conventional software, the width of the region of interest (ROI) is the same over the entire myocardial wall, ...

    Abstract Background. We assessed the usefulness of a longitudinal strain adjusted to regional thickness in hypertrophic cardiomyopathy (HCM). Indeed, with conventional software, the width of the region of interest (ROI) is the same over the entire myocardial wall, wherein the software analyzes only partially the left ventricular (LV) hypertrophic segments. Methods. We included 110 patients: 55 patients with HCM (HCM group) and 55 healthy subjects (age- and sex-matched control group). The global longitudinal strain (GLS) and regional strain for each of the 17 segments was calculated with standard software (for two groups) and with software adjusted to the myocardial wall thickness (for the HCM group). Results. GLS was significantly decreased in the HCM group compared to the control group (−15.1 ± 4.8% versus −20.5 ± 4.3%, p < 0.0001). In the HCM group, GLS (standard method versus adjusted to thickness) measurements were not significantly different (p = 0.34). Interestingly, the regional strain adjusted to thickness was significantly lower than the standard strain in the hypertrophic segments, especially in the basal inferoseptal segment (p = 0.0002), median inferoseptal segment (p < 0.001) and median anteroseptal segment (p = 0.02). The strain adjusted to thickness was still significantly lower in the most hypertrophic segments (≥20 mm) (−3.7 ± 3%, versus −5.9 ± 4.4%, p = 0.049 in the basal inferoseptal segment and −5.7 ± 3.5% versus −8.3 ± 4.5%, p = 0.0007 in the median inferoseptal segment). In the segments with significant myocardial fibrosis, the longitudinal strain adjusted to thickness was significantly lower than the conventional strain (−8.3 ± 3.3% versus −11.4 ± 4.5%, p = 0.002). The analysis of the strain adjusted to thickness had a better feasibility (97.5% versus 99%, p = 0.01). Conclusions. The analysis of a longitudinal strain adjusted to regional thickness is feasible in HCM and allows a better evaluation of myocardial deformation, especially in the most LV hypertrophic segments.
    Language English
    Publishing date 2022-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11082089
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  6. Article ; Online: Prevalence of familial hypercholesterolaemia in patients presenting with premature acute coronary syndrome.

    Hauguel-Moreau, Marie / Aïdan, Vincent / Hergault, Hélène / Beauchet, Alain / Pépin, Marion / Prati, Giulio / Pillière, Rémy / Ouadahi, Mounir / Josseran, Loïc / Rodon, Christophe / Rabès, Jean-Pierre / Charron, Philippe / Dubourg, Olivier / Massy, Ziad / Mansencal, Nicolas

    Archives of cardiovascular diseases

    2022  Volume 115, Issue 2, Page(s) 87–95

    Abstract: Background: Familial hypercholesterolaemia (FH) is responsible for severe hypercholesterolaemia and premature cardiovascular morbidity and mortality. The first clinical event is typically an acute coronary syndrome. Unfortunately, FH is largely ... ...

    Abstract Background: Familial hypercholesterolaemia (FH) is responsible for severe hypercholesterolaemia and premature cardiovascular morbidity and mortality. The first clinical event is typically an acute coronary syndrome. Unfortunately, FH is largely underdiagnosed in the general population.
    Aims: To assess the prevalence of clinical FH among patients with premature (aged≤50 years) acute myocardial infarction (MI) and compare it with FH prevalence in a control population.
    Methods: We reviewed in our database all patients with premature MI (aged≤50 years) referred to Ambroise Paré Hospital from 2014 to 2018. FH prevalence was estimated via the Dutch Lipid Clinic Network score, based on personal and family history of premature cardiovascular disease and low-density lipoprotein cholesterol concentrations. FH was "possible" with a score between 3 and 5 points, "probable" with a score between 6 and 8 and "definite" with a score above 8. FH prevalence in young patients with MI was then compared with FH prevalence in a general population of the same age from the CARVAR 92 prospective cohort.
    Results: Of the 457 patients with premature MI, 29 (6%) had "probable" or "definite" FH. In the CARVAR 92 cohort, 16 (0.16%) of 9900 subjects aged≤50 years had "probable" or "definite" FH. FH prevalence was 39 times greater among patients with premature MI than in the control population (P<0.0001). In multivariable analysis, FH was strongly associated with MI (adjusted odds ratio 38.4, 95% confidence interval 19.1-79.4).
    Conclusions: FH is>30-fold more common in patients referred for premature MI than in the general population; this highlights the need for FH screening after a first MI to enhance lipid-lowering therapy and allow early identification of family members.
    MeSH term(s) Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/epidemiology ; Humans ; Hyperlipoproteinemia Type II/diagnosis ; Hyperlipoproteinemia Type II/epidemiology ; Hyperlipoproteinemia Type II/genetics ; Middle Aged ; Prevalence ; Prospective Studies ; Risk Factors
    Language English
    Publishing date 2022-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2408778-6
    ISSN 1875-2128 ; 1875-2136
    ISSN (online) 1875-2128
    ISSN 1875-2136
    DOI 10.1016/j.acvd.2021.11.005
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  7. Article ; Online: Impact of two COVID-19 national lockdowns on acute coronary syndrome admissions.

    Hauguel-Moreau, Marie / Prati, Giulio / Pillière, Rémy / Beaune, Sébastien / Loeb, Thomas / Sawczynski, Bruno / Aïdan, Vincent / Hergault, Hélène / Ouadahi, Mounir / Szymanski, Catherine / Dubourg, Olivier / Mansencal, Nicolas

    Coronary artery disease

    2021  Volume 33, Issue 4, Page(s) 333–334

    MeSH term(s) Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/epidemiology ; Acute Coronary Syndrome/therapy ; COVID-19 ; Communicable Disease Control ; Hospitalization ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/MCA.0000000000001094
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