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Article: Prevalence and real-world management of NSTEMI with multivessel disease.

Baumann, Angus A W / Tavella, Rosanna / Air, Tracy M / Mishra, Aashka / Montarello, Nicholas J / Arstall, Margaret / Zeitz, Chris / Worthley, Matthew I / Beltrame, John F / Psaltis, Peter J

Cardiovascular diagnosis and therapy

2022 Volume 12, Issue 1, Page(s) 1–11

Abstract: Background: Non-ST elevation myocardial infarction (NSTEMI) has higher post-discharge mortality than ST-elevation myocardial infarction (STEMI). Prognosis worsens in those with multivessel coronary disease (MVD). However, information about the ... ...

Abstract	Background: Non-ST elevation myocardial infarction (NSTEMI) has higher post-discharge mortality than ST-elevation myocardial infarction (STEMI). Prognosis worsens in those with multivessel coronary disease (MVD). However, information about the prevalence and extent of MVD in NSTEMI is limited, in turn limiting insights into optimal treatment strategies. This study aimed to define the prevalence and extent of MVD, preferred treatment strategies and the predictors of MVD in a real-world NSTEMI population. Methods: The Coronary Angiogram Database of South Australia (CADOSA) was used to identify consecutive patients presenting to major teaching hospitals with NSTEMI between 2012 and 2016. Obtaining clinical and angiographic details, patients were stratified by the number of significantly diseased vessels (0,1,2,3-VD), defined by a stenosis of ≥70%, or ≥50% in the left main coronary artery. Data was analysed retrospectively. Results: The prevalence of MVD (2- or 3-VD) was 42% amongst 3,722 NSTEMI presentations. Multivariate logistic regression modelling showed age, male gender, diabetes, dyslipidaemia and prior myocardial infarction predicted MVD over 1-VD or 0-VD. Percutaneous coronary intervention (PCI) was performed in 42% of patients with MVD. This comprised 61% of 2-VD patients and only 22% of 3-VD patients, with 24% and 66% of each group referred for coronary bypass grafting, respectively. Among MVD patients treated with PCI, 76% had their culprit lesion treated alone in the index admission. Conclusions: In this NSTEMI cohort, over 40% had MVD. Notably, a minority of patients with MVD undergoing PCI received multivessel revascularisation. This real-world practice emphasises that further evaluation is required to determine whether complete revascularisation is beneficial in NSTEMI, as reported for STEMI.
Language	English
Publishing date	2022-03-07
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2685043-6
ISSN	2223-3660 ; 2223-3652
ISSN (online)	2223-3660
ISSN	2223-3652
DOI	10.21037/cdt-21-518
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Article ; Online: The relationship between social cognition and executive function in Major Depressive Disorder in high-functioning adolescents and young adults.

Förster, Katharina / Jörgens, Silke / Air, Tracy M / Bürger, Christian / Enneking, Verena / Redlich, Ronny / Zaremba, Dario / Grotegerd, Dominik / Dohm, Katharina / Meinert, Susanne / Leehr, Elisabeth J / Böhnlein, Joscha / Repple, Jonathan / Opel, Nils / Kavakbasi, Erhan / Arolt, Volker / Zwitserlood, Pienie / Dannlowski, Udo / Baune, Bernhard T

Psychiatry research

2018 Volume 263, Page(s) 139–146

Abstract: To understand how cognitive dysfunction contributes to social cognitive deficits in depression, we investigated the relationship between executive function and social cognitive performance in adolescents and young adults during current and remitted ... ...

Abstract	To understand how cognitive dysfunction contributes to social cognitive deficits in depression, we investigated the relationship between executive function and social cognitive performance in adolescents and young adults during current and remitted depression, compared to healthy controls. Social cognition and executive function were measured in 179 students (61 healthy controls and 118 patients with depression; M
MeSH term(s)	Adolescent ; Adolescent Behavior/psychology ; Adult ; Cognition/physiology ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/psychology ; Cross-Sectional Studies ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/epidemiology ; Depressive Disorder, Major/psychology ; Executive Function/physiology ; Female ; Humans ; Male ; Neuropsychological Tests ; Social Adjustment ; Social Behavior ; Young Adult
Language	English
Publishing date	2018-02-22
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2018.02.046
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Article ; Online: Changes in depression-related mental health literacy in young men from rural and urban South Australia.

Eckert, Kerena A / Kutek, Stephanie M / Dunn, Kirsten I / Air, Tracy M / Goldney, Robert D

The Australian journal of rural health

2010 Volume 18, Issue 4, Page(s) 153–158

Abstract: Objective: To examine rural and urban differences in depression-related mental health literacy, experience of depression and help-seeking.: Design: Cross-sectional population-based survey stratified by rural and urban area.: Setting: A random and ... ...

Abstract	Objective: To examine rural and urban differences in depression-related mental health literacy, experience of depression and help-seeking. Design: Cross-sectional population-based survey stratified by rural and urban area. Setting: A random and representative sample of South Australian rural and urban young men aged between 15 and 30 years. Outcome measures: Mental health literacy as determined by recognition and exposure to classical symptoms of depression; perceived helpfulness of various interventions and treatment-seeking behaviour. Results: Recognition of depression increased significantly in rural and urban young men between 1998 and 2008. More rural young men than urban men identified symptoms of depression in 1998 (odds ratio (OR): 1.53, 95% confidence interval (CI), 1.01-2.40, P < 0.05), but that was not evident in 2008 (OR: 1.32, 95% CI, 0.80-2.25, P = 0.30). Both groups were more likely to have a close friend experience symptoms of depression and to use antidepressant medications in 2008 compared with 1998. Rural young men experienced a significant increase in recognition of personal depressive symptoms (OR: 3.73, 95% CI, 1.72-8.40) and levels of confidence in psychiatrists and psychologists (OR: 2.40, 95% CI, 1.34-4.31) in 2008 compared with 1998. Both rural and urban young men were significantly less likely to rate dealing with problems on their own as helpful in 2008 as in 1998. Conclusions: There has been an increase in both rural and urban young male mental health literacy between 1998 and 2008, especially in rural young men. Whether this will translate into a reduction of depression and associated suicide, with a reversal of the rural/urban suicide differential, remains to be seen.
MeSH term(s)	Adolescent ; Adult ; Cross-Sectional Studies ; Depression/prevention & control ; Health Literacy/trends ; Health Surveys ; Humans ; Male ; Mental Health ; Patient Acceptance of Health Care ; Rural Population ; South Australia ; Urban Population ; Young Adult
Language	English
Publishing date	2010-08
Publishing country	Australia
Document type	Comparative Study ; Journal Article
ZDB-ID	2069573-1
ISSN	1440-1584 ; 1038-5282
ISSN (online)	1440-1584
ISSN	1038-5282
DOI	10.1111/j.1440-1584.2010.01135.x
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Article ; Online: Relationships between body mass index, mental health, and suicidal ideation: population perspective using two methods.

Goldney, Robert D / Dunn, Kirsten I / Air, Tracy M / Dal Grande, Eleanora / Taylor, Anne W

The Australian and New Zealand journal of psychiatry

2009 Volume 43, Issue 7, Page(s) 652–658

Abstract: Objective: The aim of the present study was to examine the relationship between body mass index (BMI), mental health, and suicidal ideation in a general population.: Method: Two random and representative samples were drawn from the South Australian ... ...

Abstract	Objective: The aim of the present study was to examine the relationship between body mass index (BMI), mental health, and suicidal ideation in a general population. Method: Two random and representative samples were drawn from the South Australian population. The interview techniques differed, as did the measures of depression and suicidality. One involved 3034 people in face-to-face interviews, and the other involved 30 214 persons providing information via a computer-assisted telephone interviewing (CATI) system. BMI was classified according to World Health Organization criteria. In face-to-face interviews, major depression was defined by the Primary Care Evaluation of Mental Disorders (PRIME-MD) and suicidal ideation by direct enquiry. In the CATI data, psychological distress was assessed on the Kessler 10 instrument and suicidal ideation by four items on the General Health Questionnaire (GHQ). Data analysis controlled for demographic and physical health variables. Results: In the face-to-face interviews, the combined obese and morbidly obese men were significantly less likely to have major depression or suicidal ideation than those of a healthy weight. For the telephone interview-derived data, the only significant finding was for overweight women to report less psychological distress than those of a healthy weight. Conclusions: It is no longer tenable to assume that increased BMI is necessarily associated with major depression, psychological distress, or suicidal ideation. Indeed, it appears protective for some people.
MeSH term(s)	Body Mass Index ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/epidemiology ; Depressive Disorder, Major/psychology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Humans ; Interviews as Topic ; Male ; Middle Aged ; Obesity/epidemiology ; Obesity/psychology ; Population Surveillance ; South Australia/epidemiology ; Suicide, Attempted/statistics & numerical data ; Surveys and Questionnaires
Language	English
Publishing date	2009-07
Publishing country	England
Document type	Journal Article
ZDB-ID	221140-3
ISSN	1440-1614 ; 0004-8674
ISSN (online)	1440-1614
ISSN	0004-8674
DOI	10.1080/00048670902970825
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Article ; Online: Frequent attenders with mental disorders at a general hospital emergency department.

Wooden, Michael D G / Air, Tracy M / Schrader, Geoffrey D / Wieland, Barbara / Goldney, Robert D

Emergency medicine Australasia : EMA

2009 Volume 21, Issue 3, Page(s) 191–195

Abstract: Objectives: To define the clinical and demographic characteristics of frequent attenders with mental disorders at a general hospital ED; to determine whether those persons had additional attendances at other ED in the same city; and to assess the ... ...

Abstract	Objectives: To define the clinical and demographic characteristics of frequent attenders with mental disorders at a general hospital ED; to determine whether those persons had additional attendances at other ED in the same city; and to assess the documented care of those frequent attenders. Method: A retrospective descriptive study of those who attended the Queen Elizabeth Hospital, Woodville South, Australia ED on average at least once per month between 1 July 2006 and 15 March 2007. Results: Of 11,594 attenders, 54 (0.47%) at the ED were frequent attenders with mental disorders. Their 735 attendances represented 4.5% of the total of 16,345 attendances. Of those frequent attenders, 34 (63%) also visited other Adelaide hospital ED on an additional 410 occasions. Presentations peaked on the weekends and between 18.00 h and midnight. Although 43% of frequent attenders had specific mental health-care plans, only two-thirds of those had been assigned to a mental health team. Conclusions: The documented management of frequent attenders with mental disorders at a general hospital ED appeared to be less than optimal. Furthermore, the majority of those frequent attenders also attended other general hospital ED in the same city, and this did not appear to be recognized.
MeSH term(s)	Adolescent ; Adult ; Aged ; Australia/epidemiology ; Emergency Service, Hospital/utilization ; Female ; Humans ; Male ; Mental Disorders/epidemiology ; Middle Aged ; Retrospective Studies
Language	English
Publishing date	2009-06
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2161824-0
ISSN	1742-6723 ; 1742-6731 ; 1035-6851
ISSN (online)	1742-6723
ISSN	1742-6731 ; 1035-6851
DOI	10.1111/j.1742-6723.2009.01181.x
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Article: The relationship between social cognition and executive function in major depressive disorder in high-functioning adolescents and young adults

Förster, Katharina / Jörgens, Silke / Air, Tracy M. / Bürger, Christian / Enneking, Verena / Redlich, Ronny / Zaremba, Dario / Grotegerd, Dominik / Dohm, Katharina / Meinert, Susanne / Leehr, Elisabeth J. / Böhnlein, Joscha / Repple, Jonathan / Opel, Nils / Kavakbasi, Erhan / Arolt, Volker / Zwitserlood, Pienie / Dannlowski, Udo / Baune, Bernhard T.

Psychiatry Research

2018 Volume 263, Page(s) 139–146

Abstract: Studied the relationship between social cognition and executive function in major depressive disorder (MDD) among high-functioning adolescents and young adults compared to healthy age-matched control subjects. 118 patients with either current (n = 70) or ...

Title translation	Der Zusammenhang zwischen sozialer Kognition und exekutiver Funktion bei schweren depressiven Störungen bei hochfunktionierenden Jugendlichen und jungen Erwachsenen (DeepL)
Abstract	Studied the relationship between social cognition and executive function in major depressive disorder (MDD) among high-functioning adolescents and young adults compared to healthy age-matched control subjects. 118 patients with either current (n = 70) or remitted (n = 48) MDD as defined by 4th text-revised version of the Diagnostic and Statistical Manual of Mental Disorders were compared to 61 healthy controls. Mean age of the entire sample was 20.6 years. Social cognition was assessed using materials from the Advanced Clinical Solutions for WAIS-IV and WMS-IV Social Cognition Stimulus Book. Executive function was assessed with a battery of standardized measures. Hierarchical regression models employed within each group were used to analyze associations between the obtained cognitive measures. No significant group differences were detected for either social cognition or executive function. No correlation emerged between executive function and social cognitive function in healthy controls or formerly depressed patients. In contrast, for patients with current MDD, lower cognitive flexibility correlated with lower performance in facial-affect recognition, theory-of-mind tests, and general affect recognition. Furthermore, depressed patients demonstrated a link between better planning abilities and decreased performance in both facial affect recognition and social cognitive performance.
Keywords	Adolescent Psychiatry ; Executive Function ; Exekutive Funktion ; Jugendpsychiatrie ; Major Depression ; Social Cognition ; Soziale Kognition ; Theory of Mind
Language	English
Document type	Article
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0165-1781 ; 0925-4927
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0165-1781 ; 0925-4927
DOI	10.1016/j.psychres.2018.02.046
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Article: Posttraumatic stress disorder and its impact on the economic and health costs of motor vehicle accidents in South australia.

Chan, Angelina O M / Medicine, M / Air, Tracy M / McFarlane, Alexander C

The Journal of clinical psychiatry

2003 Volume 64, Issue 2, Page(s) 175–181

Abstract: Background: Motor vehicle accident studies thus far have focused primarily on psychiatric consequences and outcomes and medicolegal and treatment aspects, particularly of posttraumatic stress disorder (PTSD). This study aimed to determine the impact of ... ...

Abstract	Background: Motor vehicle accident studies thus far have focused primarily on psychiatric consequences and outcomes and medicolegal and treatment aspects, particularly of posttraumatic stress disorder (PTSD). This study aimed to determine the impact of motor vehicle accident-related psychiatric disorders on health and economic costs in quantitative terms. Method: Of the 3088 victims of motor vehicle accidents who made a claim through the State Insurance Commission, South Australia, between November 27, 1996, and March 23, 1999, 391 responded to the study and were assessed using the 28-item General Health Questionnaire, the PTSD Checklist-Civilian Version, and the Dissociative Experiences Scale. At the end of the study period, computerized cost records and accounting data on the health and economic costs incurred were obtained for each of the subjects. Results: The total health and economic cost in Australian dollars for the 391 motor vehicle accident victims was A$6,369,519.52. At about 9 months after the accident, of the 391 subjects who replied to the questionnaires, 31% were identified as depressed and 62% as anxious, while 29% met criteria for PTSD. PTSD cases incurred significantly higher health care costs compared with non-PTSD cases (p <.001). Untreated PTSD cases incurred significantly higher economic losses compared with treated PTSD and non-PTSD cases (p <.05). Conclusion: The health and economic costs associated with motor vehicle accidents are enormous. Psychiatric morbidity among victims was high, and motor vehicle accident-related PTSD significantly contributed to increased overall health care and economic costs.
MeSH term(s)	Accidents, Traffic/economics ; Accidents, Traffic/statistics & numerical data ; Adult ; Cost of Illness ; Delivery of Health Care/economics ; Female ; Follow-Up Studies ; Forensic Medicine ; Health Care Costs ; Health Status ; Humans ; Insurance, Liability/economics ; Life Change Events ; Male ; Mental Disorders/economics ; Mental Disorders/epidemiology ; Prevalence ; Prospective Studies ; South Australia/epidemiology ; Stress Disorders, Post-Traumatic/economics ; Stress Disorders, Post-Traumatic/epidemiology ; Surveys and Questionnaires ; Survivors/psychology ; Survivors/statistics & numerical data
Language	English
Publishing date	2003-01-01
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	716287-x
ISSN	1555-2101 ; 0160-6689
ISSN (online)	1555-2101
ISSN	0160-6689
DOI	10.4088/jcp.v64n0210
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Article ; Online: Genetic comorbidity between major depression and cardio-metabolic traits, stratified by age at onset of major depression.

Hagenaars, Saskia P / Coleman, Jonathan R I / Choi, Shing Wan / Gaspar, Héléna / Adams, Mark J / Howard, David M / Hodgson, Karen / Traylor, Matthew / Air, Tracy M / Andlauer, Till F M / Arolt, Volker / Baune, Bernhard T / Binder, Elisabeth B / Blackwood, Douglas H R / Boomsma, Dorret I / Campbell, Archie / Cearns, Micah / Czamara, Darina / Dannlowski, Udo /

Domschke, Katharina / de Geus, Eco J C / Hamilton, Steven P / Hayward, Caroline / Hickie, Ian B / Hottenga, Jouke Jan / Ising, Marcus / Jones, Ian / Jones, Lisa / Kutalik, Zoltan / Lucae, Susanne / Martin, Nicholas G / Milaneschi, Yuri / Mueller-Myhsok, Bertram / Owen, Michael J / Padmanabhan, Sandosh / Penninx, Brenda W J H / Pistis, Giorgio / Porteous, David J / Preisig, Martin / Ripke, Stephan / Shyn, Stanley I / Sullivan, Patrick F / Whitfield, John B / Wray, Naomi R / McIntosh, Andrew M / Deary, Ian J / Breen, Gerome / Lewis, Cathryn M

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

2020 Volume 183, Issue 6, Page(s) 309–330

Abstract: It is imperative to understand the specific and shared etiologies of major depression and cardio-metabolic disease, as both traits are frequently comorbid and each represents a major burden to society. This study examined whether there is a genetic ... ...

Abstract	It is imperative to understand the specific and shared etiologies of major depression and cardio-metabolic disease, as both traits are frequently comorbid and each represents a major burden to society. This study examined whether there is a genetic association between major depression and cardio-metabolic traits and if this association is stratified by age at onset for major depression. Polygenic risk scores analysis and linkage disequilibrium score regression was performed to examine whether differences in shared genetic etiology exist between depression case control status (N cases = 40,940, N controls = 67,532), earlier (N = 15,844), and later onset depression (N = 15,800) with body mass index, coronary artery disease, stroke, and type 2 diabetes in 11 data sets from the Psychiatric Genomics Consortium, Generation Scotland, and UK Biobank. All cardio-metabolic polygenic risk scores were associated with depression status. Significant genetic correlations were found between depression and body mass index, coronary artery disease, and type 2 diabetes. Higher polygenic risk for body mass index, coronary artery disease, and type 2 diabetes was associated with both early and later onset depression, while higher polygenic risk for stroke was associated with later onset depression only. Significant genetic correlations were found between body mass index and later onset depression, and between coronary artery disease and both early and late onset depression. The phenotypic associations between major depression and cardio-metabolic traits may partly reflect their overlapping genetic etiology irrespective of the age depression first presents.
MeSH term(s)	Age Factors ; Age of Onset ; Body Mass Index ; Cardiometabolic Risk Factors ; Case-Control Studies ; Comorbidity ; Coronary Artery Disease/genetics ; Databases, Genetic ; Depression/genetics ; Depression/physiopathology ; Depressive Disorder, Major/genetics ; Depressive Disorder, Major/physiopathology ; Diabetes Mellitus, Type 2/genetics ; Female ; Genetic Association Studies/methods ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Genotype ; Humans ; Linkage Disequilibrium/genetics ; Male ; Metabolic Syndrome/genetics ; Metabolic Syndrome/physiopathology ; Multifactorial Inheritance/genetics ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Stroke/genetics
Language	English
Publishing date	2020-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2108616-3
ISSN	1552-485X ; 1552-4841 ; 0148-7299
ISSN (online)	1552-485X
ISSN	1552-4841 ; 0148-7299
DOI	10.1002/ajmg.b.32807
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Article ; Online: Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression.

Glanville, Kylie P / Coleman, Jonathan R I / Hanscombe, Ken B / Euesden, Jack / Choi, Shing Wan / Purves, Kirstin L / Breen, Gerome / Air, Tracy M / Andlauer, Till F M / Baune, Bernhard T / Binder, Elisabeth B / Blackwood, Douglas H R / Boomsma, Dorret I / Buttenschøn, Henriette N / Colodro-Conde, Lucía / Dannlowski, Udo / Direk, Nese / Dunn, Erin C / Forstner, Andreas J /

de Geus, Eco J C / Grabe, Hans J / Hamilton, Steven P / Jones, Ian / Jones, Lisa A / Knowles, James A / Kutalik, Zoltán / Levinson, Douglas F / Lewis, Glyn / Lind, Penelope A / Lucae, Susanne / Magnusson, Patrik K / McGuffin, Peter / McIntosh, Andrew M / Milaneschi, Yuri / Mors, Ole / Mostafavi, Sara / Müller-Myhsok, Bertram / Pedersen, Nancy L / Penninx, Brenda W J H / Potash, James B / Preisig, Martin / Ripke, Stephan / Shi, Jianxin / Shyn, Stanley I / Smoller, Jordan W / Streit, Fabian / Sullivan, Patrick F / Tiemeier, Henning / Uher, Rudolf / Van der Auwera, Sandra / Weissman, Myrna M / O'Reilly, Paul F / Lewis, Cathryn M

Biological psychiatry

2019 Volume 87, Issue 5, Page(s) 419–430

Abstract: Background: The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we ... ...

Abstract	Background: The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we tested whether genetic variation in the major histocompatibility complex (MHC), which is associated with risk for autoimmune diseases, is also associated with risk for depression. Methods: We fine-mapped the classical MHC (chr6: 29.6-33.1 Mb), imputing 216 human leukocyte antigen (HLA) alleles and 4 complement component 4 (C4) haplotypes in studies from the Psychiatric Genomics Consortium Major Depressive Disorder Working Group and the UK Biobank. The total sample size was 45,149 depression cases and 86,698 controls. We tested for association between depression status and imputed MHC variants, applying both a region-wide significance threshold (3.9 × 10 Results: No HLA alleles or C4 haplotypes were associated with depression at the region-wide threshold. HLA-B08:01 was associated with modest protection for depression at the candidate threshold for testing in HLA genes in the meta-analysis (odds ratio = 0.98, 95% confidence interval = 0.97-0.99). Conclusions:* We found no evidence that an increased risk for depression was conferred by HLA alleles, which play a major role in the genetic susceptibility to autoimmune diseases, or C4 haplotypes, which are strongly associated with schizophrenia. These results suggest that any HLA or C4 variants associated with depression either are rare or have very modest effect sizes.
MeSH term(s)	Alleles ; Depression ; Depressive Disorder, Major/epidemiology ; Depressive Disorder, Major/genetics ; Genetic Predisposition to Disease ; HLA Antigens ; Haplotypes ; Humans ; Major Histocompatibility Complex
Chemical Substances	HLA Antigens
Language	English
Publishing date	2019-08-05
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2019.06.031
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Article ; Online: GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.

Mullins, Niamh / Bigdeli, Tim B / Børglum, Anders D / Coleman, Jonathan R I / Demontis, Ditte / Mehta, Divya / Power, Robert A / Ripke, Stephan / Stahl, Eli A / Starnawska, Anna / Anjorin, Adebayo / Corvin, Aiden / Sanders, Alan R / Forstner, Andreas J / Reif, Andreas / Koller, Anna C / Świątkowska, Beata / Baune, Bernhard T / Müller-Myhsok, Bertram /

Penninx, Brenda W J H / Pato, Carlos / Zai, Clement / Rujescu, Dan / Hougaard, David M / Quested, Digby / Levinson, Douglas F / Binder, Elisabeth B / Byrne, Enda M / Agerbo, Esben / Streit, Fabian / Mayoral, Fermin / Bellivier, Frank / Degenhardt, Franziska / Breen, Gerome / Morken, Gunnar / Turecki, Gustavo / Rouleau, Guy A / Grabe, Hans J / Völzke, Henry / Jones, Ian / Giegling, Ina / Agartz, Ingrid / Melle, Ingrid / Lawrence, Jacob / Walters, James T R / Strohmaier, Jana / Shi, Jianxin / Hauser, Joanna / Biernacka, Joanna M / Vincent, John B / Kelsoe, John / Strauss, John S / Lissowska, Jolanta / Pimm, Jonathan / Smoller, Jordan W / Guzman-Parra, José / Berger, Klaus / Scott, Laura J / Jones, Lisa A / Azevedo, M Helena / Trzaskowski, Maciej / Kogevinas, Manolis / Rietschel, Marcella / Boks, Marco / Ising, Marcus / Grigoroiu-Serbanescu, Maria / Hamshere, Marian L / Leboyer, Marion / Frye, Mark / Nöthen, Markus M / Alda, Martin / Preisig, Martin / Nordentoft, Merete / Boehnke, Michael / O'Donovan, Michael C / Owen, Michael J / Pato, Michele T / Renteria, Miguel E / Budde, Monika / Weissman, Myrna M / Wray, Naomi R / Bass, Nicholas / Craddock, Nicholas / Smeland, Olav B / Andreassen, Ole A / Mors, Ole / Gejman, Pablo V / Sklar, Pamela / McGrath, Patrick / Hoffmann, Per / McGuffin, Peter / Lee, Phil H / Mortensen, Preben Bo / Kahn, René S / Ophoff, Roel A / Adolfsson, Rolf / Van der Auwera, Sandra / Djurovic, Srdjan / Kloiber, Stefan / Heilmann-Heimbach, Stefanie / Jamain, Stéphane / Hamilton, Steven P / McElroy, Susan L / Lucae, Susanne / Cichon, Sven / Schulze, Thomas G / Hansen, Thomas / Werge, Thomas / Air, Tracy M / Nimgaonkar, Vishwajit / Appadurai, Vivek / Cahn, Wiepke / Milaneschi, Yuri / Fanous, Ayman H / Kendler, Kenneth S / McQuillin, Andrew / Lewis, Cathryn M

The American journal of psychiatry

2019 Volume 176, Issue 8, Page(s) 651–660

Abstract: Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The ... ...

Abstract	Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium. Methods: The samples comprised 1,622 suicide attempters and 8,786 nonattempters with major depressive disorder; 3,264 attempters and 5,500 nonattempters with bipolar disorder; and 1,683 attempters and 2,946 nonattempters with schizophrenia. A GWAS on suicide attempt was performed by comparing attempters to nonattempters with each disorder, followed by a meta-analysis across disorders. Polygenic risk scoring was used to investigate the genetic relationship between suicide attempt and the psychiatric disorders. Results: Three genome-wide significant loci for suicide attempt were found: one associated with suicide attempt in major depressive disorder, one associated with suicide attempt in bipolar disorder, and one in the meta-analysis of suicide attempt in mood disorders. These associations were not replicated in independent mood disorder cohorts from the UK Biobank and iPSYCH. No significant associations were found in the meta-analysis of all three disorders. Polygenic risk scores for major depression were significantly associated with suicide attempt in major depressive disorder (R Conclusions: This study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt.
MeSH term(s)	Bipolar Disorder/genetics ; Bipolar Disorder/psychology ; Case-Control Studies ; Depressive Disorder, Major/genetics ; Depressive Disorder, Major/psychology ; Female ; Genome-Wide Association Study ; Humans ; Male ; Multifactorial Inheritance/genetics ; Risk Factors ; Schizophrenia/genetics ; Suicide, Attempted
Language	English
Publishing date	2019-06-05
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	280045-7
ISSN	1535-7228 ; 0002-953X
ISSN (online)	1535-7228
ISSN	0002-953X
DOI	10.1176/appi.ajp.2019.18080957
Database	MEDical Literature Analysis and Retrieval System OnLINE

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