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  1. Book ; Online ; E-Book: Animal Models of Disease Part A

    Galluzzi, Lorenzo / Aranda Vega, Fernando / Martinez, Aitziber Buque / Bravo-San Pedro, Jose Manuel

    2024  

    Subject code 616.027
    Language English
    Size 1 online resource (250 pages)
    Edition 1st ed.
    Publisher Elsevier Science & Technology
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-22239-8 ; 978-0-443-22239-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Autophagy in health and disease

    Buqué Martinez, Aitziber

    (Progress in molecular biology and translational science ; volume 172)

    2020  

    Author's details edited by Aitziber Buqué Martinez, Lorenzo Galluzzi
    Series title Progress in molecular biology and translational science ; volume 172
    Collection
    Language English
    Size xix, 424 Seiten, Illustrationen
    Edition First edition
    Publisher Elsevier Academic Press
    Publishing place Cambridge, MA
    Publishing country United States
    Document type Book
    HBZ-ID HT020530119
    ISBN 978-0-12-822021-4 ; 0-12-822021-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 357 -172- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Nicotinamide drives T cell activation in the mammary tumor microenvironment

    Yang Hu / Norma Bloy / Olivier Elemento / Aitziber Buqué

    Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-

    2022  Volume 3

    Abstract: Abstract Nicotinamide (NAM, a variant of vitamin B3) has recently been shown to accelerate the activation of human CD4+ and CD8+ T cells exposed to repeated CD3/CD28 agonism in vitro. Here, we demonstrate that T cells infiltrating mouse mammary ... ...

    Abstract Abstract Nicotinamide (NAM, a variant of vitamin B3) has recently been shown to accelerate the activation of human CD4+ and CD8+ T cells exposed to repeated CD3/CD28 agonism in vitro. Here, we demonstrate that T cells infiltrating mouse mammary carcinomas that are therapeutically controlled by NAM also express multiple markers of late-stage activation. Taken together, these findings lend additional support to the notion that the antineoplastic effects of NAM involve at least some degree of restored cancer immunosurveillance.
    Keywords CTLA4 ; Immune checkpoint inhibitors ; Immunotherapy ; PD-1 ; LAG3 ; TIM-3 ; Medicine ; R
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Cellular senescence in the response of HR+ breast cancer to radiotherapy and CDK4/6 inhibitors

    Vanessa Klapp / Aitziber Buqué / Norma Bloy / Ai Sato / Takahiro Yamazaki / Xi Kathy Zhou / Silvia C. Formenti / Lorenzo Galluzzi / Giulia Petroni

    Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-

    2023  Volume 10

    Abstract: Abstract Background Preclinical evidence from us and others demonstrates that the anticancer effects of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors can be enhanced with focal radiation therapy (RT), but only when RT is delivered prior to (rather than ...

    Abstract Abstract Background Preclinical evidence from us and others demonstrates that the anticancer effects of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors can be enhanced with focal radiation therapy (RT), but only when RT is delivered prior to (rather than after) CDK4/6 inhibition. Depending on tumor model, cellular senescence (an irreversible proliferative arrest that is associated with the secretion of numerous bioactive factors) has been attributed beneficial or detrimental effects on response to treatment. As both RT and CDK4/6 inhibitors elicit cellular senescence, we hypothesized that a differential accumulation of senescent cells in the tumor microenvironment could explain such an observation, i.e., the inferiority of CDK4/6 inhibition with palbociclib (P) followed by RT (P→RT) as compared to RT followed by palbociclib (RT→P). Methods The impact of cellular senescence on the interaction between RT and P was assessed by harnessing female INK-ATTAC mice, which express a dimerizable form of caspase 8 (CASP8) under the promoter of cyclin dependent kinase inhibitor 2A (Cdkn2a, coding for p16Ink4), as host for endogenous mammary tumors induced by the subcutaneous implantation of medroxyprogesterone acetate (MPA, M) pellets combined with the subsequent oral administration of 7,12-dimethylbenz[a]anthracene (DMBA, D). This endogenous mouse model of HR+ mammary carcinogenesis recapitulates key immunobiological aspects of human HR+ breast cancer. Mice bearing M/D-driven tumors were allocated to RT, P or their combination in the optional presence of the CASP8 dimerizer AP20187, and monitored for tumor growth, progression-free survival and overall survival. In parallel, induction of senescence in vitro, in cultured human mammary hormone receptor (HR)+ adenocarcinoma MCF7 cells, triple negative breast carcinoma MDA-MB-231 cells and mouse HR+ mammary carcinoma TS/A cells treated with RT, P or their combination, was determined by colorimetric assessment of senescence-associated β-galactosidase activity after 3 or 7 days of ...
    Keywords β-galactosidase ; INK-ATTAC mice ; MCF7 cells ; MDA-MB-231 cells ; MPA/DMBA-driven mammary carcinogenesis ; TS/A cells ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Thymidylate synthase expression determines pemetrexed targets and resistance development in tumour cells.

    Aitziber Buqué / Unai Aresti / Begoña Calvo / Jangi Sh Muhialdin / Alberto Muñoz / Sergio Carrera / Eider Azkona / Itziar Rubio / Guillermo López-Vivanco

    PLoS ONE, Vol 8, Iss 5, p e

    2013  Volume 63338

    Abstract: Although treatment options for cancer patients are increasing every year, the drug resistance problem remains very present. It is very difficult to find a drug that acts equally on tumours of the same histology as the individual's genetic characteristics ...

    Abstract Although treatment options for cancer patients are increasing every year, the drug resistance problem remains very present. It is very difficult to find a drug that acts equally on tumours of the same histology as the individual's genetic characteristics often determine the response to treatment. Furthermore, tumours that initially respond to anti-tumour therapy are able to adapt and develop resistance to the drug, while others do not. In addition, this usually implies resistance development to agents to which the cells have not been exposed, a phenomenon called cross-resistance or multidrug resistance. Given this situation, it has been suggested that the most appropriate treatment would be able to act in parallel on multiple pathways constitutively altered in tumour cells. Pemetrexed is a multitargeted antifolate that exerts its activity against folate-dependent enzymes involved in de novo pyrimidine and purine synthesis. It is currently in use in combination with cisplatin against malignant pleural mesothelioma and non-squamous non-small cell lung cancer with favourable results. By real-time RT-PCR gene expression assays and restoration viability assays we demonstrated that Pemetrexed targets folate-dependent enzymes involved in de novo biosynthesis of purines differently depending on the intrinsic genetic characteristics of the tumour. These differences did not, however, interfere either with the initial response to the drug or with the activation of apoptotic pathways. In addition, these genetic fingerprints can differentiate two groups of tumours: those capable of developing resistance to antifolate, and not capable. These results may be useful to employ targets gene expression as resistance markers, a valuable tool for identifying patients likely to receive combination therapy to prevent the development of resistance.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

    Aitziber Buqué / Norma Bloy / Maria Perez-Lanzón / Kristina Iribarren / Juliette Humeau / Jonathan G. Pol / Sarah Levesque / Laura Mondragon / Takahiro Yamazaki / Ai Sato / Fernando Aranda / Sylvère Durand / Alexandre Boissonnas / Jitka Fucikova / Laura Senovilla / David Enot / Michal Hensler / Margerie Kremer / Gautier Stoll /
    Yang Hu / Chiara Massa / Silvia C. Formenti / Barbara Seliger / Olivier Elemento / Radek Spisek / Fabrice André / Laurence Zitvogel / Suzette Delaloge / Guido Kroemer / Lorenzo Galluzzi

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 18

    Abstract: Current preclinical models to investigate human HR + breast cancer progression and response to immunotherapy in vivo are limited. Here, the authors demonstrate that mammary tumours driven by a synthetic progestin combined with an oral carcinogen ... ...

    Abstract Current preclinical models to investigate human HR + breast cancer progression and response to immunotherapy in vivo are limited. Here, the authors demonstrate that mammary tumours driven by a synthetic progestin combined with an oral carcinogen recapitulate several immunobiological features of human HR + breast cancers.
    Keywords Science ; Q
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Publisher Correction

    Aitziber Buqué / Norma Bloy / Maria Perez-Lanzón / Kristina Iribarren / Juliette Humeau / Jonathan G. Pol / Sarah Levesque / Laura Mondragon / Takahiro Yamazaki / Ai Sato / Fernando Aranda / Sylvère Durand / Alexandre Boissonnas / Jitka Fucikova / Laura Senovilla / David Enot / Michal Hensler / Margerie Kremer / Gautier Stoll /
    Yang Hu / Chiara Massa / Silvia C. Formenti / Barbara Seliger / Olivier Elemento / Radek Spisek / Fabrice André / Laurence Zitvogel / Suzette Delaloge / Guido Kroemer / Lorenzo Galluzzi

    Nature Communications, Vol 11, Iss 1, Pp 1-

    Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

    2020  Volume 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Science ; Q
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

    Aitziber Buqué / Norma Bloy / Maria Perez-Lanzón / Kristina Iribarren / Juliette Humeau / Jonathan G. Pol / Sarah Levesque / Laura Mondragon / Takahiro Yamazaki / Ai Sato / Fernando Aranda / Sylvère Durand / Alexandre Boissonnas / Jitka Fucikova / Laura Senovilla / David Enot / Michal Hensler / Margerie Kremer / Gautier Stoll /
    Yang Hu / Chiara Massa / Silvia C. Formenti / Barbara Seliger / Olivier Elemento / Radek Spisek / Fabrice André / Laurence Zitvogel / Suzette Delaloge / Guido Kroemer / Lorenzo Galluzzi

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 18

    Abstract: Current preclinical models to investigate human HR + breast cancer progression and response to immunotherapy in vivo are limited. Here, the authors demonstrate that mammary tumours driven by a synthetic progestin combined with an oral carcinogen ... ...

    Abstract Current preclinical models to investigate human HR + breast cancer progression and response to immunotherapy in vivo are limited. Here, the authors demonstrate that mammary tumours driven by a synthetic progestin combined with an oral carcinogen recapitulate several immunobiological features of human HR + breast cancers.
    Keywords Science ; Q
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  9. Article ; Online: Estrogen receptor 1 gene expression and its combination with estrogen receptor 2 or aromatase expression predicts survival in non-small cell lung cancer.

    Unai Aresti / Sergio Carrera / Eluska Iruarrizaga / Natalia Fuente / Ines Marrodan / Abigail Ruiz de Lobera / Alberto Muñoz / Aitziber Buque / Elizabeth Condori / Irene Ugalde / Begoña Calvo / Guillermo López Vivanco

    PLoS ONE, Vol 9, Iss 10, p e

    2014  Volume 109659

    Abstract: The biological roles of estrogen receptor 1 (ERS1), estrogen receptor 2 (ERS2), and aromatase (CYP19A1) genes in the development of non-small cell lung cancer (NSCLC) is unclear, as is the use of their expression as a prognostic factor. The aim of this ... ...

    Abstract The biological roles of estrogen receptor 1 (ERS1), estrogen receptor 2 (ERS2), and aromatase (CYP19A1) genes in the development of non-small cell lung cancer (NSCLC) is unclear, as is the use of their expression as a prognostic factor. The aim of this study was to investigate the prognostic value of estrogen receptors and aromatase mRNA expression, along with aromatase protein concentration, in resected NSCLC patients. Tumor and non-tumor lung tissue samples were analyzed for the mRNA expression of ERS1, ERS2 and CYP19A1 by RT-PCR. Aromatase concentration was measured with an ELISA. A total of 96 patients were included. ERS1 expression was significantly higher in non-tumor tissue than in tumor samples. Two gene expression categories were created for each gene (and protein): high and low. ERS1 high category showed increased overall survival (OS) when compared to the low expression category. Aromatase protein concentration was significantly higher in tumor samples. Higher ERS1 expression in tumor tissues was related to longer overall survival. The analysis of gene expression combinations provides evidence for longer OS when both ERS1 and ERS2 are highly expressed. ESR1, alone or in combination with ERS2 or CYP19A1, is the most determining prognostic factor within the analyzed 3 genes. It seems that ERS1 can play a role in NSCLC prognosis, alone or in combination with other genes such as ERS2 or Cyp19a1. ERS2 in combination with aromatase concentration could have a similar function.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.

    Galluzzi, Lorenzo / Vitale, Ilio / Warren, Sarah / Adjemian, Sandy / Agostinis, Patrizia / Martinez, Aitziber Buqué / Chan, Timothy A / Coukos, George / Demaria, Sandra / Deutsch, Eric / Draganov, Dobrin / Edelson, Richard L / Formenti, Silvia C / Fucikova, Jitka / Gabriele, Lucia / Gaipl, Udo S / Gameiro, Sofia R / Garg, Abhishek D / Golden, Encouse /
    Han, Jian / Harrington, Kevin J / Hemminki, Akseli / Hodge, James W / Hossain, Dewan Md Sakib / Illidge, Tim / Karin, Michael / Kaufman, Howard L / Kepp, Oliver / Kroemer, Guido / Lasarte, Juan Jose / Loi, Sherene / Lotze, Michael T / Manic, Gwenola / Merghoub, Taha / Melcher, Alan A / Mossman, Karen L / Prosper, Felipe / Rekdal, Øystein / Rescigno, Maria / Riganti, Chiara / Sistigu, Antonella / Smyth, Mark J / Spisek, Radek / Stagg, John / Strauss, Bryan E / Tang, Daolin / Tatsuno, Kazuki / van Gool, Stefaan W / Vandenabeele, Peter / Yamazaki, Takahiro / Zamarin, Dmitriy / Zitvogel, Laurence / Cesano, Alessandra / Marincola, Francesco M

    Journal for immunotherapy of cancer

    2020  Volume 8, Issue 1

    Abstract: Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and ... ...

    Abstract Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.
    MeSH term(s) Consensus ; Guidelines as Topic ; Humans ; Immunogenic Cell Death/genetics ; Molecular Biology/methods
    Language English
    Publishing date 2020-04-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2019-000337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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