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  1. Article: Early-Staged Carotid Artery Stenting Prior to Coronary Artery Bypass Grafting: Analysis of the Early and Mid-Term Results in Comparison with a Consecutive Cohort of Isolated Coronary Artery Surgery Patients.

    Nardi, Paolo / Altieri, Claudia / Pisano, Calogera / Oddi, Fabio Massimo / Ranucci, Alessandro / Fresilli, Mauro / Salvati, Alessandro Cristian / Buioni, Dario / Scognamiglio, Mattia / Ajello, Valentina / Bassano, Carlo / Ascoli Marchetti, Andrea / Ippoliti, Arnaldo / Ruvolo, Giovanni

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: Aim: The aim of the present study was to analyze retrospectively the results of patients who underwent early-staged, i.e., within 24-48 h, carotid artery stenting (e-s CAS) before coronary artery bypass grafting (CABG).: Methods: Between December ... ...

    Abstract Aim: The aim of the present study was to analyze retrospectively the results of patients who underwent early-staged, i.e., within 24-48 h, carotid artery stenting (e-s CAS) before coronary artery bypass grafting (CABG).
    Methods: Between December 2014 and December 2022, 1046 consecutive patients underwent CABG; 31 of these patients (3%) were subjected to e-s CAS prior to CABG (e-s CAS + CABG group). Preoperative and intraoperative variables and early and mid-term results of the e-s CAS + CABG group were compared with those of patients who underwent isolated CABG (CABG group).
    Results: As compared with the CABG group, the e-s CAS + CABG group showed a worse clinical risk profile due to higher Euroscore-2 values and incidence of obstructive pulmonary disease and bilateral carotid artery and peripheral artery diseases (
    Conclusions: CABG preceded by e-s CAS appears to be associated with satisfactory early outcomes while limiting the risk of myocardial infarction to a very short time interval between the two procedures. Freedom from late all-causes death, cardiac death, and MACCEs were comparable and equally satisfactory, underscoring the positive protective effects of CAS and CABG on the carotid and coronary territories over time.
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Imaging and monitoring in minimally invasive valve surgery using an intra-aortic occlusion device: a single center experience.

    Pisano, Calogera / Farinaccio, Andrea / Altieri, Claudia / Ajello, Valentina / Nardi, Paolo / Colella, Dionisio Ferdinando / Ruvolo, Giovanni

    Journal of thoracic disease

    2021  Volume 13, Issue 2, Page(s) 1011–1019

    Abstract: Background: Minimally invasive approach through a right mini-thoracotomy is a world-wide used procedure for mitral valve surgery. We performed a retrospective analysis based on our center experience in order to propose an effective, safe and ... ...

    Abstract Background: Minimally invasive approach through a right mini-thoracotomy is a world-wide used procedure for mitral valve surgery. We performed a retrospective analysis based on our center experience in order to propose an effective, safe and reproducible method using an intra-aortic occlusion device.
    Methods: This is a retrospective analysis on 48 consecutive patients undergoing mitral valve surgery through a right anterolateral mini-thoracotomy in our center. An intra-aortic occlusion device was used for aortic clamping and cardioplegia delivery. Simultaneous multi-plane three-dimensional echocardiography imaging was acquired to detect the venous cannulas position, the intra-aortic device location in the ascending aorta, the balloon inflation, the complete occlusion of the aorta, the cardioplegia delivery, the origin and the blood flow in the right coronary artery. Aortic root pressure was measured by the tip of the intra-aortic occlusion device. A bilateral upper extremity invasive arterial pressure monitoring was detected. Neuromonitoring was performed through bilateral cerebral oximetry.
    Results: The analysis has shown no aortic dissection, neurological damage type 1 and myocardial ischemia in the study population. In 3 cases a distal displacement of the intra-aortic occlusion device was promptly detected by the combined use of echocardiographic imaging and by a drop of the right cerebral oximetry saturation and of the right radial artery pressure.
    Conclusions: The combined use of transesophageal simultaneous multi-plane three- dimensional echocardiography imaging, bilateral upper extremity invasive arterial pressure monitoring, aortic root pressure and cerebral oximetry is an effective, safe and reproducible method in patients undergoing minimally invasive valve surgery using an intra-aortic occlusion device.
    Language English
    Publishing date 2021-02-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-20-3032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Co-ultramicronized palmitoylethanolamide/luteolin normalizes GABA

    Versace, Viviana / Ortelli, Paola / Dezi, Sabrina / Ferrazzoli, Davide / Alibardi, Alessia / Bonini, Ilenia / Engl, Michael / Maestri, Roberto / Assogna, Martina / Ajello, Valentina / Pucks-Faes, Elke / Saltuari, Leopold / Sebastianelli, Luca / Kofler, Markus / Koch, Giacomo

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2022  Volume 145, Page(s) 81–88

    Abstract: Objective: Transcranial magnetic stimulation (TMS) studies showed that patients with cognitive dysfunction and fatigue after COVID-19 exhibit impaired cortical GABA: Methods: Thirty-nine patients (26 females, mean age 49.9 ± 11.4 years, mean time ... ...

    Abstract Objective: Transcranial magnetic stimulation (TMS) studies showed that patients with cognitive dysfunction and fatigue after COVID-19 exhibit impaired cortical GABA
    Methods: Thirty-nine patients (26 females, mean age 49.9 ± 11.4 years, mean time from infection 296.7 ± 112.3 days) suffering from persistent cognitive difficulties and fatigue after mild COVID-19 were randomly assigned to receive either PEA-LUT 700 mg + 70 mg or PLACEBO, administered orally bid for eight weeks. The day before (PRE) and at the end of the treatment (POST), they underwent TMS protocols to assess LICI. We further evaluate short-latency afferent inhibition (SAI) and long-term potentiation (LTP)-like cortical plasticity.
    Results: Patients treated with PEA-LUT but not with PLACEBO showed a significant increase of LICI and LTP-like cortical plasticity. SAI remained unaffected.
    Conclusions: Eight weeks of treatment with PEA-LUT restore GABA
    Significance: This study confirms altered physiology of the motor cortex in long COVID-19 syndrome and indicates PEA-LUT as a candidate for the treatment of this post-viral condition.
    MeSH term(s) Female ; Humans ; Adult ; Middle Aged ; Luteolin/pharmacology ; Neural Inhibition/physiology ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Transcranial Magnetic Stimulation/methods ; gamma-Aminobutyric Acid ; Fatigue ; Evoked Potentials, Motor/physiology
    Chemical Substances palmidrol (6R8T1UDM3V) ; Luteolin (KUX1ZNC9J2) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2022-11-11
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2022.10.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Intracortical GABAergic dysfunction in patients with fatigue and dysexecutive syndrome after COVID-19.

    Versace, Viviana / Sebastianelli, Luca / Ferrazzoli, Davide / Romanello, Roberto / Ortelli, Paola / Saltuari, Leopold / D'Acunto, Alessia / Porrazzini, Francesco / Ajello, Valentina / Oliviero, Antonio / Kofler, Markus / Koch, Giacomo

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2021  Volume 132, Issue 5, Page(s) 1138–1143

    Abstract: Objective: A high proportion of patients experience fatigue and impairment of cognitive functions after coronavirus disease 2019 (COVID-19). Here we applied transcranial magnetic stimulation (TMS) to explore the activity of the main inhibitory ... ...

    Abstract Objective: A high proportion of patients experience fatigue and impairment of cognitive functions after coronavirus disease 2019 (COVID-19). Here we applied transcranial magnetic stimulation (TMS) to explore the activity of the main inhibitory intracortical circuits within the primary motor cortex (M1) in a sample of patients complaining of fatigue and presenting executive dysfunction after resolution of COVID-19 with neurological manifestations.
    Methods: Twelve patients who recovered from typical COVID-19 pneumonia with neurological complications and complained of profound physical and mental fatigue underwent, 9 to 13 weeks from disease onset, a psychometric evaluation including a self-reported fatigue numeric-rating scale (FRS, Fatigue Rating Scale) and the Frontal Assessment Battery (FAB). Intracortical activity was evaluated by means of well-established TMS protocols including short-interval intracortical inhibition (SICI), reflecting GABA
    Results: Post-COVID-19 patients reported marked fatigue according to FRS score (8.1 ± 1.7) and presented pathological scores at the FAB based on Italian normative data (12.2 ± 0.7). TMS revealed marked reduction of SICI, and disruption of LICI as compared to HS. SAI was also slightly diminished.
    Conclusions: The present study documents for the first time reduced GABAergic inhibition in the M1 in patients who recovered from COVID-19 with neurological complications and manifested fatigue and dysexecutive syndrome.
    Significance: TMS may serve as diagnostic tool in cognitive disturbances and fatigue in post-COVID-19 patients.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/physiopathology ; COVID-19/therapy ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/physiopathology ; Cognitive Dysfunction/therapy ; Fatigue/etiology ; Fatigue/physiopathology ; Fatigue/therapy ; Female ; GABAergic Neurons/physiology ; Humans ; Male ; Middle Aged ; Motor Cortex/physiopathology ; Transcranial Magnetic Stimulation/methods
    Language English
    Publishing date 2021-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2021.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dopamine Optimizes Venous Return During Cardiopulmonary Bypass and Reduces the Need for Postoperative Blood Transfusion.

    Moscarelli, Marco / Condello, Ignazio / Fattouch, Khalil / Punjabi, Prakash / Ajello, Valentina / Solimando, Carlo / Fiore, Flavio / Angelini, Gianni / Speziale, Giuseppe

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2019  Volume 65, Issue 8, Page(s) 882–887

    Abstract: Venodilation occurs shortly after the institution of cardiopulmonary bypass (CPB), necessitating fluid or vasoconstrictor administration to maintain adequate oxygen delivery. The vasoconstrictor effects of dopamine are not well studied in this context. ... ...

    Abstract Venodilation occurs shortly after the institution of cardiopulmonary bypass (CPB), necessitating fluid or vasoconstrictor administration to maintain adequate oxygen delivery. The vasoconstrictor effects of dopamine are not well studied in this context. Therefore, we conducted a single-center, double-blind case-control study to determine the role and utility of dopamine as a vasoconstrictor during CPB. The study included 60 adults who were scheduled for isolated elective/urgent coronary artery bypass grafting. Patients in group A (n = 30) received a dopamine bolus (2 mg) 20 min after cross-clamping, whereas patients in group B (n = 30) did not receive any intervention at a specific time point. Both groups received standard care as needed (fluid replacement or norepinephrine bolus). Venous return was measured directly in the reservoir and indirectly by Doppler measurement at the level of the inferior vena cava with transesophageal echocardiography. Both open and closed circuits were used for CPB. A single dopamine bolus (2 mg) increased volume in the venous reservoir in group A. Group A patients also received significantly fewer units of red blood cells in the intensive care unit (ICU) than did patients in group B. There were no significant between-group differences in postoperative bleeding, mechanical ventilation, or length of stay in the ICU. These findings suggest that use of a dopamine bolus can increase venous return and reduce the need for fluid replacement during and after CPB in patients undergoing coronary artery bypass grafting.
    MeSH term(s) Adult ; Aged ; Cardiopulmonary Bypass/adverse effects ; Cardiopulmonary Bypass/methods ; Case-Control Studies ; Dopamine/therapeutic use ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Vascular Resistance/drug effects ; Vasoconstrictor Agents/therapeutic use
    Chemical Substances Vasoconstrictor Agents ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2019-01-01
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000000930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evaluation of Left Ventricular Overload and Use of Unloading Techniques in Venoarterial Extracorporeal Life Support: A Nationwide Survey.

    Meani, Paolo / Veronese, Giacomo / Todaro, Serena / Marchese, Giuseppe / Mondellini, Giulio M / Protti, Ilaria / de Arroyabe, Blanca Martinez-Lopez / Epis, Francesco / Pappalardo, Federico / Pedrazzini, Giovanna / Munch, Christopher / Margari, Vito / Grazioli, Lorenzo / Lorini, Ferdinando Luca / Cattaneo, Sergio / Montisci, Andrea / Ballotta, Andrea / Raffa, Giuseppe Maria / Carboni, Pietro /
    Lucchelli, Matteo / Avalli, Leonello / Babuin, Luciano / Belliato, Mirko / Bertini, Pietro / Guarracino, Fabio / Paternoster, Gianluca / Ajello, Valentina / Catena, Emanuele / Scolletta, Sabino / Franchi, Federico / Musazzi, Andrea / Pacini, Davide / Sangalli, Fabio / Attisani, Matteo / Rinaldi, Mauro / Grasselli, Giacomo / Mondino, Michele / Ranucci, Marco / Lorusso, Roberto

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2023  Volume 70, Issue 4, Page(s) e57–e60

    MeSH term(s) Humans ; Heart Failure/surgery ; Shock, Cardiogenic ; Heart Ventricles
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000002113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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