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  1. Article: Genome editing of human embryos for research purposes: Japanese lay and expert attitudes.

    Akatsuka, Kyoko / Hatta, Taichi / Sawai, Tsutomu / Fujita, Misao

    Frontiers in genetics

    2023  Volume 14, Page(s) 1205067

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1205067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Human genome editing in clinical applications: Japanese lay and expert attitudes.

    Sawai, Tsutomu / Hatta, Taichi / Akatsuka, Kyoko / Fujita, Misao

    Frontiers in genetics

    2023  Volume 14, Page(s) 1205092

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1205092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is epigenome editing non-inheritable? Implications for ethics and the regulation of human applications.

    Sasaki-Honda, Mitsuru / Akatsuka, Kyoko / Sawai, Tsutomu

    Stem cell reports

    2023  Volume 18, Issue 11, Page(s) 2005–2009

    Abstract: Epigenome editing offers ethical advantages with non-inheritable gene expression control. However, concerns arise regarding potential transgenerational effects in humans. Ethical and regulatory evaluation is crucial, considering recent advancements and ... ...

    Abstract Epigenome editing offers ethical advantages with non-inheritable gene expression control. However, concerns arise regarding potential transgenerational effects in humans. Ethical and regulatory evaluation is crucial, considering recent advancements and enhanced understanding of transgenerational epigenetics in both mammals and humans.
    MeSH term(s) Animals ; Humans ; Epigenome ; Epigenesis, Genetic ; Epigenomics ; Gene Editing ; CRISPR-Cas Systems ; Mammals/genetics
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2023.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The regulation of human blastoid research: A bioethical discussion of the limits of regulation.

    Sawai, Tsutomu / Akatsuka, Kyoko / Okui, Go / Minakawa, Tomohiro

    EMBO reports

    2022  Volume 23, Issue 10, Page(s) e56045

    Abstract: The creation of human blastoids holds great potential for research on early human development but also raises considerations about the ethics of such research and its regulation. ...

    Abstract The creation of human blastoids holds great potential for research on early human development but also raises considerations about the ethics of such research and its regulation.
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202256045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 41: Show issues

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  5. Article ; Online: Promises and rules: The implications of rethinking the 14-day rule for research on human embryos.

    Sawai, Tsutomu / Okui, Go / Akatsuka, Kyoko / Minakawa, Tomohiro

    EMBO reports

    2021  Volume 22, Issue 9, Page(s) e53726

    Abstract: Removing the 14-day limit for research on human embryos without public deliberation could jeopardize public trust in and support of research on human development. ...

    Abstract Removing the 14-day limit for research on human embryos without public deliberation could jeopardize public trust in and support of research on human development.
    MeSH term(s) Embryo, Mammalian ; Humans ; Trust
    Language English
    Publishing date 2021-08-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202153726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 41: Show issues

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  6. Article: Public attitudes in Japan toward the creation and use of gametes derived from human-induced pluripotent stem cells.

    Sawai, Tsutomu / Hatta, Taichi / Akatsuka, Kyoko / Fujita, Misao

    Future science OA

    2021  Volume 7, Issue 10, Page(s) FSO755

    Abstract: Aim: To ascertain to what extent the Japanese general public accept the creation and use of : Materials & methods: We conducted an online survey and obtained answers from 3096 respondents.: Results: 78.6% of the respondents answered that they ... ...

    Abstract Aim: To ascertain to what extent the Japanese general public accept the creation and use of
    Materials & methods: We conducted an online survey and obtained answers from 3096 respondents.
    Results: 78.6% of the respondents answered that they would accept the creation and use of IVD-gametes for research purposes, 51.7% answered that they would accept the creation and use of embryos with IVD-gametes for research purposes, and 25.9% answered that they would accept childbirth using embryos with IVD-gametes.
    Discussion: The results that approximately half of the respondents answered that they would accept the creation of embryos with IVD-gametes, which has not been allowed in the current Japanese research guidelines, is astonishing.
    Language English
    Publishing date 2021-10-22
    Publishing country England
    Document type Journal Article
    ISSN 2056-5623
    ISSN 2056-5623
    DOI 10.2144/fsoa-2021-0066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Public attitudes in Japan toward the reproductive use of gametes derived from human-induced pluripotent stem cells.

    Akatsuka, Kyoko / Hatta, Taichi / Sawai, Tsutomu / Fujita, Misao

    Future science OA

    2021  Volume 7, Issue 10, Page(s) FSO754

    Abstract: Purpose: To investigate the interests of the Japanese general public in the reproductive use of : Methods: We conducted an online survey and obtained answers from 3096 respondents.: Results: More than half of the respondents agreed with the ... ...

    Abstract Purpose: To investigate the interests of the Japanese general public in the reproductive use of
    Methods: We conducted an online survey and obtained answers from 3096 respondents.
    Results: More than half of the respondents agreed with the reproductive use of IVD-gametes by infertile heterosexual married couples but disagreed with the same use by unmarried or homosexual individuals. Nearly 70.0% disagreed with the use for designing a baby.
    Discussion: In Japan at present, the use of IVD-gametes that deviate from societal values regarding reproduction and family prescribed by the conventional marriage system is unlikely to be accepted. It is also unlikely to be accepted for non-treatment purposes in reproduction.
    Language English
    Publishing date 2021-10-22
    Publishing country England
    Document type Journal Article
    ISSN 2056-5623
    ISSN 2056-5623
    DOI 10.2144/fsoa-2021-0065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ethical Framework for Next-Generation Genome and Epigenome Editing.

    Akatsuka, Kyoko / Sasaki-Honda, Mitsuru / Sawai, Tsutomu

    The American journal of bioethics : AJOB

    2020  Volume 20, Issue 8, Page(s) 32–36

    MeSH term(s) CRISPR-Cas Systems ; Epigenome ; Gene Editing
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2020.1782524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6814: Show issues Location:
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  9. Article ; Online: The moral status of human embryo-like structures: potentiality matters?: The moral status of human synthetic embryos.

    Sawai, Tsutomu / Minakawa, Tomohiro / Pugh, Jonathan / Akatsuka, Kyoko / Yamashita, Jun K / Fujita, Misao

    EMBO reports

    2020  Volume 21, Issue 8, Page(s) e50984

    Abstract: New techniques to generate and culture embryo-like structures from stem cells require a more fine-grained distinction of potential to define the moral status of these structures. ...

    Abstract New techniques to generate and culture embryo-like structures from stem cells require a more fine-grained distinction of potential to define the moral status of these structures.
    MeSH term(s) Beginning of Human Life ; Embryo Research ; Embryo, Mammalian ; Humans ; Moral Obligations ; Moral Status
    Language English
    Publishing date 2020-07-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202050984
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 41: Show issues

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