Artikel ; Online: In-silico
Anti-cancer agents in medicinal chemistry
2023 Band 23, Heft 12, Seite(n) 1388–1396
Abstract: Background: Breast cancer is characterized by uncontrolled cell growth in the breast tissue and is a leading cause of death globally. Cytotoxic effects and reduced efficacy of currently used therapeutics insist to look for new chemo-preventive ... ...
| Abstract | Background: Breast cancer is characterized by uncontrolled cell growth in the breast tissue and is a leading cause of death globally. Cytotoxic effects and reduced efficacy of currently used therapeutics insist to look for new chemo-preventive strategies against breast cancer. Objective: The utilization of drug-likeness filters and molecular simulation has helped evaluate the pharmacological activity and binding abilities of selected drug candidates to the target proteins in many cancer studies. Methods: The current Results: Among the three honokiol derivatives, ligand-protein binding energy of 3' formylhonokiol with Conclusion: It was further established that 3'- formylhonokiol displays an excellent profile of distribution, metabolism, and absorption, indicating it is an anticipated future drug candidate. |
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| Mesh-Begriff(e) | Humans ; Female ; Breast Neoplasms/pathology ; Molecular Docking Simulation ; Protein Serine-Threonine Kinases/metabolism ; Biphenyl Compounds/pharmacology ; Molecular Dynamics Simulation | |||||
| Chemische Substanzen | honokiol (11513CCO0N) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Biphenyl Compounds | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2023-04-03 | |||||
| Erscheinungsland | Netherlands | |||||
| Dokumenttyp | Journal Article | |||||
| ZDB-ID | 2217610-X | |||||
| ISSN | 1875-5992 ; 1871-5206 | |||||
| ISSN (online) | 1875-5992 | |||||
| ISSN | 1871-5206 | |||||
| DOI | 10.2174/1871520623666230330083630 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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