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  1. Article ; Online: Evaluation of the anti-diarrheal effects of the whole plant extracts of

    Muhammad, Naveed / Ullah, Sana / Rauf, Abdur / Atif, Muhammad / Patel, Seema / Israr, Muhammad / Akbar, Sajid / Shehzad, Omer / Saeed, Muhammad / Bawazeer, Saud / Uddin, Md Sahab / Derkho, Marina / Shariati, Mohammad Ali / Mubarak, Mohammad S

    Toxicology reports

    2021  Volume 8, Page(s) 395–404

    Abstract: Background: Cuscuta reflexa: Methods: The antidiarrheal effect of : Results: In addition to cisplatin-induced diarrhea, all paradigms tested gave significant results (: Conclusions: Taken all together, results from this study reveal that the ... ...

    Abstract Background: Cuscuta reflexa
    Methods: The antidiarrheal effect of
    Results: In addition to cisplatin-induced diarrhea, all paradigms tested gave significant results (
    Conclusions: Taken all together, results from this study reveal that the juice, aqueous, and methanol extract of
    Language English
    Publishing date 2021-02-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2021.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Evaluation of the anti-diarrheal effects of the whole plant extracts of Cuscuta reflexa Roxb in pigeons

    Muhammad, Naveed / Ullah, Sana / Rauf, Abdur / Atif, Muhammad / Patel, Seema / Israr, Muhammad / Akbar, Sajid / Shehzad, Omer / Saeed, Muhammad / Bawazeer, Saud / Uddin, Md. Sahab / Derkho, Marina / Shariati, Mohammad Ali / Mubarak, Mohammad S

    Toxicology reports. 2021, v. 8

    2021  

    Abstract: Cuscuta reflexa (dodder) belonging to the family Convolvulaceae has many ethno-medicinal uses such as antidiarrheal and antiemetic. This plant has been employed to treat diarrhea, where the antidiarrheal use of this plant is well established in different ...

    Abstract Cuscuta reflexa (dodder) belonging to the family Convolvulaceae has many ethno-medicinal uses such as antidiarrheal and antiemetic. This plant has been employed to treat diarrhea, where the antidiarrheal use of this plant is well established in different communities around the world without scientific bases. In addition, the antibacterial, anthelmintic, anticholinergic, and antihistaminic effects of this parasitic vine are partly responsible for the folkloric antidiarrheal use of this plant. In the present study, the antidiarrheal activity of C. reflexa was evaluated in pigeons (Columba livia) using the juice (JCR), aqueous (CRAE), and methanol (CRME) extracts.The antidiarrheal effect of C. reflexa was evaluated using different reported research models, with few modifications. In pigeons, diarrhea was induced by administration of castor oil (6 mL/kg, PO), ampicillin (250 mg/kg, IP), magnesium sulfate (2 gm/kg, PO), and cisplatin (6 mg/kg, IV). In these experiments, loperamide (2 mg/kg, IM) was used as a positive control, whereas JCR (1 mL/kg (1%) and 1 mL/kg (2%), CRAE (50, 100 and 200 mg/kg) and CRME (50, 100 and 200 mg/kg) were administered intramuscularly at different doses into each pigeon in the test groups.In addition to cisplatin-induced diarrhea, all paradigms tested gave significant results (P < 0.01). The JCR, at different doses, exhibited a significant (p < 0.01) a dose-dependent antidiarrheal effect on both the frequency and the onset of diarrhea. Similarly, CRAE and CRME, at doses of 100 and 200 mg/kg, showed considerable (p < 0.001) inhibition against the onset and frequency of diarrhea. On the other hand, JCR, CRAE, and CRME exerted significant effects (p < 0.001) on the percentage inhibition (PI) of diarrhea and gastrointestinal charcoal transit in a dose-dependent manner. In this respect, the maximum PI (p < 0.01) of JCR, CRAE, and CRME in different experimental paradigms was 43.13, 49.14, and 55.99 %, respectively.Taken all together, results from this study reveal that the juice, aqueous, and methanol extract of C. reflexa exhibit significant anti-motility and anti-secretory potential. These findings may explain the medicinal use of C. reflexa in folk medicine as an antidiarrheal medicinal plant.
    Keywords Columba livia ; Cuscuta reflexa ; ampicillin ; anthelmintics ; antidiarrheal effect ; antiemetics ; castor oil ; charcoal ; cisplatin ; diarrhea ; dose response ; gastrointestinal system ; juices ; magnesium sulfate ; medicinal plants ; methanol ; pigeons ; toxicology ; traditional medicine ; vines
    Language English
    Size p. 395-404.
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-light
    ZDB-ID 2805786-7
    ISSN 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2021.02.013
    Database NAL-Catalogue (AGRICOLA)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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