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  1. Article ; Online: Potential role of FKBP5 single-nucleotide polymorphisms in functional seizures.

    Asadi-Pooya, Ali A / Simani, Leila / Asadollahi, Marjan / Rashidi, Fatemeh Sadat / Ahmadipour, Ehsan / Alavi, Afagh / Roozbeh, Mehrdad / Akbari, Nayyereh / Firouzabadi, Negar

    Epilepsia open

    2023  Volume 8, Issue 2, Page(s) 479–486

    Abstract: Objective: We investigated the associations between FKBP5 single-nucleotide polymorphisms (SNPs) and functional seizures (FS).: Methods: Seventy patients with FS, 140 with major depressive disorder (MDD), and 140 healthy controls were studied. Their ... ...

    Abstract Objective: We investigated the associations between FKBP5 single-nucleotide polymorphisms (SNPs) and functional seizures (FS).
    Methods: Seventy patients with FS, 140 with major depressive disorder (MDD), and 140 healthy controls were studied. Their DNAs were analyzed for the rs1360780 in the 3' region and rs9470080 in the 5' region of the FKBP5. Childhood trauma questionnaire and hospital anxiety and depression scale were used.
    Results: Patients with FS and those with MDD had less GG and more AA genotypes in both rs9470080 and rs1360780 SNPs compared with those in healthy controls. Similar results were observed for allelic frequencies. There were no significant differences between FS and MDD groups in terms of genotype and allelic frequencies for both SNPs. The results of multinomial logistic regression analysis showed that FKBP5 polymorphisms were not associated with the diagnosis.
    Significance: Patients with FS and those with MDD had significantly different genotypes in both rs9470080 and rs1360780 SNPs compared with those in healthy controls. However, it seems that FKBP5 polymorphisms were not associated with FS in the absence of depression. Further genetic investigations of patients with FS may increase our understanding of the neurobiological underpinnings of this condition, but such studies should be large enough and very well designed; they should include a comparison group with depression in addition to a healthy control group.
    MeSH term(s) Humans ; Depressive Disorder, Major/genetics ; Polymorphism, Single Nucleotide/genetics ; Genotype ; Seizures/genetics
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of microRNAs in the pathophysiology of human central nervous system: A focus on neurodegenerative diseases.

    Rezaee, Delsuz / Saadatpour, Fatemeh / Akbari, Nayyereh / Zoghi, Anahita / Najafi, Sajad / Beyranvand, Parisa / Zamani-Rarani, Fahimeh / Rashidi, Mohammad Amin / Bagheri-Mohammadi, Saeid / Bakhtiari, Mohammad

    Ageing research reviews

    2023  Volume 92, Page(s) 102090

    Abstract: microRNAs (miRNAs) are suggested to play substantial roles in regulating the development and various physiologic functions of the central nervous system (CNS). These include neurogenesis, cell fate and differentiation, morphogenesis, formation of ... ...

    Abstract microRNAs (miRNAs) are suggested to play substantial roles in regulating the development and various physiologic functions of the central nervous system (CNS). These include neurogenesis, cell fate and differentiation, morphogenesis, formation of dendrites, and targeting non-neural mRNAs. Notably, deregulation of an increasing number of miRNAs is associated with several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis and CNS tumors. They are particularly known to affect the amyloid β (Aβ) cleavage and accumulation, tau protein homeostasis, and expression of alpha-synuclein (α-syn), Parkin, PINK1, and brain-derived neurotrophic factor (BDNF) that play pivotal roles in the pathogenesis of neurodegenerative diseases. These include miR-16, miR-17-5p, miR-20a, miR-106a, miR-106b, miR-15a, miR-15b, miR-103, miR-107, miR-298, miR-328, miR-195, miR-485, and miR-29. In CNS tumors, several miRNAs, including miR-31, miR-16, and miR-21 have been identified to modulate tumorigenesis through impacting tumor invasion and apoptosis. In this review article, we have a look at the recent advances on our knowledge about the role of miRNAs in human brain development and functions, neurodegenerative diseases, and their clinical potentials.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neurodegenerative Diseases/metabolism ; Amyloid beta-Peptides ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Central Nervous System/metabolism ; Neoplasms
    Chemical Substances MicroRNAs ; Amyloid beta-Peptides ; MIRN298 microRNA, human ; MIRN485 microRNA, human
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2023.102090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Migraine and gastric disorders: Are they associated?

    Hormati, Ahmad / Akbari, Nayyereh / Sharifipour, Ehsan / Hejazi, Seyyed Amir / Jafari, Fatemeh / Alemi, Faezeh / Mohammadbeigi, Abolfaz

    Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

    2019  Volume 24, Page(s) 60

    Abstract: Background: Migraine is a common disorder which affects quality of life. There has been an increasing interest for discovering the association of gastrointestinal (GI) disorders with migraine during past years. This study aims to evaluate the ... ...

    Abstract Background: Migraine is a common disorder which affects quality of life. There has been an increasing interest for discovering the association of gastrointestinal (GI) disorders with migraine during past years. This study aims to evaluate the association of
    Materials and methods: In this observational cross-sectional study, 341 dyspeptic patients who underwent upper GI endoscopy in Shahid Beheshti Hospital, Qom, Iran, included during 2016-2018. A checklist was used for collecting demographics, symptoms, and results from endoscopy and
    Results: Among 341 patients, 141 (% 41.3) were male and 200 (58.7%) were female. 149 (43.7%) patients were diagnosed with migraine, from which 48 (32.2%) were male and 101 (67.8%) were female. The observed difference in migraine prevalence among male and female was statistically significant (
    Conclusion: Migraine might be associated with GERD,
    Language English
    Publishing date 2019-07-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 2513029-8
    ISSN 1735-7136 ; 1735-1995
    ISSN (online) 1735-7136
    ISSN 1735-1995
    DOI 10.4103/jrms.JRMS_464_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6810: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Article ; Online: Myasthenia gravis development and crisis subsequent to multiple sclerosis.

    Gharagozli, Kurosh / Shojaei, Maziar / Harandi, Ali Amini / Akbari, Nayyereh / Ilkhani, Manouchehr

    Case reports in medicine

    2011  Volume 2011, Page(s) 291731

    Abstract: During the last decade, sporadic combination of multiple sclerosis (MS) and myasthenia gravis (MG) has been reported repeatedly. Although these are anecdotal, they are important enough to raise concerns about co-occurrence of MG and MS. Here, we present ... ...

    Abstract During the last decade, sporadic combination of multiple sclerosis (MS) and myasthenia gravis (MG) has been reported repeatedly. Although these are anecdotal, they are important enough to raise concerns about co-occurrence of MG and MS. Here, we present a case of an MS patient who developed an MG crisis. She had received interferon for relapsing remitting MS. Interestingly, she developed an MG crisis 4 years after the diagnosis of MS. MS and MG have relatively the same distribution for age, corresponding to the younger peak of the bimodal age distribution in MG. They also share some HLA typing characteristics. Furthermore, some evidences support the role of systemic immune dysregulation due to a genetic susceptibility that is common to these two diseases. The association may be underdiagnosed because of the possible overlap of symptoms especially bulbar manifestations in which either MG or MS can mimic each other, leading to underestimating incidence of the combination. The evidence warrants physicians, especially neurologists, to always consider the possibility of the other disease when encountering any patients either with MS or MG. Anecdotal and sporadic reports of combination of multiple sclerosis (MS) and myasthenia gravis (MG) have been raised concerns about co-occurrence of them.
    Language English
    Publishing date 2011-05-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2502642-2
    ISSN 1687-9635 ; 1687-9627
    ISSN (online) 1687-9635
    ISSN 1687-9627
    DOI 10.1155/2011/291731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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