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  1. Article: Autophagy and Cancer Dormancy.

    Akkoc, Yunus / Peker, Nesibe / Akcay, Arzu / Gozuacik, Devrim

    Frontiers in oncology

    2021  Volume 11, Page(s) 627023

    Abstract: Metastasis and relapse account for the great majority of cancer-related deaths. Most metastatic lesions are micro metastases that have the capacity to remain in a non-dividing state called "dormancy" for months or even years. Commonly used anticancer ... ...

    Abstract Metastasis and relapse account for the great majority of cancer-related deaths. Most metastatic lesions are micro metastases that have the capacity to remain in a non-dividing state called "dormancy" for months or even years. Commonly used anticancer drugs generally target actively dividing cancer cells. Therefore, cancer cells that remain in a dormant state evade conventional therapies and contribute to cancer recurrence. Cellular and molecular mechanisms of cancer dormancy are not fully understood. Recent studies indicate that a major cellular stress response mechanism, autophagy, plays an important role in the adaptation, survival and reactivation of dormant cells. In this review article, we will summarize accumulating knowledge about cellular and molecular mechanisms of cancer dormancy, and discuss the role and importance of autophagy in this context.
    Language English
    Publishing date 2021-03-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.627023
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  2. Article ; Online: Fatal disseminated Magnusiomyces clavatus infection with rash in pediatric acute lymphoblastic leukemia: A case report.

    Akıncı, Burcu / Atay, Didem / Yenigürbüz, Fatma Demir / Akçay, Arzu / Akar, Oğuz / Öztürk, Gülyüz

    Diagnostic microbiology and infectious disease

    2023  Volume 108, Issue 2, Page(s) 116148

    Abstract: Magnusiomyces clavatus is a rare yeast-like fungus that can cause opportunistic infections in immunocompromised patients. Here, we present a 14-year-old patient who was followed up with the diagnosis of acute lymphoblastic leukemia, developed skin rashes, ...

    Abstract Magnusiomyces clavatus is a rare yeast-like fungus that can cause opportunistic infections in immunocompromised patients. Here, we present a 14-year-old patient who was followed up with the diagnosis of acute lymphoblastic leukemia, developed skin rashes, and Magnusiomyces clavatus infection detected. The patient died shortly after the infection was diagnosed.
    MeSH term(s) Child ; Humans ; Adolescent ; Saccharomycetales ; Fungi ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Exanthema/etiology
    Language English
    Publishing date 2023-11-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2023.116148
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    Zs.A 1845: Show issues Location:
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  3. Article ; Online: Respiratory Viral Infections in the Pediatric Hematopoietic Stem Cell Transplant Population: Progression to Lower Respiratory Tract Disease.

    Demir Yenigurbuz, Fatma / Atay, Didem / Akinci, Burcu / Akcay, Arzu / Ozturk, Gulyuz

    Journal of pediatric hematology/oncology

    2022  Volume 45, Issue 1, Page(s) e75–e81

    Abstract: Background: Respiratory viral infections (RVIs) are important complications in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT); however, risk factors for lower respiratory tract infections (LRTIs) are not well characterized. ...

    Abstract Background: Respiratory viral infections (RVIs) are important complications in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT); however, risk factors for lower respiratory tract infections (LRTIs) are not well characterized. The aim of this study was to determine risk factors for the progression to LRTIs in pediatric patients with respiratory symptoms who underwent HSCT.
    Patients and methods: This retrospective study included 87 pediatric patients with respiratory symptoms who underwent HSCT. Respiratory viral polymerase chain reaction samples were obtained from all patients. The evaluated data included risk factors to progression to LRTIs, long-term pulmonary complications, transplantation-related mortality, and overall survival.
    Results: Viral pathogens were detected in 31 (48.4%) patients with upper respiratory tract infections and 13 (56.5%) patients with LRTIs. There was a statistically significant difference between the groups in engraftment delay and lymphocytopenia. Also it was determined that engraftment delay (odds ratio: 7.46 [95% CI, 1.99 to 27.86]; P = 0.003) and COVID-19 infection had statistically significant effects on overall survival in general (odds ratio: 8.06 [95% CI, 2.63 to 24.64]; P <0.001]).
    Conclusion: Not only host and transplant-related factors but also viral agent type were found to be effective in progression to LRTIs. As the available therapy for respiratory viral infections remains limited, the focus should be on the prevention of infection.
    MeSH term(s) Humans ; Child ; Retrospective Studies ; COVID-19 ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/etiology ; Respiratory Tract Infections/diagnosis ; Hematopoietic Stem Cell Transplantation/adverse effects ; Risk Factors
    Language English
    Publishing date 2022-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002525
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    Zs.A 1537: Show issues Location:
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  4. Article ; Online: Therapeutic Plasma Exchange in Pediatric Patients With Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease After Hematopoietic Stem Cell Transplantation: A Single-Center Experience.

    Akıncı, Burcu / Atay, Didem / Demir Yenigürbüz, Fatma / Akçay, Arzu / Öztürk, Gülyüz

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2022  Volume 20, Issue 7, Page(s) 680–686

    Abstract: Objectives: Sinusoidal obstruction syndrome/venoocclusive disease is a significant complication of hematopoietic stem cell transplantation. Due to high mortality rates, new treatment strategies have been investigated. Here, we have presented outcomes of ...

    Abstract Objectives: Sinusoidal obstruction syndrome/venoocclusive disease is a significant complication of hematopoietic stem cell transplantation. Due to high mortality rates, new treatment strategies have been investigated. Here, we have presented outcomes of therapeutic plasma exchange performed on patients with sinusoidal obstruction syndrome/veno-occlusive disease.
    Material and methods: Our study included 70 pediatric patients diagnosed with sinusoidal obstruction syndrome/veno-occlusive disease. Therapeutic plasma exchange procedures in patients were evaluated retrospectively.
    Results: There were 9 mild (12.9%), 9 moderate (12.9%), 21 severe (30%), and 31 very severe (44.2%) cases of sinusoidal obstruction syndrome/venoocclusive disease. Therapeutic plasma exchange was performed in 31 of the 70 study patients (59.6%). Moreover, 10/21 patients with severe (47.6%) and 21/31 patients with very severe (67.7%) disease underwent plasma exchange. Mean time from diagnosis of sinusoidal obstruction syndrome/venoocclusive disease to therapeutic plasma exchange initiation was 2.3 days. The 31 patients who received therapeutic plasma exchange had a total of 146 sessions. Overall survival rates at 100 days were 87.1% and 92.3% for patients who did and did not undergo therapeutic plasma exchange, respectively. When patients with mild and moderate disease who were not expected to undergo plasma exchange were excluded (n = 52), 100-day overall survival rates were 87.1% and 90.5% for those who did and did not undergo plasma exchange, respectively. When we compared severe versus very severe groups, no significant difference was found.
    Conclusions: Plasmapheresis had no positive effect on survival. However, overall survival in all groups was higher than that in the literature, despite the high number of patients with severe and very severe disease. Interpretation of the results is limited by the retrospective nature of the study. Thus, prospective, randomized controlled trials with larger numbers of patients are necessary to investigate the role of therapeutic plasma exchange in patients with sinusoidal obstruction syndrome/veno-occlusive disease.
    MeSH term(s) Child ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hepatic Veno-Occlusive Disease/diagnosis ; Hepatic Veno-Occlusive Disease/etiology ; Hepatic Veno-Occlusive Disease/therapy ; Humans ; Plasma Exchange/adverse effects ; Plasmapheresis/adverse effects ; Prospective Studies ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2022-05-23
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2021.0475
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    Zs.A 6632: Show issues Location:
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  5. Article ; Online: Left ventricular assist device implantation following multisystem inflammatory syndrome in children due to SARS-CoV-2.

    Konukoglu, Oguz / Dogan, Ali / Sever, Kenan / Akcay, Arzu / Balkanay, Mehmet / Mansuroglu, Denyan

    Journal of cardiac surgery

    2022  Volume 37, Issue 11, Page(s) 3947–3950

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) is rare, however, severe hyperinflammatory condition in children generally weeks after acute SARS-CoV-2 infection. A subset of MIS-C patients is presented with severe heart failure. We hereby report 8- ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C) is rare, however, severe hyperinflammatory condition in children generally weeks after acute SARS-CoV-2 infection. A subset of MIS-C patients is presented with severe heart failure. We hereby report 8-year-old girl presenting acute severe left ventricular failure. Various medical treatments including inotropic agents and drugs related to SARS-CoV-2 infection and MIS-C were applied. However, venoarterial extracorporeal membrane oxygenation (ECMO) was needed to be performed. Due to unsuccessful attempts for ECMO weaning, left ventricular assist device was implanted to the patient with temporary right ventricular support from ECMO.
    MeSH term(s) COVID-19/complications ; Child ; Female ; Heart Failure/etiology ; Heart Failure/therapy ; Heart-Assist Devices ; Humans ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/etiology ; Systemic Inflammatory Response Syndrome/therapy
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.16821
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    Zs.A 2221: Show issues Location:
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  6. Article ; Online: From Death to Life/Back to the Future: Detailed Premorbid Clinical and Family History Can Save Lives and Address the Final Diagnosis in Sudden Unexplained Deaths With Negative Autopsy.

    Turkgenc, Burcu / Baydar, Cetin L / Deniz, Idris / Akcay, Arzu / Ergoren, Mahmut Cerkez / Sag, Sebnem Ozemrı / Yakicier, Mustafa C / Temel, Sehime G

    Applied immunohistochemistry & molecular morphology : AIMM

    2023  Volume 31, Issue 10, Page(s) 690–696

    Abstract: Sudden cardiac death is a sudden, unexpected death developed by one of the many different causes of cardiac arrest that occur within 1 hour of the onset of new symptoms. Sudden unexplained death (SUD) comprises a normal heart at postmortem examination ... ...

    Abstract Sudden cardiac death is a sudden, unexpected death developed by one of the many different causes of cardiac arrest that occur within 1 hour of the onset of new symptoms. Sudden unexplained death (SUD) comprises a normal heart at postmortem examination and negative toxicological analysis. SUD often arises from cardiac genetic disease, particularly channelopathies. Channelopathies, or inherited arrhythmia syndromes, are a group of disorders characterized by an increased risk of sudden cardiac death, abnormal cardiac electrical function, and, typically, a structurally normal heart. They share an underlying genetic etiology where disease-causing genetic variants may lead to the absence or dysfunction of proteins involved in the generation and propagation of the cardiac action potential. Our study aimed to evaluate the importance of next-generation sequencing in the postmortem investigations of SUD cases. In this study, 5 forensic SUD cases were investigated for inherited cardiac disorders. We screened a total of 68 cardiac genes for the sibling of case 1, as well as case 2, and 51 genes for cases 3, 4, and 5. Of the 12 variants identified, 2 likely pathogenic variants (16.7%) were the TMEM43 _ c.1000+2T>C splice site mutation and the SCN5A _ p.W703X nonsense mutation. The remaining 10 variants of uncertain significance were detected in the TRPM4 , RANGRF , A KAP9 , KCND3 , KCNE1 , DSG2 , CASQ1 , and SNTA1 genes. Irrespective of genetic testing, all SUD families require detailed clinical testing to identify relatives who may be at risk. Molecular autopsy and detailed premorbid clinical and family histories can survive family members of SUD cases.
    MeSH term(s) Humans ; Autopsy ; Channelopathies/diagnosis ; Channelopathies/genetics ; Channelopathies/complications ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/pathology ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/complications ; Mutation
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1473273-7
    ISSN 1533-4058 ; 1062-3345 ; 1541-2016
    ISSN (online) 1533-4058
    ISSN 1062-3345 ; 1541-2016
    DOI 10.1097/PAI.0000000000001163
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    Zs.A 3783: Show issues Location:
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  7. Article ; Online: Extremity Necrosis Due to Intrauterine Arterial Ischemia

    Beken, Serdar / Sarıyılmaz, Kerim / Albayrak, Eda / Akçay, Arzu / Korkmaz, Ayşe

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2020  Volume 38, Issue 3, Page(s) 222–223

    MeSH term(s) Extremities/pathology ; Female ; Humans ; Infant, Newborn ; Ischemia/complications ; Necrosis ; Pregnancy ; Prenatal Exposure Delayed Effects
    Language English
    Publishing date 2020-10-15
    Publishing country Turkey
    Document type Case Reports
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.4274/tjh.galenos.2020.2020.0530
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    Zs.A 6534: Show issues Location:
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  8. Article ; Online: The Impact of Panel Reactive Antibodies and Different Desensitization Methods on Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Outcomes.

    Akinci, Burcu / Akçay, Arzu / Demir Yenigürbüz, Fatma / Atay, Didem / Öztürk, Gülyüz

    Journal of pediatric hematology/oncology

    2021  Volume 44, Issue 3, Page(s) e689–e694

    Abstract: Introduction: In highly sensitized patients who have panel reactive antibodies (PRAs) before hematopoietic stem cell transplantation, primary graft failure risk may increase. In this study, we aimed to determine the association of PRA with engraftment, ... ...

    Abstract Introduction: In highly sensitized patients who have panel reactive antibodies (PRAs) before hematopoietic stem cell transplantation, primary graft failure risk may increase. In this study, we aimed to determine the association of PRA with engraftment, and graft versus host disease (GVHD) in pediatric patients.
    Materials and methods: Forty-three PRA-positive and 42 PRA-negative patients were taken into study. Both groups were compared in terms of graft failure, acute GVHD, viral infection and survival rates. PRA-positive group was also divided into 2 according to treatment modality (steroid-only group/combination therapy) and compared for the same parameters.
    Results: There was no difference in PRA-positive and negative patients in terms of graft failure, acute GVHD and viral infections. Analysis of the PRA-positive group in itself showed that there was also no difference in terms of graft failure and viral infection frequency. The only difference is that acute grade 3 to 4 GVHD was higher in the steroid-only group. The 100-day overall survival was 90.2% and 90.4% for the PRA-positive and negative groups, respectively.
    Conclusions: Different treatment strategies like plasmapheresis, steroid, rituximab, or combination therapies can be used for the desensitization of PRA-positive patients before hematopoietic stem cell transplantation. Patient-specific treatment modality for sensitized patients before transplant can increase the success rate.
    MeSH term(s) Child ; Graft Rejection/prevention & control ; Graft Survival ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; HLA Antigens ; Hematopoietic Stem Cell Transplantation ; Histocompatibility Testing ; Humans
    Chemical Substances HLA Antigens
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002357
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    Zs.A 1537: Show issues Location:
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  9. Article ; Online: Co-transplantation of mesenchymal stromal cell and haploidentical hematopoietic stem cell with TCR αβ depletion in children with primary immunodeficiency syndromes.

    Atay, Didem / Akcay, Arzu / Akinci, Burcu / Yenigurbuz, Fatma Demir / Ovali, Ercument / Ozturk, Gulyuz

    Pediatric transplantation

    2021  Volume 25, Issue 8, Page(s) e14120

    Abstract: Background: Haploidentical HSCT is a good option for children with PIDs lacking an HLA-matched donor. Co-transplantation of MSCs during haploidentical HSCT in patients with PIDs may enhance engraftment, decrease the risk of GVHD, and ensure stable donor ...

    Abstract Background: Haploidentical HSCT is a good option for children with PIDs lacking an HLA-matched donor. Co-transplantation of MSCs during haploidentical HSCT in patients with PIDs may enhance engraftment, decrease the risk of GVHD, and ensure stable donor chimerism.
    Methods: Twenty-seven pediatric patients (median age, 1.4 years; range, .3-10.9) with PIDs undergoing thirty haploidentical HSCT with TCR αβ depletion and co-transplantation of MSCs were enrolled to study. Most patients (73.3%) received myeloablative conditioning consisting of treosulfan or busulfan, fludarabine, and thiotepa. The median duration of follow-up was 14.3 months (range, 1-69 months).
    Results: Acute GVHD occurred in 7 patients (grade I-II n = 5, grade III-IV n = 2). Chronic GVHD was observed in only one patient. Twenty-one patients (70.2%) had 100% donor chimerism in all cell lines including T-cell and B-cell lineages. Primary graft failure was observed in 7 patients (25.9%). The cumulative incidences of TRM were 20% at day 100, and 26.7% at one year and five years. Probabilities of OS were 80% at day 100, and 71.9% at 1 year and 5 years. Infants transplanted younger than 6 months of age had the highest 5-year survival rate (85.7%).
    Conclusion: We conclude that use of TCR αβ depleted haploidentical transplantation with MSCs may ensure a rapid engraftment rate, low incidence of significant acute and chronic GVHD, and acceptable post-transplantation morbidity, especially in patients diagnosed with SCID and may be considered in children with PIDs. In younger patients (≤6 months), survival is comparable between HLA-matched graft and CD3+ TCRαβ depleted HLA-mismatched graft recipients.
    MeSH term(s) Child ; Child, Preschool ; Female ; Graft Rejection ; Graft vs Host Disease/prevention & control ; Hematopoietic Stem Cell Transplantation ; Humans ; Infant ; Male ; Mesenchymal Stem Cell Transplantation ; Primary Immunodeficiency Diseases/therapy ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Transplantation Conditioning/methods
    Chemical Substances Receptors, Antigen, T-Cell, alpha-beta
    Language English
    Publishing date 2021-08-19
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14120
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    Zs.A 4947: Show issues Location:
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  10. Article ; Online: The Use of Umbilical Cord-derived Mesenchymal Stem Cells Seeded Fibrin Matrix in the Treatment of Stage IV Acute Graft-Versus-Host Disease Skin Lesions in Pediatric Hematopoietic Stem Cell Transplant Patients.

    Akçay, Arzu / Atay, Didem / Yilanci, Muhammet / Kongur, Merve / Eyüboğlu, Fatma / Öztürk, Gülyüz / Ovali, Ercüment

    Journal of pediatric hematology/oncology

    2020  Volume 43, Issue 3, Page(s) e312–e319

    Abstract: Mesenchymal stem cells (MSCs) have been used systemically or locally in many chronic and nonhealing skin lesions in recent years. In this study, umbilical cord-derived MSCs (UC-MSCs)-seeded fibrin matrix was used as a wound dressing in pediatric patients ...

    Abstract Mesenchymal stem cells (MSCs) have been used systemically or locally in many chronic and nonhealing skin lesions in recent years. In this study, umbilical cord-derived MSCs (UC-MSCs)-seeded fibrin matrix was used as a wound dressing in pediatric patients with stage 4 acute graft-versus-host disease (aGVHD)-induced desquamated skin lesions. This is the first study in which the UC-MSCs-seeded fibrin matrix was used as a wound dressing in aGVHD. A total of 14 times the MSCs-seeded fibrin matrix were applied to 9 patients as a wound dressing. On the seventh day, epithelialization and clinical response were evaluated. According to the size of the skin defect min: 1, max: 6 pieces were applied at a time. After 48 to 72 hours, it was observed that all of the MSCs-seeded fibrin matrixes adhered to the skin and the crustation started in 6 (43%) applications, whereas liquefaction was detected under all of them in 7 (50%) applications. Complete response was obtained in 6 applications (43%), partial response in 1 (7%), and no response in 7 applications (50%). This study showed that the MSCs-seeded fibrin matrix can be used effectively and safely in the matrix in the local treatment of aGVHD-induced skin wounds in pediatric patients.
    MeSH term(s) Adolescent ; Bandages ; Cells, Cultured ; Child ; Child, Preschool ; Female ; Fibrin/chemistry ; Graft vs Host Disease/etiology ; Graft vs Host Disease/pathology ; Graft vs Host Disease/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Infant ; Male ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/cytology ; Prospective Studies ; Skin/pathology ; Tissue Scaffolds/chemistry ; Umbilical Cord/cytology ; Wound Healing
    Chemical Substances Fibrin (9001-31-4)
    Language English
    Publishing date 2020-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000001964
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