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Article ; Online: Epigenetic cues regulating airway development in human lung organoids: Polycomb repressive complex 2 and altered chromatin accessibility determine cell fate.

Shirvaliloo, Milad / Akhavan-Sigari, Reza

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2023 Volume 37, Issue 4, Page(s) e22868

Abstract: Today, human organoids are becoming an integrated part of genomics and epigenomics, as they provide a platform that can be used for the definite study of molecular and cellular mechanisms occurring at different stages of development, particularly ... ...

Abstract	Today, human organoids are becoming an integrated part of genomics and epigenomics, as they provide a platform that can be used for the definite study of molecular and cellular mechanisms occurring at different stages of development, particularly organogenesis, within the human body. Airway development is a complex process heavily influenced by epigenetic regulatory mechanisms in response to environmental changes, and as such, human lung organoids are an indispensable asset for further exploration of these mechanisms as a mode of transition from human in vitro to human ex vivo studies. Cultured primarily in compounds mimicking the extracellular matrix, such as Matrigel, these lung organoids have helped us to come to a better understanding of the role of polycomb repressive complex 2 (PRC2) and enhancer of zeste homolog 2 (EZH2) in lung epithelial cell differentiation and airway development, which was first reported in the FASEB journal in 2019. The following is an extended account of how the histone methylation-regulating PRC2 comes to play in the molding of the human bronchial tree, along with further epigenetic insights based on more recently developed human lung organoids.
MeSH term(s)	Humans ; Polycomb Repressive Complex 2/genetics ; Epigenomics ; Cues ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Cell Differentiation ; Epigenesis, Genetic ; Chromatin/genetics ; Lung/metabolism ; Organoids/metabolism
Chemical Substances	Polycomb Repressive Complex 2 (EC 2.1.1.43) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43) ; Chromatin
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202201666R
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Article ; Online: Dietary carbohydrate quality index (CQI), cardio-metabolic risk factors and insulin resistance among adults with obesity.

Nikrad, Negin / Hosseini, Babak / Pakmehr, Azin / Tousi, Ayda Zahiri / Ardekani, Abnoos Mokhtari / Farhangi, Mahdieh Abbasalizad / Akhavan-Sigari, Reza

BMC endocrine disorders

2023 Volume 23, Issue 1, Page(s) 171

Abstract: Background: Metabolic syndrome (MetS), as a cluster of cardiometabolic risk factors, is a global public health concern due to its increasing prevalence. Considering the previous evidence of the association between carbohydrate quality and ... ...

Abstract	Background: Metabolic syndrome (MetS), as a cluster of cardiometabolic risk factors, is a global public health concern due to its increasing prevalence. Considering the previous evidence of the association between carbohydrate quality and cardiometabolic risk factors, our study was aimed to evaluate any possible association between carbohydrate quality index (CQI) and cardiometabolic risk factors among obese adults. Methods: In this cross-sectional study, 336 apparently healthy individuals with obesity were participated. Dietary intake was assessed by a semi-quantitative Food Frequency Questionnaire (FFQ), including 168 food items validated for the Iranian population. CQI was calculated with three components of solid carbohydrates to total carbohydrates ratio, dietary fiber intake, and dietary glycemic index (GI). Body composition was determined by bioelectrical impedance analysis (BIA). Blood pressure was measured by sphygmomanometer and enzymatic methods were used to evaluate serum lipid, glucose, and insulin concentrations. Results: Subjects in the third quartile of CQI had significantly lower systolic blood pressure (SBP) (P = 0.03) and diastolic blood pressure (DBP) (P = 0.01). Participants in the higher quartiles of CQI had more intake of energy, carbohydrates, fat, saturated fatty acid (SFA), and mono-saturated fatty acid (MUFA) (P < 0.05). Moreover, the homeostasis model assessment of insulin resistance (HOMA-IR) was decreased in the second quartile of CQI [odds ratio (OR) = 0.146, P = 0.01) after adjustment for age, body mass index (BMI), sex, physical activity, socioeconomic status (SES) and energy intake. Conclusion: According to our findings, a higher quality of dietary carbohydrates, determined by CQI, could be associated with a lower risk of hypertension.
MeSH term(s)	Adult ; Humans ; Dietary Carbohydrates/adverse effects ; Insulin Resistance ; Cross-Sectional Studies ; Iran/epidemiology ; Risk Factors ; Obesity/epidemiology
Chemical Substances	Dietary Carbohydrates
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2091323-0
ISSN	1472-6823 ; 1472-6823
ISSN (online)	1472-6823
ISSN	1472-6823
DOI	10.1186/s12902-023-01420-4
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Article ; Online: Hyperbaric oxygen therapy and coenzyme Q10 synergistically attenuates damage progression in spinal cord injury in a rat model.

Ghaemi, Alireza / Ghiasvand, Mohammad / Omraninava, Melody / Merza, Mohammed Yousif / Alkhafaji, Adnan Taan / Raoofi, Amir / Nasiry, Davood / Darvishi, Mohammad / Akhavan-Sigari, Reza

Journal of chemical neuroanatomy

2023 Volume 132, Page(s) 102322

Abstract: Background: Identifying effective spinal cord injury (SCI) treatments remains a major challenge, and current approaches are still unable to effectively improve its. Currently, we investigated the combined effects of hyperbaric oxygen (HBO) along with ... ...

Abstract	Background: Identifying effective spinal cord injury (SCI) treatments remains a major challenge, and current approaches are still unable to effectively improve its. Currently, we investigated the combined effects of hyperbaric oxygen (HBO) along with coenzyme Q10 (CoQ10) in the recovery of SCI in rats. Material and methods: Ninety female mature Sprague-Dawley rats were allocated into five equal groups, including; sham group, SCI group, HBO group (underwent SCI and received HBO), CoQ10 group (underwent SCI and received CoQ10), and HBO+CoQ10 group (underwent SCI and received HBO plus CoQ10). Tissue samples at the lesion site were obtained for evaluation of stereological, immunohistochemical, biochemical, molecular. Also, functional tests were performed to evaluate of behavioral properties. Results: We found that a significant increase in stereological parameters, biochemical factors (GSH, SOD and CAT), IL-10 gene expression and behavioral functions (BBB and EMG Latency) in the treatment groups, especially HBO+CoQ10 group, compared to SCI group. In addition, MDA levels, the density of apoptotic cells, as well as expression of inflammatory genes (TNF-α and IL-1β) were considerably reduced in the treatment groups, especially HBO+CoQ10 group, compared to SCI group. Conclusion: We conclude that co-administration of HBO and HBO+CoQ10 has a synergistic neuroprotective effects in animals undergoing SCI.
MeSH term(s)	Rats ; Female ; Animals ; Hyperbaric Oxygenation ; Rats, Sprague-Dawley ; Spinal Cord Injuries ; Oxygen/metabolism ; Spinal Cord/metabolism
Chemical Substances	coenzyme Q10 (EJ27X76M46) ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-08-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639443-7
ISSN	1873-6300 ; 0891-0618
ISSN (online)	1873-6300
ISSN	0891-0618
DOI	10.1016/j.jchemneu.2023.102322
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Article ; Online: Nivolumab plus ipilimumab combination therapy in cancer: Current evidence to date.

Nikoo, Marzieh / Rabiee, Fatemeh / Mohebbi, Hossein / Eghbalifard, Negar / Rajabi, Hamid / Yazdani, Yalda / Sakhaei, Delaram / Khosravifarsani, Mohammadreza / Akhavan-Sigari, Reza

International immunopharmacology

2023 Volume 117, Page(s) 109881

Abstract: Immune checkpoint inhibitors (ICIs) have revolutionized cancer immunotherapy, yielding significant antitumor responses across multiple cancer types. Combination ICI therapy with anti-CTLA-4 and anti-PD-1 antibodies outperforms either antibody alone in ... ...

Abstract	Immune checkpoint inhibitors (ICIs) have revolutionized cancer immunotherapy, yielding significant antitumor responses across multiple cancer types. Combination ICI therapy with anti-CTLA-4 and anti-PD-1 antibodies outperforms either antibody alone in terms of clinical efficacy. As a consequence, the U.S. Food and Drug Administration (FDA) approved ipilimumab (anti-CTLA-4) plus nivolumab (anti-PD-1) as the first-ever approved therapies for combined ICI in patients with metastatic melanoma. Despite the success of ICIs, treatment with checkpoint inhibitor combinations poses significant clinical challenges, such as increased rates of immune-related adverse events (irAEs) and drug resistance. Thus, identifying optimal prognostic biomarkers could help to monitor the safety and efficacy of ICIs and identify patients who may benefit the most from these treatments. In this review, we will first go over the fundamentals of the CTLA-4 and PD-1 pathways, as well as the mechanisms of ICI resistance. The results of clinical findings that evaluated the combination of ipilimumab and nivolumab are then summarized to support future research in the field of combination therapy. Finally, the irAEs associated with combined ICI therapy, as well as the underlying biomarkers involved in their management, are discussed.
MeSH term(s)	Humans ; Ipilimumab/therapeutic use ; Nivolumab/therapeutic use ; Melanoma/drug therapy ; Combined Modality Therapy ; Immunotherapy/methods
Chemical Substances	Ipilimumab ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2023-03-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.109881
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Zs.A 5408: Show issues

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Book ; Thesis: Die Expression der NO-Synthasen I - III in zerebralen Metastasen und deren Korrelation mit morphometrischen und klinischen Daten

Akhavan-Sigari, Reza

eine retrospektive Studie bei 98 Patienten

2000

Author's details	vorgelegt von Reza Akhavan-Sigari
Language	German
Size	VI, 51 Bl. : Ill., graph. Darst.
Edition	[Mikrofiche-Ausg.]
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Göttingen, Univ., Diss., 2003
HBZ-ID	HT014251970
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Author Correction: Synthesis and characterization of ZrFe

Saadh, Mohamed J / Khasawneh, Hussam Elddin Nabieh / Ortiz, Geovanny Genaro Reivan / Ahsan, Muhammad / Sain, Dinesh Kumar / Yusuf, Kareem / Sillanää, Mika / Iqbal, Amjad / Akhavan-Sigari, Reza

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7839

Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58184-7
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Article ; Online: LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review.

Khalilollah, Shayan / Kalantari Soltanieh, Sina / Obaid Saleh, Raed / Ali Alzahrani, Abdullah / Ghaleb Maabreh, Hatem / Mazin Al-Hamdani, Mais / Dehghani-Ghorbi, Mahmoud / Shafiei Khonachaei, Metanat / Akhavan-Sigari, Reza

Cytokine

2024 Volume 179, Page(s) 156585

Abstract: The pathophysiology of several illnesses, including cancer and autoimmune diseasesdepends on human regulatory T cells (Tregs), and abnormalities in these cells may function as triggers for these conditions. Cancer and autoimmune, and gynecological ... ...

Abstract	The pathophysiology of several illnesses, including cancer and autoimmune diseasesdepends on human regulatory T cells (Tregs), and abnormalities in these cells may function as triggers for these conditions. Cancer and autoimmune, and gynecological diseases are associated with the differentiation of the proinflammatory T cell subset TH17 and its balance with the production of Treg. Recently, long non-coding RNAs (lncRNAs) have become important regulatory molecules in a wide range of illnesses. During epigenetic regulation, they can control the expression of important genes at several levels by affecting transcription, post-transcriptional actions, translation, and protein modification. They might connect with different molecules, such as proteins, DNA and RNA, and their structural composition is intricate. Because lncRNAs regulatebiological processes, including cell division, death, and growth, they are linked to severaldiseases. A notable instance of this is the lncRNA NEAT1, which has been the subject of several investigations to ascertain its function in immune cell development. In the context of immune cell development, several additional lncRNAs have been connected to Treg cell differentiation. In this work, we summarize current findings about the diverse functions of lncRNAs in Treg cell differentiation and control of the Th17/Treg homeostasis in autoimmune disorders, cancers, as well as several gynecological diseases where Tregs are key players.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2024.156585
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Zs.A 2840: Show issues

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Article ; Online: Dual role of mesenchymal stem/stromal cells and their cell-free extracellular vesicles in colorectal cancer.

Saadh, Mohamed J / Mohamed, Asma'a H / Almoyad, Muhammad Ali Abdullah / Allela, Omer Qutaiba B / Amin, Ali H / Malquisto, April Ann / Jin, Wong Tze / Sârbu, Ioan / AlShamsi, Faisal / Elsaid, Fahmy Gad / Akhavan-Sigari, Reza

Cell biochemistry and function

2024 Volume 42, Issue 2, Page(s) e3962

Abstract: Colorectal cancer (CRC) is one of the main causes of cancer-related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer-related mortality. Mesenchymal stem/stromal cells (MSCs) with ...

Abstract	Colorectal cancer (CRC) is one of the main causes of cancer-related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer-related mortality. Mesenchymal stem/stromal cells (MSCs) with potential translational applications in regenerative medicine have been widely researched for several years. MSCs could affect tumor development through secreting exosomes. The beneficial properties of stem cells are attributed to their cell-cell interactions as well as the secretion of paracrine factors in the tissue microenvironment. For several years, exosomes have been used as a cell-free therapy to regulate the fate of tumor cells in a tumor microenvironment. This review discusses the recent advances and current understanding of assessing MSC-derived exosomes for possible cell-free therapy in CRC.
MeSH term(s)	Humans ; Extracellular Vesicles ; Exosomes ; Mesenchymal Stem Cells ; Cell Communication ; Colorectal Neoplasms ; Tumor Microenvironment
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	283643-9
ISSN	1099-0844 ; 0263-6484
ISSN (online)	1099-0844
ISSN	0263-6484
DOI	10.1002/cbf.3962
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Article: Melatonin attenuated the behavioral despair induced by acute neurogenic stress through blockade of N-methyl D-aspartate receptors in mice.

Hajmirzaeyian, Arwin / Chamanara, Mohsen / Rashidian, Amir / Shakyba, Saied / Nassireslami, Ehsan / Akhavan-Sigari, Reza

Heliyon

2021 Volume 7, Issue 1, Page(s) e05900

Abstract: It has been well documented that administration of melatonin could reveal antidepressant-like effect in rodents. However, the protective effect of melatonin on stress-induced depression/anxiety and its underlying mechanism is yet to be understood. In ... ...

Abstract	It has been well documented that administration of melatonin could reveal antidepressant-like effect in rodents. However, the protective effect of melatonin on stress-induced depression/anxiety and its underlying mechanism is yet to be understood. In this regard, in the current study, acute foot-shock stress (FSS) was used to evaluate the antidepressant-like effect of melatonin on neurogenic stress-induced depression in mice. Behavioral evaluation was done by using the forced swimming test (FST) and Open-field test (OFT). Melatonin, MK-801, and ketamine (NMDA receptor antagonists), and NMDA (NMDA receptor agonist) were used to elucidate any association between melatonin and NMDA pathway in behavioral despair induced by acute-FSS. Applying acute-FSS to mice significantly induced depressant-like behavior in FST without any significant impact on locomotor activity in the OFT. We observed that melatonin (dose-dependently) significantly improved the depressant-like effect of FSS, but it did not impact the locomotion in animals. Acute injection of MK-801 at sub-effective doses (0.01 mg/kg) or ketamine (0.1 mg/kg) potentiated the antidepressant-like effect of a sub-effective dose of melatonin. However, the sub-effective dose of NMDA (30 mg/kg) abolished the protective effect of melatonin on the behavioral profile of stressed animals. Our results could reflect the antidepressant-like effect of melatonin on neurogenic stress-induced depressive behaviors in mice. Also, our results showed that NMDA receptors could be involved in the antidepressant-like effect of melatonin.
Language	English
Publishing date	2021-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e05900
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Article ; Online: Value of HSP90α in Lung Cancer Diagnosis and Recurrence Prediction: A Cohort Study.

Wang, Yaqian / Seyed Barghi, Seyedeh Maryam / Yang, Yanhong / Akhavan-Sigari, Reza

Oncology research and treatment

2021 Volume 44, Issue 11, Page(s) 583–589

Abstract: Purpose: In the current study, we tried to analyze the diagnostic value of HSP90α expression during the course of disease in patients treated with and without surgery.: Methods: Three hundred and twelve patients with lung cancer who referred to ... ...

Abstract	Purpose: In the current study, we tried to analyze the diagnostic value of HSP90α expression during the course of disease in patients treated with and without surgery. Methods: Three hundred and twelve patients with lung cancer who referred to Qinhuangdao First Hospital from June 2016 to March 2021 were selected as the experimental group and 160 healthy individuals subjected as the control group in this cohort study. The ELISA method was used to detect the expression level of plasma HSP90α. Results: We observed significant differences in the level of HSP90α in pathologic type, differentiation degree, stage, and presence of lung, liver, and bone metastasis; HSP90α was significantly higher in non-small cell lung carcinoma in comparison with small cell lung carcinoma, especially in lung adenocarcinoma. Our results demonstrated that HSP90α at 71.45 ng/mL had a sensitivity of 66.3% and a specificity of 95.0% for diagnosing lung cancer. Also, we observed that the HSP90α expression was significantly increased prior to lung cancer relapse in patients treated with chemoradiotherapy and surgery. Conclusion: Serum level of plasma HSP90α could be a reliable biomarker in diagnosing lung cancer and its subtypes and might be a valid biomarker for predicting lung cancer relapse in patients treated with chemoradiotherapy and surgery.
MeSH term(s)	Biomarkers, Tumor ; Cohort Studies ; HSP90 Heat-Shock Proteins ; Humans ; Lung ; Lung Neoplasms/diagnosis ; Neoplasm Recurrence, Local/diagnosis
Chemical Substances	Biomarkers, Tumor ; HSP90 Heat-Shock Proteins ; HSP90AA2P protein, human
Language	English
Publishing date	2021-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2760274-6
ISSN	2296-5262 ; 2296-5270
ISSN (online)	2296-5262
ISSN	2296-5270
DOI	10.1159/000519277
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