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Article ; Online: Diagnostic Significance Of Bone Marrow Examination Amongst The Patients With Abnormal Haematological Parameters.

Bashir, Saima / Akhtar, Fahim / Salim, Misbah / Arshad, Maham / Khan, Zahra Tasleem / Akhtar, Farhan

Journal of Ayub Medical College, Abbottabad : JAMC

2024 Volume 35, Issue 4, Page(s) 619–622

Abstract: Background: Bone Marrow examination is considered to be the most indispensable diagnostic tool for the evaluation of many neoplastic and non-neoplastic haematological disorders. After an initial assessment of suspicious cases on abnormal laboratory ... ...

Abstract	Background: Bone Marrow examination is considered to be the most indispensable diagnostic tool for the evaluation of many neoplastic and non-neoplastic haematological disorders. After an initial assessment of suspicious cases on abnormal laboratory parameters along with the clinical presentation of the patient marrow examination is finally required for diagnosis as well as management of many haematological malignancies as it offers a clear cytological as well as histological picture of Bone Marrow aspirate and biopsy respectively. The Objective was to evaluate the significance of Bone Marrow examination in patients with abnormal haematological parameters. Methods: A retrospective study conducted at the Pathology Department of Pak Emirates Military Hospital from (Jan-June 2022) On data from150 patients who were advised to undergo bone marrow examination due to abnormal lab parameters and peripheral smear findings after informed consent and approval from the ethics review committee, to find out the correlation of abnormal haematological parameters and aspirate findings which have led to a definitive diagnosis. Data comprising basic demographic variables (age, gender etc.), Abnormal Haematological Parameters (CBC), peripheral smear findings and Aspirate findings were analyzed using SPSS version 23.0. Results: Out of 150 studied participants with abnormal haematological parameters 24 (16%) were diagnosed on bone marrow examination as acute leukaemia / Hodgkin's and Non-Hodgkin's lymphoma respectively, 13 (9%) cases of aplastic anaemia and Autoimmune HaemolyticAnaemia, 33 (22%)cases of hypersplenism, CML and multiple myeloma. While 22 (15%) cases were diagnosed with BME as CKD and reactive changes. Moreover, 22(15%) cases were found to have Iron Deficiency anaemia respectively. Conclusions: The study revealed that patients with abnormal haematological parameters should undergo bone marrow examination to ascertain the diagnosis for malignant as well as non-malignant conditions that could cause abnormal lab parameters.
MeSH term(s)	Humans ; Bone Marrow Examination ; Retrospective Studies ; Bone Marrow/pathology
Language	English
Publishing date	2024-02-26
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2192473-9
ISSN	1819-2718 ; 1025-9589
ISSN (online)	1819-2718
ISSN	1025-9589
DOI	10.55519/JAMC-04-12357
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Microstructural, Mechanical, and Electrochemical Characterization of CrMoNbTiZr High-Entropy Alloy for Biomedical Application.

Akinwekomi, Akeem / Akhtar, Farid

Materials (Basel, Switzerland)

2023 Volume 16, Issue 15

Abstract: High-entropy alloys (HEA) with superior biocompatibility, high pitting resistance, minimal debris accumulation, and reduced release of metallic ions into surrounding tissues are potential replacements for traditional metallic bio-implants. A novel ... ...

Abstract	High-entropy alloys (HEA) with superior biocompatibility, high pitting resistance, minimal debris accumulation, and reduced release of metallic ions into surrounding tissues are potential replacements for traditional metallic bio-implants. A novel equiatomic HEA based on biocompatible metals, CrMoNbTiZr, was consolidated by spark plasma sintering (SPS). The relative sintered density of the alloy was about 97% of the theoretical density, indicating the suitability of the SPS technique to produce relatively dense material. The microstructure of the sintered HEA consisted of a BCC matrix and Laves phase, corresponding to the prediction of the thermodynamic CALPHAD simulation. The HEA exhibited a global Vickers microhardness of 531.5 ± 99.7 HV, while the individual BCC and Laves phases had hardness values of 364.6 ± 99.4 and 641.8 ± 63.0 HV, respectively. Its ultimate compressive and compressive yield strengths were 1235.7 ± 42.8 MPa and 1110.8 ± 78.6 MPa, respectively. The elasticity modulus of 34.9 ± 2.9 GPa of the HEA alloy was well within the range of cortical bone and significantly lower than the values reported for commonly used biomaterials made from Ti-based and Cr-Co-based alloys. In addition, the alloy exhibited good resistance to bio-corrosion in PBS and Hanks solutions. The CrMoNbTiZr HEA exhibited an average COF of 0.43 ± 0.06, characterized mainly by abrasive and adhesive wear mechanisms. The CrMoNbTiZr alloy's mechanical, bio-corrosion, and wear resistance properties developed in this study showed a good propensity for application as a biomaterial.
Language	English
Publishing date	2023-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16155320
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tunability of mechanical and biodegradation properties of zinc-based biomaterial with calcium Micronutrient alloying.

Akinwekomi, Akeem Damilola / Akhtar, Farid

Journal of the mechanical behavior of biomedical materials

2023 Volume 140, Page(s) 105724

Abstract: Biodegradable metals are being investigated as temporary implants that dissolve safely in the body after bone regeneration. Zinc (Zn) has an intermediate biodegradation rate between magnesium and stainless steels, yet its degradation rate is too slow to ... ...

Abstract	Biodegradable metals are being investigated as temporary implants that dissolve safely in the body after bone regeneration. Zinc (Zn) has an intermediate biodegradation rate between magnesium and stainless steels, yet its degradation rate is too slow to function as a temporary orthopedic implant. Alloying with nutrient elements is considered a strategy to tune its mechanical properties and in vivo biodegradability. Zn/calcium (Zn/Ca) alloys (with 0.5, 1, and 2 wt% Ca) were processed by spark plasma sintering and their microstructure, mechanical, and biodegradation properties were investigated. Ca was distributed in the grain boundary regions of Zn due to its low miscibility in Zn. Furthermore, the corrosion rates of Zn/Ca alloys determined from linear polarization measurements (0.164-0.325 mm/yr) accelerated by at least 10% compared with pure sintered Zn (0.149 mm/yr) with simultaneous dissolution of Zn and Ca, as verified from X-ray diffraction analysis of the corrosion products. The alloy specimens exhibited hardness (52-58 HV) and compressive strength (93-119 MPa) comparable with those of human cortical and cancellous bones (49 HV; 90-209 MPa). This study demonstrated the tunability of the mechanical and biodegradation properties of Zn-based materials by alloying them with a nutrient element for potential application as temporary orthopedic implants.
MeSH term(s)	Humans ; Biocompatible Materials/chemistry ; Zinc/chemistry ; Calcium/chemistry ; Materials Testing ; Alloys/chemistry ; Micronutrients ; Absorbable Implants ; Corrosion
Chemical Substances	Biocompatible Materials ; Zinc (J41CSQ7QDS) ; Calcium (SY7Q814VUP) ; Alloys ; Micronutrients
Language	English
Publishing date	2023-02-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2023.105724
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Article: Bolivian natural zeolite as a low-cost adsorbent for the adsorption of cadmium: Isotherms and kinetics.

Velarde, Lisbania / Nikjoo, Dariush / Escalera, Edwin / Akhtar, Farid

Heliyon

2024 Volume 10, Issue 1, Page(s) e24006

Abstract: Population growth in recent years has led to increased wastewater production and pollution of water resources. This situation also heavily affects Bolivia, so wastewater treatment methods and materials suitable for Bolivian society should be explored. ... ...

Abstract	Population growth in recent years has led to increased wastewater production and pollution of water resources. This situation also heavily affects Bolivia, so wastewater treatment methods and materials suitable for Bolivian society should be explored. This study investigated the natural Bolivian Zeolite (BZ) and its NaCl-modified structure (NaBZ) as adsorbents for cadmium removal from water. The natural BZ and the modified form NaBZ were investigated by different physicochemical characterization techniques. Furthermore, XPS and FT-IR techniques were used to investigate the adsorption mechanisms. The cadmium adsorption on BZ and NaBZ was analyzed using various mathematical models, and the Langmuir model provided a better description of the experimental adsorption data with cadmium adsorption capacities of 20.2 and 25.6 mg/g for BZ and NaBZ, respectively. The adsorption followed the pseudo-second order kinetics. The effect of different parameters, such as initial cadmium concentration and pH on the adsorption was studied. In addition, the results of the regeneration test indicated that both BZ and NaBZ can be regenerated by using hydrochloric acid (HCl). Finally, the adsorption experiment of BZ and NaBZ on a real water sample (brine from Salar de Uyuni salt flat) containing a mixture of different heavy metals was carried out. The results obtained in this study demonstrate the effectiveness of natural BZ and modified NaBZ in the removal of heavy metals from wastewater.
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24006
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Article ; Online: Bibliometric Mapping of Literature on High-Entropy/Multicomponent Alloys and Systematic Review of Emerging Applications.

Akinwekomi, Akeem Damilola / Akhtar, Farid

Entropy (Basel, Switzerland)

2022 Volume 24, Issue 3

Abstract: High-entropy/multicomponent alloy (HEA/MCA) has received significant research attention in the last decade. There is a dearth of data-driven works dedicated to assessing and visualizing the HEA/MCA literature from a global perspective. To this end, we ... ...

Abstract	High-entropy/multicomponent alloy (HEA/MCA) has received significant research attention in the last decade. There is a dearth of data-driven works dedicated to assessing and visualizing the HEA/MCA literature from a global perspective. To this end, we present the first bibliometric literature analysis of more than 3500 HEA/MCA articles, published between 2004 and 2021, in the Scopus database. We identify the most prolific authors, their collaborators, institutions, and most prominent research outlet. Co-occurrence networks of keywords are mapped and analyzed. A steep rise in research outputs is observed from 2013, when the number of annual publications doubled the previous years. The top five preferred research outlets include
Language	English
Publishing date	2022-02-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e24030329
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: First substantiation of clinico-molecular investigation of pathogenic

Munir, M Z / Khan, J A / Ijaz, M / Akhtar, F

Iranian journal of veterinary research

2022 Volume 23, Issue 2, Page(s) 120–127

Abstract: Background: Listeriosis is a zoonotic disease of humans, animals, birds, fish, and crustaceans worldwide. Domestic animals, especially ruminants, are more susceptible to listeriosis. This infectious disease is caused by : Aims: This study was ... ...

Abstract	Background: Listeriosis is a zoonotic disease of humans, animals, birds, fish, and crustaceans worldwide. Domestic animals, especially ruminants, are more susceptible to listeriosis. This infectious disease is caused by Aims: This study was designed to inspect listeriosis in buffaloes through molecular techniques and haemato-biochemical analyses. Methods: A total of 230 samples (115 milk and 115 faecal samples) were collected from symptomatic listeriosis cases in Nili-Ravi buffaloes of 3 geographical districts (Rawalpindi, Faisalabad, and Muzaffargarh) Punjab, Pakistan. These samples were processed for DNA extraction using commercialized kits, and Results: The results revealed that 6.08% and 4.34% of the isolates from milk and faecal samples were found positive for Conclusion: The occurrence of listeriosis in buffaloes urges continuous monitoring and surveillance to prevent this emerging disease in Pakistan.
Language	English
Publishing date	2022-09-14
Publishing country	Iran
Document type	Journal Article
ISSN	1728-1997
ISSN	1728-1997
DOI	10.22099/IJVR.2022.41671.6062
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Article ; Online: Septin Defects Favour Symmetric Inheritance of the Budding Yeast Deceptive Courtship Memory.

Akhtar, Fozia / Brignola, Bastien / Caudron, Fabrice

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: Mnemons are prion-like elements that encode cellular memories of past cellular adaptations and do not spread to progenies during cell divisions. During the deceptive courtship in budding yeast, the Whi3 mnemon ( ... ...

Abstract	Mnemons are prion-like elements that encode cellular memories of past cellular adaptations and do not spread to progenies during cell divisions. During the deceptive courtship in budding yeast, the Whi3 mnemon (Whi3
MeSH term(s)	Septins/genetics ; Septins/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomycetales/metabolism ; Courtship ; Pheromones/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; RNA-Binding Proteins/metabolism
Chemical Substances	Septins (EC 3.6.1.-) ; Pheromones ; Saccharomyces cerevisiae Proteins ; Whi3 protein, S cerevisiae ; RNA-Binding Proteins
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24033003
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Article ; Online: Antimicrobial photodynamic therapy (aPDT) against vancomycin resistant Staphylococcus aureus (VRSA) biofilm disruption: A putative role of phagocytosis in infection control.

Akhtar, Farheen / Khan, Asad U

Photodiagnosis and photodynamic therapy

2021 Volume 36, Page(s) 102552

Abstract: Biofilm mediated infections have major clinical impact. Staphylococcus aureus is a pathogen that frequently causes biofilm forming infections, such as those associated with medical devices and persistent wounds. Microorganisms embedded in biofilm are ... ...

Abstract	Biofilm mediated infections have major clinical impact. Staphylococcus aureus is a pathogen that frequently causes biofilm forming infections, such as those associated with medical devices and persistent wounds. Microorganisms embedded in biofilm are impervious to antibiotics and other antimicrobial agents, thus they are difficult to eliminate. The upsurge of multi-drug resistant strains makes treating such illnesses even more difficult. Therefore, new strategies are required to combat such type of infections. In this work, we have proposed an alternative therapeutic option to eradicate preformed biofilm of vancomycin resistant Staphylococcus aureus (VRSA) and enhanced phagocytosis by neutrophils in fresh human blood using curcumin mediated antimicrobial photodynamic therapy (aPDT).At sub-MIC of curcumin, different anti-biofilm assays and microscopic examinations were performed, followed by 20 J/cm
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents ; Biofilms ; Humans ; Infection Control ; Methicillin-Resistant Staphylococcus aureus ; Phagocytosis ; Photochemotherapy/methods ; Photosensitizing Agents/pharmacology ; Vancomycin-Resistant Staphylococcus aureus
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Photosensitizing Agents
Language	English
Publishing date	2021-09-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2021.102552
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Article ; Online: Reliable metal-graphene contact formation process flows in a CMOS-compatible environment.

Elviretti, M / Lisker, M / Lukose, R / Lukosius, M / Akhtar, F / Mai, A

Nanoscale advances

2022 Volume 4, Issue 20, Page(s) 4373–4380

Abstract: The possibility of exploiting the enormous potential of graphene for microelectronics and photonics must go through the optimization of the graphene-metal contact. Achieving low contact resistance is essential for the consideration of graphene as a ... ...

Abstract	The possibility of exploiting the enormous potential of graphene for microelectronics and photonics must go through the optimization of the graphene-metal contact. Achieving low contact resistance is essential for the consideration of graphene as a candidate material for electronic and photonic devices. This work has been carried out in an 8'' wafer pilot-line for the integration of graphene into a CMOS environment. The main focus is to study the impact of the patterning of graphene and passivation on metal-graphene contact resistance. The latter is measured by means of transmission line measurement (TLM) with several contact designs. The presented approaches enable reproducible formation of contact resistivity as low as 660 Ω μm with a sheet resistance of 1.8 kΩ/□ by proper graphene patterning, passivation of the channel and a post-processing treatment such as annealing.
Language	English
Publishing date	2022-09-08
Publishing country	England
Document type	Journal Article
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/d2na00351a
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Article ; Online: Inducing hierarchical pores in nano-MOFs for efficient gas separation.

Landström, Kritika Narang / Nambi, Ashwin / Kaiser, Andreas / Akhtar, Farid

RSC advances

2023 Volume 13, Issue 24, Page(s) 16039–16046

Abstract: The synthesis of metal-organic frameworks (MOFs) and their processing into structures with tailored hierarchical porosity is essential for using MOFs in the adsorption-driven gas separation process. We report the synthesis of modified Cu-MOF nanocrystals ...

Abstract	The synthesis of metal-organic frameworks (MOFs) and their processing into structures with tailored hierarchical porosity is essential for using MOFs in the adsorption-driven gas separation process. We report the synthesis of modified Cu-MOF nanocrystals for CO
Language	English
Publishing date	2023-05-30
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra01175e
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