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Article: Anti-Inflammatory Medicinal Plants of Bangladesh-A Pharmacological Evaluation.

Akhtar, Most Afia

2022 Volume 13, Page(s) 809324

Abstract: Inflammatory diseases are considered major threats to human health worldwide. In Bangladesh, a number of medicinal plants have been used in traditional medicine from time immemorial in the treatment of diverse diseases, including inflammatory disorders. ... ...

Abstract	Inflammatory diseases are considered major threats to human health worldwide. In Bangladesh, a number of medicinal plants have been used in traditional medicine from time immemorial in the treatment of diverse diseases, including inflammatory disorders. This assignment aims at providing the status of the medicinal plants of Bangladesh which are traditionally used in the management of inflammatory disorders and are investigated for their anti-inflammatory prospects using different preclinical studies and future research directions. The information of medicinal plants assembled in this review was obtained from a literature search of electronic databases such as Google Scholar, PubMed, Scopus, Web of Science and ScienceDirect up to December, 2020 from publications on plants investigated for their anti-inflammatory activities, in which the place of plant sample collection was identified as Bangladesh. Keywords for primary searches were "anti-inflammatory," "Bangladeshi," and "medicinal plants." Criteria followed to include plant species were plants that showed significant anti-inflammatory activities in 1) two or more sets of experiments in a single report, 2) same or different sets of experiments in two or more reports, and, 3) plants which are traditionally used in the treatment of inflammation and inflammatory disorders. In this study, 48 species of medicinal plants have been reviewed which have been used in traditional healing practices to manage inflammatory disorders in Bangladesh. The mechanistic pathways of the
Language	English
Publishing date	2022-03-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.809324
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Article ; Online: Risk factors for femoral stem fracture following total hip arthroplasty: a systematic review and meta analysis.

Turnbull, Gareth S / Soete, Sam / Akhtar, Muhammad Adeel / Ballantyne, James Anderson

Archives of orthopaedic and trauma surgery

2024

Abstract: Background: Femoral stem fracture following total hip arthroplasty (THA) is an infrequent but nevertheless devastating complication, with an increasing worldwide prevalence as demand for primary THA continues to increase. The aim of this study was to ... ...

Abstract	Background: Femoral stem fracture following total hip arthroplasty (THA) is an infrequent but nevertheless devastating complication, with an increasing worldwide prevalence as demand for primary THA continues to increase. The aim of this study was to perform a systematic review and meta-analysis of risk factors for femoral stem fracture to help identify at risk patients. Methods: A systematic search was conducted on EMBASE, MEDLINE and AMED to identify relevant studies. Data regarding study design, source, population, intervention, and outcomes was collated. Data extraction was performed on a custom form generated using Cochrane recommended methodology and analysis of risk factors performed including odds ratios (ORs) with 95% confidence intervals (CIs). Results: A total of 15 studies reporting a total of 402 stem fractures in 49 723 THAs were identified. The median time from index procedure to stem fracture was 68 months (IQR 42.5-118) whilst mean age at index surgery was 61.8 years (SD 6.9). Male gender (OR = 3.27, 95% CI = 2.59-4.13, p < 0.001), patient weight above 80 kg (OR = 3.55, 95% CI = 2.88-4.37, p < 0.001), age under 63 years (OR = 1.22, 95% CI = 1.01-1.49, p < 0.001), varus stem alignment (OR = 5.77, 95% CI = 3.83-8.7, p < 0.001), use of modular implants (OR = 1.95, 95% CI = 1.56-2.44, p < 0.01) and undergoing revision arthroplasty (OR = 3.33, 95% CI = 2.70-4.1, p < 0.001) were significant risk factors for prosthetic stem fracture. A risk window of 15 years post-surgery was identified. Conclusions: This review concludes that patient weight, younger age, male sex, varus stem alignment, revision arthroplasty and use of modular stems are significant risk factors for femoral stem fracture. Modifying these risk factors where possible may help reduce incidence of femoral stem fracture in at risk patients.
Language	English
Publishing date	2024-04-12
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	80407-1
ISSN	1434-3916 ; 0003-9330 ; 0344-8444
ISSN (online)	1434-3916
ISSN	0003-9330 ; 0344-8444
DOI	10.1007/s00402-024-05281-x
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Article ; Online: Transfemoral amputation versus knee arthrodesis for failed total knee replacement: A systematic review of outcomes.

Low, Juin / Hoellwarth, Jason Shih / Akhtar, Muhammad Adeel / Tetsworth, Kevin / Al-Muderis, Munjed

The Knee

2024 Volume 47, Page(s) 63–80

Abstract: Background: The options available to salvage a failed total knee replacement (TKR) include transfemoral amputation (TFA) and knee arthrodesis (KA). This systematic review aims to evaluate outcomes following either TFA or KA, comparing ambulatory status, ...

Abstract	Background: The options available to salvage a failed total knee replacement (TKR) include transfemoral amputation (TFA) and knee arthrodesis (KA). This systematic review aims to evaluate outcomes following either TFA or KA, comparing ambulatory status, additional subsequent surgery, postoperative infection, pain, health-related quality of life (HRQoL), and mortality rate. Methods: A literature search was conducted in EMBASE, Ovid Medline, and PubMed. Only primary research studies were included and data were independently extracted using a standardized form. The methodological quality of the studies was evaluated using Newcastle-Ottawa Scale. Results: Forty-four papers were included, comprising 470 TFA and 1034 KA patients. The methodological quality of the studies was moderate. No TFA versus KA randomized controlled trials could be identified. Pooled data totals via subgroup analyses were performed, owing to inconsistent reporting methods in the included studies. Prosthesis use rate by TFA patients was 157/316 = 49.7%. Significant differences included that TFA patients had lower rates of ambulatory capacity than KA patients (139/294 = 45.6% versus 248/287 = 86.4%, p < 0.001), TFA ambulators were less likely to use an ambulatory aid (55/135 = 40.7% versus 167/232 = 72.0%, p < 0.001), and TFA was associated with a greater postoperative infection rate than KA (29/118 = 24.6% versus 129/650 = 17.2%, p = 0.054). There was a similar rate of revision surgery between TFA and KA (37/183 = 20.2% versus 145/780 = 18.6%, p = 0.612). Data on HRQoL for both TFA and KA were limited, contradictory, and heterogeneous. Conclusion: No randomized controlled trials comparing TFA versus KA exist;therefore, current data likely reflects substantial selection bias. The currently available evidence suggests that KA patients are significantly more likely to achieve independent bipedal ambulation than TFA patients. In both treatment cohorts, subsequent infection and revision surgery remain a relatively common occurrence.
Language	English
Publishing date	2024-01-19
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1200476-5
ISSN	1873-5800 ; 0968-0160
ISSN (online)	1873-5800
ISSN	0968-0160
DOI	10.1016/j.knee.2023.12.012
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Article: Surface Modification of 3D-Printed PCL/BG Composite Scaffolds via Mussel-Inspired Polydopamine and Effective Antibacterial Coatings for Biomedical Applications.

Ilyas, Kanwal / Akhtar, Muhammad Asim / Ammar, Ezzeddine Ben / Boccaccini, Aldo R

Materials (Basel, Switzerland)

2022 Volume 15, Issue 23

Abstract: A wide variety of composite scaffolds with unique geometry, porosity and pore size can be fabricated with versatile 3D printing techniques. In this work, we fabricated 3D-printed composite scaffolds of polycaprolactone (PCL) incorporating bioactive glass ...

Abstract	A wide variety of composite scaffolds with unique geometry, porosity and pore size can be fabricated with versatile 3D printing techniques. In this work, we fabricated 3D-printed composite scaffolds of polycaprolactone (PCL) incorporating bioactive glass (BG) particles (13-93 and 13-93B3 compositions) by using fused deposition modeling (FDM). The scaffolds were modified with a "mussel-inspired surface coating" to regulate biological properties. The chemical and surface properties of scaffolds were analyzed by Fourier transform infrared spectroscopy (FTIR), contact angle and scanning electron microscopy (SEM). Polydopamine (PDA) surface-modified composite scaffolds exhibited attractive properties. Firstly, after the surface modification, the adhesion of a composite coating based on gelatin incorporated with strontium-doped mesoporous bioactive glass (Sr-MBGNs/gelatin) was significantly improved. In addition, cell attachment and differentiation were promoted, and the antibacterial properties of the scaffolds were increased. Moreover, the bioactivity of these scaffolds was also significantly influenced: a hydroxyapatite layer formed on the scaffold surface after 3 days of immersion in SBF. Our results suggest that the promoting effect of PDA coating on PCL-BG scaffolds leads to improved scaffolds for bone tissue engineering.
Language	English
Publishing date	2022-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15238289
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Article ; Online: Ethnic group and reason for assisted reproductive technology failure: analysis of the Human Fertilisation and Embryology Authority registry data from 2017 to 2018.

Henderson, Ian / Lacey, Lauren / Akhtar, Muhammad Ahsan / Quenby, Siobhan

Fertility and sterility

2022 Volume 119, Issue 2, Page(s) 241–249

Abstract: Objective: To understand how the risk of different assisted reproductive technology (ART) failure types varies by ethnic group and explore the role of mediation by maternal age and suspected etiology.: Design: An observational study of 48,750 women ... ...

Abstract	Objective: To understand how the risk of different assisted reproductive technology (ART) failure types varies by ethnic group and explore the role of mediation by maternal age and suspected etiology. Design: An observational study of 48,750 women who undertook treatment with ART in the United Kingdom between January 2017 and December 2018. Setting: The Human Fertilisation and Embryology Authority national ART registry of the United Kingdom. Patient(s): Women who commenced a first cycle of ART for the purpose of primary fresh embryo transfer using their own oocytes were included. Intervention(s): Maternal ethnic group. Main outcome measure(s): The ART failure types were modeled on the maternal ethnic group using the Poisson regression to produce relative risks (RRs) with 95% confidence intervals. The potential indirect effects of maternal age and etiology of subfertility were estimated, and the RRs with 95% confidence intervals were produced. Result(s): Black women were at greater risk of treatment failure with respect to live birth than women who were white: cycle cancellation, RR of 2.15 (1.78-2.62); failed fertilization, RR of 2.36 (1.90-2.93); unintended freeze-all, RR of 1.71 (1.43-2.05); failed implantation, RR of 1.23 (1.12-1.34); and pregnancy loss, RR of 1.38 (1.15-1.64). Women who were Asian were at moderately increased risk: RRs of 1.31 (1.17-1.47), 1.60 (1.42-1.80), 1.25 (1.14-1.38), 1.11 (1.07-1.16), and 1.13 (1.03-1.23), across the same outcomes, respectively. Inequality may have been reduced had women of all ethnicities initiated treatment at the same age. Conclusion(s): Black women were at greatest risk of all failure types, and women who were Asian were at intermediate risk compared with women who were white. Some of the risks among women who were black may be mediated by maternal age.
MeSH term(s)	Pregnancy ; Humans ; Female ; Ethnicity ; Routinely Collected Health Data ; Reproductive Techniques, Assisted/adverse effects ; Live Birth ; Fertilization
Language	English
Publishing date	2022-11-09
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2022.11.005
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Article ; Online: Cost-effective treatment of genotype-3 chronic hepatitis C.

Akhtar, Mahmud Ahmad

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2015 Volume 25, Issue 1, Page(s) 78

MeSH term(s)	Antiviral Agents/therapeutic use ; Female ; Hepacivirus/genetics ; Humans ; Interferons/therapeutic use ; Male ; Ribavirin/therapeutic use
Chemical Substances	Antiviral Agents ; Ribavirin (49717AWG6K) ; Interferons (9008-11-1)
Language	English
Publishing date	2015-01
Publishing country	Pakistan
Document type	Comment ; Letter
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	01.2015/JCPSP.7879
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Article: The Clinical History and Basic Science Origins of Transcutaneous Osseointegration for Amputees.

Hoellwarth, Jason Shih / Tetsworth, Kevin / Akhtar, Muhammad Adeel / Al Muderis, Munjed

Advances in orthopedics

2022 Volume 2022, Page(s) 7960559

Abstract: Transcutaneous osseointegration for amputees (TOFA) refers to an intramedullary metal endoprosthesis which passes transcutaneously to connect with a limb exoprosthesis. The first recognizably modern experiments and attempts occurred in the 1940s. ... ...

Abstract	Transcutaneous osseointegration for amputees (TOFA) refers to an intramedullary metal endoprosthesis which passes transcutaneously to connect with a limb exoprosthesis. The first recognizably modern experiments and attempts occurred in the 1940s. Multiple researchers using a plethora of materials and techniques over the following 50 years identified principles and obstacles which informed the first long-term successful surgery in 1990. Unfortunately, the current mainstream TOFA literature presents almost exclusively subsequent developments, generally omitting prior research, leading to some historical mistakes being repeated. Given the increasing interest and surgical volume of TOFA, this literature review was performed to delineate TOFA's basic science and surgical origins and to integrate these early efforts within the contemporary understanding. Studying this research could protect and benefit future patients, surgeons, and implant developers as TOFA is entering a phase of increased attention and innovation. The aim of this article is to provide a focused reference of foundational research, much of which is difficult to identify and retrieve, for clinicians and researchers.
Language	English
Publishing date	2022-03-18
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2621436-2
ISSN	2090-3472 ; 2090-3464
ISSN (online)	2090-3472
ISSN	2090-3464
DOI	10.1155/2022/7960559
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Article ; Online: Isotope hydrology tools in the assessment of arsenic contamination in groundwater: An overview.

Ansari, Md Arzoo / Saravana Kumar, U / Noble, Jacob / Akhtar, Naima / Akhtar, M Arslaan / Deodhar, Archana

Chemosphere

2023 Volume 340, Page(s) 139898

Abstract: Groundwater is important for the survival of humanity and the demand for the same is drastically increasing globally. The precious water resources are under constant threat, either as a result of natural processes or due to the influence of the ... ...

Abstract	Groundwater is important for the survival of humanity and the demand for the same is drastically increasing globally. The precious water resources are under constant threat, either as a result of natural processes or due to the influence of the anthropogenic activities. Arsenic contamination of groundwater is one of those threats that have affected approximately over 500 million people in 107 countries globally. Although, many studies (
MeSH term(s)	Humans ; Arsenic ; Hydrology ; Isotopes ; Groundwater ; Water
Chemical Substances	Arsenic (N712M78A8G) ; Isotopes ; Water (059QF0KO0R)
Language	English
Publishing date	2023-08-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139898
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Article: Bilateral Simultaneous Asymmetrical Anterior Shoulder Dislocation With a Fracture.

Al-Khatib, Yousef / Akhtar, Muhammad Adeel / Kasis, Ata

Cureus

2021 Volume 13, Issue 7, Page(s) e16783

Abstract: In this case report, we present the case of a 19-year-old male who presented to the emergency department with bilateral shoulder pain and significantly decreased range of motion. His X-rays showed a bilateral dislocation of the glenohumeral joints, along ...

Abstract	In this case report, we present the case of a 19-year-old male who presented to the emergency department with bilateral shoulder pain and significantly decreased range of motion. His X-rays showed a bilateral dislocation of the glenohumeral joints, along with a proximal humeral fracture. Shoulder dislocations were manipulated, while the proximal humeral fracture was conservatively managed. Bilateral simultaneous asymmetric anterior shoulder dislocations are uncommon in such a young age group, especially when associated with a sports injury.
Language	English
Publishing date	2021-07-31
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.16783
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Article ; Online: The Miraculous Journey of TAVR: Beware of Rare!

Akhtar, Mohammed A / Argulian, Edgar

JACC. Case reports

2019 Volume 1, Issue 2, Page(s) 118–119

Language	English
Publishing date	2019-08-21
Publishing country	Netherlands
Document type	Editorial
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2019.06.004
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