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Book: Emerging Modalities in Mitigation of Antimicrobial Resistance

Akhtar, Nadeem / Goyal, Dinesh / Prerna / Singh, Kumar Siddharth

2022

Author's details	Nadeem Akhtar, PhD, Department of Animal Biosciences, University of Guelph, Ontario N1G 2W1, Canada. Email: nadeembiotech@gmail.com. Dr. Nadeem Akhtar, Ph.D., currently works at the University of Guelph, Canada as a Research Associate. His current research focuses on biotechnology in animal nutrition, where the main objective is to improve animals' health for a better and disease-free lifestyle. Before the Research Associate role, he has worked as a Post-doctoral Researcher in the Department of Chemical Engineering, University of Waterloo, Canada (2019-2020), and in the Department of Animal Biosciences, University of Guelph, Canada (2015-2019). Dr. Akhtar was awarded a Ph.D. from the Department of Biotechnology, Thapar University, India. He has qualified National Eligibility test (NET-2010) and Graduate Aptitude Test (GATE) in Life Sciences (2010) and Biotechnology (2011). His scientific contributions include more than 22 articles in peer-reviewed international journals, 10 book cha
Keywords	Bacteriophage ; Nanotherapeutics ; MicrobialCommunity ; high-throughputsequencing ; ArtificialIntelligence ; microbialstewardship ; Novelmitigationtechnologies ; RapidDetection ; surveillance ; Multidrugresistance ; nanoparticle ; Microbial community ; High-throughput sequencing ; artificial intelligence ; microbial stewardship ; Novel mitigation technologies ; Rapid detection ; Surveillance ; Multidrug resistance ; Nanoparticle
Language	English
Size	592 p.
Edition	1
Publisher	Springer International Publishing
Document type	Book
Note	PDA Manuell_13
Format	160 x 241 x 38
ISBN	9783030841256 ; 3030841251
Database	PDA

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Book: Handbook of person-centered mental health care

Akhtar, Nosheen / Forchuk, Cheryl / McKay, Katherine / Fisman, Sandra / Rudnick, Abraham

2021

Author's details	Nosheen Akhtar, Cheryl Forchuk, Katherine McKay, Sandra Fisman, & Abraham Rudnick
Keywords	client-centered approaches ; humanistic psychology ; serious mental illness ; Psychische Störung ; Psychiatrie ; Psychiatrische Behandlung ; Nichtdirektivität
Subject	Klientenzentrierte Methode ; Nichtdirektive Methode ; Nichtdirektives Verfahren ; Personenzentrierter Ansatz ; Personzentrierter Ansatz ; Seelenheilkunde ; Seelische Störung ; Mental disorder ; Psychische Krankheit ; Seelische Krankheit ; Psychiatrische Krankheit ; Psychische Erkrankung ; Psychische Störungen
Subject code	150
Language	English
Size	x, 193 Seiten, Illustrationen
Publisher	Hogrefe
Publishing place	Toronto
Publishing country	Germany
Document type	Book
HBZ-ID	HT021070233
ISBN	978-0-88937-568-0 ; 0-88937-568-2 ; 9781616765682 ; 9781613345689 ; 1616765682 ; 1613345682
Database	Catalogue ZB MED Medicine, Health

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2021 A 1129	available for loan (reading room)	Lesesaal EG

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Article ; Online: 'Cine-Psych': Mental health educational film-making.

Akhtar, Nadeem

Medical education

2022 Volume 56, Issue 5, Page(s) 581–582

MeSH term(s)	Humans ; Mental Health ; Motion Pictures
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	195274-2
ISSN	1365-2923 ; 0308-0110
ISSN (online)	1365-2923
ISSN	0308-0110
DOI	10.1111/medu.14782
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Book ; Online: A Survey of Explainable AI in Deep Visual Modeling

Akhtar, Naveed

Methods and Metrics

2023

Abstract: Deep visual models have widespread applications in high-stake domains. Hence, their black-box nature is currently attracting a large interest of the research community. We present the first survey in Explainable AI that focuses on the methods and metrics ...

Abstract	Deep visual models have widespread applications in high-stake domains. Hence, their black-box nature is currently attracting a large interest of the research community. We present the first survey in Explainable AI that focuses on the methods and metrics for interpreting deep visual models. Covering the landmark contributions along the state-of-the-art, we not only provide a taxonomic organization of the existing techniques, but also excavate a range of evaluation metrics and collate them as measures of different properties of model explanations. Along the insightful discussion on the current trends, we also discuss the challenges and future avenues for this research direction. Comment: Short accessible survey (9pgs)
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning
Publishing date	2023-01-31
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations.

Akhtar, Naheed / Akhtar, Naveed

Journal of cosmetic dermatology

2022 Volume 21, Issue 10, Page(s) 4942–4955

Abstract: Background: Tocopherol succinate (TS) represents synthetic derivative of α-tocopherol (vitamin E), it act as anti-aging, moisturizing, and antioxidant. Ultraviolet (UV) photo stability of TS is low, and it cause skin irritation.: Aim: To develop ... ...

Abstract	Background: Tocopherol succinate (TS) represents synthetic derivative of α-tocopherol (vitamin E), it act as anti-aging, moisturizing, and antioxidant. Ultraviolet (UV) photo stability of TS is low, and it cause skin irritation. Aim: To develop tocopherol succinate loaded ethosomal gel for topical TS delivery and to evaluate its moisturizing and anti-aging effects. Method: Cold method technique was used to produce ethosomal formulations (N = 9) by varying ethanol and lipid concentrations (F1-F9). The most optimized formulation (F5) was selected for further study on the basis of characterization. F5 Formulation was incorporated into gel. Ex vivo permeation study was done by using Franz diffusion cell. Non-invasive in vivo study was performed using corneometer for the evaluation of skin moisture content and skin mechanical properties by using cutometer, for 12 weeks on human subjects (N = 13). Results: Particle size (PS), zeta potential (ZP) and polydispersity index (PDI), Entrapment efficiency were found to be 179.1 nm, -13.7 mV and 0.345, and 99.71%, respectively. Transmission electron microscopy (TEM) depicted spherical ethosomal particles. Ethosomal gel and control gel were evaluated for conductivity and pH. Rheological analysis revealed a non-Newtonian flow. The release profile showed initial burst and then, sustained release, release data followed Korsmeyer-Peppas model. TS-loaded ethosomal gel appeared physically stable and showed significant results in terms of skin capacitance and mechanical properties. Conclusion: The prepared ethosomal gel formulation containing TS is more stable with enhanced antioxidant, moisturizing properties, and increased TS deposition into the skin layer.
MeSH term(s)	Humans ; alpha-Tocopherol/pharmacology ; alpha-Tocopherol/metabolism ; Skin Absorption ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Administration, Cutaneous ; Skin/metabolism ; Liposomes/chemistry ; Liposomes/metabolism
Chemical Substances	alpha-Tocopherol (H4N855PNZ1) ; Antioxidants ; Liposomes
Language	English
Publishing date	2022-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14907
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Article ; Online: Quantitative ethnomedicinal study and conservation status of medicinal flora used by the indigenous peoples of Sultan Khail valley, Dir Upper, Pakistan.

Rahman, K / Akhtar, N / Subhan, F / Ali, K

Brazilian journal of biology = Revista brasleira de biologia

2023 Volume 83, Page(s) e267583

Abstract: The present study was conducted to explore the ethnomedicinal uses, quantitative analysis and conservation status of medicinal flora of Sultan Khail valley, Dir Upper, Pakistan. The data was collected during 2017-2019 using a semi-structured ... ...

Abstract	The present study was conducted to explore the ethnomedicinal uses, quantitative analysis and conservation status of medicinal flora of Sultan Khail valley, Dir Upper, Pakistan. The data was collected during 2017-2019 using a semi-structured questionnaire. Ethnomedicinal uses of plant species were determined and the plant species were classified based on habits, parts used, and method of preparation of remedies. Frequency of citation (FC), relative frequency of citation (RFC) and family importance values (FIV) were calculated. The plant species were assessed for their conservation status as per IUCN standard criteria. The inhabitants of the Sultan Khail valley use 88 plant species belonging to 57 families for the treatment of different human diseases. Lamiaceae was the dominant family represented with 8 medicinal species (9%) followed by Rosaceae (5 species, 6%). The most commonly used plant parts were leaves (33.1%) followed by fruits (16.1%), while the main method of remedy preparation was decoctions (33.3%). The highest RFC value was recorded for Geranium wallichianum (0.47), followed by Berberis lycium (0.44). Lamiaceae was the most cited family (FIV, 231), followed by Polygonaceae (73). Five plant species were found to be endangered, 39 species were vulnerable, 32 species were rare, and 12 species were found to be infrequent. The medicinal flora of the area is under severe biotic pressure and needs proper conservation; otherwise, they will be lost in the near future.
MeSH term(s)	Humans ; Plants, Medicinal ; Pakistan ; Medicine, Traditional/methods ; Phytotherapy ; Lamiaceae ; Indigenous Peoples ; Ethnobotany
Language	English
Publishing date	2023-12-22
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2036257-2
ISSN	1678-4375 ; 1519-6984
ISSN (online)	1678-4375
ISSN	1519-6984
DOI	10.1590/1519-6984.267583
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Article: Insecticidal and genotoxic activities of some indigenous weed plant extracts in fruit fly, Drosophila melanogaster

Akhtar, N.

Zeitschrift für Arznei- und Gewürzpflanzen

2019 Volume 24, Issue 1, Page(s) 10

Language	German ; English
Document type	Article
ZDB-ID	1353645-x
ISSN	1431-9292
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin.

Akhtar, Naheed / Menaa, Farid / Akhtar, Naveed / Javed, Nayla / Sethi, Aisha / Khan, Muhammad Shahzad

Journal of cosmetic dermatology

2024 Volume 23, Issue 3, Page(s) 1015–1028

Abstract: Background: Tocopherols are well-known antioxidant and moisturizing agent. Tocopherol succinate (TS) are widely used in many skin products especially used in anti-aging and skin whitening product formulation.: Aim: We previously reported the ... ...

Abstract	Background: Tocopherols are well-known antioxidant and moisturizing agent. Tocopherol succinate (TS) are widely used in many skin products especially used in anti-aging and skin whitening product formulation. Aim: We previously reported the successful synthesis and preliminary characterizations of stable TS ethosomal gels (TSEG) (DOI: 10.1111/jocd.14907). Herein, we develop and further characterize TSEG to enhance the stability of the developed formulation with increased permeation through skin. Methods: Cold method technique was used to prepare TS ethosomes. The developed ethosomal vesicle size was 250 nm, which allowed TS to penetrate through the stratum corneum layer and act on melanocytes. For stability study was assessed by thermogravimetric analysis (TGA) by placing TSEG and unloaded/control ethosomal gel (CEG) at various temperature conditions, that is, 8°C, 25°C, 40°C, and 40°C ± 75% RH for 3 months. Organoleptic evaluation was done in terms of color, odor, and phase separation. Transmission electron microscopy (TEM), Fourier Transform infrared spectroscopy (FTIR), x-ray diffraction spectroscopy (XRD), zeta potential (ZP) and particle size (PS) was used for TSEG physical characterizations. In vitro dissolution and ex-vivo permeation studies (using Franz diffusion cell) were performed for both TSEG and CEG formulations. Human women (N = 34) were used to evaluate in vivo biophysical parameters including erythema, melanin, moisture content, sebum level, and skin elasticity. Results: Developed formulation was highly thermostable during the 3 months. Erythema, melanin, and sebum level decreased while marked improvement (p < 0.05) in moisture content and elasticity have been observed for the developed TSEG. Conclusion: The developed TSEG formulation was found to be efficient, safe (no adverse effects observed), stable (at least for 3 months), and easy to use for topical application with improved skin complexation and skin integrity.
MeSH term(s)	Humans ; Female ; Skin Absorption ; alpha-Tocopherol/metabolism ; Administration, Cutaneous ; Melanins/metabolism ; Liposomes/metabolism ; Skin/metabolism ; Erythema ; Gels/metabolism
Chemical Substances	alpha-Tocopherol (H4N855PNZ1) ; Melanins ; Liposomes ; Gels
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.16054
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Article ; Online: Formulation, characterization of Quercus infectoria (Olivier) emulsions, and in vitro, in vivo evaluation as cosmeceutical formulation.

Choudhry, Ammara / Akhtar, Naveed

Journal of cosmetic dermatology

2023 Volume 22, Issue 12, Page(s) 3480–3490

Abstract: Background: Pharmacological properties of Quercus infectoria Olivier (galls) have been determined to be astringent, antidiabetic, antipyretic, anti-tremor, local anesthetic, and anti-parkinsonism. The galls of Quercus infectoria have been used for ... ...

Abstract	Background: Pharmacological properties of Quercus infectoria Olivier (galls) have been determined to be astringent, antidiabetic, antipyretic, anti-tremor, local anesthetic, and anti-parkinsonism. The galls of Quercus infectoria have been used for millennia in traditional oriental medicine in Asian nations to treat inflammatory illnesses. Aims: The study's objective was to create a Quercus infectoria Olivier gall extract in stable water in oil (w/o) emulsion and to check its effects on the mechanical properties of skin and antiaging effects. Method: The galls were macerated in absolute methanol. Quercus infectoria Olivier gall extract's antioxidant property was evaluated using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) technique. Stearic acid, cetyl alcohol, KOH, glycerin, and distilled water were used to create the emulsion. The test (with extract) and control (without extract) emulsions were made, respectively, using the same process. Stability tests (color, liquefaction, microscopy, phase separation, and pH) are performed in in vitro, lasted 72 days at four distinct storage temperatures that is 8°C, 25°C, 40°C, and 40°C + 75% RH for both the control and test formulations. By using spectrophotometry, the (SPF) sun protection factors of the two formulations were calculated at various concentrations. Extract from Quercus infectoria underwent phytochemical investigation as well. Results: The results showed that Quercus infectoria Olivier has antioxidant and (SPF) sun protection properties, reduce sebum, increases elasticity and stable emulsion containing 04% Quercus infectoria gall extract which might be used as topical antiaging formulation.
MeSH term(s)	Humans ; Plant Extracts/therapeutic use ; Antioxidants/pharmacology ; Quercus/chemistry ; Cosmeceuticals ; Emulsions ; Water
Chemical Substances	Plant Extracts ; Antioxidants ; Cosmeceuticals ; Emulsions ; Water (059QF0KO0R)
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.15865
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Article: A cross-sectional observational study for ethno-geographical disparities in sleep quality, brain morphometry and cognition (a SOLACE study) in Indians residing in India, and South Asians and Europeans residing in the UK - a study protocol.

Soni, Rishabh / Dale, Caroline / Garfield, Victoria / Akhtar, Nasreen

Frontiers in aging neuroscience

2024 Volume 16, Page(s) 1294681

Abstract: Introduction: As individuals age, their sleep patterns change, and sleep disturbances can increase the risk of dementia. Poor sleep quality can be a risk factor for mild cognitive impairment (MCI) and dementia. Epidemiological studies show a connection ... ...

Abstract	Introduction: As individuals age, their sleep patterns change, and sleep disturbances can increase the risk of dementia. Poor sleep quality can be a risk factor for mild cognitive impairment (MCI) and dementia. Epidemiological studies show a connection between sleep quality and cognitive changes, with brain imaging revealing grey matter volume reduction and amyloid beta accumulation in Alzheimer's disease. However, most research has focused on Europeans, with little attention to other ethnic groups. Methods: This is a cross sectional study comparing effects across countries and ethnicities. Group 1 ( Discussion: Racial and ethnic differences can impact the relationships of cognitive function, sleep quality and brain structure in older adults. Earlier studies have highlighted higher prevalence of poor sleep among black individuals compared to white individuals. Genetic or epigenetic mechanisms may contribute to these variations. Socio-cultural and environmental factors, such as neighbourhood, migration, lifestyle, stress and perceived discrimination may influence sleep patterns. The aim of the study is to examine the ethnogeographic variations in sleep quality, cognitive performance and brain morphometry among Indians living in India, and South Asians and Europeans residing in the UK.
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2024.1294681
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