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  1. Article ; Online: Bone scintigraphy for cardiac amyloidosis: A Canadian perspective.

    Miller, Robert Jh / Akincioglu, Cigdem

    Journal of medical imaging and radiation sciences

    2024  

    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2426513-5
    ISSN 1876-7982 ; 1939-8654
    ISSN (online) 1876-7982
    ISSN 1939-8654
    DOI 10.1016/j.jmir.2024.02.009
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  2. Article ; Online: Nuclear imaging in chronic thromboembolic pulmonary hypertension: increasingly central to diagnosis and management.

    Akincioglu, Cigdem / Mehta, Sanjay

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2022  Volume 29, Issue 6, Page(s) 3401–3404

    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnostic imaging ; Pulmonary Artery ; Diagnostic Imaging ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/therapy ; Chronic Disease
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-022-03056-8
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  3. Article ; Online: Progressive development of cardiac amyloidosis in a hereditary transthyretin gene carrier on serial Tc-99m PYP SPECT-CT.

    Abazid, Rami M / Davey, Ryan A / Romsa, Jonathan / Florendo-Cumbermack, Anita / Akincioglu, Cigdem

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2024  Volume 31, Page(s) 101774

    MeSH term(s) Humans ; Prealbumin/genetics ; Amyloidosis ; Heart/diagnostic imaging ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed ; Cardiomyopathies ; Technetium Tc 99m Pyrophosphate ; Radiopharmaceuticals
    Chemical Substances Prealbumin ; Technetium Tc 99m Pyrophosphate (5L76I61H2B) ; Radiopharmaceuticals
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1016/j.nuclcard.2023.101774
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  4. Article ; Online: Comparison of cardio-focal and chest reconstruction of technetium-99m pyrophosphate scintigraphy for diagnosis of transthyretin cardiac amyloidosis: a quality assurance study.

    Akincioglu, Cigdem / Murthi, Mukunthan / Romsa, Jonathan / Warrington, James / Malhotra, Saurabh

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2023  Volume 30, Issue 6, Page(s) 2607–2614

    Abstract: Background: SPECT improves diagnostic specificity of Technetium-99m pyrophosphate (PYP) scintigraphy. Diagnostic performance of PYP data, reconstructed as either chest or cardio-focal SPECT is not known.: Methods: In this quality assurance study, ... ...

    Abstract Background: SPECT improves diagnostic specificity of Technetium-99m pyrophosphate (PYP) scintigraphy. Diagnostic performance of PYP data, reconstructed as either chest or cardio-focal SPECT is not known.
    Methods: In this quality assurance study, blinded evaluation of PYP SPECT/CT data from 102 Caucasian patients (mean age 76 ± 11 years, 67% men) was performed by two readers. Reader 1 reviewed planar and PYP chest SPECT, while reader 2 reviewed planar and cardio-focal PYP SPECT. Demographic, clinical, and other testing data were obtained from the electronic medical records.
    Results: A total of 41 patients (40%) were considered positive based on myocardial uptake on chest PYP SPECT. Of these, 98% of the patients had a Perugini score ≥ 2 on planar imaging. There was good agreement between the two readers for visual score ≥ 2 (k = .88, P < .001) and excellent agreement for myocardial uptake on tomographic imaging (98%, P < .001). Only one study was categorized as false negative by cardio-focal SPECT reconstruction. Non-diffuse myocardial uptake was identified in 22% of those with a positive PYP SPECT.
    Conclusion: When read by experienced readers, chest and cardio-focal reconstruction of PYP SPECT have comparable diagnostic performance. A substantial proportion of patients with a positive PYP SPECT have a non-diffuse distribution of PYP. Given the possibility of misclassification of non-diffuse myocardial uptake on cardio-focal reconstruction alone, chest reconstruction of PYP scintigraphy should be strongly considered.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Amyloidosis/diagnostic imaging ; Cardiomyopathies/diagnostic imaging ; Diphosphates ; Prealbumin ; Radionuclide Imaging ; Technetium ; Technetium Tc 99m Pyrophosphate ; Quality Assurance, Health Care
    Chemical Substances Diphosphates ; Prealbumin ; Technetium (7440-26-8) ; Technetium Tc 99m Pyrophosphate (5L76I61H2B)
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-023-03256-w
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  5. Article ; Online: Low yield of routine stress testing in patients awaiting liver transplantation.

    Akincioglu, Cigdem / Malhotra, Saurabh

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2018  Volume 27, Issue 1, Page(s) 266–268

    MeSH term(s) Exercise Test ; Humans ; Liver Transplantation ; Myocardial Perfusion Imaging ; Tomography, Emission-Computed, Single-Photon
    Language English
    Publishing date 2018-08-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-018-1409-2
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  6. Article: Prognostic value of coronary computed tomography angiography compared to radionuclide myocardial perfusion imaging in patients With coronary stents.

    Abazid, Rami M / Romsa, Jonathan G / Warrington, James C / Akincioglu, Cigdem / Smettei, Osama A / Bureau, Yves / Tzemos, Nikolaos / Vezina, William C

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1087113

    Abstract: Objectives: The aim of this study is to compare the prognostic value of coronary computed tomography angiography (CCTA) with single-photon emission computed tomography (SPECT) in predicting cardiovascular events in patients with stents.: Design: ... ...

    Abstract Objectives: The aim of this study is to compare the prognostic value of coronary computed tomography angiography (CCTA) with single-photon emission computed tomography (SPECT) in predicting cardiovascular events in patients with stents.
    Design: Retrospective analysis.
    Setting: University Hospital, London, Ontario Canada
    Participants: Between January 2007 and December 2018, 119 patients post-percutaneous coronary intervention (PCI) who were referred for hybrid imaging with CTA and 2-day rest/stress SPECT were enrolled.
    Primary and secondary outcome measures: Patients were followed for any major adverse cardiovascular event (MACE) including: All-cause mortality, Non-fatal myocardial infarction (MI), Unplanned revascularization, Cerebrovascular accident and hospitalization for arrhythmia or heart failure. We define hard cardiac events (HCE) as: cardiac death, non-fatal MI or unplanned revascularization. We used two cut-off values to define obstructive lesions with CCTA ≥50% and ≥70% in any coronary segment. SPECT scan defined as abnormal in the presence of >5% reversible myocardial perfusion defect.
    Results: During the follow-up period of 7.2 ± 3.4 years. 45/119 (37.8%) patients experienced 57 MACE: Ten deaths (2 cardiac deaths and 8 of non-cardiac deaths), 29 acute coronary syndrome including non-fatal MI (25 required revascularization), 7 hospitalizations for heart failure, 6 cerebrovascular accidents and 5 new atrial fibrillation. 31 HCEs were reported. Cox regression analysis showed that obstructive coronary stenosis (≥50% and ≥70%) and abnormal SPECT were associated of MACE (
    Conclusion: Obstructive coronary artery stenosis on CCTA can predict MACE and HCE. However, abnormal SPECT can only predict MACE but not HCE in patients post-PCI with a follow-up period of approximately 7 years.
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1087113
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  7. Article ; Online: Prognostic value of coronary calcium score post coronary artery bypass graft surgery.

    Abazid, Rami M / Almohideb, Monerah A / Smettei, Osama / Alruwaili, Ahmed A / Romsa, Jonathan G / Warrington, James / Akincioglu, Cigdem / Vezina, William C

    Journal of cardiovascular computed tomography

    2022  Volume 17, Issue 1, Page(s) 64–65

    MeSH term(s) Humans ; Prognosis ; Calcium ; Predictive Value of Tests ; Coronary Artery Bypass ; Coronary Vessels ; Treatment Outcome
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Letter
    ZDB-ID 2394360-9
    ISSN 1876-861X ; 1934-5925
    ISSN (online) 1876-861X
    ISSN 1934-5925
    DOI 10.1016/j.jcct.2022.11.002
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    Zs.A 6761: Show issues Location:
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  8. Article ; Online: Complementary role of computed tomography angiography with fixed perfusion defects on SPECT myocardial perfusion imaging.

    Abazid, Rami M / Sallam, Yasmine T / Romsa, Jonathan G / Warrington, James C / Akincioglu, Cigdem / De, Sabe / Tzemos, Nikolaos / Vezina, William C

    European journal of hybrid imaging

    2022  Volume 6, Issue 1, Page(s) 3

    Abstract: Purpose: We present this case series exploring the complementary role of coronary computed tomography angiography (CCTA) to SPECT myocardial perfusion imaging (MPI) in the detection of myocardial necrosis.: Methods: A cardiac hybrid imaging database ... ...

    Abstract Purpose: We present this case series exploring the complementary role of coronary computed tomography angiography (CCTA) to SPECT myocardial perfusion imaging (MPI) in the detection of myocardial necrosis.
    Methods: A cardiac hybrid imaging database search identified 144 patients with a previous history of ST-segment elevation myocardial infarction treated with coronary revascularization. CCTA and MPI scans were evaluated to determine whether CCTA had an added value to MPI in detecting myocardial necrosis.
    Results: Five patients with patent stents and/or bypass grafts and both fixed perfusion defects on MPI and sub-endocardial hypo-perfusion on CCTA were identified. The extent and location of the perfusion defects were closely correlated between the CCTA and SPECT MPI images.
    Conclusion: In this series, CCTA and SPECT MPI were found to play a complementary role in the assessment of fixed perfusion defect, with CCTA adding specificity to the diagnosis of myocardial necrosis.
    Language English
    Publishing date 2022-02-01
    Publishing country England
    Document type Journal Article
    ISSN 2510-3636
    ISSN (online) 2510-3636
    DOI 10.1186/s41824-021-00124-z
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  9. Article ; Online: Total-Body PET/CT Applications in Cardiovascular Diseases: A Perspective Document of the SNMMI Cardiovascular Council.

    Slart, Riemer H J A / Bengel, Frank M / Akincioglu, Cigdem / Bourque, Jamieson M / Chen, Wengen / Dweck, Marc R / Hacker, Marcus / Malhotra, Saurabh / Miller, Edward J / Pelletier-Galarneau, Matthieu / Packard, René R S / Schindler, Thomas H / Weinberg, Richard L / Saraste, Antti / Slomka, Piotr J

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2024  

    Abstract: Digital PET/CT systems with a long axial field of view have become available and are emerging as the current state of the art. These new camera systems provide wider anatomic coverage, leading to major increases in system sensitivity. Preliminary results ...

    Abstract Digital PET/CT systems with a long axial field of view have become available and are emerging as the current state of the art. These new camera systems provide wider anatomic coverage, leading to major increases in system sensitivity. Preliminary results have demonstrated improvements in image quality and quantification, as well as substantial advantages in tracer kinetic modeling from dynamic imaging. These systems also potentially allow for low-dose examinations and major reductions in acquisition time. Thereby, they hold great promise to improve PET-based interrogation of cardiac physiology and biology. Additionally, the whole-body coverage enables simultaneous assessment of multiple organs and the large vascular structures of the body, opening new opportunities for imaging systemic mechanisms, disorders, or treatments and their interactions with the cardiovascular system as a whole. The aim of this perspective document is to debate the potential applications, challenges, opportunities, and remaining challenges of applying PET/CT with a long axial field of view to the field of cardiovascular disease.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.123.266858
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    Zs.MO 328: Show issues

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  10. Article ; Online: Internal Jugular Vein and Cerebral Venous Sinus Infective Thrombophlebitis Detected With 99mTc-HMPAO White Blood Cell Scintigraphy.

    Sistani, Golmehr / Zukotynski, Katherine A / Akincioglu, Cigdem / Romsa, Jonathan G / Warrington, James C

    Clinical nuclear medicine

    2020  Volume 46, Issue 2, Page(s) e112–e113

    Abstract: Abstract: A 35-year-old man with a history of renal transplant, congenital cystinosis, and diabetes was admitted to the hospital with fever, bilateral parotid gland swelling, and acute renal failure. He had 99mTc-HMPAO-WBC (99mTc- ... ...

    Abstract Abstract: A 35-year-old man with a history of renal transplant, congenital cystinosis, and diabetes was admitted to the hospital with fever, bilateral parotid gland swelling, and acute renal failure. He had 99mTc-HMPAO-WBC (99mTc-hexamethylpropyleneamineoxime white blood cell) imaging for the evaluation of possible parotitis. There was intense radiopharmaceutical uptake along the right internal jugular vein extending to the right sigmoid and transverse and superior sagittal sinuses, suggestive of infective thrombophlebitis or Lemierre syndrome. This study illustrates the value of 99mTc-HMPAO-WBC imaging as a tool for evaluating thrombophlebitis, particularly in patients with renal failure in whom contrast-enhanced CT may not be possible.
    MeSH term(s) Adult ; Cavernous Sinus Thrombosis/diagnostic imaging ; Humans ; Jugular Veins/diagnostic imaging ; Leukocytes/metabolism ; Male ; Radionuclide Imaging ; Technetium Tc 99m Exametazime
    Chemical Substances Technetium Tc 99m Exametazime (3B744AG22N)
    Language English
    Publishing date 2020-10-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003352
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