Article: Precise Pediatric Cancer Diagnosis Using Immunohistochemistry: Reducing Cost of Care and Improving Outcomes in a Low and Middle-Income Setting.
West African journal of medicine
2024 Volume 40, Issue 12, Page(s) 1341–1346
Abstract: Childhood cancer is a significant cause of morbidity and mortality worldwide. It is the second-leading cause of non-communicable deaths among children worldwide with more than 90% of childhood cancer-associated mortality occurring in low-income and ... ...
| Abstract | Childhood cancer is a significant cause of morbidity and mortality worldwide. It is the second-leading cause of non-communicable deaths among children worldwide with more than 90% of childhood cancer-associated mortality occurring in low-income and middle-income countries. Disparity in mortality rates has been linked to late presentation, inaccurate diagnosis, treatment abandonment and poor access to appropriate therapy. Access to enhanced diagnostics such as immunohistochemistry (IHC) is vital for proper diagnosis and prompt institution of appropriate treatment for children with cancers. However, despite the ever-increasing insight into the use of these techniques for timely and accurate diagnosis of pediatric cancers; simple histological diagnosis remains the mainstay in most of the LMIC owing to financial constraints, unavailability of facilities and skilled manpower. Limited access results in imprecise diagnosis including missed diagnosis, misdiagnosis, and wrong diagnosis, subsequently resulting in increased cost of care and poor treatment outcomes. This article focuses on the benefits of precise diagnosis among children who presented with cancers in an LMIC and the observed reduction in the cost of care, length of hospital stay, and improved outcome in the observed cohort as well as how to improve and promote access. |
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| MeSH term(s) | Humans ; Child ; Developing Countries ; Immunohistochemistry ; Neoplasms ; Health Facilities ; Length of Stay |
| Language | English |
| Publishing date | 2024-01-25 |
| Publishing country | Nigeria |
| Document type | Journal Article |
| ZDB-ID | 1132088-6 |
| ISSN | 0189-160X |
| ISSN | 0189-160X |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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