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Article ; Online: Assessment of the anxiolytic, antidepressant, and antioxidant potential of Parquetina nigrescens (Afzel.) Bullock in Wistar rats.

Akinduko, Ayokunmi Adebukola / Salawu, Sule Ola / Akinmoladun, Afolabi Clement / Akindahunsi, Afolabi Akintunde / Osemwegie, Osarenkhoe Omorefosa

Journal of ethnopharmacology

2023 Volume 322, Page(s) 117597

Abstract: Ethnopharmacological relevance: The recent growing concerns about the multisystemic nature of mental health conditions in the global population are facilitating a new paradigm involving alternative natural, nutritional, and complementary therapies. ... ...

Abstract	Ethnopharmacological relevance: The recent growing concerns about the multisystemic nature of mental health conditions in the global population are facilitating a new paradigm involving alternative natural, nutritional, and complementary therapies. Herbal remedies despite accounts in literature of their ethnobotanical as alternative remedies for diverse ailments, remain underexplored for psychiatric disorders like anxiety, depression, and insomnia. Aim of the study: Hence, the anxiolytic, antidepressant, and antioxidant properties of a hydro-ethanolic leaf extract of Parquetina nigrescens (PN) in male Wistar rats were investigated. Materials and methods: The sedative effect was evaluated using the Diazepam sleeping time test while anxiety was induced with a single intraperitoneal injection of 20 mg/kg pentylenetetrazol (PTZ). This was after pre-treatment with 100, 150, and 250 mg/kg of PN or the standard drugs (1 mg/kg diazepam and 30 mg/kg imipramine) for 14 consecutive days. Behavioral tests (Open Field test, Elevated Plus-Maze test, and Forced Swim test) were performed on days 1 and 14, to evaluate the antidepressant and anxiolytic activities of PN. Oxidative stress and neurochemical markers were determined in the brain homogenates of the animals. Results: The duration of sleep was significantly (p < 0.001) increased in the PN-administered group compared to the control. The behavioral models showed that PN exhibited antidepressant and anxiolytic properties in PTZ-induced animals. Significant reductions were observed in GSH level and SOD activity while MDA, nitrite, and GPx levels were significantly increased in PTZ-induced rats. However, treatment with PN significantly improved brain antioxidant status by ameliorating the PTZ-induced oxidative stress. Dopamine, cortisol, and acetylcholine esterase activity levels were significantly (p < 0.05) elevated while serotonin and brain-derived neurotrophic factors were reduced in PTZ-induced rats compared with the control. Conclusion: The PN demonstrated neurotransmitter modulatory ability by ameliorating the PTZ-induced neurochemical dysfunction. Findings from this study showed that PN exhibited sedative, antidepressant, and anxiolytic activities in rats.
MeSH term(s)	Humans ; Rats ; Male ; Animals ; Anti-Anxiety Agents/pharmacology ; Anti-Anxiety Agents/therapeutic use ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Rats, Wistar ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/chemistry ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Diazepam/pharmacology ; Diazepam/therapeutic use ; Hypnotics and Sedatives/pharmacology ; Behavior, Animal ; Depression/drug therapy
Chemical Substances	Anti-Anxiety Agents ; Antioxidants ; Plant Extracts ; Antidepressive Agents ; Diazepam (Q3JTX2Q7TU) ; Hypnotics and Sedatives
Language	English
Publishing date	2023-12-19
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117597
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Article ; Online: Time and Brain Region-Dependent Excitatory Neurochemical Alterations in Bilateral Common Carotid Artery Occlusion Global Ischemia Model.

Ojo, Olubukola Benedicta / Amoo, Zainab Abiola / Olaleye, Mary Tolulope / Jha, Sushil Kumar / Akinmoladun, Afolabi Clement

Neurochemical research

2022

Abstract: Strict metabolic regulation in discrete brain regions leads to neurochemical changes in cerebral ischemia. Accumulation of extracellular glutamate is one of the early neurochemical changes that take place during cerebral ischemia. Understanding the ... ...

Abstract	Strict metabolic regulation in discrete brain regions leads to neurochemical changes in cerebral ischemia. Accumulation of extracellular glutamate is one of the early neurochemical changes that take place during cerebral ischemia. Understanding the sequential neurochemical processes involved in cerebral ischemia-mediated excitotoxicity before the clinical intervention of revascularization and reperfusion may greatly influence future therapeutic strategies for clinical stroke recovery. This study investigated the influence of time and brain regions on excitatory neurochemical indices in the bilateral common carotid artery occlusion (BCCAO) model of global ischemia. Male Wistar rats were subjected to BCCAO for 15 and 60 min to evaluate the effect of ischemia duration on excitatory neurochemical indices (dopamine level, glutamine synthetase, glutaminase, glutamate dehydrogenase, aspartate aminotransferase, monoamine oxidase, acetylcholinesterase, and Na
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	199335-5
ISSN	1573-6903 ; 0364-3190
ISSN (online)	1573-6903
ISSN	0364-3190
DOI	10.1007/s11064-022-03732-8
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Article: Quercetin and catechin assuage redox imbalance and neurochemical dysfunction in rotenone-induced neurotoxicity: A comparative in vivo experiment supported by in silico study

Solomon Josiah, Sunday / Umar, Haruna Isiyaku / Saliu, Ibrahim Olabayode / Akinmoladun, Afolabi Clement

Phytomedicine plus. 2021 Nov., v. 1, no. 4

2021

Abstract: Quercetin and catechin are structurally-related compounds that are capable of preventing or attenuating oxidative damage and mitochondrial dysfunction. Rotenone is a naturally occurring compound that has been used to model neurotoxicity characterized by ... ...

Abstract	Quercetin and catechin are structurally-related compounds that are capable of preventing or attenuating oxidative damage and mitochondrial dysfunction. Rotenone is a naturally occurring compound that has been used to model neurotoxicity characterized by Parkinson disease-like symptoms. This study investigated the comparative property of quercetin and catechin, to ameliorate oxidative damage and neurochemical dysfunction in hippocampal and cortical regions of brain of rats intoxicated with rotenone in vivo, supported by in silico study. Male Wistar rats were subcutaneously administered rotenone for 10 days followed by post-treatment with catechin or quercetin (5, 10 and 20 mg/kg) for 3 days. Markers of oxidative stress and neurochemical dysfunction were biochemically estimated in the hippocampus and cortex of the brain of rats while in silico study was carried out to evaluate the molecular interaction of some neurochemical enzymes with the compounds. Quercetin and catechin ameliorated the reduction in complex 1 and Na⁺K⁺ATPase activities while attenuating the elevated lactate dehydrogenase activity in the brain of rotenone-intoxicated rats. Disturbances in acetylcholine, dopamine and glutamate metabolism as well as the evoked oxidative stress in rotenone-intoxicated rats were mitigated by quercetin and catechin. The in silico study revealed the key molecular interaction between the flavonoids and targeted enzymes (tyrosine hydroxylase, monoamine oxidase, glutamine synthetase and Na⁺K⁺ATPase) to be by hydrogen bond and hydrophobic interaction. Catechin and quercetin significantly assuaged cortical and hippocampal redox stress and attenuated neurochemical dysfunction caused by rotenone toxicity. Furthermore, this study highlighted that the neuroprotective potentials of the flavonoids is a function of their structural patterns, and quercetin elicited superior activity over catechin due to its structural advantages.
Keywords	acetylcholine ; amine oxidase (flavin-containing) ; catechin ; computer simulation ; cortex ; dopamine ; glutamate-ammonia ligase ; glutamic acid ; hippocampus ; hydrogen bonding ; hydrophobic bonding ; lactate dehydrogenase ; males ; metabolism ; mitochondria ; neurotoxicity ; oxidative stress ; quercetin ; rotenone ; tyrosine 3-monooxygenase
Language	English
Dates of publication	2021-11
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2667-0313
DOI	10.1016/j.phyplu.2021.100077
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Article: Antioxidant property of Eucalyptus globulus Labill. Extracts and inhibitory activities on carbohydrate metabolizing enzymes related to type-2 diabetes

Bello, Morenikejimi / Jiddah-kazeem, Bidemi / Fatoki, Toluwase Hezekiah / Ibukun, Emmanuel Oluwafemi / Akinmoladun, Afolabi Clement

Biocatalysis and agricultural biotechnology. 2021 Sept., v. 36

2021

Abstract: This research evaluated the antioxidant property and carbohydrate metabolizing enzyme inhibitory activity of Eucalyptus globulus Labill leaf extracts. Ethanol extracts of the prior hexane-defatted (DEE) and the non-defatted (NEE) leaf samples of the ... ...

Abstract	This research evaluated the antioxidant property and carbohydrate metabolizing enzyme inhibitory activity of Eucalyptus globulus Labill leaf extracts. Ethanol extracts of the prior hexane-defatted (DEE) and the non-defatted (NEE) leaf samples of the plant were prepared and screened for constituent phytochemicals by HPLC-DAD. The extracts were tested for antioxidant activity, α-amylase and α-glucosidase inhibitory activities and molecular docking with selected protein targets were carried out. The two extracts showed notable antioxidant property. Lipid peroxidation inhibitory activities of DEE, NEE and ascorbic acid were 28.4 ± 1.1 μg/ml, 33.3 ± 1.1 μg/ml, and 34.5 ± 1.2 μg/ml, respectively, in terms of IC₅₀. The extracts also demonstrated appreciable inhibition of the carbohydrate metabolizing enzymes when compared to acarbose. IC₅₀ values for α-amylase inhibition were 23.6 ± 1.2 μg/ml, 14.8 ± 1.2 μg/ml and 5.2 ± 1.3 μg/ml for DEE, NEE and acarbose, respectively (p < 0.05), while IC₅₀ values for α-glucosidase inhibition were 30.0 ± 1.1 μg/ml, 6.5 ± 1.2 μg/ml and 29.8 ± 1.8 μg/ml for DEE, NEE and acarbose, respectively (p < 0.05). HPLC analysis of the extracts indicated that the defatting process eliminated pinitol and robinetinidol, and reduced the concentration the remaining phytoconstituents in the defatted extract. Catechin, ergosterol, pinitol, quercetin and robinetinidol identified by HPLC from the defatted and non-defatted extract displayed good interaction with the carbohydrate metabolizing enzymes with ergosterol presenting the best interaction. These results show that both extracts could be explored in alternative therapeutic approaches for type-2 diabetes. The non-defatted extract appeared to demonstrate superior activities suggesting a positive contribution from the lipophilic constituents of the plant.
Keywords	Eucalyptus globulus ; acarbose ; agricultural biotechnology ; alpha-amylase ; antioxidant activity ; ascorbic acid ; biocatalysis ; catechin ; chemical constituents of plants ; defatting ; enzyme inhibitors ; ergosterol ; ethanol ; leaves ; lipid peroxidation ; lipophilicity ; noninsulin-dependent diabetes mellitus ; pinitol ; quercetin ; therapeutics
Language	English
Dates of publication	2021-09
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2642052-1
ISSN	1878-8181
ISSN	1878-8181
DOI	10.1016/j.bcab.2021.102111
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Article ; Online: Ameliorative influence of Garcinia kola seed extracts against multiple organ toxicity in monosodium glutamate-administered Wistar rats

Kareem, Akeem / Josiah, Sunday Solomon / Saliu, Ibrahim Olabayode / Olayeriju, Olanrewaju Sam / Akinmoladun, Afolabi Clement / Akindahunsi, Akintunde Afolabi

Comp Clin Pathol. 2022 Dec., v. 31, no. 6, p. 987-1004

2022 , Page(s) 987–1004

Abstract: Monosodium glutamate (MSG) is a food additive that can be toxic to multiple organs of the body. It has been demonstrated that Garcinia kola seed has enormous health benefits and protects against exposure to toxicants. This study aimed to investigate the ... ...

Abstract	Monosodium glutamate (MSG) is a food additive that can be toxic to multiple organs of the body. It has been demonstrated that Garcinia kola seed has enormous health benefits and protects against exposure to toxicants. This study aimed to investigate the effect of Garcinia kola seed extracts on multi-organ toxicity in MSG-administered rats. Methanol and alkaloid-rich extracts of Garcinia kola seeds (GKME and GKAE, respectively) were prepared and phytochemically characterized using HPLC–DAD. Adult male Wistar rats received 2 g/kg MSG orally for 21 days with or without co-treatment with GKME, GKAE, quercetin, or nicotinic acid. Biochemical analyses were carried out on the plasma, kidney, heart, liver, and the striatum, hippocampus, and cortex of the brain of the rats. Histopathological analysis was also carried out on the tissues and organs. Intoxication with MSG caused marked negative alterations to the levels of liver function markers, kidney function markers, and the lipid profile. MSG administration also produced deleterious effects on biomarkers related to cardiac and neurologic function as echoed by increased atherogenic and coronary risk indices, and altered levels of lactate dehydrogenase, acetylcholinesterase and dopamine. Also, MSG-intoxication evoked oxidative damage in the kidney, heart, liver, and discrete brain regions. These biochemical findings were corroborated by histopathological observation which revealed abnormalities in the tissues of MSG-administered rats. The multiorgan deteriorative and oxidative damage, and the histopathological aberrations of MSG toxicity were mitigated by GKME and GKAE. These findings suggest that Garcinia kola is beneficial in ameliorating MSG-induced toxicity.
Keywords	Garcinia kola ; acetylcholinesterase ; adults ; biomarkers ; cortex ; dopamine ; food additives ; heart ; hippocampus ; histopathology ; kidneys ; lactate dehydrogenase ; lipid composition ; liver ; liver function ; males ; methanol ; monosodium glutamate ; niacin ; poisoning ; quercetin ; renal function ; risk ; toxic substances ; toxicity
Language	English
Dates of publication	2022-12
Size	p. 987-1004
Publishing place	Springer London
Document type	Article ; Online
ZDB-ID	2070651-0
ISSN	1618-565X ; 1618-5641
ISSN (online)	1618-565X
ISSN	1618-5641
DOI	10.1007/s00580-022-03406-5
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Article: Nutritional benefits, phytochemical constituents, ethnomedicinal uses and biological properties of Miracle fruit plant (

Akinmoladun, Afolabi Clement / Adetuyi, Aanuoluwapo Ruth / Komolafe, Kayode / Oguntibeju, Oluwafemi Omoniyi

Heliyon

2020 Volume 6, Issue 12, Page(s) e05837

Abstract: Miracle fruit plant or Miracle berry plant ( ...

Abstract	Miracle fruit plant or Miracle berry plant (
Language	English
Publishing date	2020-12-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e05837
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Article ; Online: Kigelia africana

Falode, John Adeolu / Akinmoladun, Afolabi Clement / Olaleye, Mary Tolulope / Akindahunsi, Afolabi Akintunde

Drug and chemical toxicology

2020 Volume 45, Issue 4, Page(s) 1614–1624

Abstract: The effect ... ...

Abstract	The effect of
MeSH term(s)	Adenosine Triphosphatases/metabolism ; Adenosine Triphosphatases/pharmacology ; Animals ; Brain/metabolism ; Calcium/metabolism ; Liver/metabolism ; Mitochondria, Liver ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Membrane Transport Proteins/pharmacology ; Mitochondrial Membranes ; Mitochondrial Permeability Transition Pore ; Permeability ; Plant Extracts/chemistry ; Rats ; Rats, Wistar
Chemical Substances	Mitochondrial Membrane Transport Proteins ; Mitochondrial Permeability Transition Pore ; Plant Extracts ; Adenosine Triphosphatases (EC 3.6.1.-) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	548368-2
ISSN	1525-6014 ; 0148-0545
ISSN (online)	1525-6014
ISSN	0148-0545
DOI	10.1080/01480545.2020.1850757
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Article ; Online: Protective properties of

Akinmoladun, Afolabi Clement / Adelabu, Adesola Adebusayo / Saliu, Ibrahim Olabayode / Adetuyi, Aanuoluwapo Ruth / Olaleye, Mary Tolulope

Science progress

2021 Volume 104, Issue 2, Page(s) 368504211011866

Abstract: Cyanide is an environmental neurotoxin which has been reported to arrest the normal functioning of the brain. This study investigated the protective properties of methanol and flavonoid-rich extracts of the leaves ... ...

Abstract	Cyanide is an environmental neurotoxin which has been reported to arrest the normal functioning of the brain. This study investigated the protective properties of methanol and flavonoid-rich extracts of the leaves of
MeSH term(s)	Anacardiaceae ; Animals ; Cholinergic Agents ; Cyanides ; Flavonoids/pharmacology ; Male ; Methanol ; Oxidation-Reduction ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats ; Rats, Wistar
Chemical Substances	Cholinergic Agents ; Cyanides ; Flavonoids ; Plant Extracts ; Methanol (Y4S76JWI15)
Language	English
Publishing date	2021-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	128412-5
ISSN	2047-7163 ; 0036-8504 ; 0302-1785
ISSN (online)	2047-7163
ISSN	0036-8504 ; 0302-1785
DOI	10.1177/00368504211011866
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Article ; Online: Nutritional benefits, phytochemical constituents, ethnomedicinal uses and biological properties of Miracle fruit plant (Synsepalum dulcificum Shumach. & Thonn. Daniell)

Akinmoladun, Afolabi Clement / Adetuyi, Aanuoluwapo Ruth / Komolafe, Kayode / Oguntibeju, Oluwafemi Omoniyi

Heliyon. 2020 Dec., v. 6, no. 12 p.e05837-

2020

Abstract: Miracle fruit plant or Miracle berry plant (Synsepalum dulcificum) is a peculiar medicinal plant because of the unique taste-modifying property of its fruit which is due to the presence of the glycoprotein, miraculin. This property has been known for ... ...

Abstract	Miracle fruit plant or Miracle berry plant (Synsepalum dulcificum) is a peculiar medicinal plant because of the unique taste-modifying property of its fruit which is due to the presence of the glycoprotein, miraculin. This property has been known for centuries to the people of tropical Western and Central Africa who also employ different parts of the plant in the management of various ailments. Scientific investigations have unravelled several pharmacological properties of the plant which include antidiabetic, blood cholesterol-lowering, anti-hyperuricaemia, antioxidant, anticonvulsant and anticancer properties. Also, subacute administration of the plant extract up to 200 mg/kg was not found to be toxic in rats. Apart from miraculin, other pharmacologically active compounds have been identified in the plant including alkaloids (dihydro-feruloyl-5-methoxytyramine, N-cis-caffeoyltyramine, N-cis-feruloyl-tyramine), lignins (+-syringaresinol, +-epi-syringaresinol), phytosterols, triterpenoids, phenolic acids, flavonoids, and amino acids. The plant has also been credited with notable nutritional benefits. Proper documentation of available information on folkloric use, biological activity, constituent phytocompounds, and nutritional benefits of ethnobotanicals will go a long way in affording optimal benefits from their therapeutic potentials. This can also aid in the conservation of species at risk of extinction. This work presents an up-to-date review of the ethnobotany, phytochemistry, biological and nutritional properties of Synsepalum dulcificum.
Keywords	Synsepalum dulcificum ; anticonvulsants ; antioxidants ; blood ; ethnobotany ; extinction ; flavonoids ; fruits ; glycoproteins ; lignin ; medicinal plants ; medicinal properties ; people ; phytosterols ; plant extracts ; risk ; therapeutics ; toxicity ; triterpenoids ; Central Africa ; Miracle fruit ; Ethnobotanical use ; Bioactivities ; Phytochemicals ; Nutritional benefits ; Commercial applications
Language	English
Dates of publication	2020-12
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e05837
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Article ; Online: Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB, IκKB, and p53 genes in male Wistar rats.

Josiah, Sunday Solomon / Famusiwa, Courage Dele / Crown, Olamide Olajusi / Lawal, Akeem O / Olaleye, Mary Tolulope / Akindahunsi, Afolabi Akintunde / Akinmoladun, Afolabi Clement

Neurotoxicology

2022 Volume 90, Page(s) 158–171

Abstract: The neurobehavioral, brain redox-stabilizing and neurochemical modulatory properties of catechin and quercetin in rotenone-induced Parkinsonism, and the involvement of NF-κB-mediated inflammation, were investigated. Male Wistar rats subcutaneously ... ...

Abstract	The neurobehavioral, brain redox-stabilizing and neurochemical modulatory properties of catechin and quercetin in rotenone-induced Parkinsonism, and the involvement of NF-κB-mediated inflammation, were investigated. Male Wistar rats subcutaneously administered with multiple doses of 1.5 mg/kg rotenone were post-treated with 5-20 mg/kg catechin or quercetin. This was followed by neurobehavioral evaluation, biochemical estimations, and assessment of neurotransmitter metabolism in the striatum. Expression of genes involved in the canonical pathway for the activation of NF-κB mediated inflammation (IL-1β, TNF-α, NF-κB, and IκKB) and the pro-apoptotic gene, p53, in the striatum was determined by RT-qPCR. Catechin and quercetin mitigated neurobehavioral deficits caused by rotenone. Both flavonoids attenuated striatal redox stress and neurochemical dysfunction, optimized disturbed dopamine metabolism, and improved depletion of neuron density caused by rotenone toxicity. While administration of catechin produced a more pronounced attenuating effect on IL-1β, TNF-α, and p53 genes, the attenuating effect of quercetin (20 mg/kg) was more pronounced on NF-κB and IκKB gene expressions when compared to the group administered with rotenone only. Comparatively, quercetin demonstrated superior protection against rotenone neurotoxicity. It is concluded that catechin and quercetin have potential relevance in Parkinson's disease therapy through amelioration of redox stress, optimization of dopamine metabolism, and modulation of anti-inflammatory and anti-apoptotic pathways.
MeSH term(s)	Animals ; Catechin/adverse effects ; Dopamine/metabolism ; Genes, p53 ; Inflammation/metabolism ; Male ; NF-kappa B/metabolism ; Neuroprotective Agents/therapeutic use ; Oxidative Stress ; Parkinsonian Disorders/chemically induced ; Parkinsonian Disorders/drug therapy ; Quercetin/pharmacology ; Rats ; Rats, Wistar ; Rotenone/toxicity ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	NF-kappa B ; Neuroprotective Agents ; Tumor Necrosis Factor-alpha ; Rotenone (03L9OT429T) ; Catechin (8R1V1STN48) ; Quercetin (9IKM0I5T1E) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2022-03-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800820-6
ISSN	1872-9711 ; 0161-813X
ISSN (online)	1872-9711
ISSN	0161-813X
DOI	10.1016/j.neuro.2022.03.004
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