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  1. AU="Akinwunmi, Adenike O"
  2. AU="Gopalakrishnan, Shyam"
  3. AU="Muralidharan, K K"
  4. AU="Andersson, Borje S"
  5. AU="Bajaj, Sumali"
  6. AU="Iwanaga, Terunao"
  7. AU="Alanazi, Bader S"
  8. AU="Tsuda, Kazutoshi"
  9. AU=Gilroy Derek W
  10. AU="Yang, Shaofan"
  11. AU="Cucui, Andrea"
  12. AU="Sarma, Birinchi Kumar"
  13. AU="Schrader, Thomas"
  14. AU="Macleod, Kay F"
  15. AU="Vishnuprabha, R. Sangeetha"
  16. AU=Singh B N
  17. AU="Shahir Asfahan"
  18. AU="A.E.Pace, "
  19. AU="Scharbert, J"
  20. AU=Alganabi Mashriq
  21. AU=Balthazar Emil J
  22. AU="Pallos, Debora"
  23. AU="Tatsuya Igarashi"
  24. AU="Martinez, Randy"
  25. AU="Fu, Yayan"
  26. AU=Hertel Laura
  27. AU="Sasivimolrattana, Thanayod"
  28. AU="McAuley, Arnold" AU="McAuley, Arnold"
  29. AU="Reithmeier, Reinhart A F"
  30. AU="Ma, Dongmei"
  31. AU="Suh, M. H"
  32. AU="Xiao-Cheng Sun"
  33. AU="Belizario Quispe, Germán"

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  1. Artikel ; Online: The Hydrophobic Extract of

    Owumi, Solomon E / Ajakaiye, Blessing / Akinwunmi, Adenike O / Nwozo, Sarah O / Oyelere, Adegboyega K

    Molecules (Basel, Switzerland)

    2023  Band 28, Heft 7

    Abstract: Aflatoxin B1 ( ... ...

    Abstract Aflatoxin B1 (AFB
    Mesh-Begriff(e) Adult ; Rats ; Male ; Humans ; Animals ; Aflatoxin B1/toxicity ; Sorghum ; Apigenin/pharmacology ; Apigenin/metabolism ; Liver ; Inflammation/metabolism ; Biomarkers/metabolism
    Chemische Substanzen Aflatoxin B1 (9N2N2Y55MH) ; Apigenin (7V515PI7F6) ; Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2023-03-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28073013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Hefte anzeigen

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  2. Artikel ; Online: Aflatoxin B1-induced dysfunction in male rats' reproductive indices were abated by Sorghum bicolor (L.Moench) hydrophobic fraction.

    Owumi, Solomon E / Akinwunmi, Adenike O / Nwozo, Sarah O / Arunsi, Uche O / Oyelere, Adegboyega K

    Reproductive toxicology (Elmsford, N.Y.)

    2023  Band 120, Seite(n) 108425

    Abstract: The burden of infertility distresses millions of families worldwide. The harmful effects of aflatoxin B1 (AFB1) on the reproductive system involve oxidative stress, culminating in inflammation and cellular apoptosis. The phytochemical in Sorghum bicolor ... ...

    Abstract The burden of infertility distresses millions of families worldwide. The harmful effects of aflatoxin B1 (AFB1) on the reproductive system involve oxidative stress, culminating in inflammation and cellular apoptosis. The phytochemical in Sorghum bicolor is rich in antioxidants and anti-inflammatory activities. The effect of Sorghum bicolor (L.) Moench (SBE-HP) extract -hydrophobic fraction- enriched in Apigenin (API) was investigated in rats chronically dosed with AFB1 and the likely mechanism (s) of SBE-HP to protect against AFB1-induced reproductive toxicity. Adult Wistar male rats (twenty-four) were selected randomly and allocated into four groups. Cohort 1 was administered 0.05 % carboxymethyl cellulose (CMC); cohort 2 received AFB1 (50 µg/kg) alone; while cohorts 3 and 4 received 5 & 10 mg/kg of (SBE-HP) respectively, along with 50 µg/kg of AFB1. After 28 days, AFB1 induced remarkable reproductive toxicity as evidenced by increased sperm abnormalities, lowered sperm quality and motility, altered serum hormonal levels and testicular enzyme activities, decreased anti-oxidants, increased pro-oxidants, apoptotic and inflammatory biomarkers, as well as altered histoarchitectural structure of the testis, epididymis, and hypothalamus of rats. API-enriched extract of S. bicolor reduced AFB1-induced oxidative, inflammatory, apoptotic, and histological derangement by improving sperm function parameters, testicular enzymes, and reproductive hormones. Anti-oxidant levels and anti-inflammatory mediators were increased while decreases in the activities and levels of pro-oxidants, pro-inflammatory molecules and caspase-9 occurred in the rats' testes, epididymis, and hypothalamus. API-enriched S. bicolor protected the testes, epididymis, and hypothalamus of male rats exposed to AFB1 by modulating oxidative stress, inflammation, and apoptosis.
    Mesh-Begriff(e) Rats ; Male ; Animals ; Rats, Wistar ; Aflatoxin B1/toxicity ; Sorghum/metabolism ; Reactive Oxygen Species ; Seeds/metabolism ; Antioxidants/metabolism ; Oxidative Stress ; Inflammation/chemically induced ; Anti-Inflammatory Agents/therapeutic use
    Chemische Substanzen Aflatoxin B1 (9N2N2Y55MH) ; Reactive Oxygen Species ; Antioxidants ; Anti-Inflammatory Agents
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 639342-1
    ISSN 1873-1708 ; 0890-6238
    ISSN (online) 1873-1708
    ISSN 0890-6238
    DOI 10.1016/j.reprotox.2023.108425
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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