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  1. AU="Akira Goto"
  2. AU="Javier Pizarro-Cerda"
  3. AU="Oakley, James V"
  4. AU="Wen, Teresa H"
  5. AU="Li, Huiyu"
  6. AU="Pannala, Ananth S"
  7. AU="Noda, K."
  8. AU="Almeida, Carolina Aparecida Faria"
  9. AU=Khoshakhlagh Arezou
  10. AU="Sofija Glamočlija"
  11. AU="Fleming, Sherry D"
  12. AU="Minkina, Tatiana M"
  13. AU="Fonseca, Danielle"
  14. AU="Maximilian, Carmen-Rodica"
  15. AU="Heuer, Lauren B"
  16. AU="Pan, Judy"
  17. AU="Doro, M."
  18. AU="Navarro-Zapata, Alfonso"
  19. AU="Martin, Emanuel H"
  20. AU="Biswas, Arnab"
  21. AU="Kurt Pfister"
  22. AU="Stefano Brignola"
  23. AU="Nierzwicki, Łukasz"
  24. AU="Benvin, Iva"
  25. AU="Sardesai, S. C."
  26. AU="Aldrees, Rana"

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  1. Artikel ; Online: Individuals reciprocate negative actions revealing negative upstream reciprocity.

    Ryohei Umetani / Hitoshi Yamamoto / Akira Goto / Isamu Okada / Eizo Akiyama

    PLoS ONE, Vol 18, Iss 7, p e

    2023  Band 0288019

    Abstract: Indirect reciprocity is widely recognized as a mechanism for explaining cooperation and can be divided into two sub-concepts: downstream and upstream reciprocity. Downstream reciprocity is supported by reputation; if someone sees you helping someone else, ...

    Abstract Indirect reciprocity is widely recognized as a mechanism for explaining cooperation and can be divided into two sub-concepts: downstream and upstream reciprocity. Downstream reciprocity is supported by reputation; if someone sees you helping someone else, the person who sees this will think higher of you, and you will be more likely to be helped. Upstream reciprocity is helping someone because you are being helped by somebody else, which often happens in everyday life and experimental games. This paper focuses on the behavior of "take" and examines negative upstream reciprocity using an upstream reciprocity framework. The term "take" is defined as "to steal rather than give resources to others." "If something is taken from you, do you take from others?" is an important extension for indirect reciprocity research; subsequently, this paper discusses experiments conducted on whether negative upstream reciprocity is chained and what causes it. The results demonstrated differences between positive and negative upstream reciprocity. In analyzing the data of nearly 600 participants to determine the extent to which negative upstream reciprocity is observed and the causes of negative upstream reciprocity, the study found that If individual A takes resources from individual B, then B is more likely to take resources from a third-party, individual C. Notably, some causes of positive upstream reciprocity were found to have no effect or the opposite effect on negative upstream reciprocity. The results also demonstrate that the first person to take can cause a chain reaction. This paper demonstrates the importance of the first person not taking from someone else and suggests the need to consider various behavioral options for future research on cooperation.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 940
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Verloren negatively regulates the expression of IMD pathway dependent antimicrobial peptides in Drosophila

    Pragya Prakash / Arghyashree Roychowdhury-Sinha / Akira Goto

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Band 13

    Abstract: Abstract Drosophila immune deficiency (IMD) pathway is similar to the human tumor necrosis factor receptor (TNFR) signaling pathway and is preferentially activated by Gram-negative bacterial infection. Recent studies highlighted the importance of IMD ... ...

    Abstract Abstract Drosophila immune deficiency (IMD) pathway is similar to the human tumor necrosis factor receptor (TNFR) signaling pathway and is preferentially activated by Gram-negative bacterial infection. Recent studies highlighted the importance of IMD pathway regulation as it is tightly controlled by numbers of negative regulators at multiple levels. Here, we report a new negative regulator of the IMD pathway, Verloren (Velo). Silencing of Velo led to constitutive expression of the IMD pathway dependent antimicrobial peptides (AMPs), and Escherichia coli stimulation further enhanced the AMP expression. Epistatic analysis indicated that Velo knock-down mediated AMP upregulation is dependent on the canonical members of the IMD pathway. The immune fluorescent study using overexpression constructs revealed that Velo resides both in the nucleus and cytoplasm, but the majority (~ 75%) is localized in the nucleus. We also observed from in vivo analysis that Velo knock-down flies exhibit significant upregulation of the AMP expression and reduced bacterial load. Survival experiments showed that Velo knock-down flies have a short lifespan and are susceptible to the infection of pathogenic Gram-negative bacteria, P. aeruginosa. Taken together, these data suggest that Velo is an additional new negative regulator of the IMD pathway, possibly acting in both the nucleus and cytoplasm.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Habitat preference and diverse migration in threespine sticklebacks, Gasterosteus aculeatus and G. nipponicus

    Takaomi Arai / Daisuke Ueno / Takefumi Kitamura / Akira Goto

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Band 15

    Abstract: Abstract Threespine sticklebacks of the genus Gasterosteus, are small teleost fish that are widely distributed across the northern hemisphere. The fish is believed to have two major types of life history, freshwater resident and anadromous; however ... ...

    Abstract Abstract Threespine sticklebacks of the genus Gasterosteus, are small teleost fish that are widely distributed across the northern hemisphere. The fish is believed to have two major types of life history, freshwater resident and anadromous; however little is known about their migration ecology. Comprehensive research on the migratory history, habitat use and relative composition of migratory types was conducted by analysing the otolith strontium and calcium concentrations collected in various environments of northern Japan. The present study first demonstrated that approximately 90% of morphologically anadromous sticklebacks had estuarine resident migration pattern, consistently living in brackish water and/or marine environments through their life cycle without any time spent in freshwater. The dominant occurrence of the estuarine resident was temporally and spatially consistent with their general migration ecology. The estuarine resident is thought to be the ancestral migrations of G. aculeatus and G. nipponicus, which thereafter gradually immigrated into freshwater habitats and settled in the anadromous form in both species and finally became the freshwater resident G. aculeatus. Thus, this study provides novel insights into the evolutionary migration of these fish, as well as a new discovery regarding the dominant migratory history and habitat use in threespine sticklebacks.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 590
    Sprache Englisch
    Erscheinungsdatum 2020-08-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Asymmetric effects of social and economic incentives on cooperation in real effort based public goods games.

    Jakob Hackel / Hitoshi Yamamoto / Isamu Okada / Akira Goto / Alfred Taudes

    PLoS ONE, Vol 16, Iss 4, p e

    2021  Band 0249217

    Abstract: Many practitioners as well as researchers explore promoting environmentally conscious behavior in the context of public goods systems. Numerous experimental studies revealed various types of incentives to increase cooperation on public goods. There is ... ...

    Abstract Many practitioners as well as researchers explore promoting environmentally conscious behavior in the context of public goods systems. Numerous experimental studies revealed various types of incentives to increase cooperation on public goods. There is ample evidence that monetary and non-monetary incentives, such as donations, have a positive effect on cooperation in public goods games that exceeds fully rational and optimal economic decision making. Despite an accumulation of these studies, in the typical setting of these experiments participants decide on an allocation of resources to a public pool, but they never exert actual effort. However, in reality, we often observe that players' real effort is required in these public goods game situations. Therefore, more analysis is needed to draw conclusions for a wider set of incentive possibilities in situations similar to yet deviating from resource allocation games. Here we construct a real effort public goods game in an online experiment and statistically analyze the effect different types of incentives have on cooperation. In our experiment, we examine combinations of monetary and social incentives in a setting aimed closer to practical realities, such as financial costs and real effort forming part of the decision to cooperate on a public good. In our real effort public goods game participants cooperate and defect on image-scoring tasks. We find that in our setting economic and social incentives produce an asymmetric effect. Interestingly economic incentives decreased the share of highly uncooperative participants, while social incentives raised the share of highly cooperative participants.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 336
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Land subsidence modeling in the Mekong Delta

    Dinh Giang Nam Nguyen / Akira Goto / Kazutoshi Osawa

    Can Tho University Journal of Science, Vol 54, Iss

    A case study in Soc Trang and Can Tho city

    2018  Band 5

    Abstract: In this study, the three-factor rheology model was applied to simulate land subsidence associated to the groundwater decline in the urban area (Can Tho) and the coastal area (Soc Trang) of the Mekong Delta (of Viet Nam). The considered three factors are: ...

    Abstract In this study, the three-factor rheology model was applied to simulate land subsidence associated to the groundwater decline in the urban area (Can Tho) and the coastal area (Soc Trang) of the Mekong Delta (of Viet Nam). The considered three factors are: (1) the elasticity coefficient; (2) the viscosity coefficient of the Voigt part; and (3) the viscosity coefficient of the Damper part, were calibrated to get the matching with limited observed values. As the results, the long-term transient simulation in the period of 2000-2013 showed the land subsidence rate in Can Tho city was around 2.6 cm/year. For the coastal area, transient simulation showed the cumulated subsidence for the period of 1994-2014 was 65 cm which means around 3 cm per year. To maintain the groundwater pumping under future rainfall condition, another 60 cm of land subsidence was expected over the next 21 years in the coastal area. To understand the subsidence under increase in pumping (1.8% per year), the cumulative land subsidence in the period of 2014-2035 was estimated around 71.4 cm at the coastal area of Mekong Delta.
    Schlagwörter Land subsidence ; Mekong Delta ; Rheology model ; Three factors ; Social sciences (General) ; H1-99 ; Agriculture (General) ; S1-972 ; Engineering (General). Civil engineering (General) ; TA1-2040
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2018-07-01T00:00:00Z
    Verlag CAN THO UNIVERSITY PUBLISHING HOUSE
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Imigrantes japoneses em Marco zero e Amar, verbo intransitivo

    Roberto Akira Goto

    Revista do Instituto de Estudos Brasileiros , Iss 55, Pp 149-

    2012  Band 164

    Abstract: Este artigo analisa as imagens que Marco zero, de Oswald de Andrade, e Amar, verbo intransitivo, de Mário de Andrade, projetam dos imigrantes japoneses, contra o pano de fundo de suas relações com o povo brasileiro. Tal análise leva em conta a ... ...

    Abstract Este artigo analisa as imagens que Marco zero, de Oswald de Andrade, e Amar, verbo intransitivo, de Mário de Andrade, projetam dos imigrantes japoneses, contra o pano de fundo de suas relações com o povo brasileiro. Tal análise leva em conta a caracterização dos personagens nipônicos pelos romancistas, sobretudo no que diz respeito às suas individualidades.
    Schlagwörter Japoneses ; brasileiros ; imigrantes ; Social sciences (General) ; H1-99
    Sprache Englisch
    Erscheinungsdatum 2012-09-01T00:00:00Z
    Verlag Instituto de Estudos Brasileiros
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Single Cell Analysis of the Fate of Injected Oncogenic RasV12 Cells in Adult Wild Type Drosophila

    Di Chen / Xiao Lan / Xiaoming Huang / Jieqing Huang / Xiaojing Zhou / Zhichao Miao / Yuting Ma / Akira Goto / Shanming Ji / Jules A. Hoffmann

    Journal of Innate Immunity, Vol 15, Iss 1, Pp 442-

    2023  Band 467

    Abstract: We have injected dish-cultured oncogenic RasV12 cells into adult male flies and analyzed by single cell transcriptomics their destiny within the host after 11 days. We identified in the preinjection samples and in the 11-day postinjection samples in all ... ...

    Abstract We have injected dish-cultured oncogenic RasV12 cells into adult male flies and analyzed by single cell transcriptomics their destiny within the host after 11 days. We identified in the preinjection samples and in the 11-day postinjection samples in all 16 clusters of cells, of which 5 disappeared during the experiment in the host. The other cell clusters expanded and expressed genes involved in the regulation of cell cycle, metabolism, and development. In addition, three clusters expressed genes related to inflammation and defense. Predominant among these were genes coding for phagocytosis and/or characteristic for plasmatocytes (the fly equivalent of macrophages). A pilot experiment indicated that the injection into flies of oncogenic cells, in which two of most strongly expressed genes had been previously silenced by RNA interference, into flies resulted in a dramatic reduction of their proliferation in the host flies as compared to controls. As we have shown earlier, the proliferation of the injected oncogenic cells in the adult flies is a hallmark of the disease and induces a wave of transcriptions in the experimental flies. We hypothesize that this results from a bitter dialogue between the injected cells and the host, while the experiments presented here should contribute to deciphering this dialogue.
    Schlagwörter oncogenic cells ; destiny after injection ; drosophila ; Medicine ; R ; Internal medicine ; RC31-1245
    Thema/Rubrik (Code) 612 ; 572
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag Karger Publishers
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Fertility risk factors in transferring Japanese Black embryos into dairy heifers

    Akira Goto / Koh Hayama / Manami Urakawa / Yoshio Oono / Ken Hazano / Mitsunori Kayano / Shingo Haneda / Ken Nakada / Yrjö Tapio Gröhn / Motozumi Matsui

    Veterinary and Animal Science, Vol 13, Iss , Pp 100193- (2021)

    An epidemiological study

    2021  

    Abstract: The aims of this study were 1) to summarize the current status of Japanese Black (JB) embryo transfer into Holstein heifers, which is carried out on a commercial basis in Japan, and 2) to reveal fertility risk factors, including those from the ... ...

    Abstract The aims of this study were 1) to summarize the current status of Japanese Black (JB) embryo transfer into Holstein heifers, which is carried out on a commercial basis in Japan, and 2) to reveal fertility risk factors, including those from the environment (year and season of transfer), recipient (age, number of transfers, clinical status of the ovaries) and embryo (quality, stage, state, genetic background). We used data from 4467 JB fresh or frozen embryo transfers into Holstein heifers conducted by Zen-noh Embryo Transfer Center during 2016–2018, and the differences in fertility risk due to factors related to the environment, recipient, and embryo were statistically evaluated. Differences in fertility risk due to each variable were observed, leading to significant differences in fertility with respect to year of transfer, embryo quality, embryo state, and embryo breed. These results suggest that the fertility of JB embryos might depend on differences in genetic background. There have been no previous reports of differences in embryo fertility due to the differences among JB's bloodline combinations. In the future, overall reproductive efficiency must be monitored, including the effects of different bloodline combinations on the success of embryo recovery and transfer.
    Schlagwörter Beef cattle ; Bloodline ; Embryo transfer ; Japanese black ; Reproductive epidemiology ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 515
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Coleopteran Antimicrobial Peptides

    Monde Ntwasa / Akira Goto / Shoichiro Kurata

    International Journal of Microbiology , Vol

    Prospects for Clinical Applications

    2012  Band 2012

    Schlagwörter Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Sprache Englisch
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag Hindawi Publishing Corporation
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  10. Artikel ; Online: Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila.

    Alexandre Cammarata-Mouchtouris / Xuan-Hung Nguyen / Adrian Acker / François Bonnay / Akira Goto / Amir Orian / Marie-Odile Fauvarque / Michael Boutros / Jean-Marc Reichhart / Nicolas Matt

    PLoS Pathogens, Vol 16, Iss 4, p e

    2020  Band 1008458

    Abstract: The Immune Deficiency (IMD) pathway in Drosophila melanogaster is activated upon microbial challenge with Gram-negative bacteria to trigger the innate immune response. In order to decipher this nuclear factor κB (NF-κB) signaling pathway, we undertook an ...

    Abstract The Immune Deficiency (IMD) pathway in Drosophila melanogaster is activated upon microbial challenge with Gram-negative bacteria to trigger the innate immune response. In order to decipher this nuclear factor κB (NF-κB) signaling pathway, we undertook an in vitro RNAi screen targeting E3 ubiquitin ligases specifically and identified the HECT-type E3 ubiquitin ligase Hyperplastic discs (Hyd) as a new actor in the IMD pathway. Hyd mediated Lys63 (K63)-linked polyubiquitination of the NF-κB cofactor Akirin was required for efficient binding of Akirin to the NF-κB transcription factor Relish. We showed that this Hyd-dependent interaction was required for the transcription of immunity-related genes that are activated by both Relish and Akirin but was dispensable for the transcription of genes that depend solely on Relish. Therefore Hyd is key in NF-κB transcriptional selectivity downstream of the IMD pathway. Drosophila depleted of Akirin or Hyd failed to express the full set of genes encoding immune-induced anti-microbial peptides and succumbed to immune challenges. We showed further that UBR5, the mammalian homolog of Hyd, was also required downstream of the NF-κB pathway for the activation of Interleukin 6 (IL6) transcription by LPS or IL-1β in cultured human cells. Our findings link the action of an E3 ubiquitin ligase to the activation of immune effector genes, deepening our understanding of the involvement of ubiquitination in inflammation and identifying a potential target for the control of inflammatory diseases.
    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2020-04-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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