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Article: [Ⅳ. Delirium in Cancer Patients].

Akizuki, Nobuya

Gan to kagaku ryoho. Cancer & chemotherapy

2021 Volume 48, Issue 6, Page(s) 782–785

MeSH term(s)	Delirium/diagnosis ; Delirium/epidemiology ; Delirium/etiology ; Humans ; Neoplasms/complications ; Neoplasms/therapy
Language	Japanese
Publishing date	2021-06-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Development of an Online Communication Skills Training Program for Oncologists Working with Adolescents and Young Adults.

Okamura, Masako / Fujimori, Maiko / Saito, Eiichi / Osugi, Yuko / Akizuki, Nobuya / Uchitomi, Yosuke

Journal of adolescent and young adult oncology

2023 Volume 12, Issue 3, Page(s) 433–439

Abstract: There are two purposes to this study. The first purpose was to develop a communication skills training (CST) program for oncologists working with adolescents and young adults (AYA-CST). The second purpose was to evaluate the program's feasibility. The ... ...

Abstract	There are two purposes to this study. The first purpose was to develop a communication skills training (CST) program for oncologists working with adolescents and young adults (AYA-CST). The second purpose was to evaluate the program's feasibility. The online AYA-CST program was a half-day workshop including a didactic lecture, role-playing with simulated patients and discussions in a small group. All six oncologists who participated in the program satisfactorily completed it. Our AYA-CST program seems feasible and will be tested further in a randomized control study.
MeSH term(s)	Humans ; Young Adult ; Adolescent ; Medical Oncology/education ; Communication ; Oncologists
Language	English
Publishing date	2023-03-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2607978-1
ISSN	2156-535X ; 2156-5333
ISSN (online)	2156-535X
ISSN	2156-5333
DOI	10.1089/jayao.2022.0102
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Article: [The role of psycho-oncology in cancer care in Japan].

Akizuki, Nobuya

Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica

2010 Volume 112, Issue 12, Page(s) 1210–1215

Abstract: With cancer the leading cause of death in Japan since 1981, the cancer care medical system is a critical issue. Psycho-oncology is expected to play an important role in cancer care. The "Basic Plan to Promote Cancer Control Programs" was launched in 2007 ...

Abstract	With cancer the leading cause of death in Japan since 1981, the cancer care medical system is a critical issue. Psycho-oncology is expected to play an important role in cancer care. The "Basic Plan to Promote Cancer Control Programs" was launched in 2007 under the Cancer Control Act, and it noted the need to increase the number of psycho-oncologists in order to promote palliative care in the early phases of cancer treatment. Additionally, guidelines for new cancer care systems incorporating psychiatrists were established; these guidelines included provisions stipulating that designated cancer care hospitals should have psychiatry departments, and that palliative care teams including psychiatrists were to be covered by insurance. This report describes the first year of operation of the newly established psycho-oncology department at the Chiba Cancer Center. The primary clinical activities of the psycho-oncology department comprise psychiatric consultations for inpatients and psychiatric care for outpatients with cancer and their family caregivers; there is no psychiatric ward. More than half of referred patient were diagnosed with adjustment disorders, major depression, or normal reactions. These patients required support in connection with the psychological adjustment to cancer distress or rehabilitation. The education and training of hospital staff and community medical staff is another role for psycho-oncology. In one palliative care training program, a psycho-oncologist directed the psychological symptoms management module and medical communications module. Psychiatrists at cancer centers or designated cancer care hospitals are expected to play multiple roles in the care of cancer patients and their families. They are occasionally unable to meet these expectations, however, due to a lack of understanding by hospital administrators, lack of time to spend on activities other than standard psychiatric services, and, in the case of some psychiatrists, a lack of interest in cancer care. It is important to develop a realistic and effective medical model of cancer care that includes psychiatrists. Training psychiatrists in psycho-oncology is also an important issue.
MeSH term(s)	Humans ; Japan ; Medical Oncology ; Neoplasms/psychology ; Neoplasms/therapy ; Palliative Care ; Patient Care Team ; Psychology ; Role
Language	Japanese
Publishing date	2010
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604306-9
ISSN	0033-2658
ISSN	0033-2658
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Article ; Online: Conserved infections and reproductive phenotypes of Wolbachia symbionts in Asian tortrix moths.

Arai, Hiroshi / Ueda, Masatoshi / Hirano, Tatsuya / Akizuki, Naoya / Lin, Shiou-Ruei / Hanh, Duong Kieu / Widada, Jaka / Rohman, Muhammad Saifur / Nakai, Madoka / Kunimi, Yasuhisa / Vang, Le Van / Wijonarko, Arman / Inoue, Maki N

Environmental microbiology reports

2023 Volume 16, Issue 1, Page(s) e13219

Abstract: Wolbachia is a ubiquitous endosymbiotic bacterium that manipulates insect reproduction. A notable feature of Wolbachia is male killing (MK), whereby sons of infected females are killed during development; however, the evolutionary processes by which ... ...

Abstract	Wolbachia is a ubiquitous endosymbiotic bacterium that manipulates insect reproduction. A notable feature of Wolbachia is male killing (MK), whereby sons of infected females are killed during development; however, the evolutionary processes by which Wolbachia acquired the MK ability remain unclear. The tea tortrix moth Homona magnanima (Tortricidae) harbours three non-MK Wolbachia strains (wHm-a, wHm-b and wHm-c) and an MK strain wHm-t. Although wHm-t and wHm-c are closely related, only wHm-t has an MK-associated prophage region. To understand the evolutionary processes underlying the emergence of MK wHm-t, we examined Wolbachia infections and phenotypes in 62 tortricid species collected from 39 localities across Japan, Taiwan, Vietnam and Indonesia. PCR assays detected wHm-c relatives in 51 species and triple infection of wHm-a, wHm-b and wHm-c in 31 species. Apart from Taiwanese H. magnanima, no species exhibited the MK phenotype and were positive for the wHm-t-specific prophage. While wHm-t infection was dominant in Taiwanese H. magnanima, wHm-a, wHm-b and wHm-c were dominant in Japanese H. magnanima populations. These results suggest that wHm-a, wHm-b and wHm-c strains descended from a common ancestor with repeated infection loss and that wHm-t evolved from the wHm-c acquiring MK ability in allopatric populations of H. magnanima.
MeSH term(s)	Animals ; Female ; Male ; Moths/genetics ; Moths/microbiology ; Wolbachia/genetics ; Reproduction ; Phenotype ; Bacteria ; Symbiosis
Language	English
Publishing date	2023-12-09
Publishing country	United States
Document type	Journal Article
ISSN	1758-2229
ISSN (online)	1758-2229
DOI	10.1111/1758-2229.13219
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Article ; Online: Effectiveness of primary series, first, and second booster vaccination of monovalent mRNA COVID-19 vaccines against symptomatic SARS-CoV-2 infections and severe diseases during the SARS-CoV-2 omicron BA.5 epidemic in Japan: vaccine effectiveness real-time surveillance for SARS-CoV-2 (VERSUS).

Maeda, Haruka / Saito, Nobuo / Igarashi, Ataru / Ishida, Masayuki / Terada, Mayumi / Masuda, Shingo / Osawa, Ryosuke / Hosokawa, Naoto / Nakashima, Kei / Kamura, Hiroshi / Imura, Haruki / Inoue, Hiroki / Matsuzaka, Suguru / Sugimoto, Yukihiro / Kuwamitsu, Osamu / Motohashi, Iori / Morikawa, Toru / Oda, Rentaro / Hoshina, Yuiko /

Matono, Takashi / Teshigahara, Osamu / Sando, Eiichiro / Asami, Sadaharu / Kudo, Satoshi / Akizuki, Noboru / Muto, Yoshikazu / Hayakawa, Tomoichiro / Kishaba, Tomoo / Ohara, Yasuji / Kubo, Yoshinao / Suzuki, Motoi / Morimoto, Konosuke

Expert review of vaccines

2024 Volume 23, Issue 1, Page(s) 213–225

Abstract: Background: This study aimed to evaluate VE of primary, first, and second booster ancestral-strain monovalent mRNA COVID-19 vaccination against symptomatic infections and severe diseases in Japan.: Methods: We conducted a test-negative case-control ... ...

Abstract	Background: This study aimed to evaluate VE of primary, first, and second booster ancestral-strain monovalent mRNA COVID-19 vaccination against symptomatic infections and severe diseases in Japan. Methods: We conducted a test-negative case-control study. We included medically attended episodes and hospitalizations involving individuals aged Results: For VE against symptomatic infections among individuals aged 16 to 59, VE of primary vaccination at > 180 days was 26.1% (95% CI: 10.6-38.8%); VE of the first booster was 58.5% (48.4-66.7%) at Conclusion: mRNA booster vaccination provided moderate protection against symptomatic infections and high-level protection against severe diseases during the BA.5 epidemic in Japan.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Japan/epidemiology ; Case-Control Studies ; Vaccine Efficacy ; RNA, Messenger ; Vaccination
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2181284-6
ISSN	1744-8395 ; 1476-0584
ISSN (online)	1744-8395
ISSN	1476-0584
DOI	10.1080/14760584.2024.2310807
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Article ; Online: Efficient near-infrared up-conversion photoluminescence in carbon nanotubes.

Akizuki, Naoto / Aota, Shun / Mouri, Shinichiro / Matsuda, Kazunari / Miyauchi, Yuhei

Nature communications

2015 Volume 6, Page(s) 8920

Abstract: Photoluminescence phenomena normally obey Stokes' law of luminescence according to which the emitted photon energy is typically lower than its excitation counterparts. Here we show that carbon nanotubes break this rule under one-photon excitation ... ...

Abstract	Photoluminescence phenomena normally obey Stokes' law of luminescence according to which the emitted photon energy is typically lower than its excitation counterparts. Here we show that carbon nanotubes break this rule under one-photon excitation conditions. We found that the carbon nanotubes exhibit efficient near-infrared photoluminescence upon photoexcitation even at an energy lying >100-200 meV below that of the emission at room temperature. This apparently anomalous phenomenon is attributed to efficient one-phonon-assisted up-conversion processes resulting from unique excited-state dynamics emerging in an individual carbon nanotube with accidentally or intentionally embedded localized states. These findings may open new doors for energy harvesting, optoelectronics and deep-tissue photoluminescence imaging in the near-infrared optical range.
Language	English
Publishing date	2015-11-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/ncomms9920
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Article ; Online: A Self-Check Program Targeting Quality Improvement in a Hospital-Based Palliative Care Consultation Team, Japanese Society for Palliative Medicine: Issues Regarding Team Activities Identified through the Plan-Do-Check-Act Cycle.

Nakazawa, Yoko / Sakashita, Akihiro / Kaizu, Mikiko / Abo, Hirofumi / Ise, Yuya / Shinada, Yuichi / Sugano, Koji / Yamashiro, Akiko / Akizuki, Nobuya / Kato, Masashi

Journal of palliative medicine

2019 Volume 23, Issue 3, Page(s) 359–367

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Hospitals ; Humans ; Japan ; Palliative Care ; Palliative Medicine ; Patient Care Team ; Quality Improvement ; Referral and Consultation
Language	English
Publishing date	2019-10-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1427361-5
ISSN	1557-7740 ; 1096-6218
ISSN (online)	1557-7740
ISSN	1096-6218
DOI	10.1089/jpm.2019.0236
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Article ; Online: Effects of a Rebamipide Mouthwash on Stomatitis Caused by Cancer Chemotherapy-Evaluation of the Efficacy by Patients Themselves.

Ishii, Naoko / Kawano, Yayoi / Sakai, Hideki / Hayashi, Seitaku / Akizuki, Norikazu / Komoda, Masayo / Hanawa, Takehisa

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2017 Volume 137, Issue 8, Page(s) 1027–1034

Abstract: Anticancer drug-induced stomatitis develops in 30% to 40% of cancer cases that undergo chemotherapy. However, medications for this condition are not commercially available in Japan. Upon obtaining approval of the ethics committee, a mouthwash containing ... ...

Abstract	Anticancer drug-induced stomatitis develops in 30% to 40% of cancer cases that undergo chemotherapy. However, medications for this condition are not commercially available in Japan. Upon obtaining approval of the ethics committee, a mouthwash containing rebamipide as the active ingredient (rebamipide mouthwash) was administered to one inpatient and four outpatients, who had developed stomatitis caused by cancer chemotherapy. Starting from 14 d after the administration of the rebamipide mouthwash, the patients scored a stomatitis survey on oral state, pain level, and diet and recorded the number of times they gargled, as well as any stomatitis observations, in a stomatitis diary. The total scores for the points for each of the three types of survey sections were classified into Grades 0 to 4 and evaluated as a stomatitis evaluation score (SES). The SES became "0" in three out of the five patients within 14 d of treatment. No change in SES was found in one patient. In the remaining patients, SES became "0" once but increased again later. Using image analysis software (ImageJ), the area at which the stomatitis was observed was measured. When comparing SES and change in the area in patients who agreed to participate, gradual reductions in the extent of stomatitis was observed even during the period when SES did not change. Having patients fill in an observation chart was effective for grasping changes in symptoms in outpatients.
MeSH term(s)	Aged ; Aged, 80 and over ; Alanine/administration & dosage ; Alanine/analogs & derivatives ; Antineoplastic Agents/adverse effects ; Colorectal Neoplasms/drug therapy ; Humans ; Lung Neoplasms/drug therapy ; Male ; Middle Aged ; Mouthwashes/administration & dosage ; Quinolones/administration & dosage ; Rectal Neoplasms/drug therapy ; Stomatitis/chemically induced ; Stomatitis/drug therapy ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; Mouthwashes ; Quinolones ; rebamipide (LR583V32ZR) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2017-08-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.17-00042
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Article ; Online: Development of a Standard for Hospital-Based Palliative Care Consultation Teams in Japan Using a Modified Delphi Method.

Sakashita, Akihiro / Kizawa, Yoshiyuki / Kato, Masashi / Akizuki, Nobuya / Nakazawa, Yoko / Kaizu, Mikiko / Yano, Kazumi / Sato, Tetsumi / Tokoro, Akihiro

Journal of pain and symptom management

2018 Volume 56, Issue 5, Page(s) 746–751.e5

Abstract: Context: Hospital-based palliative care consultation teams (PCCTs) are rapidly being disseminated throughout Japan. The roles of PCCTs have changed during the past decade, particularly with the introduction of a modified national cancer care act to ... ...

Abstract	Context: Hospital-based palliative care consultation teams (PCCTs) are rapidly being disseminated throughout Japan. The roles of PCCTs have changed during the past decade, particularly with the introduction of a modified national cancer care act to promote early palliative care and integrated oncology and palliative care. Objectives: This study aimed to develop a consultation team standard for hospital-based palliative care in Japan. Methods: We developed a provisional standard based on literature review and used a modified questionnaire-based Delphi method. Our Delphi panel comprises 20 experts selected from all relevant disciplines. Results: All experts selected responded to the surveys over all rounds, and 14 of the 20 participated in the panel meeting. In the first round, 79 of 109 statements were judged to be appropriate, and 30 of 109 statements led to disagreements. About 16 of those 30 statements underwent minor revision, 1 was divided into two statements, and 13 remained unchanged. We then added six statements based on a discussion among participants and authors. In addition, based on comments from an external reviewer, we revised the standard, resulting in four statements being combined into two for a new total of 114 statements. In the second round, 108 of 114 statements were judged to be appropriate, and in the third round, none of the six controversial statements were judged to be appropriate. The final version comprises 108 statements. Conclusion: We developed a standard for PCCTs in Japanese cancer hospitals. This standard provides a useful guide for clinical activities and a tool to evaluate quality of palliative care.
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Delphi Technique ; Female ; Hospitals/standards ; Humans ; Infant ; Infant, Newborn ; Japan ; Male ; Middle Aged ; Neoplasms/therapy ; Palliative Care/standards ; Patient Care Team/standards ; Practice Guidelines as Topic ; Quality of Health Care ; Referral and Consultation/standards ; Young Adult
Language	English
Publishing date	2018-08-24
Publishing country	United States
Document type	Consensus Development Conference ; Journal Article ; Review
ZDB-ID	639142-4
ISSN	1873-6513 ; 0885-3924
ISSN (online)	1873-6513
ISSN	0885-3924
DOI	10.1016/j.jpainsymman.2018.08.013
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Article ; Online: Multiple Infection and Reproductive Manipulations of Wolbachia in Homona magnanima (Lepidoptera: Tortricidae).

Arai, Hiroshi / Hirano, Tatsuya / Akizuki, Naoya / Abe, Akane / Nakai, Madoka / Kunimi, Yasuhisa / Inoue, Maki N

Microbial ecology

2018 Volume 77, Issue 1, Page(s) 257–266

Abstract: Endosymbiotic bacterium Wolbachia interacts with host in either a mutualistic or parasitic manner. Wolbachia is frequently identified in various arthropod species, and to date, Wolbachia infections have been detected in different insects. Here, we found ... ...

Abstract	Endosymbiotic bacterium Wolbachia interacts with host in either a mutualistic or parasitic manner. Wolbachia is frequently identified in various arthropod species, and to date, Wolbachia infections have been detected in different insects. Here, we found a triple Wolbachia infection in Homona magnanima, a serious tea pest, and investigated the effects of three infecting Wolbachia strains (wHm-a, -b, and -c) on the host. Starting with the triple-infected host line (W
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Physiological Phenomena ; Cytoplasm ; DNA, Bacterial/analysis ; Female ; Larva/microbiology ; Male ; Moths/drug effects ; Moths/genetics ; Moths/microbiology ; Phenotype ; Pupa/microbiology ; Reproduction/physiology ; Sex Ratio ; Symbiosis ; Wolbachia/classification ; Wolbachia/genetics ; Wolbachia/physiology
Chemical Substances	Anti-Bacterial Agents ; DNA, Bacterial
Language	English
Publishing date	2018-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1462065-0
ISSN	1432-184X ; 0095-3628
ISSN (online)	1432-184X
ISSN	0095-3628
DOI	10.1007/s00248-018-1210-4
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