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Article ; Online: A Case Series of Life-Threatening Complications of Central Venous Catheter Insertion.

Akkuzu, Emine / Sincar, Şahin / Kalkan, Gökhan

2021 Volume 37, Issue 11, Page(s) e775–e778

Abstract: Abstract: Central venous catheters are commonly used in emergency department and the intensive care units for the treatment of critically ill patients. Reports on the rate of mechanical complications of catheter insertion are around 1%. Mechanical ... ...

Abstract	Abstract: Central venous catheters are commonly used in emergency department and the intensive care units for the treatment of critically ill patients. Reports on the rate of mechanical complications of catheter insertion are around 1%. Mechanical complications related with the insertion of the catheter mainly depend on the anatomic location, the use of ultrasound, and experience of the operator. The rate of complication is higher in places where central lines are not routinely inserted as in emergency department. Here, we report a case series of 4 patients who had life-threatening complications of central venous catheter insertion, including venous intimal injury leading to pleural effusion, kinked central venous catheter in the superior vena cava, knotted guidewire with the separation of coil and core, and a missed guidewire with their respective insertion history and imaging. Increasing the awareness of and developing strategies to prevent these rare but potentially fatal conditions may have impact on patient outcomes.
MeSH term(s)	Catheterization, Central Venous/adverse effects ; Central Venous Catheters/adverse effects ; Critical Illness ; Humans ; Intensive Care Units ; Vena Cava, Superior
Language	English
Publishing date	2021-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000002390
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Article ; Online: The impact of antimicrobial use on potential major drug-drug interactions in the pediatric intensive care unit patients at University Hospital, Turkey.

Albayrak, Aslınur / Akkuzu, Emine / Karahalil, Bensu

Minerva pediatrics

2021

Abstract: Background: Antimicrobials, especially antibiotics, are among the most widely used drugs in the pediatric intensive care unit. Pediatrics patients in intensive care unit are exposed to potential drug-drug interactions (PDDIs) and suffered from their ... ...

Abstract	Background: Antimicrobials, especially antibiotics, are among the most widely used drugs in the pediatric intensive care unit. Pediatrics patients in intensive care unit are exposed to potential drug-drug interactions (PDDIs) and suffered from their adverse and side effects. The aim of this study is to evaluate the impact of antimicrobial use on PDDIs, as well as to examine the rate and the risk factors PDDIs, furthermore the management of PDDIs. Methods: The present retrospective cohort study included 179 patients under 18 years of age who were hospitalized in Pediatric Intensive Care Unit in Turkey. Drug interactions were evaluated using the Lexicomp® drug interaction tool which provides evidence-based drug information. Results: Our study results showed that the frequency of the use of antimicrobial drugs (antibiotic, antifungal, antiviral) was found to be statistically significantly higher (p<0.05) in the group with PDDIs compared to the group without PDDIs. Especially, the use of carbapenem, cephalosporin among the antibiotic groups significantly increased the frequency of PDDIs (p<0.05). While the probability PDDIs statistically significantly increased 3.73 times (OR (Odds Ratio) =3.73; 95% CI= 1.47-9.50) in patients who used a single antibiotic compared to patients who did not use antibiotics (p=0.006), the probability of the occurrence of PDDIs by using more than one antibiotic was statistically significantly 8.5 times (95% CI =3.30-21.89) (p <0.001). Conclusions: Our study results showed that the use of antimicrobial drugs (antibiotic, antifungal, antiviral) was found to be statistically significantly higher (p<0.05) in the group with PDDIs.
Language	English
Publishing date	2021-04-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062664-X
ISSN	2724-5780
ISSN (online)	2724-5780
DOI	10.23736/S2724-5276.21.06173-9
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Article ; Online: Croup as a Previously Unrecognized Symptom of COVID-19 in Infants.

Dasdemir, Sevgi / Uysal Yazici, Mutlu / Gudeloglu, Elif / Akkuzu, Emine / Tezer, Hasan

The Pediatric infectious disease journal

2022 Volume 41, Issue 8, Page(s) e332

Abstract: Although the most common symptoms of coronavirus disease 2019 (COVID-19) in children are fever and cough, cases of croup associated with COVID-19 are reported in the literature and have increased sharply with the Omicron variant. We present severe acute ... ...

Abstract	Although the most common symptoms of coronavirus disease 2019 (COVID-19) in children are fever and cough, cases of croup associated with COVID-19 are reported in the literature and have increased sharply with the Omicron variant. We present severe acute respiratory syndrome coronavirus 2 as a viral agent in an infant presenting with croup.
MeSH term(s)	COVID-19/diagnosis ; Child ; Croup/complications ; Croup/diagnosis ; Humans ; Infant ; Respiratory Tract Infections ; SARS-CoV-2
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003565
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Zs.A 1852: Show issues

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Article ; Online: A pediatric case series of invasive pneumococcal disease caused by

Cura Yayla, Burcu Ceylan / Bedir Demirdag, Tugba / Akkuzu, Emine / Kara, Nursel / Tezer, Hasan / Tapisiz, Anıl

Human vaccines & immunotherapeutics

2023 Volume 19, Issue 2, Page(s) 2219186

Abstract: Streptococcus ... ...

Abstract	Streptococcus pneumoniae
MeSH term(s)	Child ; Humans ; Infant ; Serogroup ; Pneumococcal Infections/microbiology ; Streptococcus pneumoniae ; Pneumococcal Vaccines ; Pneumonia ; Vaccination ; Vaccines, Conjugate
Chemical Substances	Pneumococcal Vaccines ; Vaccines, Conjugate
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2023.2219186
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Article ; Online: Tracheal Deviation and Life-threatening Presentation of Congenital Branchial Cleft Cyst Abscess due to Rare Pathogens and Difficult Airway Management.

Daşdemir, Sevgi / Sanar, Aydan Yılmaz / Yazici, Mutlu Uysal / Gudeloglu, Elif / Akkuzu, Emine / Düzlü, Mehmet / Tezer, Hasan

Klinische Padiatrie

2023 Volume 235, Issue 2, Page(s) 98–100

Title translation	Deviation der Trachea und lebensbedrohlicher Zustand bei Infektion einer angeborenen lateralen Halszyste mit Abszessbildung durch seltene Erreger und schwierigem Atemwegsmanagement.
MeSH term(s)	Humans ; Branchioma/diagnostic imaging ; Branchioma/surgery ; Abscess/diagnostic imaging ; Abscess/surgery ; Diagnosis, Differential
Language	English
Publishing date	2023-01-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	120650-3
ISSN	1439-3824 ; 0300-8630
ISSN (online)	1439-3824
ISSN	0300-8630
DOI	10.1055/a-2004-3380
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Article ; Online: A rare cause and an even rarer treatment of hypertension in a 5-year-old boy: Mid-aortic syndrome.

İriz, Erkan / Tak, Sercan / Yiğiter, Eda Nur / Leventoğlu, Emre / Demirtaş, Hüseyin / Akkuzu, Emine / Uysal Yazıcı, Mutlu / Fidan, Kibriya / Dalgıç, Aydın

Nephrology (Carlton, Vic.)

2023 Volume 29, Issue 4, Page(s) 230–234

Abstract: Renal artery stenosis is one of the common vascular diseases that cause hypertension in children. However, renal artery aneurysms and abdominal aortic aneurysms, which may be components of mid-aortic syndrome, are rarely associated with renal artery ... ...

Abstract	Renal artery stenosis is one of the common vascular diseases that cause hypertension in children. However, renal artery aneurysms and abdominal aortic aneurysms, which may be components of mid-aortic syndrome, are rarely associated with renal artery stenosis. Despite its rarity, early diagnosis and treatment are critical to prevent fatal complications. Currently, non-surgical invasive techniques are considered the first choice for treatment, but in some cases, surgery is inevitable. Here, we present a 5-year-old boy with a mid-aortic syndrome. The patient presented with a history of severe headache and epistaxis 5-6 times a day and was diagnosed with hypertension. A 9 × 9 mm saccular aneurysm on the anterior surface of the abdominal aorta at the level of the left renal artery ostium, and a 12 mm aneurysm in the left renal artery after a stenotic segment at the hilum level was detected in the doppler USG and contrast-enhanced imaging techniques. The patient was operated on electively. We used a PTFE patch to repair the abdominal aorta and, saphenous vein which was taken from his father to repair the renal artery. The patient recovered well and was discharged on the 18th day.
MeSH term(s)	Male ; Child ; Humans ; Child, Preschool ; Renal Artery Obstruction/diagnosis ; Renal Artery Obstruction/diagnostic imaging ; Antihypertensive Agents/therapeutic use ; Renal Artery/diagnostic imaging ; Renal Artery/surgery ; Aorta, Abdominal/diagnostic imaging ; Aorta, Abdominal/surgery ; Hypertension/complications ; Hypertension/diagnosis
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2023-12-18
Publishing country	Australia
Document type	Case Reports
ZDB-ID	1303661-0
ISSN	1440-1797 ; 1320-5358
ISSN (online)	1440-1797
ISSN	1320-5358
DOI	10.1111/nep.14262
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Zs.A 4822: Show issues

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Article: Prevalence and Time Course of Thiamine Deficiency in Critically Ill Children: A Multicenter, Prospective Cohort Study in Turkey.

Akkuzu, Emine / Yavuz, Sinan / Ozcan, Serhan / Sincar, Sahin / Bayrakci, Benan / Kendirli, Tanil / Pasaoglu, Hatice / Kalkan, Gokhan

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2022 Volume 23, Issue 5, Page(s) 399–404

Abstract: Objectives: To determine the prevalence and time course of thiamine deficiency (TD) in PICU patients.: Design: Multicenter, prospective, cohort study between May 2019 and November 2019.: Setting: Three university-based tertiary care, mixed medical- ...

Abstract	Objectives: To determine the prevalence and time course of thiamine deficiency (TD) in PICU patients. Design: Multicenter, prospective, cohort study between May 2019 and November 2019. Setting: Three university-based tertiary care, mixed medical-surgical PICUs in Ankara, Turkey. Patients: PICU patients 1 month to 18 years old. Interventions: None. Measurements and main results: We studied 476 patients and grouped them by TD status on days 1 and 3 of the PICU admission. There might be a risk of unintended bias since we excluded 386 patients because of the absence of consent, inadequate blood samples, loss of identifier information, and recent vitamin supplementation. On day 1, TD was present in 53 of 476 patients (11.1%) and median (minimum-maximum) thiamine levels were 65.5 ng/mL (5-431 ng/mL). On day 3, TD was present in 27 of 199 patients (13.6%) with repeated measurement. The median (minimum-maximum) thiamine levels were 63 ng/mL (13-357 ng/mL). The time course of TD from day 1 to day 3 in these 199 patients was as follows. In 21 of 199 patients (10.6%) with TD on day 1, 11 of 21 (52%) continued to have TD on day 3 and the other 10 of 21 patients (48%) improved to no longer having TD. In 178 of 199 patients (89.4%) without TD on day 1, 16 of 178 (9%) went on to develop TD by day 3, and the other 162 of 178 (91%) continued to have normal thiamine status. Conclusions: In the PICU population in three centers in Turkey, the prevalence of TD in the sample of patients was 11.1%. In those TD patients who had serial studies, we also identified that by day 3 some continued to be TD, and some patients improved to normal thiamine status. Of concern, however, is the population who develop TD over the course of PICU stay.
MeSH term(s)	Child ; Cohort Studies ; Critical Illness ; Humans ; Intensive Care Units, Pediatric ; Prevalence ; Prospective Studies ; Thiamine ; Thiamine Deficiency/epidemiology ; Turkey/epidemiology
Chemical Substances	Thiamine (X66NSO3N35)
Language	English
Publishing date	2022-05-05
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000002931
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Article: [No title information]

Daşdemir, Sevgi / Sanar, Aydan Yılmaz / Yazici, Mutlu Uysal / Gudeloglu, Elif / Akkuzu, Emine / Düzlü, Mehmet / Tezer, Hasan

Klinische Pädiatrie

2023 Volume 235, Issue 02, Page(s) 98–100

Language	English
Publishing date	2023-01-31
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	120650-3
ISSN	1439-3824 ; 0300-8630
ISSN (online)	1439-3824
ISSN	0300-8630
DOI	10.1055/a-2004-3380
Database	Thieme publisher's database

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Article: Autoimmune Hemolytic Anemia, Erythrophagocytosis and Liver Dysfunction After Cefixime Use for Urinary Tract Infection in a Child.

Kaya, Zühre / Kürekçi, Fulya / Akkuzu, Emine / Göral, Seniz / Kalkan, Gökhan

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

2018 Volume 35, Issue 1, Page(s) 203–204

Language	English
Publishing date	2018-09-01
Publishing country	India
Document type	Journal Article
ZDB-ID	2422370-0
ISSN	0974-0449 ; 0971-4502
ISSN (online)	0974-0449
ISSN	0971-4502
DOI	10.1007/s12288-018-1006-1
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Article ; Online: COVID-19-associated multisystem inflammatory syndrome in children: Experiences of three centres in Turkey.

Salman, Hakan / Aslan, Nagehan / Akçam, Mustafa / Arslan, Müjgan / Akkuzu, Emine / Yılmaz Keskin, Ebru / Açarı, Ceyhun / Keskin, Mahmut / Atar, Müge / Köşker, Muhammet / Sinanoğlu, Selçuk / Çetin, Hasan / Akçam, Füsun Zeynep

Modern rheumatology

2021 Volume 32, Issue 2, Page(s) 460–466

Abstract: Background: The pathogenesis and clinical manifestations of the multisystem inflammatory syndrome in children (MIS-C) has not yet been fully elucidated and there is no clear consensus on its treatment yet.: Objectives: To evaluate our patients ... ...

Abstract	Background: The pathogenesis and clinical manifestations of the multisystem inflammatory syndrome in children (MIS-C) has not yet been fully elucidated and there is no clear consensus on its treatment yet. Objectives: To evaluate our patients diagnosed with MIS-C and present them to the literature in order to contribute to the better understanding of this new disease, which entered paediatric practice with the SARS-CoV-2 peak. Methods: In this study, 17 MIS-C cases diagnosed according to the Centers for Disease Control and Prevention criteria were included. Results: Of the patients, 7 (41.2%) had a comorbidity. Gastrointestinal system involvement was the most prominent in the patients (70.6%). Laparotomy was performed in 3 patients due to acute abdomen. Two patients had neurological involvement. Of the patients, 15 (88.2%) received intravenous immunoglobulin and 13 (76.5%) received both intravenous immunoglobulin and methylprednisolone. Two patients received invasive mechanical ventilation and 4 patients received high flow rate nasal cannula oxygen therapy. One of our patients who needed invasive mechanical ventilation and high vasoactive-inotrope support died despite all supportive treatments including plasmapheresis and extracorporeal membrane oxygenation. Conclusions: MIS-C picture can have a fatal course and may present with severe gastrointestinal and neurological signs. Unnecessary laparotomy should be avoided.
MeSH term(s)	COVID-19/complications ; Child ; Humans ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/complications ; Systemic Inflammatory Response Syndrome/diagnosis ; Turkey ; United States
Language	English
Publishing date	2021-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.1093/mr/roab042
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