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  1. Article ; Online: Renal artery stenosis: to intervene, or not to intervene, "that is the question".

    Haqqie, Syed S / Nappi, Anthony / Siskin, Gary / Syed, Nouman A / Ghate, Ketan / Mathew, Roy O / Wang, Jeffrey / Sidhu, Mandeep S / Kumar, Vishesh / Salman, Loay / Merrill, Donna / Akmal, Muhammad U T / Nayer, Ali / Asif, Arif

    Seminars in dialysis

    2014  Volume 27, Issue 1, Page(s) E4–7

    Abstract: Renal artery stenosis (RAS) due to atherosclerosis continues to be a major cause of secondary hypertension. It can also lead to renal dysfunction due to ischemic nephropathy. While major clinical trials have emphasized that medical management should be ... ...

    Abstract Renal artery stenosis (RAS) due to atherosclerosis continues to be a major cause of secondary hypertension. It can also lead to renal dysfunction due to ischemic nephropathy. While major clinical trials have emphasized that medical management should be preferred over angioplasty and stenting for the treatment of renal artery stenosis, clinical scenarios continue to raise doubts about the optimal management strategy. Herein, we present two cases that were admitted with hypertensive emergency and renal function deterioration. Medical therapy failed to control the blood pressure and in one patient, renal failure progressed to a point where renal replacement therapy was required. Both patients underwent angioplasty (for >90% stenosis) and stent insertion with successful resolution of stenosis by interventional radiology. Postoperatively, blood pressure gradually decreased with improvement in serum creatinine. Dialysis therapy was discontinued. At 4- and 8-month follow-up, both patients continue to do well with blood pressure readings in the 132-145/70-90 mmHg range. This article highlights the importance of percutaneous interventions in the management of atherosclerotic RAS and calls for heightened awareness and careful identification of candidates who would benefit from angioplasty and stent insertion.
    MeSH term(s) Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Angioplasty ; Atherosclerosis/complications ; Female ; Humans ; Hypertension, Renovascular/etiology ; Hypertension, Renovascular/therapy ; Male ; Middle Aged ; Radiography ; Renal Artery/diagnostic imaging ; Renal Artery Obstruction/complications ; Renal Artery Obstruction/etiology ; Renal Artery Obstruction/therapy ; Renal Replacement Therapy ; Stents
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1028193-9
    ISSN 1525-139X ; 0894-0959
    ISSN (online) 1525-139X
    ISSN 0894-0959
    DOI 10.1111/sdi.12140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Blood pressure recordings during hemodialysis access interventions: implications for acute management.

    Asif, Arif / Castro, Hector / Waheed, Ahmed Ameen / Kumar, Vishesh / Haqqie, Syed S / Siskin, Gary / Mathew, Roy O / Mason, Darius / Vachharajani, Tushar / Nayer, Ali / Merrill, Donna / Akmal, Muhammad U T / Salman, Loay

    Seminars in dialysis

    2013  Volume 26, Issue 4, Page(s) E30–2

    Abstract: A retrospective study evaluating the pattern of blood pressure and its related complications before, during, and after percutaneous hemodialysis interventions was performed in patients presenting with asymptomatic hypertension. Hemodialysis patients ... ...

    Abstract A retrospective study evaluating the pattern of blood pressure and its related complications before, during, and after percutaneous hemodialysis interventions was performed in patients presenting with asymptomatic hypertension. Hemodialysis patients undergoing percutaneous interventions including tunneled hemodialysis catheter insertion, percutaneous balloon angioplasty and thrombectomy procedure, and stage II hypertension (systolic blood pressure ≥160 mmHg) were included in this analysis. Blood pressure medications were not used while midazolam and fentanyl were routinely administered. Patients were followed for up to 4 weeks to monitor any complications. The mean blood pressure before, during, and after the procedures were 185 ± 18/96 ± 14, 172 ± 22/92 ± 15, and 153 ± 25/87 ± 14, respectively. There was a statistically significant difference between the blood pressure readings before and after the procedure (before = 185 ± 18/96 ± 14, after = 153 ± 25/87 ± 14; p = 0.001). None of the patients had a stroke, myocardial infarction, or acute pulmonary edema before, during, or after the procedure or during the 4-week follow-up period. A significant reduction in blood pressure was observed after the procedure without the administration of any antihypertensive medication. These results suggest that the reduction in blood pressure observed after percutaneous dialysis access interventions (particularly in the presence of midazolam and fentanyl) may make it unnecessary to treat asymptomatic hypertension prior to these procedures.
    MeSH term(s) Aged ; Angioplasty, Balloon, Coronary/adverse effects ; Angioplasty, Balloon, Coronary/methods ; Antihypertensive Agents/therapeutic use ; Blood Pressure Determination ; Blood Pressure Monitoring, Ambulatory/methods ; Cohort Studies ; Coronary Disease/complications ; Coronary Disease/diagnostic imaging ; Coronary Disease/therapy ; Female ; Follow-Up Studies ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/drug therapy ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Myocardial Infarction/complications ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/therapy ; Radiography ; Renal Dialysis/adverse effects ; Renal Dialysis/methods ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome ; Vascular Access Devices
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2013-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1028193-9
    ISSN 1525-139X ; 0894-0959
    ISSN (online) 1525-139X
    ISSN 0894-0959
    DOI 10.1111/sdi.12083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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