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Article ; Online: Evaluation of the validity and reliability of the KFORCE Sens® electrogoniometer in evaluation of wrist proprioception.

Tekin, F / Can-Akman, T / Kitiş, A

2021 Volume 41, Issue 2, Page(s) 183–188

Abstract: The aim of this study was to determine the validity and reliability of the KFORCE Sens® electrogoniometer in the evaluation of wrist proprioception. Wrist position sense was assessed on a Baseline® 360° universal goniometer and a KFORCE Sens® device. The ...

Abstract	The aim of this study was to determine the validity and reliability of the KFORCE Sens® electrogoniometer in the evaluation of wrist proprioception. Wrist position sense was assessed on a Baseline® 360° universal goniometer and a KFORCE Sens® device. The validity and reliability of the KFORCE Sens® device for wrist position sense evaluation were investigated by comparing the two data sets. Fifty-three healthy volunteers (39 female, 14 male) with a mean age of 22.83 ± 1.28 years (range, 21-27 years) were included. Joint position sense test-retest reliability (intra-class correlation coefficient) on KFORCE Sens® was "very good" for all wrist movements. There was a very strong correlation between flexion-extension movements on the dominant side (r = 0.955), and a strong correlation between ulnar-radial deviation movements (r = 0.745). There was also a very strong (r = 0.863) correlation between flexion-extension movements on the non-dominant side and a strong correlation (r = 0.690) between ulnar-radial deviation movements (p < 0.05). Our results showed that the KFORCE Sens® device was a valid and reliable evaluation means of assessing wrist position sense.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Proprioception ; Range of Motion, Articular ; Reproducibility of Results ; Wrist ; Wrist Joint ; Young Adult
Language	English
Publishing date	2021-12-30
Publishing country	France
Document type	Journal Article
ZDB-ID	2848776-X
ISSN	2468-1210
ISSN (online)	2468-1210
DOI	10.1016/j.hansur.2021.12.006
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Article ; Online: Modeling of Mouse Experiments Suggests that Optimal Anti-Hormonal Treatment for Breast Cancer is Diet-Dependent.

Akman, Tuğba / Arendt, Lisa M / Geisler, Jürgen / Kristensen, Vessela N / Frigessi, Arnoldo / Köhn-Luque, Alvaro

Bulletin of mathematical biology

2024 Volume 86, Issue 4, Page(s) 42

Abstract: Estrogen receptor positive breast cancer is frequently treated with anti-hormonal treatment such as aromatase inhibitors (AI). Interestingly, a high body mass index has been shown to have a negative impact on AI efficacy, most likely due to disturbances ... ...

Abstract	Estrogen receptor positive breast cancer is frequently treated with anti-hormonal treatment such as aromatase inhibitors (AI). Interestingly, a high body mass index has been shown to have a negative impact on AI efficacy, most likely due to disturbances in steroid metabolism and adipokine production. Here, we propose a mathematical model based on a system of ordinary differential equations to investigate the effect of high-fat diet on tumor growth. We inform the model with data from mouse experiments, where the animals are fed with high-fat or control (normal) diet. By incorporating AI treatment with drug resistance into the model and by solving optimal control problems we found differential responses for control and high-fat diet. To the best of our knowledge, this is the first attempt to model optimal anti-hormonal treatment for breast cancer in the presence of drug resistance. Our results underline the importance of considering high-fat diet and obesity as factors influencing clinical outcomes during anti-hormonal therapies in breast cancer patients.
MeSH term(s)	Humans ; Animals ; Mice ; Female ; Breast Neoplasms/pathology ; Drug Resistance, Neoplasm ; Models, Biological ; Mathematical Concepts ; Aromatase Inhibitors/therapeutic use ; Aromatase Inhibitors/pharmacology ; Diet
Chemical Substances	Aromatase Inhibitors
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	184905-0
ISSN	1522-9602 ; 0007-4985 ; 0092-8240
ISSN (online)	1522-9602
ISSN	0007-4985 ; 0092-8240
DOI	10.1007/s11538-023-01253-1
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Article: Selection of authors, titles and writing a manuscript abstract.

Akman, Tolga

Turkish journal of urology

2015 Volume 39, Issue Suppl 1, Page(s) 5–7

Abstract: Title of the study, authors list and abstract are not only the most widely read parts in an article but also determine whether the remaining sections are worth to be read. The first author in an article should be the planner and performer of the research. ...

Abstract	Title of the study, authors list and abstract are not only the most widely read parts in an article but also determine whether the remaining sections are worth to be read. The first author in an article should be the planner and performer of the research. Researchers who have actively conducted the study and written the manuscript should be sorted in the authors list according to the importance of their individual contribution. However, researchers who do not directly contribute to the study but take part in data collection process should not be included in the ideal authors list. The title should be comprised of a brief statement or one or two short sentences that best reflect the original and gripping aspects of the study. On the other hand, abstract should provide answers to the following questions in advance of reading the full text: Why this study was performed?, What was the procedure?, What was found?, and What were the outcomes? In this manuscript, writing of an abstract was reviewed in addition to author and title selection.
Language	English
Publishing date	2015-06-01
Publishing country	Turkey
Document type	Journal Article
ISSN	2149-3235
ISSN	2149-3235
DOI	10.5152/tud.2013.045
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Article: A metabolomics study: Could plasma metabolites be a guide for the prevention of tamsulosin side effects?

Akman, T C / Kadioglu, Y / Senol, O / Erkayman, B

Annales pharmaceutiques francaises

2022 Volume 81, Issue 2, Page(s) 220–232

Abstract: Background: The understanding of precision medicine, which aims for high efficacy and low toxicity in treatments, has gained more importance with omics technologies. In this study, it was aimed to reach new suggestions for low-toxicity treatment by ... ...

Abstract	Background: The understanding of precision medicine, which aims for high efficacy and low toxicity in treatments, has gained more importance with omics technologies. In this study, it was aimed to reach new suggestions for low-toxicity treatment by clarifying the relationship between tamsulosin side effects and metabolome profiles. Materials and methods: Plasma samples of control and tamsulosin-treated rats were analyzed by LC-Q-TOF/MS/MS. MS/MS data was processed in XCMS software for the identification of metabolite and metabolic pathway analysis. Data were classified with MATLAB 2019b for multivariate data analysis. 34m/z values were found to be significantly different between the drug and control groups (P≤0.01 and fold analysis≥1.5) and identified by comparing METLIN and HMDB databases. Results: According to multivariate data analysis, α-Linolenic Acid, Thiamine, Retinoic acid, 1.25-Dihydroxyvitamin D3-26.23-Lactone, L-Glutamine, L-Serine, Retinaldehyde, Sphingosine 1-phosphate, L-Lysine, 23S.25-Dihydroxyvitamin D3, Sphinganine, L-Cysteine, Uridine 5'-diphosphate, Calcidiol, L-Tryptophan, L-Alanine levels changed significantly compared to the control group. Differences in the metabolisms of Retinol, Sphingolipid, Alanine-Aspartate-Glutamate, Glutathione, Fatty Acid, Tryptophan, and biosynthesis of Aminoacyl-tRNA, and Unsaturated Fatty Acid have been successfully demonstrated by metabolic pathway analysis. According to our study, vitamin A and D supplements can be recommended to prevent side effects such as asthenia, rhinitis, nasal congestion, dizziness and IFIS in the treatment of tamsulosin. Alteration of aminoacyl-tRNA biosynthesis and sphingolipid metabolism pathways during tamsulosin treatment is effective in the occurrence of nasal congestion. Conclusions: Our study provides important information for tamsulosin therapy with high efficacy and low side effects in precision medicine.
MeSH term(s)	Rats ; Animals ; Tamsulosin ; Tandem Mass Spectrometry ; Metabolomics ; Iatrogenic Disease ; Sphingolipids ; RNA, Transfer ; Biomarkers ; Chromatography, High Pressure Liquid
Chemical Substances	Tamsulosin (G3P28OML5I) ; Sphingolipids ; RNA, Transfer (9014-25-9) ; Biomarkers
Language	English
Publishing date	2022-09-17
Publishing country	France
Document type	Journal Article
ZDB-ID	307-4
ISSN	0003-4509
ISSN	0003-4509
DOI	10.1016/j.pharma.2022.09.004
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Zs.A 223: Show issues

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Article ; Online: LC-ESI-MS/MS Chemical Characterization, Antioxidant and Antidiabetic Properties of Propolis Extracted with Organic Solvents from Eastern Anatolia Region.

Cagri Akman, Tugrul / Simsek, Samed / Kayir, Ömer / Aksit, Zeynep / Aksit, Hüseyin / Genc, Nusret

Chemistry & biodiversity

2023 Volume 20, Issue 5, Page(s) e202201189

Abstract: Geographic conditions (altitude, climate, and local flora) lead to significant differences in the chemical composition of propolis. Therefore, more research is needed for propolis in different geographical regions. So, the aim of this study was to ... ...

Abstract	Geographic conditions (altitude, climate, and local flora) lead to significant differences in the chemical composition of propolis. Therefore, more research is needed for propolis in different geographical regions. So, the aim of this study was to evaluate the phenolic profile, total phenolic content, antioxidant, and antidiabetic properties of Pülümür propolis from Turkey. Methanol (MeOH), chloroform (CHCl
MeSH term(s)	Antioxidants/chemistry ; Propolis/chemistry ; Turkey ; Tandem Mass Spectrometry ; Hypoglycemic Agents/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Solvents ; Phenols/chemistry ; Methanol
Chemical Substances	Antioxidants ; Propolis (9009-62-5) ; Hypoglycemic Agents ; Plant Extracts ; Solvents ; Phenols ; Methanol (Y4S76JWI15)
Language	English
Publishing date	2023-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202201189
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Article ; Online: Frequency of Euthyroid Sick Syndrome before and after renal transplantation in patients with end stage renal disease and its association with oxidative stress.

Akman, Tugce / Topaloglu, Oya / Altunoglu, Alparslan / Neselioglu, Salim / Erel, Ozcan

Postgraduate medicine

2021 Volume 134, Issue 1, Page(s) 52–57

Abstract: Objective: In this study, we aimed to evaluate the frequency of euthyroid sick syndrome (ESS) before and after renal transplantation in patients with end-stage renal disease (ESRD), and its association with oxidative stress (OS) by evaluating thiol- ... ...

Abstract	Objective: In this study, we aimed to evaluate the frequency of euthyroid sick syndrome (ESS) before and after renal transplantation in patients with end-stage renal disease (ESRD), and its association with oxidative stress (OS) by evaluating thiol-disulfide levels. Methods: Free triiodothyronine (fT3), free thyroxine (fT4) thyroid stimulating hormone (TSH), and thiol and disulfide levels were recorded before and after renal transplantation in patients with ESRD. ESS was diagnosed in patients with unresponsive TSH to low fT3 and/or fT4 levels. Results: A total of 121 patients were included in the study. Of these, 69 (57%) were males and 52 (43%) were females. The mean age was 45 ± 12.61 years. ESS was detected in 39 (32%) of 121 patients. Of 39 patients, 24 (61%) had ESS before transplantation and 15 (39%) after transplantation. Sixteen of 24 (66.7%) patients with ESS before transplantation reached normal thyroid functions after transplantation. In post transplantation period, patients with ESS had significantly higher urea and creatinine (p = 0.025 and p = 0.009, respectively) compared to patients without ESS. Furthermore, thiol-disulfide levels of 20 patients with ESS at any time compared with 68 patients without ESS. It was found that native thiol and total thiol were significantly lower in patients with ESS (p = 0.025 and p = 0.044, respectively). Conclusion: The present study is an initial evaluation of the OS and antioxidant status in the etiology of ESS in patients with renal transplantation. These patients have markedly low levels of antioxidant products, which support the possible role of OS in ESS.
MeSH term(s)	Adult ; Euthyroid Sick Syndromes/complications ; Euthyroid Sick Syndromes/epidemiology ; Female ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Oxidative Stress ; Thyroid Function Tests ; Thyroxine ; Triiodothyronine
Chemical Substances	Triiodothyronine (06LU7C9H1V) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2021-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	410138-8
ISSN	1941-9260 ; 0032-5481
ISSN (online)	1941-9260
ISSN	0032-5481
DOI	10.1080/00325481.2021.1994267
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Article ; Online: Therapeutic effects of syringaldehyde on spinal cord ischemia in rabbits.

Malçok, Ümit A / Aras, Adem B / Şehitoğlu, Müşerref H / Akman, Tarık / Yüksel, Yasemin

Saudi medical journal

2020 Volume 41, Issue 4, Page(s) 341–350

Abstract: ... Şehitoğlu MH, Akman T, Yüksel Y. Therapeutic effects of syringaldehyde on spinal cord ischemia in rabbits ...

Abstract	Objectives: To investigate the effects of syringaldehyde (SA) on the antioxidant and oxidant system in spinal cord ischemia (SCI). Methods: These study and experiments were conducted at Medical Research Center, Çanakkale Onsekiz Mart University, Çanakkale, Turkey, between 2014-2018. Eighteen New Zealand White adult male rabbits were randomly divided into 3 groups (n=6). Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), myeloperoxidase (MPO) activities, and malondialdehyde (MDA) levels were measured in the spinal cord tissues. Degenerated neurons, hemorrhage and in ammatory cell migration in the spinal cord were investigated histopathologically. Expressions of neuronal nitric oxide synthase (nNOS), caspase-3, and nuclear factor-κB (NF-κB) were evaluated immunohistochemically. Clinically, it was evaluated with modified Tarlov score. Results: Biochemically, there was an expected decrease in SOD, CAT, and GPx enzyme activities in ischemia groups, there was also an increase in MPO activity at the same time. When the enzyme activities spinal cord ischemia/ reperfusion (SCI/R)+SA, control and SCI/R groups were compared, the difference was found to be statistically significant (p less than 0.05). Glutathione peroxidase enzyme activity levels were very low in ischemia group compared to the significant increase in the SA group (p less than 0.05). Histopathologically, when SCI/R and SCI/R+SA groups were compared, there were statistically significant differences in the number of degenerative neurons and amount of hemorrhage; this comparison shows the significance of treatment in terms of inflammatory cell migration (p less than 0.05). The expressions of nNOS, caspase-3, and NF-κB were found significantly increased in SCI/R group compared to the control group (p less than 0.05). Syringaldehyde treatment decreased nNOS, caspase-3, and NF-κB expressions immunohistochemically. Clinical evaluation showed improvement in the SA-treated group. Conclusion: Syringaldehyde therapy administered for protective purposes may reduce oxidative stress, degenerative changes and in ammatory cell migration in the ischemic spinal cord.Saudi Med J 2020; Vol. 41 (4): 341-350doi: 10.15537/smj.2020.4.24993 How to cite this article:Malçok UA, Aras AB, Şehitoğlu MH, Akman T, Yüksel Y. Therapeutic effects of syringaldehyde on spinal cord ischemia in rabbits. Saudi Med J 2020; Vol. 41: 341-350. doi: 10.15537/smj.2020.4.24993.
MeSH term(s)	Animals ; Antioxidants ; Benzaldehydes/pharmacology ; Benzaldehydes/therapeutic use ; Caspase 3/metabolism ; Cell Movement/drug effects ; Immunohistochemistry ; Inflammation ; Male ; NF-kappa B/metabolism ; Nerve Regeneration/drug effects ; Nitric Oxide Synthase/metabolism ; Oxidative Stress/drug effects ; Rabbits ; Spinal Cord Ischemia/drug therapy ; Spinal Cord Ischemia/metabolism ; Spinal Cord Ischemia/pathology ; Spinal Cord Ischemia/physiopathology
Chemical Substances	Antioxidants ; Benzaldehydes ; NF-kappa B ; syringaldehyde (2ZR01KTT21) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2020-04-10
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	392302-2
ISSN	1658-3175 ; 0379-5284
ISSN (online)	1658-3175
ISSN	0379-5284
DOI	10.15537/smj.2020.4.24993
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Zs.B 2330: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 6: Show issues

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Article ; Online: Duration of priapism is associated with increased corporal oxidative stress and antioxidant enzymes in a rat model.

Kucukdurmaz, F / Kucukgergin, C / Akman, T / Salabas, E / Armagan, A / Seckin, S / Kadıoglu, A

Andrologia

2016 Volume 48, Issue 4, Page(s) 374–379

Abstract: Ischaemic priapism is characterised by hypoxia, hypercapnia and acidosis with resultant corporal fibrosis. Studies reported decreased erectile recovery after treatment of priapism longer than 36 h. However, a recent study revealed that half of patients ... ...

Abstract	Ischaemic priapism is characterised by hypoxia, hypercapnia and acidosis with resultant corporal fibrosis. Studies reported decreased erectile recovery after treatment of priapism longer than 36 h. However, a recent study revealed that half of patients with 3 days of priapism achieved recovery after T-shunt, although mechanism remains unclear. We aimed to investigate the effect of priapism duration on oxidative stress and antioxidant enzymes. Twenty-four male rats were divided into four groups. Group 1 served as control. Groups 2, 3 and 4 represented 1, 2 and 4 h, respectively, of priapism induced by vacuum device and rubber band placed at base of erect penis. After 30 min of reperfusion, penectomy and blood withdrawal were performed to investigate levels of malondialdehyde (MDA), protein carbonyl (PC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). Corporal MDA progressively increased with priapism duration (P = 0.01). Corporal SOD significantly differed between groups 1, 2 and 4. Also, there were significant differences in corporal GPx in groups 1 and 4 (P = 0.004) and groups 2 and 4 (P = 0.01). Corporal CAT was higher in group 4, but multivariable analysis revealed insignificant differences. Plasma MDA of the experimental groups was significantly higher than that of controls. There were no differences among groups in terms of other parameters. Increased antioxidant enzymes according to duration of priapism suggest that immediate treatment to relieve oxidative stress should be initiated in prolonged cases. However, further studies should be conducted to determine resistance mechanisms of the corpora to prolonged ischaemia.
MeSH term(s)	Animals ; Antioxidants/analysis ; Catalase/analysis ; Disease Models, Animal ; Glutathione Peroxidase/analysis ; Humans ; Ischemia/complications ; Male ; Malondialdehyde/analysis ; Oxidative Stress ; Penis/metabolism ; Priapism/blood ; Priapism/metabolism ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase/analysis
Chemical Substances	Antioxidants ; Malondialdehyde (4Y8F71G49Q) ; Catalase (EC 1.11.1.6) ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2016-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	7280-1
ISSN	1439-0272 ; 0303-4569
ISSN (online)	1439-0272
ISSN	0303-4569
DOI	10.1111/and.12455
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Article ; Online: Can Inflammatory and Nutritional Serum Markers Predict Chemotherapy Outcomes and Survival in Advanced Stage Nonsmall Cell Lung Cancer Patients?

Cehreli, Ruksan / Yavuzsen, Tugba / Ates, Halil / Akman, Tulay / Ellidokuz, Hulya / Oztop, Ilhan

BioMed research international

2019 Volume 2019, Page(s) 1648072

Abstract: Purpose. ...

Abstract	Purpose.
MeSH term(s)	Biomarkers/blood ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Female ; Humans ; Inflammation/blood ; Lung Neoplasms/blood ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Nutritional Status ; Survival Analysis ; Treatment Outcome
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2019/1648072
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Article ; Online: Beyond traditional therapies: clinical significance of complex molecular profiling in patients with advanced solid tumours-results from a Turkish multi-centre study.

Japanese journal of clinical oncology

2024 Volume 54, Issue 5, Page(s) 562–568

Abstract: Objective: The objective of this multi-centre, real-world study was to examine the potential influence of comprehensive molecular profiling on the development of treatment decisions or adjustments for patients with advanced solid malignancies. We then ... ...

Abstract	Objective: The objective of this multi-centre, real-world study was to examine the potential influence of comprehensive molecular profiling on the development of treatment decisions or adjustments for patients with advanced solid malignancies. We then evaluated the impact of these informed choices on patient treatment outcomes. Methods: The study encompassed 234 adult patients (mean age: 52.7 ± 14.3 years, 54.7% women) who were diagnosed with solid tumours at 21 different medical centres in Turkey. Remarkably, 67.9% of the patients exhibited metastasis at the time of diagnosis. We utilized an OncoDNA (Gosselies, Belgium) platform (OncoDEEP) integrating next-generation sequencing with additional tests to harvest complex molecular profiling data. The results were analyzed in relation with two specific outcomes: (i) the impact on therapeutic decisions, including formulation or modifications, and (ii) associated treatment response. Results: Out of the 228 patients with final molecular profiling results, 118 (50.4%) had their treatment modified, whilst the remaining 110 (47.0%) did not. The response rates were comparable, with 3.9 versus 3.4% for complete response, 13.6 versus 29.3% for partial response, 66.9 versus 51.7% for progressive disease and 15.5 versus 15.5% for stable disease for treatments informed and not informed by complex molecular profiling, respectively (P = 0.16). Conclusion: Our real-world findings highlight the significant impact of complex molecular profiling on the treatment decisions made by oncologists for a substantial portion of patients with advanced solid tumours. Regrettably, no significant advantage was detected in terms of treatment response or disease control rates.
MeSH term(s)	Humans ; Female ; Male ; Middle Aged ; Neoplasms/genetics ; Neoplasms/pathology ; Turkey ; Adult ; Aged ; High-Throughput Nucleotide Sequencing ; Gene Expression Profiling ; Biomarkers, Tumor/genetics ; Precision Medicine ; Treatment Outcome ; Clinical Relevance
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyae002
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