Article ; Online: Early-Onset Colorectal Cancer in Egypt: Pathological Characters, Patterns of Care, and Survival Compared to Average-Age Onset Colorectal Cancer: A Retrospective Multicenter Study.
JCO global oncology
2024 Volume 10, Page(s) e2300372
Abstract: Purpose: Early-onset colorectal cancer (EOCRC) is a rising health problem. The incidence of EOCRC has increased over the past 2 decades all over the world. Reports from Egypt since the 1990s have reported a higher incidence among young populations with ... ...
| Abstract | Purpose: Early-onset colorectal cancer (EOCRC) is a rising health problem. The incidence of EOCRC has increased over the past 2 decades all over the world. Reports from Egypt since the 1990s have reported a higher incidence among young populations with no identifiable risk factors. The aim of this study was to assess EOCRC in Egypt regarding incidence, characteristics, treatment pattern, and survival compared with average age onset and elderly patients. Materials and methods: This was a retrospective, record-based, cohort study combining data from four different cancer centers in Egypt. We grouped patients according to age into three categories: the EOCRC group for patients age ≤45 years and the average age onset and elderly cancer group (for patients age ≥65 years). Results: The study included 1,310 patients with histopathologically proven colorectal cancer, representing four different geographical areas in Egypt. Patients with EOCRC represented 42.4% of the study population. Female patients were 50.6% among the EOCRC group and 52.5% among the average age group. Rectal tumors were significantly higher in EOCRC (54.7% Conclusion: A comprehensive framework for the study of EOCRC is required in Egypt as well as a genomic analysis to identify possible underlying genetic alterations responsible for the high incidence of EOCRC. |
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| MeSH term(s) | Aged ; Humans ; Female ; Middle Aged ; Cohort Studies ; Egypt/epidemiology ; Retrospective Studies ; Disease-Free Survival ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/therapy |
| Language | English |
| Publishing date | 2024-03-29 |
| Publishing country | United States |
| Document type | Multicenter Study ; Journal Article |
| ISSN | 2687-8941 |
| ISSN (online) | 2687-8941 |
| DOI | 10.1200/GO.23.00372 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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