Article ; Online: A review of the rationale for the testing of the calcineurin inhibitor tacrolimus for post-ERCP pancreatitis prevention.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.
2022 Volume 22, Issue 6, Page(s) 678–682
Abstract: Endoscopic retrograde cholangiopancreatography (ERCP) is commonly performed for the management of pancreaticobiliary disorders. The most troublesome ERCP-associated adverse event is post-ERCP pancreatitis (PEP), which occurs in up to 15% of all patients ... ...
| Abstract | Endoscopic retrograde cholangiopancreatography (ERCP) is commonly performed for the management of pancreaticobiliary disorders. The most troublesome ERCP-associated adverse event is post-ERCP pancreatitis (PEP), which occurs in up to 15% of all patients undergoing ERCP. A substantial body of preclinical data support a mechanistic rationale for calcineurin inhibitors in preventing PEP. The findings are coupled with recent clinical data suggesting lower rates of PEP in patients who concurrently use the calcineurin inhibitor tacrolimus (e.g., solid organ transplant recipients). In this review, we will firstly summarize data in support of testing the use of tacrolimus for PEP prophylaxis, either in combination with rectal indomethacin or by itself. Secondly, we propose that administering tacrolimus through the rectal route could be favorable for PEP prophylaxis over other routes of administration. |
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| MeSH term(s) | Administration, Rectal ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Calcineurin Inhibitors/therapeutic use ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Humans ; Pancreatitis/drug therapy ; Pancreatitis/etiology ; Pancreatitis/prevention & control ; Risk Factors ; Tacrolimus/therapeutic use |
| Chemical Substances | Anti-Inflammatory Agents, Non-Steroidal ; Calcineurin Inhibitors ; Tacrolimus (WM0HAQ4WNM) |
| Language | English |
| Publishing date | 2022-07-13 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2056680-3 |
| ISSN | 1424-3911 ; 1424-3903 |
| ISSN (online) | 1424-3911 |
| ISSN | 1424-3903 |
| DOI | 10.1016/j.pan.2022.07.003 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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