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Article ; Online: Great Hospitals of Central Asia: The Kazakhstan National Centre for Neurosurgery.

Akshulakov, Serik

2023 Volume 183, Page(s) 58–62

Abstract: Background: This paper aimed to describe the National Centre for Neurosurgery, the only specialized hospital in the treatment of neurological diseases in Kazakhstan and the leading neurosurgical hospital in Central Asia.: Methods: Historical data ... ...

Abstract	Background: This paper aimed to describe the National Centre for Neurosurgery, the only specialized hospital in the treatment of neurological diseases in Kazakhstan and the leading neurosurgical hospital in Central Asia. Methods: Historical data were collected from the archive materials of the National Centre for Neurosurgery. Results: The paper outlines the achievements of the Centre in providing neurosurgical care to the population over the past 15 years, commencing with its establishment in 2008. During this period, there has been a 2.3-fold increase in the number of neurosurgeons at the Centre, accompanied by a significant seven-fold rise in the number of surgeries conducted. Additionally, the Centre has hosted international conferences and educational programs in collaboration with the Asian Congress of Neurological Surgeons and the European Association of Neurosurgical Societies. Throughout the last 15 years, more than 70 treatment techniques were introduced, and subsequent technology transfer initiatives extended these methods to regions within the country. Conclusions: The National Centre for Neurosurgery has achieved remarkable progress in delivering patient-centered neurosurgical care, rehabilitation programs, and innovative treatments, supported by state funding, benefitting patients across Central Asia.
MeSH term(s)	Humans ; Neurosurgery ; Kazakhstan ; Neurosurgical Procedures ; Neurosurgeons ; Hospitals
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.12.044
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Article: A case report of multi-step management of extracranial carotid artery aneurysm and carotid-cavernous fistula combination in patients.

Nurimanov, Chingiz / Makhambetov, Yerbol / Kaliyev, Assylbek / Akshulakov, Serik

Frontiers in neurology

2023 Volume 14, Page(s) 1120786

Abstract: Extracranial carotid artery aneurysms (ECAA) and carotid-cavernous fistulas (CCF) are rare arterial pathologies with severe complications and increased risk of mortality. The optimal treatment approach for this combined condition is a topic of debate ... ...

Abstract	Extracranial carotid artery aneurysms (ECAA) and carotid-cavernous fistulas (CCF) are rare arterial pathologies with severe complications and increased risk of mortality. The optimal treatment approach for this combined condition is a topic of debate among neurosurgeons and neuroradiologists, and a standardized treatment protocol has yet to be established. The aim of this case report was to demonstrate the management of a rare combination of ECAA and CCF in patients. The treatment strategy included a two-step procedure of endovascular embolization of CCF followed by dual antiplatelet therapy and endovascular stenting of an aneurysm. Control angiograms showed the exclusion of an aneurysm from the blood circulation and CCF symptoms were resolved.
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1120786
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Article ; Online: An Uncommon Case of Moyamoya Syndrome Is Accompanied by an Arteriovenous Malformation with the Involvement of Dural Arteries.

Nurimanov, Chingiz / Mammadinova, Iroda / Makhambetov, Yerbol / Akshulakov, Serik

International journal of molecular sciences

2023 Volume 24, Issue 6

Abstract: 1) Background: This report describes the surgical management of a case of concurrent AVM with the involvement of dural arteries and moyamoya syndrome. Given the infrequency of this combination, there is currently no established management strategy ... ...

Abstract	(1) Background: This report describes the surgical management of a case of concurrent AVM with the involvement of dural arteries and moyamoya syndrome. Given the infrequency of this combination, there is currently no established management strategy available. (2) Case Description: A 49-year-old male patient with multiple symptoms including headaches, tinnitus, and visual impairment diagnosed with the coexistence of an arteriovenous malformation with the involvement of dural arteries and moyamoya syndrome was admitted to the national tertiary hospital. The patient underwent surgical management through embolization of the AVM from the afferents of the dural arteries, which has resulted in positive clinical outcomes. However, this approach may not be suitable for all cases, and a multidisciplinary team approach may be required to develop an individualized treatment strategy. (3) Conclusion: The contradictory nature of the treatment approaches in cases of combined AVM with the involvement of dural arteries and MMD highlights the complex nature of this condition and the need for further research to identify the most effective treatment strategies.
MeSH term(s)	Male ; Humans ; Middle Aged ; Moyamoya Disease/complications ; Moyamoya Disease/diagnosis ; Intracranial Arteriovenous Malformations/complications ; Intracranial Arteriovenous Malformations/diagnostic imaging ; Arteries ; Treatment Outcome
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24065911
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Article: The Current State of Adult Glial Tumor Patients' Care in Kazakhstan: Challenges in Diagnosis and Patterns in Survival Outcomes.

Babi, Aisha / Menlibayeva, Karashash / Bex, Torekhan / Kuandykova, Shynar / Akshulakov, Serik

Biomedicines

2023 Volume 11, Issue 3

Abstract: Background: The study aimed to analyze the 5-year survival of adult patients with glial tumors and to define characteristics that are associated with the disease outcomes in Kazakhstan.: Methods: Medical records of patients that were surgically ... ...

Abstract	Background: The study aimed to analyze the 5-year survival of adult patients with glial tumors and to define characteristics that are associated with the disease outcomes in Kazakhstan. Methods: Medical records of patients that were surgically treated at the National Center for Neurosurgery during the 5-year period from 2016 to 2020 were collected retrospectively. Patients with a histologically confirmed diagnosis of diffuse astrocytic or oligodendroglial tumor type were included and their survival was assessed with life tables, Kaplan-Meier plot, and Cox regression using STATA 16 statistical software. Results: Almost half of the patients had glioblastoma. The 5-year survival rate of the whole sample was 45.93%. Among Grade 4 patients, 15.6% survived the 5-year mark. Differences in survival between grades 1-3 were not significant. Grade 1 patients demonstrated worse survival rates compared to Grade 2 patients (69% vs. 74%). Worse survival rates were observed among patients of Russian ethnicity and in rural residents. Conclusions: The study described the unusual patterns in survival rates of glial tumor patients in Kazakhstan, pointing to the need for reassessment of diagnostic accuracy and resulting treatment of glial patients in Kazakhstan, and the need to introduce molecular and genetic parameters in tumor type classification. Moreover, the observed difference in survival of different ethnic groups and residents of rural and urban areas should be further investigated and addressed by healthcare professionals.
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11030886
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Article ; Online: Challenges in Neurosurgery During the COVID-19 Pandemic: The Experience of Kazakhstan.

Menlibayeva, Karashash / Babi, Aisha / Makhambetov, Yerbol / Akshulakov, Serik

World neurosurgery

2022 Volume 161, Page(s) e376–e383

Abstract: Background: The practice of neurosurgery has been profoundly affected by the coronavirus disease 2019 (COVID-19) pandemic in Kazakhstan. Many elective surgeries were postponed or canceled, which resulted in difficulties in hospitalization. In the ... ...

Abstract	Background: The practice of neurosurgery has been profoundly affected by the coronavirus disease 2019 (COVID-19) pandemic in Kazakhstan. Many elective surgeries were postponed or canceled, which resulted in difficulties in hospitalization. In the present study, we aimed to describe the effects of COVID-19 on neurosurgical practice and to determine whether a discrepancy was present in the effects between metropolises and regional cities in Kazakhstan. Methods: We performed an electronic internet-based survey among Kazakhstan's neurosurgeons using the virtual snowball sampling method. The invitation link to complete the questionnaire was sent to neurosurgeons through personal and corporate electronic mail and social networks. The data were analyzed using Excel and Stata. Results: A total of 43 neurosurgeons completed the survey. The distribution of regional and urban respondents was almost equal. The male neurosurgeons outnumbered the female neurosurgeons (93.02% vs. 6.98%). A decrease in consultations (65.34% ± 28.24%) and surgeries (56.55% ± 26.34%) had been observed by all neurosurgeons, regardless of city type. However, the proportion of neurosurgeons who had attended online educational courses during the pandemic was significantly higher (P = 0.001) for the surgeons from major cities (68.18%) compared with the surgeons from smaller cities (19.05%). The regional neurosurgeons tended to perform urgent surgeries on COVID-19-positive patients 3 times more often than had the metropolitan neurosurgeons (P < 0.001). Conclusions: The true effect of the pandemic remains unknown for Kazakhstan. A discrepancy between the metropolitan and regional cities was found in the present study. Efforts are required and relevant guidelines must be developed to ensure that the neurosurgical treatment of various conditions continues to be available during health emergencies and that the disparities are addressed.
MeSH term(s)	COVID-19 ; Female ; Humans ; Kazakhstan/epidemiology ; Male ; Neurosurgery ; Neurosurgical Procedures ; Pandemics
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2022.02.011
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Article: Long-Term Outcomes of Endovascular Embolization in a Vein of Galen Aneurysmal Malformation: A Single-Center Experience.

Nurimanov, Chingiz / Makhambetov, Yerbol / Menlibayeva, Karashash / Nurakay, Nurtay / Makhambetov, Nursultan / Zholdybayeva, Elena / Akshulakov, Serik

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 16

Abstract: Background: A vein of Galen aneurysmal malformation (VGAM) is a rare congenital cerebral vascular condition with a high mortality rate if left untreated. This study describes the long-term outcomes of patients with VGAM, who were treated with ... ...

Abstract	Background: A vein of Galen aneurysmal malformation (VGAM) is a rare congenital cerebral vascular condition with a high mortality rate if left untreated. This study describes the long-term outcomes of patients with VGAM, who were treated with endovascular embolization. Methods: This retrospective analysis focused on VGAM patients who underwent one or more endovascular embolization sessions between January 2008 and December 2022. The study included newborns and children under 18 years. Data encompassed clinical and demographic characteristics, types of endovascular embolization, treatment complications, mortality rates, and long-term outcomes. Results: Out of 22 VGAM cases, the majority were boys (86.36%), and the average age of the participants was 38 months, ranging from 25 days to 17 years. Endovascular embolization using liquid embolizing agents was the most common intervention (50%), and around 73% of patients underwent multiple sessions. Some patients underwent ventriculoperitoneal shunting (VPS) due to persistent hydrocephalus. In long-term outcomes, four patients (18.2%) showed developmental delays, and 16 patients (72.7%) had a positive outcome. Conclusions: Combining endovascular therapy with a comprehensive management strategy significantly reduces mortality rates and improves the possibility of normal neurological development in patients.
Language	English
Publishing date	2023-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13162704
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Article ; Online: A Rare Co-Occurrence of Maffucci Syndrome and Astrocytoma with IDH1 R132H Mutation: A Case Report.

Ashirov, Nurali / Mammadinova, Iroda / Moldabekov, Aidos / Zhetpisbaev, Berik / Teltayev, Daniyar / Ryskeldiyev, Nurzhan / Akshulakov, Serik

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 6

Abstract: ... ...

Abstract	Background
MeSH term(s)	Humans ; Enchondromatosis/complications ; Enchondromatosis/genetics ; Enchondromatosis/pathology ; Mutation ; Astrocytoma/complications ; Astrocytoma/genetics ; Genetic Testing ; Isocitrate Dehydrogenase/genetics ; Brain Neoplasms/complications ; Brain Neoplasms/genetics
Chemical Substances	Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.)
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59061056
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Article: Role of the Asian Congress of Neurological Surgeons in neurosurgery development of Kazakhstan.

Akshulakov, Serik

Asian journal of neurosurgery

2012 Volume 7, Issue 3, Page(s) 107–108

Language	English
Publishing date	2012-12-28
Publishing country	India
Document type	Journal Article
ZDB-ID	2621446-5
ISSN	2248-9614 ; 1793-5482
ISSN (online)	2248-9614
ISSN	1793-5482
DOI	10.4103/1793-5482.103702
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Article: Targeting Heat Shock Proteins in Malignant Brain Tumors: From Basic Research to Clinical Trials.

Babi, Aisha / Menlibayeva, Karashash / Bex, Torekhan / Doskaliev, Aidos / Akshulakov, Serik / Shevtsov, Maxim

Cancers

2022 Volume 14, Issue 21

Abstract: Heat shock proteins (HSPs) are conservative and ubiquitous proteins that are expressed both in prokaryotic and eukaryotic organisms and play an important role in cellular homeostasis, including the regulation of proteostasis, apoptosis, autophagy, ... ...

Abstract	Heat shock proteins (HSPs) are conservative and ubiquitous proteins that are expressed both in prokaryotic and eukaryotic organisms and play an important role in cellular homeostasis, including the regulation of proteostasis, apoptosis, autophagy, maintenance of signal pathways, protection from various stresses (e.g., hypoxia, ionizing radiation, etc.). Therefore, HSPs are highly expressed in tumor cells, including malignant brain tumors, where they also associate with cancer cell invasion, metastasis, and resistance to radiochemotherapy. In the current review, we aimed to assess the diagnostic and prognostic values of HSPs expression in CNS malignancies as well as the novel treatment approaches to modulate the chaperone levels through the application of inhibitors (as monotherapy or in combination with other treatment modalities). Indeed, for several proteins (i.e., HSP10, HSPB1, DNAJC10, HSPA7, HSP90), a direct correlation between the protein level expression and poor overall survival prognosis for patients was demonstrated that provides a possibility to employ them as prognostic markers in neuro-oncology. Although small molecular inhibitors for HSPs, particularly for HSP27, HSP70, and HSP90 families, were studied in various solid and hematological malignancies demonstrating therapeutic potential, still their potential was not yet fully explored in CNS tumors. Some newly synthesized agents (e.g., HSP40/DNAJ inhibitors) have not yet been evaluated in GBM. Nevertheless, reported preclinical studies provide evidence and rationale for the application of HSPs inhibitors for targeting brain tumors.
Language	English
Publishing date	2022-11-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14215435
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Article ; Online: Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary.

Medetov, Yerkin / Babi, Aisha / Makhambetov, Yerbol / Menlibayeva, Karashash / Bex, Torekhan / Kaliyev, Assylbek / Akshulakov, Serik

BMC neurology

2022 Volume 22, Issue 1, Page(s) 357

Abstract: Background: Rupture of intracranial aneurysms (RIA) leads to subarachnoid hemorrhage (SAH) with severe consequences. Although risks for RIA are established, the results vary between ethnic groups and were never studied in Kazakhstan. This study aimed to ...

Abstract	Background: Rupture of intracranial aneurysms (RIA) leads to subarachnoid hemorrhage (SAH) with severe consequences. Although risks for RIA are established, the results vary between ethnic groups and were never studied in Kazakhstan. This study aimed to establish the risk factors of RIA in the Kazakh population. METHODS: Retrospective analysis of 762 patients with single IAs, who attended the neurosurgical center from 2008 until 2018, was conducted. Demographic characteristics, such as age, sex, smoking status, and hypertension were considered. Descriptive and bivariate analyses were performed. A multivariable logistic regression model was built to identify factors correlated with RIA. Results: The mean age of participants was 48.49 ± 0.44 years old. The majority (68.37%) of IAs have ruptured. Of the ruptured aneurysms, 43.76% were < 6 mm, and 38.39% were located on the anterior cerebral and anterior communicating arteries (ACA). Logistic regression model indicates younger age group (16-40 years), smoking, having stage 3 hypertension, smaller IA size and its location on ACA increase the odds of rupture. Conclusions: This study has revealed that younger, smoking patients with stage 3 arterial hypertension are at higher risk for RIA. Small aneurysms (< 6 mm) and location on ACA had increased odds of rupture, while larger aneurysms on internal carotid arteries had lower odds.
MeSH term(s)	Adolescent ; Adult ; Aneurysm, Ruptured/epidemiology ; Aneurysm, Ruptured/surgery ; China ; Humans ; Hypertension/complications ; Hypertension/epidemiology ; Intracranial Aneurysm/epidemiology ; Intracranial Aneurysm/surgery ; Middle Aged ; Retrospective Studies ; Risk Factors ; Young Adult
Language	English
Publishing date	2022-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2041347-6
ISSN	1471-2377 ; 1471-2377
ISSN (online)	1471-2377
ISSN	1471-2377
DOI	10.1186/s12883-022-02892-y
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