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  1. Article ; Online: Impact of pharmacist-led educational intervention on pneumococcal vaccination rates in cancer patients: a randomized controlled study.

    Ozdemir, Nesligul / Aktas, Burak Y / Gulmez, Ahmet / Inkaya, Ahmet C / Bayraktar-Ekincioglu, Aygin / Kilickap, Saadettin / Unal, Serhat

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 31, Issue 3, Page(s) 194

    Abstract: Purpose: This study aimed to evaluate clinical pharmacist's contribution to the pneumococcal vaccination rate by providing education to cancer patients in hospital settings.: Methods: This study was conducted in 2 tertiary-care hospitals' medical ... ...

    Abstract Purpose: This study aimed to evaluate clinical pharmacist's contribution to the pneumococcal vaccination rate by providing education to cancer patients in hospital settings.
    Methods: This study was conducted in 2 tertiary-care hospitals' medical oncology outpatient clinics. Patients over 18 years of age and diagnosed with cancer for less than 2 years, in remission stage, and have not previously received the pneumococcal vaccine were included. Patients were randomized to intervention and control groups. The intervention group was provided vaccination education and recommended to receive the PCV13 vaccine. The control group received routine care. Patients' knowledge about pneumonia/pneumococcal vaccine, Vaccine Attitude Examination Scale (VAX) score, and vaccination rates were evaluated at baseline and 3 months after the education.
    Results: A total of 235 patients (intervention: 117, control: 118) were included. The mean age ± SD was 57.86 ± 11.88 years in the control and 60.68 ± 11.18 years in the intervention groups. The numbers of correct answers about pneumonia/pneumococcal vaccine (p = 0.482) and VAX scores (p = 0.244) of the groups were similar at baseline. After the intervention, the median (IQR) number of correct answers in intervention group [10(3)] was higher than control group [8(4)] (p < 0.001). After the education, the total VAX score (mean ± SD) was less in intervention group (33.09 ± 7.018) than the control group (36.07 ± 6.548) (p = 0.007). Three months after the education, 20.2% of the patients in the intervention and 6.1% in the control groups were vaccinated with pneumococcal vaccine (p = 0.003).
    Conclusions: The pneumococcal vaccination rate in cancer patients has increased significantly by the education provided by a clinical pharmacist in hospital settings.
    MeSH term(s) Humans ; Adolescent ; Adult ; Pharmacists ; Research Design ; Vaccination ; Neoplasms ; Pneumococcal Vaccines
    Chemical Substances Pneumococcal Vaccines
    Language English
    Publishing date 2023-03-01
    Publishing country Germany
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-023-07652-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Vitamin D Supplementation and Prevention of Type 2 Diabetes.

    Aktaş, Burak Y / Öztürk Aktaş, Özge

    The New England journal of medicine

    2019  Volume 381, Issue 18, Page(s) 1784

    MeSH term(s) Diabetes Mellitus, Type 2 ; Dietary Supplements ; Humans ; Vitamin D ; Vitamin D Deficiency
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2019-10-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1912185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer.

    Aktas, Burak Y / Taban, Hakan / Aksoy, Sercan

    The New England journal of medicine

    2019  Volume 380, Issue 10, Page(s) 985–986

    MeSH term(s) Albumins ; Antibodies, Monoclonal ; Humans ; Paclitaxel ; Triple Negative Breast Neoplasms
    Chemical Substances 130-nm albumin-bound paclitaxel ; Albumins ; Antibodies, Monoclonal ; atezolizumab (52CMI0WC3Y) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2019-02-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1900150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Complete responses to two different anti-PD1 agents in a metastatic melanoma patient.

    Kilickap, Saadettin / Guven, Deniz C / Aktepe, Oktay H / Aktas, Burak Y / Dizdar, Omer

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2019  Volume 26, Issue 2, Page(s) 496–499

    Abstract: In the last decade, immune checkpoint inhibitors changed the landscape of metastatic melanoma. However, the optimal duration of treatment and treatment cessation in responders is largely unknown. Herein, we represent a heavily pretreated metastatic ... ...

    Abstract In the last decade, immune checkpoint inhibitors changed the landscape of metastatic melanoma. However, the optimal duration of treatment and treatment cessation in responders is largely unknown. Herein, we represent a heavily pretreated metastatic melanoma case who had a complete response to pembrolizumab and also a complete response with nivolumab after progression during drug-free follow-up. We think that reinduction with a different anti-PD1 antibody may be used in patients with metastatic melanoma responders. Clinical trials with prespecified sequential treatment protocols and large real-life data can further delineate this subject.
    MeSH term(s) Antibodies, Monoclonal, Humanized/administration & dosage ; Antineoplastic Agents, Immunological/administration & dosage ; Female ; Humans ; Melanoma/diagnosis ; Melanoma/drug therapy ; Middle Aged ; Neoplasms, Second Primary/diagnosis ; Neoplasms, Second Primary/drug therapy ; Nivolumab/administration & dosage ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Remission Induction ; Skin Neoplasms/diagnosis ; Skin Neoplasms/drug therapy ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Immunological ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor ; Nivolumab (31YO63LBSN) ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2019-06-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/1078155219858657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lower prognostic nutritional index is associated with poorer survival in patients receiving immune checkpoint inhibitors.

    Guven, Deniz C / Aktepe, Oktay H / Taban, Hakan / Aktas, Burak Y / Guner, Gurkan / Yildirim, Hasan C / Sahin, Taha K / Aksun, Melek S / Dizdar, Omer / Aksoy, Sercan / Erman, Mustafa / Yalcin, Suayib / Kilickap, Saadettin

    Biomarkers in medicine

    2021  Volume 15, Issue 13, Page(s) 1123–1130

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy/methods ; Kaplan-Meier Estimate ; L-Lactate Dehydrogenase/metabolism ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Nutrition Assessment ; Prognosis ; Retrospective Studies ; Young Adult
    Chemical Substances Biomarkers, Tumor ; Immune Checkpoint Inhibitors ; L-Lactate Dehydrogenase (EC 1.1.1.27)
    Language English
    Publishing date 2021-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2020-0674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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