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Article ; Online: Effect of ASP8062 on morphine self-administration and morphine-induced respiratory suppression in monkeys.

Akuzawa, Shinobu / Irie, Megumi / Kanki, Masayuki / Shirakawa, Takafumi / Sato, Yuichiro

2023 Volume 151, Issue 4, Page(s) 171–176

Abstract: ASP8062 is an orally available ... ...

Abstract	ASP8062 is an orally available GABA
MeSH term(s)	Animals ; Morphine ; Macaca fascicularis ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Dose-Response Relationship, Drug
Chemical Substances	Morphine (76I7G6D29C) ; ASP8062
Language	English
Publishing date	2023-02-15
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1016/j.jphs.2023.02.003
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Article ; Online: A novel GABA

Murai, Nobuhito / Kondo, Yuji / Akuzawa, Shinobu / Mihara, Takuma / Shiraishi, Nobuyuki / Kakimoto, Shuichiro / Matsumoto, Mitsuyuki

European journal of pharmacology

2019 Volume 865, Page(s) 172750

Abstract: The gamma-aminobutyric acid type B ( ... ...

Abstract	The gamma-aminobutyric acid type B (GABA
MeSH term(s)	Allosteric Regulation ; Analgesics/therapeutic use ; Animals ; Calcium/metabolism ; Disease Models, Animal ; Electroencephalography/drug effects ; Fibromyalgia/chemically induced ; Fibromyalgia/drug therapy ; HEK293 Cells ; Humans ; Male ; Morpholines/therapeutic use ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/physiology ; Myalgia/chemically induced ; Myalgia/drug therapy ; Pyrimidines/therapeutic use ; Rats, Sprague-Dawley ; Receptors, GABA-B/metabolism ; Reserpine ; Sleep/drug effects ; Sleep/physiology ; gamma-Aminobutyric Acid/pharmacology
Chemical Substances	ASP8062 ; Analgesics ; Morpholines ; Pyrimidines ; Receptors, GABA-B ; gamma-Aminobutyric Acid (56-12-2) ; Reserpine (8B1QWR724A) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2019-10-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2019.172750
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Article: Synthesis and structure–activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT₂B and 5-HT₇ receptor antagonists

Moritomo, Ayako / Yamada, Hiroyoshi / Watanabe, Toshihiro / Itahana, Hirotsune / Akuzawa, Shinobu / Okada, Minoru / Ohta, Mitsuaki

Bioorganic & medicinal chemistry. 2013 Dec. 15, v. 21, no. 24

2013

Abstract: To identify potent dual 5-HT₂B and 5-HT₇ receptor antagonists, we synthesized a series of novel carbonyl guanidine derivatives and examined their structure–activity relationships. Among these compounds, N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (10) ... ...

Abstract	To identify potent dual 5-HT₂B and 5-HT₇ receptor antagonists, we synthesized a series of novel carbonyl guanidine derivatives and examined their structure–activity relationships. Among these compounds, N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (10) had a good in vitro profile, that is, potent affinity for human 5-HT₂B and 5-HT₇ receptor subtypes (Kᵢ=1.8nM and Kᵢ=17.6nM, respectively) and high selectivity over 5-HT₂A, 5-HT₂C, α₁, D₂ and M₁ receptors. Compound 10 also showed a suppressing effect on 5-HT-induced dural protein extravasation in guinea pigs when orally administered.
Keywords	antagonists ; guinea pigs ; humans ; oral administration ; receptors ; structure-activity relationships
Language	English
Dates of publication	2013-1215
Size	p. 7841-7852.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2013.10.010
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT₂B and 5-HT₇ receptor antagonists. Part 2.

Moritomo, Ayako / Yamada, Hiroyoshi / Watanabe, Toshihiro / Itahana, Hirotsune / Koga, Yuji / Akuzawa, Shinobu / Okada, Minoru

Bioorganic & medicinal chemistry

2014 Volume 22, Issue 15, Page(s) 4323–4337

Abstract: We previously reported that the novel dual 5-HT₂B and 5-HT7 receptor antagonist N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (4) exerted a suppressing effect on 5-HT-induced dural protein extravasation in guinea pigs. To develop a synthetic strategy, we ...

Abstract	We previously reported that the novel dual 5-HT₂B and 5-HT7 receptor antagonist N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (4) exerted a suppressing effect on 5-HT-induced dural protein extravasation in guinea pigs. To develop a synthetic strategy, we performed docking studies of lead compound 4 bound to 5-HT₂B and 5-HT₇ receptors, and observed that the carbonyl guanidine group forms a tight interaction network with an active center Asp (D135:5-HT2B, D162:5-HT₇), Tyr (Y370:5-HT₂B, Y374:5-HT₇) and aromatic residue (W131:5-HT2B, F158:5-HT₇). Based on molecular modeling results, we optimized the substituents at the 5- to 8-position and 9-position of the fluorene ring and identified N-(diaminomethylene)-9-hydroxy-9-methyl-9H-fluorene-2-carboxamide (24a) exhibits potent affinity for 5-HT₂B (Ki=4.3 nM) and 5-HT7 receptor (Ki=4.3 nM) with high selectivity over 5-HT₂A, 5-HT₂C, α₁, D₂ and M₁ receptors. Compound 24a reversed the hypothermic effect of 5-carboxamidotryptamine (5-CT) in mice and also showed a suppressing effect on 5-HT-induced dural protein extravasation in guinea pigs when orally administered at 30 mg/kg. Compound 24a is therefore a promising candidate for a novel class of anti-migraine agent without any adverse effects.
MeSH term(s)	Administration, Oral ; Animals ; Binding Sites ; Body Temperature/drug effects ; CHO Cells ; Cricetinae ; Cricetulus ; Guanidine/analogs & derivatives ; Guanidine/chemical synthesis ; Guanidine/pharmacokinetics ; Guinea Pigs ; HEK293 Cells ; Humans ; Hypothermia, Induced ; Male ; Mice ; Molecular Docking Simulation ; Protein Binding ; Protein Structure, Tertiary ; Receptor, Serotonin, 5-HT2B/chemistry ; Receptor, Serotonin, 5-HT2B/genetics ; Receptor, Serotonin, 5-HT2B/metabolism ; Receptors, Serotonin/chemistry ; Receptors, Serotonin/genetics ; Receptors, Serotonin/metabolism ; Serotonin/analogs & derivatives ; Serotonin/pharmacology ; Serotonin Antagonists/chemical synthesis ; Serotonin Antagonists/chemistry ; Serotonin Antagonists/pharmacokinetics ; Structure-Activity Relationship
Chemical Substances	Receptor, Serotonin, 5-HT2B ; Receptors, Serotonin ; Serotonin Antagonists ; serotonin 7 receptor ; Serotonin (333DO1RDJY) ; 5-carboxamidotryptamine (91H76044O0) ; Guanidine (JU58VJ6Y3B)
Language	English
Publishing date	2014-08-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2014.05.027
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Article ; Online: Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists.

Moritomo, Ayako / Yamada, Hiroyoshi / Watanabe, Toshihiro / Itahana, Hirotsune / Akuzawa, Shinobu / Okada, Minoru / Ohta, Mitsuaki

Bioorganic & medicinal chemistry

2013 Volume 21, Issue 24, Page(s) 7841–7852

Abstract: To identify potent dual 5-HT2B and 5-HT7 receptor antagonists, we synthesized a series of novel carbonyl guanidine derivatives and examined their structure-activity relationships. Among these compounds, N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (10) ... ...

Abstract	To identify potent dual 5-HT2B and 5-HT7 receptor antagonists, we synthesized a series of novel carbonyl guanidine derivatives and examined their structure-activity relationships. Among these compounds, N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (10) had a good in vitro profile, that is, potent affinity for human 5-HT2B and 5-HT7 receptor subtypes (Ki=1.8 nM and Ki=17.6 nM, respectively) and high selectivity over 5-HT2A, 5-HT2C, α1, D2 and M1 receptors. Compound 10 also showed a suppressing effect on 5-HT-induced dural protein extravasation in guinea pigs when orally administered.
MeSH term(s)	Dose-Response Relationship, Drug ; Guanidine/analogs & derivatives ; Guanidine/chemistry ; Guanidine/pharmacology ; Humans ; Molecular Structure ; Receptor, Serotonin, 5-HT2B/metabolism ; Receptors, Serotonin/metabolism ; Serotonin Antagonists/chemical synthesis ; Serotonin Antagonists/chemistry ; Serotonin Antagonists/pharmacology ; Structure-Activity Relationship
Chemical Substances	Receptor, Serotonin, 5-HT2B ; Receptors, Serotonin ; Serotonin Antagonists ; serotonin 7 receptor ; Guanidine (JU58VJ6Y3B)
Language	English
Publishing date	2013-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2013.10.010
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Article ; Online: Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists.

Moritomo, Ayako / Yamada, Hiroyoshi / Matsuzawa-Nomura, Takaho / Watanabe, Toshihiro / Itahana, Hirotsune / Oku, Makoto / Akuzawa, Shinobu / Okada, Minoru

Bioorganic & medicinal chemistry

2014 Volume 22, Issue 21, Page(s) 6026–6038

Abstract: A series of 9-disubstituted N-(9H-fluorene-2-carbonyl)guanidine derivatives have been discovered as potent and orally active dual 5-HT(2B) and 5-HT(7) receptor antagonists. Upon screening several compounds, N-(diaminomethylene)-4',5'-dihydro-3'H-spiro[ ... ...

Abstract	A series of 9-disubstituted N-(9H-fluorene-2-carbonyl)guanidine derivatives have been discovered as potent and orally active dual 5-HT(2B) and 5-HT(7) receptor antagonists. Upon screening several compounds, N-(diaminomethylene)-4',5'-dihydro-3'H-spiro[fluorene-9,2'-furan]-2-carboxamide (17) exhibited potent affinity for both 5-HT(2B) (Ki = 5.1 nM) and 5-HT(7) (K(i) = 1.7 nM) receptors with high selectivity over 5-HT(2A), 5-HT(2C), α(1), D(2) and M(1) receptors. Optical resolution of the intermediate carboxylic acid 16 via the formation of diastereomeric salts using chiral alkaloids gave the optically pure compounds (R)-17 and (S)-17. Both enantiomers suppressed 5-HT-induced dural protein extravasation in guinea pigs in a dose-dependent manner and the amount of leaked protein was suppressed to near normal levels when orally administrated at 10 mg/kg. (R)-17 and (S)-17 were therefore selected as candidates for human clinical trials.
MeSH term(s)	Animals ; CHO Cells ; Cricetulus ; Guinea Pigs ; HEK293 Cells ; Humans ; Molecular Docking Simulation ; Receptor, Serotonin, 5-HT2B/metabolism ; Receptors, Serotonin/metabolism ; Serotonin 5-HT2 Receptor Antagonists/chemical synthesis ; Serotonin 5-HT2 Receptor Antagonists/chemistry ; Serotonin 5-HT2 Receptor Antagonists/pharmacology ; Serotonin Antagonists/chemical synthesis ; Serotonin Antagonists/chemistry ; Serotonin Antagonists/pharmacology
Chemical Substances	Receptor, Serotonin, 5-HT2B ; Receptors, Serotonin ; Serotonin 5-HT2 Receptor Antagonists ; Serotonin Antagonists ; serotonin 7 receptor
Language	English
Publishing date	2014-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2014.09.005
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Article: Evaluation of the pharmacological profile of ramosetron, a novel therapeutic agent for irritable bowel syndrome.

Hirata, Takuya / Keto, Yoshihiro / Funatsu, Toshiyuki / Akuzawa, Shinobu / Sasamata, Masao

Journal of pharmacological sciences

2007 Volume 104, Issue 3, Page(s) 263–273

Abstract: We examined the pharmacological profile of ramosetron, a 5-HT(3)-receptor antagonist for irritable bowel syndrome with diarrhea, comparing it with those of other 5-HT(3)-receptor antagonists, alosetron and cilansetron, and the anti-diarrheal agent ... ...

Abstract	We examined the pharmacological profile of ramosetron, a 5-HT(3)-receptor antagonist for irritable bowel syndrome with diarrhea, comparing it with those of other 5-HT(3)-receptor antagonists, alosetron and cilansetron, and the anti-diarrheal agent loperamide. Ramosetron showed high affinity for cloned human and rat 5-HT(3) receptors, with K(i) values of 0.091 +/- 0.014 and 0.22 +/- 0.051 nmol/L, respectively, while its affinities for other receptors, transporters, ion channels, and enzymes were negligible. Dissociation of ramosetron from the human 5-HT(3) receptor was extremely slow (t(1/2) = 560 min), while alosetron (t(1/2) = 180 min) and cilansetron (t(1/2) = 88 min) dissociated relatively rapidly. Ramosetron competitively inhibited 5-HT-induced contraction of isolated guinea-pig colon, with pA(2) values of 8.6 (8.5 - 9.0). Ramosetron given orally also dose-dependently inhibited the von Bezold-Jarisch reflex in rats, with an ED(50) value of 1.2 (0.93 - 1.6) microg/kg. In addition, oral ramosetron dose-dependently inhibited restraint stress-induced defecation in rats, with an ED(50) value of 0.62 (0.17 - 1.2) microg/kg. In all of these experiments, the potencies of ramosetron were greater than those of alosetron, cilansetron, or loperamide. These results indicate that ramosetron is a highly potent and selective 5-HT(3)-receptor antagonist, with beneficial effects against stress-induced abnormal defecation in rats.
MeSH term(s)	Animals ; Benzimidazoles/pharmacology ; Carbazoles/pharmacology ; Carbolines/pharmacology ; Carrier Proteins/metabolism ; Colon/drug effects ; Defecation/drug effects ; Gastrointestinal Agents/pharmacology ; Guinea Pigs ; Humans ; Ion Channels/drug effects ; Ion Channels/metabolism ; Irritable Bowel Syndrome/drug therapy ; Loperamide/pharmacology ; Male ; Muscle, Smooth/drug effects ; Pyridines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Receptors, Serotonin/drug effects ; Receptors, Serotonin/metabolism ; Receptors, Serotonin, 5-HT3/drug effects ; Restraint, Physical ; Serotonin Antagonists/pharmacology ; Stress, Psychological/physiopathology ; Stress, Psychological/psychology
Chemical Substances	Benzimidazoles ; Carbazoles ; Carbolines ; Carrier Proteins ; Gastrointestinal Agents ; Ion Channels ; Pyridines ; Receptors, Serotonin ; Receptors, Serotonin, 5-HT3 ; Serotonin Antagonists ; alosetron (13Z9HTH115) ; cilansetron (2J6DQ1U5B5) ; Loperamide (6X9OC3H4II) ; ramosetron (7ZRO0SC54Y)
Language	English
Publishing date	2007-07-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1254/jphs.fp0070620
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Article: Inhibitory effects of ramosetron, a potent and selective 5-HT3-receptor antagonist, on conditioned fear stress-induced abnormal defecation and normal defecation in rats: comparative studies with antidiarrheal and spasmolytic agents.

Hirata, Takuya / Funatsu, Toshiyuki / Keto, Yoshihiro / Akuzawa, Shinobu / Sasamata, Masao / Miyata, Keiji

Journal of pharmacological sciences

2008 Volume 106, Issue 2, Page(s) 264–270

Abstract: We examined the effect of ramosetron, a potent serotonin (5-HT)(3)-receptor antagonist for irritable bowel syndrome with diarrhea, on conditioned fear stress (CFS)-induced defecation and normal (non-stressed) defecation in rats and compared ramosetron ... ...

Abstract	We examined the effect of ramosetron, a potent serotonin (5-HT)(3)-receptor antagonist for irritable bowel syndrome with diarrhea, on conditioned fear stress (CFS)-induced defecation and normal (non-stressed) defecation in rats and compared ramosetron with the antidiarrheal agent loperamide and the spasmolytic agents trimebutine and tiquizium. Ramosetron, loperamide, trimebutine, and tiquizium significantly inhibited CFS-induced defecation in a dose-dependent manner with ED(50) (95% confidence limit) values of 0.019 (0.01 - 0.028), 9.4 (4.0 - 22), 850 (520 - 2,400), and 300 (190 - 450) mg/kg, respectively. A significant effect of ramosetron on CFS-induced defecation appeared at 10 min after dosing and was sustained for 8 h. In contrast, loperamide, trimebutine, and tiquizium significantly inhibited CFS-induced defecation between 1 - 8, 1 - 4, and 1 - 8 h after administration, respectively. High doses of ramosetron did not affect normal defecation, whereas loperamide, trimebutine, and tiquizium significantly inhibited this process. In conclusion, ramosetron has potent, rapid-onset, and long-lasting inhibitory effects on CFS-induced defecation in rats, but does not influence normal defecation. The present findings indicate that ramosetron will be a useful therapeutic agent for irritable bowel syndrome with diarrhea, showing greater efficacy and safety than other antidiarrheal and spasmolytic agents.
MeSH term(s)	Animals ; Antidiarrheals/pharmacology ; Benzimidazoles/pharmacology ; Conditioning, Classical ; Defecation/drug effects ; Fear ; Irritable Bowel Syndrome/drug therapy ; Loperamide/pharmacology ; Male ; Parasympatholytics/pharmacology ; Quinolizines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Serotonin 5-HT3 Receptor Antagonists ; Serotonin Antagonists/pharmacology ; Stress, Physiological/complications ; Stress, Physiological/physiopathology ; Trimebutine/pharmacology
Chemical Substances	Antidiarrheals ; Benzimidazoles ; Parasympatholytics ; Quinolizines ; Serotonin 5-HT3 Receptor Antagonists ; Serotonin Antagonists ; Loperamide (6X9OC3H4II) ; thiaton (71731-58-3) ; ramosetron (7ZRO0SC54Y) ; Trimebutine (QZ1OJ92E5R)
Language	English
Publishing date	2008-02-19
Publishing country	Japan
Document type	Comparative Study ; Journal Article
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1254/jphs.fp0071943
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Article: Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats.

Funatsu, Toshiyuki / Takeuchi, Asako / Hirata, Takuya / Keto, Yoshihiro / Akuzawa, Shinobu / Sasamata, Masao

European journal of pharmacology

2007 Volume 573, Issue 1-3, Page(s) 190–195

Abstract: The aim of this study was to establish a pathophysiologic model of irritable bowel syndrome, and then to evaluate the pharmaceutical efficacy of ramosetron, a potent serotonin 3 (5-HT(3)) receptor antagonist, and other anti-irritable bowel syndrome ... ...

Abstract	The aim of this study was to establish a pathophysiologic model of irritable bowel syndrome, and then to evaluate the pharmaceutical efficacy of ramosetron, a potent serotonin 3 (5-HT(3)) receptor antagonist, and other anti-irritable bowel syndrome agents in this model. Rats stressed by a conditioned stress procedure exhibited marked prolongation of freezing time, an index of fear level, and an increase in the frequency of defecation (P<0.01). A corticotropin-releasing factor (CRF) antagonist, alpha-helical CRF, inhibited both defecation and freezing behavior, while the antidiarrheal loperamide inhibited defecation only. The 5-HT(3) receptor antagonists ramosetron, cilansetron and alosetron also inhibited defecation (ED(50) values: 0.012, 0.094, 0.078 mg/kg p.o., respectively) without affecting freezing behavior. Ramosetron showed longer-lasting effect on defecation than cilansetron. Stress also resulted in increases in both proximal and distal colonic transit rates. Ramosetron and other 5-HT(3) receptor antagonists at doses inhibiting stress-induced defecation also ameliorated both stress-stimulated colonic transit rates. These results suggest that ramosetron, as well as agents used for the treatment of irritable bowel syndrome with diarrhea, has beneficial effects against emotional stress-induced colonic dysfunction. Furthermore, this emotional stress model may be useful in evaluation of drugs to treat irritable bowel syndrome presenting with diarrhea.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Benzimidazoles/pharmacology ; Carbazoles/pharmacology ; Carbolines/pharmacology ; Colon/drug effects ; Colon/physiopathology ; Colonic Diseases, Functional/etiology ; Colonic Diseases, Functional/physiopathology ; Colonic Diseases, Functional/prevention & control ; Conditioning (Psychology)/drug effects ; Corticotropin-Releasing Hormone/pharmacology ; Defecation/drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Fear/drug effects ; Fear/psychology ; Gastrointestinal Transit/drug effects ; Immobilization/psychology ; Irritable Bowel Syndrome/physiopathology ; Irritable Bowel Syndrome/prevention & control ; Irritable Bowel Syndrome/psychology ; Loperamide/pharmacology ; Male ; Peptide Fragments/pharmacology ; Pyridines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Serotonin, 5-HT3/physiology ; Serotonin 5-HT3 Receptor Antagonists ; Serotonin Antagonists/pharmacology ; Stress, Psychological/complications ; Stress, Psychological/physiopathology ; Time Factors ; Treatment Outcome
Chemical Substances	Benzimidazoles ; Carbazoles ; Carbolines ; Peptide Fragments ; Pyridines ; Receptors, Serotonin, 5-HT3 ; Serotonin 5-HT3 Receptor Antagonists ; Serotonin Antagonists ; alosetron (13Z9HTH115) ; cilansetron (2J6DQ1U5B5) ; Loperamide (6X9OC3H4II) ; ramosetron (7ZRO0SC54Y) ; Corticotropin-Releasing Hormone (9015-71-8) ; corticotropin releasing hormone (9-41) (96118-75-1)
Language	English
Publishing date	2007-11-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2007.06.041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Pharmacological and clinical profile of ramosetron hydrochloride (Irribow), a novel therapeutic agent for irritable bowel syndrome with diarrhea].

Hirata, Takuya / Funatsu, Toshiyuki / Keto, Yoshihiro / Akuzawa, Shinobu / Akiho, Hiraku / Nishida, Akito / Sasamata, Masao / Miyata, Keiji

Nihon yakurigaku zasshi. Folia pharmacologica Japonica

2009 Volume 133, Issue 5, Page(s) 281–291

MeSH term(s)	Animals ; Benzimidazoles/adverse effects ; Benzimidazoles/pharmacology ; Benzimidazoles/therapeutic use ; Clinical Trials as Topic ; Diarrhea/drug therapy ; Diarrhea/etiology ; Dose-Response Relationship, Drug ; Humans ; Irritable Bowel Syndrome/drug therapy ; Irritable Bowel Syndrome/etiology ; Randomized Controlled Trials as Topic ; Serotonin 5-HT3 Receptor Antagonists ; Serotonin Antagonists/adverse effects ; Serotonin Antagonists/pharmacology ; Serotonin Antagonists/therapeutic use ; Stress, Psychological/complications
Chemical Substances	Benzimidazoles ; Serotonin 5-HT3 Receptor Antagonists ; Serotonin Antagonists ; ramosetron (7ZRO0SC54Y)
Language	Japanese
Publishing date	2009-05-01
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1097532-9
ISSN	1347-8397 ; 0015-5691
ISSN (online)	1347-8397
ISSN	0015-5691
DOI	10.1254/fpj.133.281
Database	MEDical Literature Analysis and Retrieval System OnLINE

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